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Physical Sciences and Mathematics

Western University

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Full-Text Articles in Medical Sciences

Rheological Characterization Of Blood-Mimicking Fluids For Use In Particle Image Velocimetry, Anorin S. Ali Aug 2022

Rheological Characterization Of Blood-Mimicking Fluids For Use In Particle Image Velocimetry, Anorin S. Ali

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Blood-mimicking fluids (BMFs) are often used to investigate blood flow using physical replicas of vessels with cardiovascular disease. Particle image velocimetry (PIV) is used with silicone poly-dimethyl siloxane (PDMS) vascular models to visualize this flow. The challenge is creating a blood-mimicking fluid that matches the viscosity profile, viscoelasticity, and density of whole blood while also matching the refractive index (RI) of PDMS. Water-glycerol solutions are commonly used with sodium iodide (NaI) added to increase the RI without changing viscosity. However, NaI is expensive, stains easily, and turns fluids from optically clear to yellow in less than a day. Furthermore, without …


Development Of A Low Field Mri-Based Approach For Observation Of Water Penetration Into Clay: Preliminary Results, Shivam Gupta Aug 2021

Development Of A Low Field Mri-Based Approach For Observation Of Water Penetration Into Clay: Preliminary Results, Shivam Gupta

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Magnetic resonance imaging (MRI) are considered one of the most efficient and non-invasive methods of observing water content in permeable substances. MRI can visualize and quantify the movement of water in real time. In this study, MRI was used to observe the water penetration through clay. Furthermore, MRI can acquire three-dimensional data due to its radio-frequency signals from any orientation. The contrast of the images produced by MRI is a display of the fluid concentration. As such, any change in the contrast intensity is interpreted as a regional change in the concentration of fluid. This report summarizes the preliminary results …


Simulating 129-Xe Hyperpolarization, Jacob F. Abiad Aug 2021

Simulating 129-Xe Hyperpolarization, Jacob F. Abiad

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Hyperpolarized 129-Xe is an important resource in many fields of medical physics and MRI research. The physics of the efficient production of hyperpolarized 129-Xe is therefore equally worth investigation. The main process of hyperpolarizing 129-Xe is Spin Exchange Optical Pumping (SEOP) and is dependent on several physical factors that can be difficult to constantly change in a lab setting. Physical modelling of 129-Xe hyperpolarization allows for the more efficient testing of hyperpolarization physics in a wide array of experimental setups to better determine the optimal values for hyperpolarization. This research project attempted to create a working model for 129-Xe hyperpolarization …