Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Immunology (33)
- Allergy and Immunology (32)
- Public Health (9)
- COVID-19 (7)
- Clinical Epidemiology (7)
-
- Women's Health (3)
- Biological Phenomena, Cell Phenomena, and Immunity (2)
- Community Health and Preventive Medicine (2)
- Life Sciences (2)
- Medical Genetics (2)
- Neoplasms (2)
- Obstetrics and Gynecology (2)
- Oncology (2)
- Pediatrics (2)
- Pulmonology (2)
- Cognition and Perception (1)
- Critical Care (1)
- Epidemiology (1)
- Geriatrics (1)
- Immunology and Infectious Disease (1)
- Immunotherapy (1)
- Maternal and Child Health (1)
- Medical Microbiology (1)
- Microbiology (1)
- Orthopedics (1)
- Keyword
-
- Humans (18)
- Animals (10)
- Female (10)
- Mice (7)
- COVID-19 (6)
-
- SARS-CoV-2 (6)
- Lung (4)
- Placenta (4)
- Pregnancy (4)
- Urinary Bladder (4)
- Urinary Tract Infections (4)
- Adult (3)
- HIV Infections (3)
- Inflammation (3)
- Alzheimer Disease (2)
- Angiotensin-Converting Enzyme 2 (2)
- Autoimmunity (2)
- Autophagy (2)
- COVID-19 Vaccines (2)
- Cancer (2)
- Cell Differentiation (2)
- Cohort Studies (2)
- Cystitis (2)
- DNA Glycosylases (2)
- Fragility fractures (2)
- HIV (2)
- Immune checkpoint inhibitors (2)
- Immunotherapy (2)
- Lymphoid Tissue (2)
- Macrophages (2)
Articles 31 - 36 of 36
Full-Text Articles in Immune System Diseases
The Effects Of Glucocorticoids And Immunosuppressants On Cancer Outcomes In Checkpoint Inhibitor Therapy, Sebastian Bruera, Maria E Suarez-Almazor
The Effects Of Glucocorticoids And Immunosuppressants On Cancer Outcomes In Checkpoint Inhibitor Therapy, Sebastian Bruera, Maria E Suarez-Almazor
Faculty, Staff and Students Publications
The emergence of checkpoint inhibitors has created a paradigm shift for the treatment of various malignancies. However, although these therapies are associated with improved survival rates, they also carry the risk of immune-related adverse events (irAEs). Moderate to severe irAEs are typically treated with glucocorticoids, sometimes with the addition of immunosuppressants as steroid-sparing therapy. However, it is unclear how glucocorticoids and immunosuppressants may impact cancer survival and the efficacy of immune checkpoint therapy on cancer. In this narrative review, we discuss the effects of glucocorticoids and immunosuppressants including methotrexate, hydroxychloroquine, azathioprine, mycophenolate mofetil, tumor-necrosis factor (TNF)-inhibitors, interleukin-6 inhibitors, interleukin-1 inhibitors, …
Acute Encephalitis, Myoclonus And Sweet Syndrome After Mrna-1273 Vaccine, Gabriel Torrealba-Acosta, Jennifer C Martin, Yve Huttenbach, Catherine R Garcia, Muhammad R Sohail, Sandeep Krishna Agarwal, Carina Wasko, Eric M Bershad, Mohammad I Hirzallah
Acute Encephalitis, Myoclonus And Sweet Syndrome After Mrna-1273 Vaccine, Gabriel Torrealba-Acosta, Jennifer C Martin, Yve Huttenbach, Catherine R Garcia, Muhammad R Sohail, Sandeep Krishna Agarwal, Carina Wasko, Eric M Bershad, Mohammad I Hirzallah
Faculty, Staff and Students Publications
A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.
Intrapulmonary Administration Of Purified Neil2 Abrogates Nf-Κb-Mediated Inflammation, Nisha Tapryal, Shandy Shahabi, Anirban Chakraborty, Koa Hosoki, Maki Wakamiya, Gobinda Sarkar, Gulshan Sharma, Victor J Cardenas, Istvan Boldogh, Sanjiv Sur, Gourisankar Ghosh, Tapas K Hazra
Intrapulmonary Administration Of Purified Neil2 Abrogates Nf-Κb-Mediated Inflammation, Nisha Tapryal, Shandy Shahabi, Anirban Chakraborty, Koa Hosoki, Maki Wakamiya, Gobinda Sarkar, Gulshan Sharma, Victor J Cardenas, Istvan Boldogh, Sanjiv Sur, Gourisankar Ghosh, Tapas K Hazra
Faculty, Staff and Students Publications
Aberrant or constitutive activation of nuclear factor kappa B (NF-κB) contributes to various human inflammatory diseases and malignancies via the upregulation of genes involved in cell proliferation, survival, angiogenesis, inflammation, and metastasis. Thus, inhibition of NF-κB signaling has potential for therapeutic applications in cancer and inflammatory diseases. We reported previously that Nei-like DNA glycosylase 2 (NEIL2), a mammalian DNA glycosylase, is involved in the preferential repair of oxidized DNA bases from the transcriptionally active sequences via the transcription-coupled base excision repair pathway. We have further shown that Neil2-null mice are highly sensitive to tumor necrosis factor α (TNFα)- and lipopolysaccharide-induced …
Molecular Mechanisms And Epidemiology Of Covid-19 From An Allergist’S Perspective, Koa Hosoki, Abhijit Chakraborty, Sanjiv Sur
Molecular Mechanisms And Epidemiology Of Covid-19 From An Allergist’S Perspective, Koa Hosoki, Abhijit Chakraborty, Sanjiv Sur
Faculty, Staff and Students Publications
The global pandemic caused by the newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused worldwide suffering and death of unimaginable magnitude from coronavirus disease 2019 (COVID-19). The virus is transmitted through aerosol droplets, and causes severe acute respiratory syndrome. SARS-CoV-2 uses the receptor-binding domain of its spike protein S1 to attach to the host angiotensin-converting enzyme 2 receptor in lung and airway cells. Binding requires the help of another host protein, transmembrane protease serine S1 member 2. Several factors likely contribute to the efficient transmission of SARS-CoV-2. The receptor-binding domain of SARS-CoV-2 has a 10- to 20-fold …
Dynamic Ultrasound Uniquely Reveals Anterior Capsular Tear Communicating With Vastus Intermedius Fibers, Shiv J Patel, Jasvinder A Singh, Max H Epstein, Prathap Jayaram
Dynamic Ultrasound Uniquely Reveals Anterior Capsular Tear Communicating With Vastus Intermedius Fibers, Shiv J Patel, Jasvinder A Singh, Max H Epstein, Prathap Jayaram
Faculty, Staff and Students Publications
We present a case of an anterior capsular tear of the right knee in a previously healthy, active individual. The patient was a 31-year-old male seen one month after the onset of throbbing anterior right knee pain, which progressed to sharp suprapatellar pain over the next three months. Both dynamic ultrasound (US) and MRI were obtained. Dynamic US revealed a tear of the anterior capsule of the right knee complicated by a suprapatellar effusion communicating into the vastus intermedius fibers of the quadriceps tendon. However, these findings were not evident on MRI. In addition to discussing this unique pathology, we …
Adjuvant Therapy In Adrenocortical Carcinoma: Reflections And Future Directions, Sara Bedrose, Marilyne Daher, Lina Altameemi, Mouhammed Amir Habra
Adjuvant Therapy In Adrenocortical Carcinoma: Reflections And Future Directions, Sara Bedrose, Marilyne Daher, Lina Altameemi, Mouhammed Amir Habra
Faculty, Staff and Students Publications
Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production, certain genetic alterations, and high proliferation rate (Ki-67 proliferation index). Mitotane has been the mainstay adjuvant therapy of ACC. However, the use of mitotane is based on retrospective and occasionally conflicting evidence. As mitotane levels can take a few months before reaching therapeutic levels, there is an emerging practice of combining platinum-based chemotherapy with mitotane in the adjuvant setting. Retrospective data indicate that radiotherapy is an …