Medical Sciences Commons^™

Activity Of An Identified Histaminergic Neuron, And Its Possible Role In Arousal Of Feeding Behavior In Semi-Intact Aplysia, Hillel J. Chiel

Faculty Scholarship

The possible functions of histaminergic neuron C2 were studied in an isolated head preparation from which it was possible to obtain intracellular recordings while the buccal mass exhibited feeding-like responses. Application of food to the lips of the isolated head preparation elicited rhythmic buccal movements that appeared to be ingestion responses, since they moved seaweed into the buccal cavity and towards the esophagus, and their frequency and regularity was similar to the ingestion responses studied in a group of intact animals. The ingestion responses of the buccal mass consisted of 2 main phases of movement of the radula from a …

An Identified Histaminergic Neuron Modulates Feeding Motor Circuitry In Aplysia, Hillel J. Chiel

Faculty Scholarship

An identified histaminergic neuron, C2, in the marine mollusk Aplysia is a complex mechanoafferent which appears to contribute to the maintenance of food arousal by means of its synaptic connections to the metacerebral cell (MCC). Because C2 also has extensive synaptic outputs to neurons other than the MCC, we studied its possible motor functions. We identified several synaptic followers of C2 and found that some were excitatory motor neurons for extrinsic muscles of the buccal mass, while others were modulatory motor neurons that inhibited contractions. In addition, we found that these neurons and other synaptic followers of C2 received powerful …

Neurological Soft Signs: Their Relationship To Psychiatric Disorder And Iq In Childhood And Adolescence, David Shaffer, Irvin Sam Schonfeld, Patricia A. O'Connor, Cornelius Stokman, Paul Trautman, Stephen Shafer, Stephen Ng

Publications and Research

Defines a neurological soft sign (NSS) as a particular form of deviant performance on a motor or sensory test in a neurological status examination. In the present study, 63 male and 26 female 17-yr-olds who had NSSs at 7 yrs of age were compared with sex- and age-matched controls with no NSSs at age 7 yrs. Data obtained on Ss included behavioral and neurological examination at age 7 yrs and psychiatric, neurologic, and IQ (e.g., WAIS) assessment at adolescence. All 6 females and 12 of the 15 males with an anxiety-withdrawal diagnosis and 13 of the 20 males with an …

Increased Metabolic Rate In X-Linked Hypophosphatemic Mice, Linda K. Vaughn, Ralph A. Meyer, M. H. Meyer

Biomedical Sciences Faculty Research and Publications

Hyp mice are a model for human X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. It has previously been observed that Hyp mice have a greater food consumption per gram body weight than do normal mice. This led to the search for some alteration in metabolism in Hyp mice. We found that oxygen consumption was significantly higher in Hyp mice than in normal C57BL/6J mice and this was accompanied by an increased percentage of cardiac output being delivered to organs of heat production (liver and skeletal muscle), to the skin, and to bone and a decreased percentage to …

Electrophysiology Of Flounder Intestinal Mucosa. I. Conductance Properties Ofthe Cellular And Paracellular Pathways, Dan R. Halm, Edward J. Krasny Jr., Raymond A. Frizzell

Neuroscience, Cell Biology & Physiology Faculty Publications

We evaluated the conductances for ion flow across the cellular and paracellular pathways of flounder intestine using microelectrode techniques and ion-replacement studies. Apical membrane conductance properties are dominated by the presence of Ba-sensitive K channels. An elevated mucosal solution K concentration, [K]_m, depolarized the apical membrane potential (ψ_a) and, at [K]_m less than 40 mM, the K dependence of ψ_a was abolished by 1-2 mM mucosal Ba. The basolateral membrane displayed Cl conductance behavior, as evidenced by depolarization of the basolateral membrane potential (ψ_b) with reduced serosal Cl concentrations, [Cl]_s. …

Electrophysiology Of Flounder Intestinal Mucosa. Ii. Relation Of The Electrical Potential Profile To Coupled Nacl Absorption, Dan R. Halm, Edward J. Krasny Jr., Raymond A. Frizzell

Neuroscience, Cell Biology & Physiology Faculty Publications

We characterized the hyperpolarization of the electrical potential profile of flounder intestinal cells that accompanies inhibition of NaCl cotransport. Several observations indicate that hyperpolarization of ψ_a and ψ_b (Δψ_a,b) results from inhibition of NaCl entry across the apical membrane: (a) the response was elicited by replacement of mucosal solution Cl or Na by nontransported ions, and (b) mucosal bumetanide or serosal cGMP, inhibitors of NaCl influx, elicited Δψ_a,b and decreased the transepithelial potential (ψ_t) in parallel. Regardless of initial values, ψ_a and ψ_b approached the equilibrium potential for K (E^{K …}

Anterior Communicating Artery Aneurysm And Vasospasm – A Computer Model [Poster Boards], G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Poster presentation boards for “Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model,” G. Austin and R. Gaskell – Storke [sic] Research Foundation, Santa Barbara, Ca. and Dept. of Neurosurgery, Univ. of S. Cal., L.A., 5 p.

Metabolism In Preimplantation Mouse Embryos, Harry M. Weitlauf, Gary L. Nieder

Neuroscience, Cell Biology & Physiology Faculty Publications

The ability of preimplantation mouse embryos to utilize glucose oxidatively is controlled, in part at least, at the level of glycolysis. Various experimental observations are reviewed that indicate the regulatory mechanism in delayed implanting blastocysts involves the classic negative allosteric feedback of high levels of ATP on phosphofructokinase while the situation in 2-cell embryos appears to be more complicated. That is, in addition to the usual negative effect of ATP and citrate on phosphofructokinase, there appears to be a modification of hexokinase that prevents phosphorylation of adequate amounts of glucose and results in low levels of fructose-6-phosphate at the 2-cell …

Digital Computer Model Of An Intracranial Aneurysm, G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Digital Computer Model of an Intracranial Aneurysm. G. Austin, R. Gaskell. Poster presentation. American Association of Neurologic Surgeons, April 8-12, 1984.

File includes Abstract, 1 pg; Presentation, 2 pg; Presentation draft, 3 pgs.

The Changes Of Cortical Blood Flow And Cortical Oxygen Tension In Focal Ischemia, K. Kaminoga, Y. Taguchi, G. Austin

The Dr. George M. Austin Neurology Research Collection

The Changes of Cortical Blood Flow and Cortical Oxygen Tension in Focal Ischemia. K. Kaminoga, M.D., Y. Taguchi, M.D., G. Austin. The Stroke Research Foundation and Department of Environmental Stress, UC-Santa Barbara, Ca. Presented at the Southern California Chapter American college of Surgeons, Santa Barbara, Calif. 28 January 1984. 2 pg.

[3 Cortical Blood Flow And Oxygenation Abstracts], Y. Taguchi, M. Kaminogo, G. Austin

The Dr. George M. Austin Neurology Research Collection

Three presentations stapled together:

The Changes of Cortical Blood Flow and Cortical Oxygen Tension in Focal Ischemia. M. Kaminoga, M.D., Y. Taguchi, G. Austin, M.D. Conference presentation. American College of Surgeon Annual Meeting, January 28, 1984. NOTE 2nd page of this abstract not present in this file. 2nd page is present in Individual presentation posted separately.

Effect of Hypoxia and Hyperoxia of NADH Redox State and Cortical PO₂ in the Rabbit. Y Taguchi, M.D.; M. Kaminogo, M.D.; G. Austin, M.D. Conference Presentation. Southern California Chapter, American College of Surgeons, Santa Barbara, Calif, January 28, 1984.

Autoregulation of Cortical …

The Effects Of Triethyltin Bromide On Red Cell And Brain Cyclic Amp-Dependent Protein Kinases, Kevin R. Siebenlist, Fumito Taketa

Biomedical Sciences Faculty Research and Publications

Triethyltin bromide activates the cyclic AMP-dependent protein kinases of human red cell membranes and of bovine brain. Additions of 25-500 microM triethyltin to red cell ghosts resulted in enhanced phosphorylation of ghost proteins. When added to partially purified cyclic AMP-dependent protein kinases from red cell ghosts or bovine brain, stimulation of the phosphorylation of calf thymus histone was observed. The enhancement of kinase activity was due to release of catalytic subunits from the intact protein kinase. Brief exposure of the partially purified enzymes to triethyltin, followed by DE52 chromatography, resulted in elution profiles for regulatory and catalytic subunits that were …

Neuroscience, Lee A. Christoferson

UND Departmental Histories

This departmental history was written on the occasion of the UND Centennial in 1983.

Antibiotic Susceptibility Of Black-Pigmented Bacteroides Isolates From The Human Oral Cavity, Linda Jean Laatsch, Paul R. Hohenfeldt, William L. Kos

Biomedical Sciences Faculty Research and Publications

The minimal inhibitory concentrations of penicillin and six other antibiotics were determined for 66 oral black-pigmented Bacteroides isolates by using the National Committee for Clinical Laboratory Standards proposed standard agar dilution technique. These results plus iodometric determination of β-lactamase activity showed that oral isolates of black-pigmented Bacteroides are remaining relatively susceptible to commonly used antibiotics.

Alteration Of Regional Blood Flow And Autoregulation Test In Patients With Vertebrobasilar Disease, Hiroaki Koga, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Alteration of Regional Blood Flow and Autoregulation Test in Patients with Vertebrobasilar Disease. Hiroaki Koga, M.D., George M. Austin, M.D. Conference presentation. International Symposium on Microsurgical Anastomoses for Cerebral Ischemia. September 1982. 9 pg.

Prevention And Treatment Of Stroke By Ec-Ic Bypass, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Prevention and Treatment of Stroke by EC-IC Bypass. George Austin, M.D. 12 pg. Lecture given on three different dates with variations:

Thursday, Dec. 17, 1981, Cottage Hospital

Monday, Dec. 21, 1981, Santa Ynez Valley Hospital

Monday, Jan. 18, 1982, The Hospital of the Good Samaritan

Synopsis Of “Background And Indications For Extracranial-Intracranial (Ec-Ic) Bypass Surgery", George M. Austin

The Dr. George M. Austin Neurology Research Collection

Synopsis of “Background and Indications for Extracranial-Intracranial (EC-IC) Bypass Surgery,” George M. Austin, M.D., Neurological Surgery, 4 p. Written on Dr. Austin's letterhead. No date, Similar to a 1982 lecture.

Measurement Of Aneurysm Blood Flow, George Austin, R. Vasudevan

The Dr. George M. Austin Neurology Research Collection

Measurement of Aneurysm Blood Flow. George Austin, M.D., R. Vasudevan, Ph.D. Conference presentation. International Symposium on Microsurgery. July 09-11, 1981. 2 pg.

Theory And Measurement Of Intracranial Aneurysm Blood Flow, George Austin, R. Vasudevan

The Dr. George M. Austin Neurology Research Collection

Theory and Measurement of Intracranial Aneurysm Blood Flow. George Austin, M.D., R. Vasudevan, Ph.D. Conference presentation. International Symposium on Microneurosurgery, 1981. 2 pg.

Collateral Flow Variation Of Orbital Anastomoses Following Sta-Mca Microneurosurgical Vascular Procedures, Joseph R. Thompson, Jacques Moret, George M. Austin, Anton N. Hasso

The Dr. George M. Austin Neurology Research Collection

Collateral Flow Variation of Orbital Anastomoses Following STA-MCA Microneurosurgical Vascular Procedures. Joseph R. Thompson, M.D., Jacques Moret, M.D., George M. Austin, M.D., Anton N. Hasso, M.D. Conference presentation. Int. Symposium on Microsurgical Anastomoses for Cerebral Ischemia, September 07, 1978. 3 pg.

Monitoring Of Cortical Mitochondrial Respiration During Microanastomosis, George Austin, Britton Chance, William Hill, Clyde Barlow

The Dr. George M. Austin Neurology Research Collection

Monitoring of Cortical Mitochondrial Respiration During Microanastomosis. George Austin, M.D., Britton Chance, Ph.D., William Hill, M.D., Clyde Barlow, Ph.D.

Section of Neurological surgery, Loma Linda University School of medicine, Loma Linda, California, and Johnson foundation for Biophysics and Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

April 1978. 2 pg. Conference presentation

Cortical Mitochondrial Respiration Following Microanastomosis, G. Austin, G. Haugen, D. Brown, E. Lichter, W. Hayward

The Dr. George M. Austin Neurology Research Collection

Cortical Mitochondrial Respiration Following Microanastomosis. G. Austin, G. Haugen, D. Brown, E. Lichter, W. Hayward. Conference presentation. American Association of Neurological Surgeons. Toronto, Canada, April, 1977. 4 pg.

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …

Diffuse Head Cooling As A Method For Producing A Gradient Of Brain Hypothermia And Decreased Blood Volume, Arthur Cushman, Niall Horn, Stanley Rouhe, George Austin, Conrad Ciesel

The Dr. George M. Austin Neurology Research Collection

Diffuse Head Cooling as a Method for Producing a Gradient of Brain Hypothermia and Decreased Blood Volume. Arthur Cushman, M.F., Niall Horn, Ph.D., Stanley Rouhe, M.D., George Austin, M.D., Conrad Ciesel. Paper submission for the ACS Meeting, Atlantic City, New Jersey (October 21, 1971). Typewritten manuscript, 3 pg.

An Investigation Of Cerebrovascular Factors In Head Injury: A Multifaceted Multidisciplinary Approach. Nih Proposal For A Head Injury Center At Loma Linda University, George M. Austin

The Dr. George M. Austin Neurology Research Collection

An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach. NIH proposal for a Head Injury Center at Loma Linda University. George Austin.

1. Typewritten letter. G.A. to Matilda Solowey, Extra Mural Programs, National Institutes of Health, Washington D.C., May 30, 1970. 1 pg.
2. “Head Injury Center; Supplement to: An Investigation of Cerebrovascular Factors in Head Injury: A Multifaceted Multidisciplinary Approach,” 14 pg.
3. “Specialized Clinical Research Head Injury Center, Loma Linda University School of Medicine, Loma Linda, California, George M. Austin, M.D., Professor of Neurosurgery, Additional Supporting Bibliography,” 1 p. Contains entries 90-97.
4. “Cerebral Blood Flow Changes in Vasospasm …

Pan Pacific Surgery Association Presentation Draft And Notes, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Pan Pacific Surgery Association presentation draft and notes. Possibly c. 1970 as document mentions new bibliography entry published in 1970. Includes:

1. Handwritten page of text beginning “Brain Aneurysms are considered the most dangerous of all intracranial lesions…”
2. Hand drawn figure titled “Visual Field Defects”
3. Personal notes
4. Handwritten page discussing a set of symptoms and physician response / treatment
5. Figure titled “Distribution of Blood Flow in the Circle of Willis”

A Computerized Model Of The Circle Of Willis With Clinical Application, G. Austin, L. Smith, I. Neilsen, J. Chrispens, D. Hinshaw

The Dr. George M. Austin Neurology Research Collection

A Computerized Model of the Circle of Willis with Clinical Application. G. Austin, L. Smith, I. Neilsen, J. Chrispens, D. Hinshaw. Southern California Neurosurgical Society (1968). 2 pg.

The Esophageal Propulsive Force: Esophageal Response To Acute Obstruction, Daniel H. Winship, F. Frank Zboralske

Biomedical Sciences Faculty Research and Publications

The response of the normal human esophagus to an obstructing intraluminal bolus was investigated and compared to the response evoked by transient intraluminal distention. A balloon, immobilized within the esophagus by external attachment to a force transducer, was inflated with from 3 to 25 ml of air for from 3 to 210 sec. Pressure phenomena occurring in the esophagus were simultaneously recorded from the body of the esophagus above and below the balloon.

Transient distention (5 sec or less) with small volumes (5 ml or less) often evoked a secondary peristaltic wave in the esophagus distal to the balloon, but …

Studies Of The Mechanism By Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion In Man, Jacob Lemann Jr., John R. Litzow, Edward J. Lennon

Biomedical Sciences Faculty Research and Publications

We carried out clearance studies in nine healthy adults and four patients with hypoparathyroidism before and after inducing stable metabolic acidosis with either NH₄Cl or acetazolamide. Clearances were repeated in seven normal subjects and three of the patients 3 days after stopping these agents.

During acidosis in the normal subjects, serum ultrafilterable calcium concentration rose significantly, but inulin clearance fell to a greater extent, so that the calculated filtered load of calcium fell significantly. Despite this, urinary calcium excretion rose. Urinary calcium excretion remained elevated in the recovery studies when the serum ultrafilterable calcium concentration and filtered load …

The Effect Of Treatment Of Acidosis On Calcium Balance In Patients With Chronic Azotemic Renal Disease, John R. Litzow, Jacob Lemann Jr., Edward J. Lennon

Biomedical Sciences Faculty Research and Publications

Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present. Only small quantities of calcium were excreted in the urine, but fecal calcium excretion equaled or exceeded dietary intake. Complete and continuous correction of acidosis by NaHCO₃ therapy reduced both urinary and fecal calcium excretion and produced a daily calcium balance indistinguishable from zero.

Apparent acid retention was found throughout the studies during acidosis, despite no further reduction of the serum bicarbonate concentration. The negative calcium balances that accompanied acid retention …