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Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Maternal Coxsackievirus B Induced Dysregulation Of Sumoylation Processes As A Potential Cause Of Hypoplastic Left Heart Syndrome, Bailey Kemp, Sarah Severson
Maternal Coxsackievirus B Induced Dysregulation Of Sumoylation Processes As A Potential Cause Of Hypoplastic Left Heart Syndrome, Bailey Kemp, Sarah Severson
Undergraduate Research Symposium 2018
Hypoplastic Left Heart Syndrome (HLHS) is a life-threatening congenital heart defect with unknown etiology. Here we hypothesize that HLHS has etiologic roots in maternal asymptomatic coxsackievirus B infection. Coxsackievirus has been demonstrated to disrupt normal distribution of small ubiquitin-like modifiers (SUMO) in the cell. The vital cardiac transcription factor, Nkx2-5, has been shown to be dependent on SUMOylation for proper function. Specifically, co-localization of SUMO and Nkx2.5 has been identified, as well as decreased SUMOylation associated with Nkx2-5 mutants. As Nxk2-5 is essential for fetal heart development and mutations in the gene for this vital transcription factor have been linked …
Hemophilia In Man: The Need For Complete Familial Data, Clarence P. Oliver, Eleanor H. Lindeman
Hemophilia In Man: The Need For Complete Familial Data, Clarence P. Oliver, Eleanor H. Lindeman
Journal of the Minnesota Academy of Science
No abstract provided.
A Case Of Mongolism With Some References To The Collection Of Data, Clarence P. Oliver
A Case Of Mongolism With Some References To The Collection Of Data, Clarence P. Oliver
Journal of the Minnesota Academy of Science
No abstract provided.