Eye Diseases Commons^™

Frequency Of Retinopathy Of Prematurity In Premature Neonates With A Birth Weight Below 1500 Grams And A Gestational Age Less Than 32 Weeks: A Study From A Tertiary Care Hospital In A Lower-Middle Income Country, Arjumand Sohaila, Shiyam Sunder Tikmani, Iqtidar Ahmed Khan, Huba Atiq, Ali Syed Muhammad Akhtar, Prem Kumar, Kishwer Kumar

Department of Emergency Medicine

Introduction: Retinopathy of prematurity (ROP) is a treatable cause of blindness in neonates. In Pakistan, ROP is often not recognized early because screening and treatment programs are not yet in place in most neonatal units, even in tertiary care hospitals. It is hoped that this report will help inform medical professionals of the magnitude of the problem and help to design appropriate management strategies.

Objectives: The aim was to determine the frequency of ROP in premature and very low birth weight (BW) neonates (BW(GA)weeks).

Study Design: Cross-sectional study.

Study Setting : Neonatal intensive care unit (NICU) of a tertiary care …

Labeling Of Retinal Ganglion Cells In A Rat Glaucoma Model, Lucia Rodriguez

Honors Theses

Glaucoma is a degenerative disease of the retina containing multifactorial structural and functional defects. There is a loss of retinal ganglion cells (RGCs) seen in this optic disorder. Cupping of the optic disk seen in glaucoma is a result of the loss of RGC axons at the optic nerve head where the nerve fibers connect. As a result of these factors, visual field loss is common among glaucoma patients.¹ In the United States, this visual field loss associated with glaucoma is one of the leading causes of blindness since glaucoma is difficult to detect.² Usually, increased intraocular pressure …

Environmental Factors And Progressive Myopia: A Global Health Problem, Jeffrey Weissman

The Science Journal of the Lander College of Arts and Sciences

Myopia, or nearsightedness, is a refractive error whose prevalence has increased over the past three decades, leading to a growing concern and interest among both the public and scientific communities. For years, the only explanation and basis for myopia has been genetic factors. However, the genetic model does not explain the dramatic increase in prevalence. Current research suggests that the increase is also due to environmental factors, such as fewer hours of outdoor activities, early educational pressures requiring intense close work, as well as a lack of exposure to sunlight. One study compared the prevalence and risk factors for myopia …

Cytotoxic Clinical Isolates Of Pseudomonas Aeruginosa Identified During The Steroids For Corneal Ulcers Trial Show Elevated Resistance To Fluoroquinolones, Durga S. Borkar, Nisha R. Acharya, Chelsia Leong, Prajna Lalitha, Muthiah Srinivasan, Catherine E. Oldenburg, David J. Evans

Faculty Publications & Research of the TUC College of Pharmacy

Background: To determine the relationship between type three secretion genotype and fluoroquinolone resistance for P. aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (SCUT) and for two laboratory strains, PA103 and PAO1.

Methods: Confirmed P. aeruginosa isolates from the SCUT were divided into exoU(+) or exoU(−). The exoU(+) strains contained the gene encoding ExoU, a powerful phospholipase toxin delivered into host cells by the type three secretion system. Isolates were then assessed for susceptibility to fluoroquinolone, cephalosporin, and aminoglycoside antibiotics using disk diffusion assays. Etest was used to determine the MIC of moxifloxacin …

In Adult Patients With Diabetic Macular Edema Are Intravetrial Bevacizumab Injections More Effective Than Laser Therapy At Improving Best-Corrected Visual Acuity?, Heather Bladek

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not in adult patients with diabetic macular edema intravetrial bevacizumab injections are more effective than laser therapy at improving best-corrected visual acuity.

STUDY DESIGN: Review of three English language non-blinded randomized control trials from 2010 and 2012.

DATA SOURCES: Non-blinded randomized control trials comparing intravetrial bevacizumab injections to macular laser therapy found using Pubmed and EBSCOhost web databases. All articles were published in peer-reviewed journals.

OUTCOMES MEASURED: The primary outcome of best-corrected visual acuity (BCVA) was measured using the Early Treatment of Diabetic …

Is 2% Pirenzephine Gel Effective In Slowing The Progression Of Myopia In Children Aged 7-12 Years Old?, Melissa J. Rivera

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not 2% pirenzepine gel is effective in slowing the progression of myopia in children aged 7-12 years old?

STUDY DESIGN: Systemic review of three primary randomized controlled trials, which were published in 2008, 2004, and 2005.

DATA SOURCES: Multicenter, randomized double masked, placebo controlled, randomized controlled trials (RCT) were found using PubMed, COCHRANE, and OVID databases.

OUTCOMES MEASURED: The outcome, slowing of myopia progression, was measured similarly in all three trials. Progression of myopia was measured via changes in refractory status and spherical …