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Full-Text Articles in Hemic and Lymphatic Diseases
Minerals And Macrophages: Testing The Silica Paradigm And Soil Toxicity In The Etiology Of Podoconiosis, Jamey N. Cooper
Minerals And Macrophages: Testing The Silica Paradigm And Soil Toxicity In The Etiology Of Podoconiosis, Jamey N. Cooper
Loma Linda University Electronic Theses, Dissertations & Projects
Certain earth materials, most famously silica and asbestos, are harmful to humans and can induce systemic disease. Podoconiosis is a disease affecting a large population in Ethiopia. Existing etiological models invoke a link to the composition of specific local volcanic soils. Silica and aluminum-containing minerals are hypothesized to induce inflammation, leading to obstructions within the lymphatic system of the legs. Multivariate analyses of bedrock geochemistry from regions associated with podoconiosis suggest an association with rocks composed of high levels of alkalines and silica. Soil samples from 29 towns with and without cases of podoconiosis were collected from across Ethiopia. Geological …
Tslp-Induced Mechanisms And Potential Therapies For Crlf2 B-Cell Acute Lymphoblastic Leukemia, Olivia L. Francis
Tslp-Induced Mechanisms And Potential Therapies For Crlf2 B-Cell Acute Lymphoblastic Leukemia, Olivia L. Francis
Loma Linda University Electronic Theses, Dissertations & Projects
Childhood CRLF2 B-cell Acute Lymphoblastic Leukemia (CRLF2 B-ALL) is a high-risk form of leukemia that is associated with poor patient survival outcomes. CRLF2 B-ALL is five times more prevalent in Hispanic children than others and is associated with a higher rate of relapse, thus contributing significantly to childhood cancer health disparities. This disease occurs due to alterations of the CRLF2 gene, leading to overexpression of the CRLF2 protein- a component of the receptor signaling complex for the cytokine Thymic Stromal LymphoPoietin (TSLP) on the surface of B-ALL cells. TSLP has been shown to induce proliferation of human and mouse B-cell …