Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Hemic and Lymphatic Diseases
The Interleukin-12 Family Of Cytokines And Receptor Signaling In Graft-Versus-Host Disease, David Bastian
The Interleukin-12 Family Of Cytokines And Receptor Signaling In Graft-Versus-Host Disease, David Bastian
MUSC Theses and Dissertations
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is an effective means by which to treat a wide variety of diseases resulting from dysfunctional hematopoiesis due to a potent anti-tumor response known as the graft-versus-tumor (GVT) effect after chemotherapy and/or irradiation. The necessity of donor T cells to mediate GVT is offset by the consequential development of graft-versus-host disease (GVHD); a leading cause of mortality among allo- HCT recipients. The IL-12 family of cytokines signals through Janus Kinase 2 (JAK2) and is comprised of IL-12, IL-23, IL-27, IL-35 and IL-39. IL-12 (p35+p40) and IL-23 (p19+p40) have well documented proinflammatory functions responsible for …
The Roles Of Transferrin Receptor In T Cell Activation, Allison Lorayne Bayer
The Roles Of Transferrin Receptor In T Cell Activation, Allison Lorayne Bayer
MUSC Theses and Dissertations
Transferrin receptor (TfR) appears on activated T cells following interaction of the antigen-major histocompatibility complex (MHC) with the T cell receptor (TCR) and the resulting expression of IL-2 receptor (IL-2R). Previous work in the laboratory has demonstrated allograft prolongation following administration of anti-TfR monoclonal antibody (mAb). Studies in the area of cancer immunotherapy have shown that TfR blockade and modulation deprives the tumor of iron, which is essential for continued growth and proliferation, while TfR modulation results in poor T cell proliferation, respectively. This dissertation focuses on the hypothesis that modulation of T cell TfR expression is associated with altered …