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Articles 31 - 35 of 35
Full-Text Articles in Health Information Technology
Improved Genome-Scale Multitarget Virtual Screening Via A Novel Collaborative Filtering Approach To Cold-Start Problem, Hansaim Lim, Paul Gray, Lei Xie, Aleksandar Poleksic
Improved Genome-Scale Multitarget Virtual Screening Via A Novel Collaborative Filtering Approach To Cold-Start Problem, Hansaim Lim, Paul Gray, Lei Xie, Aleksandar Poleksic
Publications and Research
Conventional one-drug-one-gene approach has been of limited success in modern drug discovery. Polypharmacology, which focuses on searching for multi-targeted drugs to perturb disease-causing networks instead of designing selective ligands to target individual proteins, has emerged as a new drug discovery paradigm. Although many methods for single-target virtual screening have been developed to improve the efficiency of drug discovery, few of these algorithms are designed for polypharmacology. Here, we present a novel theoretical framework and a corresponding algorithm for genome-scale multitarget virtual screening based on the one-class collaborative filtering technique. Our method overcomes the sparseness of the protein-chemical interaction data by …
Spatial Heterogeneity Analysis In Evaluation Of Cell Viability And Apoptosis For Colorectal Cancer Cells, Aydin Saribudak, Herman Kucharavy, Karen Hubbard, Muharrem Umit Uyar
Spatial Heterogeneity Analysis In Evaluation Of Cell Viability And Apoptosis For Colorectal Cancer Cells, Aydin Saribudak, Herman Kucharavy, Karen Hubbard, Muharrem Umit Uyar
Publications and Research
In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3-D in vitro cell-based assays under the impact of anti-cancer agents. In 48-h experiments using human colorectal cancer cell lines of HCT-116, SW-620, and SW-480, incubated cells are divided into control and drug administered groups, to be grown in matrigel and FOLFOX solution, respectively. Our 3-D cell tracking and data acquisition system guiding an inverted microscope with a digital camera is utilized to capture bright field and fluorescent images of colorectal cancer cells at multiple time points. Identifying the locations of live and dead …
The Fight For Zadroga, Naeisha Rose
The Fight For Zadroga, Naeisha Rose
Capstones
The attack on the World Trade Center cost many first responders and volunteers, like Ken George, a retired highway crewmember who was part of the search and rescue, to lose their health. Ken had needs a respirator for his restricted airway disease, he is o n 33 medications and five years ago he had a heart attack. Bi- =weekly or monthly, he visits a doctor for his PTSD, his heart, his lungs and general healthcare. After seeing the devastating conditions that the responders like Ken worked in, Congresswoman C arolyn Maloney (D-12) worked tirelessly with many politicians, both Democrats and …
Development Of A Technology-Based Behavioral Vaccine To Prevent Adolescent Depression: A Health System Integration Model, Benjamin W. Van Voorhees, Tracy Gladstone, Stephanie Cordel, Monika Marko-Holguin, William Beardslee, Sachiko Kuwabara, Mark Allan Kaplan, Joshua Fogel, Anne Diehl, Chris Hansen, Carl Bell
Development Of A Technology-Based Behavioral Vaccine To Prevent Adolescent Depression: A Health System Integration Model, Benjamin W. Van Voorhees, Tracy Gladstone, Stephanie Cordel, Monika Marko-Holguin, William Beardslee, Sachiko Kuwabara, Mark Allan Kaplan, Joshua Fogel, Anne Diehl, Chris Hansen, Carl Bell
Publications and Research
Efforts to prevent depression have become a key health system priority. Currently, there is a high prevalence of depression among adolescents, and treatment has become costly due to the recurrence patterns of the illness, impairment among patients, and the complex factors needed for a treatment to be effective. Primary care may be the optimal location to identify those at risk by offering an Internet-based preventive intervention to reduce costs and improve outcomes. Few practical interventions have been developed. The models for Internet intervention development that have been put forward focus primarily on the Internet component rather than how the program …
Dynamic Optimization Of Caregiver Schedules Based On Vital Sign Streams, Mohamed Saad, Bilal Khan
Dynamic Optimization Of Caregiver Schedules Based On Vital Sign Streams, Mohamed Saad, Bilal Khan
Publications and Research
Hospital facilities use a collection of heterogeneous devices, produced by many different vendors, to monitor the state of patient vital signs. The limited interoperability of current devices makes it difficult to synthesize multivariate moni- toring data into a unified array of real-time information regarding the patients state. Without an infrastructure for the integrated evaluation, display, and storage of vital sign data, one cannot adequately ensure that the assignment of care- givers to patients reflects the relative urgency of patient needs. This is an especially serious issue in critical care units (CCUs). We present a formal mathematical model of an operational …