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Full-Text Articles in Cardiovascular Diseases
Heritability Of 596 Lipid Species And Genetic Correlation With Cardiovascular Traits In The Busselton Family Heart Study, Gemma Cadby, Phillip E. Melton, Nina S. Mccarthy, Corey Giles, Natalie A. Mellett, Kevin Huynh, Joseph Hung, John Beilby, Marie-Pierre Dube, Gerald F. Watts, John Blangero, Peter J. Meikle, Eric K. Moses
Heritability Of 596 Lipid Species And Genetic Correlation With Cardiovascular Traits In The Busselton Family Heart Study, Gemma Cadby, Phillip E. Melton, Nina S. Mccarthy, Corey Giles, Natalie A. Mellett, Kevin Huynh, Joseph Hung, John Beilby, Marie-Pierre Dube, Gerald F. Watts, John Blangero, Peter J. Meikle, Eric K. Moses
School of Medicine Publications and Presentations
Introduction: Cardiovascular disease (CVD) is the leading cause of death worldwide, and genetic investigations into the human lipidome may provide insight into CVD risk. The aim of this study was to estimate the heritability of circulating lipid species and their genetic correlation with CVD traits.
Methods: Targeted lipidomic profiling was performed on 4492 participants from the Busselton Family Heart Study to quantify the major fatty acids of 596 lipid species from 33 classes. We estimated narrow-sense heritabilities of lipid species/classes, and their genetic correlations with eight CVD traits – body mass index, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglycerides, …