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Articles 91 - 93 of 93
Full-Text Articles in Diseases
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important For Generation Of An Optimal Polymorphonuclear Response Against Toxoplasma Gondii Infection, Michelle N. Kelly, Jay K. Kolls, Kyle Happel, Joseph D. Schwartzman
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important For Generation Of An Optimal Polymorphonuclear Response Against Toxoplasma Gondii Infection, Michelle N. Kelly, Jay K. Kolls, Kyle Happel, Joseph D. Schwartzman
Dartmouth Scholarship
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
Combining Cytotoxic And Immune-Mediated Gene Therapy To Treat Brain Tumors, James Curtin, Gwendalyn King, Marianela Candolfi, Remy Greeno, Kurt Kroeger, Pedro Lowenstein, Maria Castro
Combining Cytotoxic And Immune-Mediated Gene Therapy To Treat Brain Tumors, James Curtin, Gwendalyn King, Marianela Candolfi, Remy Greeno, Kurt Kroeger, Pedro Lowenstein, Maria Castro
Articles
Glioblastoma (GBM) is a type of intracranial brain tumor, for which there is no cure. In spite of advances in surgery, chemotherapy and radiotherapy, patients die within a year of diagnosis. Therefore, there is a critical need to develop novel therapeutic approaches for this disease. Gene therapy, which is the use of genes or other nucleic acids as drugs, is a powerful new treatment strategy which can be developed to treat GBM. Several treatment modalities are amenable for gene therapy implementation, e.g. conditional cytotoxic approaches, targeted delivery of toxins into the tumor mass, immune stimulatory strategies, and these will all …
'The Aids Is Coming And There Is Nowhere To Run...': Culture, Gender, And The Politics Of Kisongo Maasai Women And Girls' Vulnerability To Hiv/Aids (Immune Deficiency, Tanzania), V. Corey Wright
Theses and Dissertations (Comprehensive)
This thesis outlines the research findings and implications for practice generated from the, “A Gender Issue: Reducing the Vulnerability of Kisongo Maasai Girls to HIV/AIDS” project, which was a participatory action research (PAR) study in collaboration with the Kisongo Maasai in Northern Tanzania. The objectives of the study were to explore the factors that may contribute to girls’ vulnerability to HIV/AIDS, and develop a culturally-specific framework that may contribute to effective design and administration of program and policy-level interventions. The findings of this study illustrate the ‘politics of health’ that determine girls’ vulnerability to HIV/AIDS. It presents a cultural analysis …