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Full-Text Articles in Bacterial Infections and Mycoses
Immunophenotyping And Functional Assessment Of Antiviral Cd8+ T Cells In A Clp Mouse Model Of Immunosuppression, Alex R. Michaud
Immunophenotyping And Functional Assessment Of Antiviral Cd8+ T Cells In A Clp Mouse Model Of Immunosuppression, Alex R. Michaud
Electronic Thesis and Dissertation Repository
Sepsis causes millions of deaths every year with 70% of them being attributed to the immunosuppressive phase of the syndrome, which occurs shortly after the onset and leads to a severe immunodeficiency. Currently, there is not enough known about antigen specific CD8+ T cell responses during the immunosuppressive phase of sepsis and the studies that have been done, have shown controversial findings. In my thesis research, I have utilized the cecal ligation and puncture (CLP) model of polymicrobial sepsis – which closely mimics the progression of human sepsis – to study antigen specific CD8+ T cell responses by examining their …
Systematic Assessment Of The Contribution Of Superantigens To Nasopharyngeal Colonization In A Mouse Model Of Streptococcal Infection, Katherine J. Kasper
Systematic Assessment Of The Contribution Of Superantigens To Nasopharyngeal Colonization In A Mouse Model Of Streptococcal Infection, Katherine J. Kasper
Electronic Thesis and Dissertation Repository
Streptococcus pyogenes is adapted for persistence in humans. It typically colonizes the tonsils and skin, and humans are the only known reservoir. S. pyogenes can cause a wide range of mild to serious infections. Most streptococci-related deaths are due to complications of rheumatic fever and invasive infections. S. pyogenes produces virulence factors that contribute to the pathogen’s ability to colonize and cause disease, including streptococcal superantigens (SAgs), also known as streptococcal pyrogenic exotoxins (Spes). SAgs function by cross-linking T cells and antigen presenting cells (APC) which may cause a massive inflammatory response, and as such have been found to contribute …