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Full-Text Articles in Medical Sciences
Gamma Motor Neurons Express Distinct Genetic Markers At Birth And Require Muscle Spindle-Derived Gdnf For Postnatal Survival, Neil A. Shneider, Meghan N. Brown, Courtney A. Smith, James Pickel, Francisco J. Alvarez
Gamma Motor Neurons Express Distinct Genetic Markers At Birth And Require Muscle Spindle-Derived Gdnf For Postnatal Survival, Neil A. Shneider, Meghan N. Brown, Courtney A. Smith, James Pickel, Francisco J. Alvarez
Neuroscience, Cell Biology & Physiology Faculty Publications
Background: Gamma motor neurons (γ-MNs) selectively innervate muscle spindle intrafusal fibers and regulate their sensitivity to stretch. They constitute a distinct subpopulation that differs in morphology, physiology and connectivity from α-MNs, which innervate extrafusal muscle fibers and exert force. The mechanisms that control the differentiation of functionally distinct fusimotor neurons are unknown. Progress on this question has been limited by the absence of molecular markers to specifically distinguish and manipulate γ-MNs. Recently, it was reported that early embryonic γ-MN precursors are dependent on GDNF. Using this knowledge we characterized genetic strategies to label developing γ-MNs based on GDNF receptor expression, …
Study Of The Four Factor Theory Of Women’S Sexual Function, Julie M. Merrell
Study Of The Four Factor Theory Of Women’S Sexual Function, Julie M. Merrell
Loma Linda University Electronic Theses, Dissertations & Projects
Tiefer, Hall, and Tavris (2002) described factors comprising four categories of female sexual function. They suggested that unique factors need to be examined to understand sexual function in women. Socio-cultural, political, or economic factors, partner and relationship factors, psychological factors, and medical factors were described as aspects of women’s lives that can be the source of sexual dysfunction. In a previous study, Merrell (2007) utilized Tiefer et al’s (2002) four factor model of sexual functioning to examine female sexual functioning looking specifically at body shame, relationship satisfaction, positive and negative affect, sexual self-schema, and overall health. Based on the results …
Effect Of Growth Hormone On Hippocampal Synaptic Function During Sleep Deprivation, Eun Young Kim
Effect Of Growth Hormone On Hippocampal Synaptic Function During Sleep Deprivation, Eun Young Kim
Theses, Dissertations and Capstones
Long term potentiation (LTP) in the hippocampus is considered a cellular basis of learning memory. Sleep deprivation, especially rapid eye movement (REM) sleep deprivation, impairs learning and memory as well as LTP. Since most of the previous LTP studies were conducted in the in vitro condition, the full consequences of sleep deprivation (SD) in the living animal are yet to be found. Thus, I tested hippocampal LTP in living animals after 5 days of REM sleep deprivation to determine the effect of SD in vivo. SD also disrupts growth hormone (GH) release. Recent evidence indicates that GH regulates cognitive and …