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The B Subunit Of Escherichia Coli Heat-Labile Toxin Alters The Development And Antigen-Presenting Capacity Of Dendritic Cells, Jing Ji, Kristin Grifftiths, Peter Milburn, Timothy Hirst, Helen O'Neill
The B Subunit Of Escherichia Coli Heat-Labile Toxin Alters The Development And Antigen-Presenting Capacity Of Dendritic Cells, Jing Ji, Kristin Grifftiths, Peter Milburn, Timothy Hirst, Helen O'Neill
Helen O'Neill
Escherichia coli's heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen. Here, we investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen. EtxB treatment appears to enhance the development and turnover of dendritic and myeloid cells from precursors within the spleen. EtxB treatment also gives a dendritic cell (DC) population with higher viability and lower activation status based on the reduced expression of MHC-II, CD80 and CD86. In this respect, the in vivo effect of …