Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Astrocyte (1)
- Brainstem (1)
- Concussion (1)
- Epilepsy (1)
- GABA (1)
-
- Glia (1)
- Gliosis (1)
- GlyT2 (1)
- Glycinergic neurons (1)
- Hyperekplexia (1)
- Interneurons (1)
- KCNQ2 (1)
- Localization (1)
- Microglia (1)
- Mouse (1)
- NG2 (1)
- Neurons (1)
- OPC (1)
- Potassium channels (1)
- QPCR (1)
- Repeated Concussive Traumatic Brain Injury (1)
- TBI (1)
- Transfection (1)
- Ventricle (1)
- Ventriculomegaly (1)
- Weight Drop (1)
Articles 1 - 3 of 3
Full-Text Articles in Nervous System Diseases
Kcnq2 Localization In The Brainstem, Christina Valera
Kcnq2 Localization In The Brainstem, Christina Valera
Honors Scholar Theses
KCNQ2 channels are potassium channels that serve to control neuronal excitability. Loss of function mutations in these channels are known to cause various forms of epilepsy. Recently, KCNQ2 R201C and R201H gain of function mutations have been shown to exhibit an exaggerated startle response and other unique phenotypes uncharacteristic of epilepsy. These phenotypes resemble hyperekplexia, a condition in which glycine neurotransmission in the spinal cord and brainstem is affected. While KCNQ2 has widespread localization throughout the brain, its presence in the brainstem remains unknown. We used immunostaining to determine the localization of KCNQ2 in the vagus nerve and hypoglossal nerve …
Quantifying Expression Of Interneuron Subtype Markers For Dlx-2 Transfected Ng2 Cells, Timothy Nolan
Quantifying Expression Of Interneuron Subtype Markers For Dlx-2 Transfected Ng2 Cells, Timothy Nolan
Honors Scholar Theses
Neurons are a post-mitotic cell population, and therefore, they are not able to regenerate in vivo after a traumatic injury. Because inhibitory GABAergic interneurons and oligodendrocyte precursor cells (OPCs) are derived from the same precursor, recent studies have focused on transforming these OPCs into GABAergic neurons. However, there are different types of GABAergic interneurons that have different electrophysiological responses, which can lead to functional differences. The Nishiyama laboratory had already used a key gene in GABAergic interneuron and OPC differentiation, Distal-less homeobox 2 (Dlx-2), to transfect OPCs; early electrophysiology tests showed most of these transfected cells behaved like immature neurons, …
Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.
Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.
Honors Scholar Theses
Repeated concussive traumatic brain injury (rcTBI) is the most prominent form of head injury affecting the brain, with an estimated 1.7 million Americans affected each year (Kuhn 2012). Neurologists have been concerned about the danger of repeated head impacts since the 1920’s, but researchers have only begun to understand the long-term effects of rcTBI (McKee 2009). Although symptoms can be as mild as dizziness, current research suggests that multiple concussions can lead to a progressive degenerative brain disease known as chronic traumatic encephalopathy (CTE) (Luo 2008, McKee 2009, Kane 2013). Research on the brain is just beginning to scratch the …