Hemic and Lymphatic Diseases Commons^™

The Roles Of Transferrin Receptor In T Cell Activation, Allison Lorayne Bayer

MUSC Theses and Dissertations

Transferrin receptor (TfR) appears on activated T cells following interaction of the antigen-major histocompatibility complex (MHC) with the T cell receptor (TCR) and the resulting expression of IL-2 receptor (IL-2R). Previous work in the laboratory has demonstrated allograft prolongation following administration of anti-TfR monoclonal antibody (mAb). Studies in the area of cancer immunotherapy have shown that TfR blockade and modulation deprives the tumor of iron, which is essential for continued growth and proliferation, while TfR modulation results in poor T cell proliferation, respectively. This dissertation focuses on the hypothesis that modulation of T cell TfR expression is associated with altered …