Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
- File Type
Articles 1 - 3 of 3
Full-Text Articles in Eye Diseases
Diabetic Retinopathy And The Role Of Vegf, Aishwarya Gatiganti, Laura Valdez, Andrew Tsin Ph.D.
Diabetic Retinopathy And The Role Of Vegf, Aishwarya Gatiganti, Laura Valdez, Andrew Tsin Ph.D.
School of Medicine Publications
Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population. It works by disrupting the neural and vascular components in the retina and leads to loss of neural interaction/function, vascular permeability, and angiogenesis. It can be classified into two general stages: non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). DR can also lead to vascular leakage and cause diabetic macular edema (DME), the most common cause of vision loss in DR (Duh, Sun et al. 2017). There are currently a wide range of therapies, but they are limited in their efficacy and side effects. None of …
Cellular And Molecular Mechanisms Of Neuronal Degeneration In Early Stage Diabetic Retinopathy, Sonal V. Jha, Laura Valdez, Andrew T C Tsin
Cellular And Molecular Mechanisms Of Neuronal Degeneration In Early Stage Diabetic Retinopathy, Sonal V. Jha, Laura Valdez, Andrew T C Tsin
School of Medicine Publications
DR is a common complication of diabetes in which every cell type in the retina is affected or damaged, resulting in irreversible vision loss. Although DR was classically considered a vascular disease, evidence now supports DR as a neurovascular disease, in which neuronal damage is present much earlier than vascular pathology or clinically observable abnormalities. The mechanisms by which neurons are damaged in early DR are linked to the effects of reactive oxygen species, apoptotic signaling by capase-dependent, caspase-independent, and Fas/FasL pathways and glial cell reactivity resulting in excitotoxicity, neurotrophin imbalance, and breakdown of neurovascular coupling. Although some features of …
Observing Growth Effects Of Pigment Epithelium-Derived Factor On Human Retinal Pericytes In Vitro, Anjalee Choudhury, Andrew Tsin, Zachary Perez, Fransisco Elisarraras
Observing Growth Effects Of Pigment Epithelium-Derived Factor On Human Retinal Pericytes In Vitro, Anjalee Choudhury, Andrew Tsin, Zachary Perez, Fransisco Elisarraras
School of Medicine Publications
The purpose of this study is to investigate and determine the role of PEDF in the pathogenesis of diabetic retinopathy as induced by advanced glycation end-products (AGEs). Human retinal pericytes were isolated from donors and will be measured for cell proliferation under the influence of PEDF both in the presence and absence of AGEs. Expected outcomes involve both the maintenance and increased survival of HRPs after treatment with PEDF under stimulated hyperglycemic conditions.