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Full-Text Articles in Medical Sciences
The B Subunit Of Escherichia Coli Heat-Labile Toxin Alters The Development And Antigen-Presenting Capacity Of Dendritic Cells, Jing Ji, Kristin Grifftiths, Peter Milburn, Timothy Hirst, Helen O'Neill
The B Subunit Of Escherichia Coli Heat-Labile Toxin Alters The Development And Antigen-Presenting Capacity Of Dendritic Cells, Jing Ji, Kristin Grifftiths, Peter Milburn, Timothy Hirst, Helen O'Neill
Helen O'Neill
Escherichia coli's heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen. Here, we investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen. EtxB treatment appears to enhance the development and turnover of dendritic and myeloid cells from precursors within the spleen. EtxB treatment also gives a dendritic cell (DC) population with higher viability and lower activation status based on the reduced expression of MHC-II, CD80 and CD86. In this respect, the in vivo effect of …
Etxb Alters The Activation State Of Mature Dendritic Cell Subsets, J Ji, Kristin Griffiths, P Milburn, T Hirst, Helen O'Neill
Etxb Alters The Activation State Of Mature Dendritic Cell Subsets, J Ji, Kristin Griffiths, P Milburn, T Hirst, Helen O'Neill
Helen O'Neill
No abstract provided.
Expression Of Tcr-Vbeta Peptides By Murine Bone Marrow Cells Does Not Identify T Cell Progenitors, Janice Abbey, Holger Karunsky, Thomas Serwold, Peter Papathanasiou, Irving Weissman, Helen O'Neill
Expression Of Tcr-Vbeta Peptides By Murine Bone Marrow Cells Does Not Identify T Cell Progenitors, Janice Abbey, Holger Karunsky, Thomas Serwold, Peter Papathanasiou, Irving Weissman, Helen O'Neill
Helen O'Neill
Germline transcription has been described for both immunoglobulin and T-cell receptor (TCR) genes, raising questions of their functional significance during haematopoiesis. Previously, an immature murine T-cell line was shown to bind antibody to TCR-Vβ8.2 in absence of anti-Cβ antibody binding, and an equivalent cell subset was also identified in the mesenteric lymph node. Here, we investigate whether germline transcription and cell surface Vβ8.2 expression could therefore represent a potential marker of T-cell progenitors. Cells with the TCR phenotype of Vβ8.2+Cβ- are found in several lymphoid sites, and among the lineage-negative (Lin-) fraction of hematopoietic progenitors in bone marrow (BM). Cell …
Delineation Of A Novel Dendritic-Like Subset In Human Spleen., Sawang Petvises, D Talaulikar, Helen O'Neill
Delineation Of A Novel Dendritic-Like Subset In Human Spleen., Sawang Petvises, D Talaulikar, Helen O'Neill
Helen O'Neill
No abstract provided.