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Effect Of Growth Hormone On Hippocampal Synaptic Function During Sleep Deprivation, Eun Young Kim
Effect Of Growth Hormone On Hippocampal Synaptic Function During Sleep Deprivation, Eun Young Kim
Theses, Dissertations and Capstones
Long term potentiation (LTP) in the hippocampus is considered a cellular basis of learning memory. Sleep deprivation, especially rapid eye movement (REM) sleep deprivation, impairs learning and memory as well as LTP. Since most of the previous LTP studies were conducted in the in vitro condition, the full consequences of sleep deprivation (SD) in the living animal are yet to be found. Thus, I tested hippocampal LTP in living animals after 5 days of REM sleep deprivation to determine the effect of SD in vivo. SD also disrupts growth hormone (GH) release. Recent evidence indicates that GH regulates cognitive and …