Open Access. Powered by Scholars. Published by Universities.®
Bacterial Infections and Mycoses Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Acid stress (1)
- Active-site model (1)
- Ankyrin (1)
- Carbon catabolite repression (1)
- Cysteine protease (1)
-
- Ecology (1)
- Enzyme kinetics (1)
- Exportin (1)
- Importin (1)
- Infective endocarditis (1)
- Metabolomics (1)
- N-terminal processing (1)
- NF-kB (1)
- Obligate intracellular bacteria (1)
- Ribosomal protein L27 (1)
- Site-specific cleavage (1)
- Substrate specificity (1)
- T1ss (1)
- Transcriptomics (1)
- ZIP family protein (1)
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Bacterial Infections and Mycoses
Exploring The Dynamics Of Bacterial Populations In The Gut Microbiota, Shaikh Obaidullah
Exploring The Dynamics Of Bacterial Populations In The Gut Microbiota, Shaikh Obaidullah
Biology and Medicine Through Mathematics Conference
No abstract provided.
The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio
The Role Of Manganese In Streptococcus Sanguinis, Tanya M. Puccio
Theses and Dissertations
Streptococcus sanguinis is primarily associated with oral health as a commensal bacterium. As an opportunistic pathogen, S. sanguinis is capable of colonizing heart valve vegetations, leading to the disease infective endocarditis. Previous studies from our lab have identified the high-affinity manganese transporter SsaACB as important for endocarditis virulence. The impact that manganese depletion has on S. sanguinis had never been evaluated and a secondary manganese transporter has not been identified. Thus, we employed the use of a fermentor to control large-scale growth over time and depleted manganese in an ΔssaACB mutant using a metal chelator, EDTA. The changes in …
Orientia Tsutsugamushi Secretes Two Ankyrin Repeat-Containing Effectors Via A Type 1 Secretion System To Inhibit Host Nf-Κb Function, Sean M. Evans
Orientia Tsutsugamushi Secretes Two Ankyrin Repeat-Containing Effectors Via A Type 1 Secretion System To Inhibit Host Nf-Κb Function, Sean M. Evans
Theses and Dissertations
Scrub typhus is a potentially fatal infection that threatens one billion persons in the Asia-Pacific region and is caused by the obligate intracellular bacterium, Orientia tsutsugamushi. How this organism facilitates its intracellular survival and pathogenesis is poorly understood. Intracellular bacterial pathogens utilize the Type 1 (T1SS) or Type 4 secretion system (T4SS) to translocate ankyrin repeat-containing proteins (Anks) into the host cell to modulate host cell processes. The O. tsutsugamushi genome encodes one of the largest known bacterial Ank libraries as well as Type 1 and Type 4 secretion systems (T1SS and T4SS), which are expressed during infection. In …
Characterization Of A Novel Protease In Staphylococcus Aureus, Adam L. Johnson
Characterization Of A Novel Protease In Staphylococcus Aureus, Adam L. Johnson
Theses and Dissertations
A newly discovered cysteine protease, Prp, has been shown to perform an essential, site-specific cleavage of ribosomal protein L27 in Staphylococcus aureus. In Firmicutes and related bacteria, ribosomal protein L27 is encoded with a conserved N-terminal extension that must be removed to expose residues critical for ribosome function. Uncleavable and pre-cleaved variants were unable to complement an L27 deletion in S. aureus, indicating that this N-terminal processing event is essential and likely plays an important regulatory role. The gene encoding the responsible protease (prp) has been shown to be essential, and is found in all organisms …