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Full-Text Articles in Parasitic Diseases
Tickborne Colpodella Species Infections: Time For A New Integrated Approach To Understand Transmission And Pathogenicity, T. Y. Sam-Yellowe, Trinity Nims, Sona Qaderi, Mary M. Asraf
Tickborne Colpodella Species Infections: Time For A New Integrated Approach To Understand Transmission And Pathogenicity, T. Y. Sam-Yellowe, Trinity Nims, Sona Qaderi, Mary M. Asraf
Biological, Geological, and Environmental Faculty Publications
Colpodella species are free-living predatory protists that prey on algae, ciliates and bodonids using myzocytosis. Colpodella species have been reported in human and animal infections. Polymerase chain reaction (PCR) using primers targeting 18S rRNA genes of Cryptosporidium and piroplasms have identified Colpodella species in arthropods, host blood and feces, demonstrating the phylogenetic closeness of Colpodella species to the apicomplexa. However, in human, animal and arthropod hosts, the life cycle stages of Colpodella are unknown. In this literature review, we provide an overview of the widespread occurrence of Colpodella species in ticks, and pathogenicity in humans and animals. We discuss methods …
From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe
From Myzocytosis To Cytostomal Nutrient Uptake And Transport By Intracellular Plasmodium Species, T. Y. Sam-Yellowe
Biological, Geological, and Environmental Faculty Publications
No abstract provided.
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Biological, Geological, and Environmental Faculty Publications
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere …
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Biological, Geological, and Environmental Faculty Publications
Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. Many subtelomeric genes are important for responding to environmental cues, and subtelomeric instability can facilitate organismal adaptation to extracellular changes, which is a common theme in a number of microbial pathogens. In this review, I will focus on the delicate and important balance between stability and plasticity at telomeres and subtelomeres of a kinetoplastid parasite, Trypanosoma brucei, which causes human African trypanosomiasis and undergoes antigenic variation to evade the …