Diseases Commons^™

Association Of Viral Genome With Graft Loss In Children After Cardiac Transplantation., Girish S. Shirali, J Ni, R E. Chinnock, J K. Johnston, G L. Rosenthal, N E. Bowles, J A. Towbin

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The survival of recipients of cardiac allografts is limited by rejection, lymphoproliferative disease, and coronary vasculopathy. The purpose of this study in children who had received heart transplants was to evaluate the cardiac allografts for myocardial viral infections and to determine whether the presence of viral genome in the myocardium correlates with rejection, coronary vasculopathy, or graft loss.

METHODS: We enrolled heart-transplant recipients 1 day to 18 years old who were undergoing evaluation for possible rejection and coronary vasculopathy. Endomyocardial-biopsy specimens were evaluated for evidence of rejection with the use of standard criteria and were analyzed for the presence …

Special Report On Children Born To Hiv Positive Parents In Nevada, 1991-1999, Drew Mather, Mary Guinan, Richard Whitley, Wei Yang

School of Public Health Faculty Research

Background:

This report encompasses an effort to look at the number of children born to HIV (Human Immunodeficiency Virus) and/or AIDS (Acquired Immunodeficiency Syndrome) infected parents during the years 1991 to 1999 in Nevada.

According to the Healthy People 2000 (HP 2000) Review for the years 1998- 1999, infants of untreated or undetected HIV positive women have been identified as a distinct population at risk for contracting the virus that causes AIDS.

The State of Nevada’s Bureau of Disease Control and Intervention Services in collaboration with the Bureau of Health Planning and Statistics has taken the initial step to “cross …

Characterization Of The Cd154-Positive And Cd40-Positive Cellular Subsets Required For Pathogenesis In Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Randolph J. Noelle, Brigit G. Durell, William R. Green

Dartmouth Scholarship

Genetically susceptible C57BL/6 (B6) mice that are infected with the LP-BM5 isolate of murine retroviruses develop profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, terminal B-cell lymphomas, and an immunodeficiency state bearing many similarities to the pathologies seen in AIDS. Because of these similarities, this syndrome has been called murine AIDS (MAIDS). We have previously shown that CD154 (CD40 ligand)-CD40 molecular interactions are required both for the initiation and progression of MAIDS. Thus, in vivo anti-CD154 monoclonal antibody (MAb) treatment inhibited MAIDS symptoms in LP-BM5-infected wild-type mice when either a short course of anti-CD154 MAb treatment was started on the day of infection or …

A Study From Uganda: Hiv Causal Attributional Structuring, Negative Affect, And Coping Among People With Hiv/Aids. Part Ii, Ibpp Editor

International Bulletin of Political Psychology

Note: The following is the last section of the article authored by Dr. Peter Kakubeire Baguma, Institute of Psychology, Makerere University, Kampala, Uganda. (See the IBPP issue of February 16 for the first section.) Dr. Baguma's work is extremely timely for three reasons. First, AIDS continues as a pandemic, and culturally relevant theory and data continue to be crucial in developing primary, secondary, and tertiary intervention strategies. Second, AIDS continues as a global security issue with implications for economics, politics, governmental stability, and war and peace. The psychology of AIDS bears on this issue and implications. Third, Baguma's efforts …

A Study From Uganda: Hiv Causal Attributional Structuring, Negative Affect, And Coping Among People With Hiv/Aids. Errata., Ibpp Editor

International Bulletin of Political Psychology

Readers should access http://www.pr.erau.edu/~security/baguma-tables.html for the conclusion of this article and twelve data tables.

A Study From Uganda: Hiv Causal Attributional Structuring, Negative Affect, And Coping Among People With Hiv/Aids [Part I], Ibpp Editor

International Bulletin of Political Psychology

Weiner's attribution theory suggests relationships between attributions, emotions, coping, and behavioral consequences (Weiner, 1986, Amirkhan, 1990). Studies supporting the theory are still limited especially in the health area and AIDS in particular.

Transitions To Adulthood In The Context Of Aids In South Africa: Report Of Wave I, Naomi Rutenberg, Cathrien Kehus-Alons, Lisanne Brown, Kate Macintyre, Anthea Dallimore, Carol E. Kaufman

HIV and AIDS

This is a prospective study of reproductive behavior and sexual health of adolescents in South Africa as well as their education and employment experiences, family and environmental conditions, and other factors in their lives that may influence their sexual behavior and choices. This report is designed to inform educators, policymakers, and the public in South Africa and beyond of the initial findings of the study, with the ultimate goal of helping to design and refine policies and programs that will improve opportunities and capacities of adolescents and may contribute to changing behaviors and choices. The report focuses on describing the …

Prevention Of Trafficking And The Care And Support Of Trafficked Persons In The Context Of An Emerging Hiv/Aids Epidemic In Nepal, Celine Daly

HIV and AIDS

This study is a collaborative effort between the Asia Foundation (Kathmandu) and the Horizons project of the Population Council (New Delhi) to document the current intervention models and community-based study of human trafficking in the context of an emerging HIV/AIDS epidemic in Nepal. To address the human rights component of trafficking, the three components of this study focus on the rights and needs of trafficked persons as well as those who are vulnerable to trafficking. An analysis and assessment of the effectiveness of laws, policies, and interventions in the apprehension, prosecution, and conviction of alleged traffickers is not included in …

Hormonal And Barrier Methods Of Contraception, Oncogenic Human Papillomaviruses, And Cervical Squamous Intraepithelial Lesion Development, Ann L. Coker, Laura C. Sanders, Sharon M. Bond, Tsilya Gerasimova, Lucia Pirisi

CRVAW Faculty Journal Articles

We assessed the influence of hormonal (oral, injectable, or levonorgestrel [Norplant, Wyeth-Ayerst, Philadelphia, PA]) and barrier methods of contraception on the risk of cervical squamous intraepithelial lesions (SIL), while adjusting for high-risk (HR) HPV infection. Subjects were women receiving family planning services through the state health department clinics from 1995 to 1998. We selected 60 cases with high-grade cervical/SIL (HSIL) and 316 with low-grade cervical/SIL (LSIL) and controls (427 women with normal cervical cytology) and analyzed cervical DNA for HR-HPV, using Hybrid Capture I (Digene; Gaithersburg, MD).When assessing ever use, duration, recency, latency, and age at first use, neither oral …

Hiv And Partner Violence: Implications For Hiv Voluntary Counseling And Testing Programs In Dar Es Salaam, Tanzania, Suzanne Maman, Jessie K. Mbwambo, Margaret Hogan, Gad P. Kilonzo, Michael D. Sweat, Ellen Weiss

HIV and AIDS

This study explored the links between HIV infection, serostatus disclosure, and partner violence among women attending a VCT clinic in Dar es Salaam, Tanzania. Men and women both perceive HIV testing as a way to plan for the future but are motivated to undergo testing by a number of different individual, relationship, and environmental factors. The women in our study described more barriers to HIV testing than did men, and women who have communicated with their partners about VCT before seeking services are significantly more likely to share their HIV test results than those who have not talked with their …

The Case For Microbicides: A Global Priority, Kathy Attawell

HIV and AIDS

The HIV/AIDS epidemic continues to spread, undermining development, reversing health gains, and exacerbating poverty. It will be some time before a vaccine is available and accessible, thus there is an urgent need to identify additional prevention options, in particular a method that women control, which could save millions of lives. This report from the Population Council and International Family Health presents the case for microbicides—products used vaginally to prevent infection from HIV and other STIs in women and their sexual partners—and discusses recent progress and developments, outstanding challenges, and the action required to ensure that products will be made available …

Vertical Transmission Of Kaposi's Sarcoma-Associated Herpesvirus, Hamakwa Mantina, Chipepo Kankasa, Winslow Klaskala, Brad Brayfield, James Campbell, Quijiang Du, Ganapati Bhat, Francis Kasolo, Charles Mitchell, Charles Wood

Nebraska Center for Virology: Faculty Publications

Little is presently known about the specific routes of transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain …

Living With Hepatitis C : A Literature Review, & The Physical, Psychological And Social Impacts Of Hepatitis C And The Effects On Quality Of Life, Narelle Cockman

Theses : Honours

Hepatitis C (HCV) is a blood borne virus that affects the liver. It has become one of the most widespread blood borne viruses in Australia, now reaching epidemic proportions within the population. Given that HCV is a chronic long-term illness, with long term effects, a positive diagnosis potentially impacts on various aspects of' a person's life. The aim of this paper was to review HCV related research to examine what it is like for people living with the virus and the possible personal and social impacts of a positive diagnosis. The nature of HCV, including current incidence and prevalence rates, …

Bragdon V. Abbott: Extending The Americans With Disabilities Act To Asymptomatic Individuals, Eugenia Liu

Journal of Health Care Law and Policy

No abstract provided.

Discrimination Based On Hiv/Aids And Other Health Conditions: "Disability" As Defined Under Federal And State Law, David W. Webber

Journal of Health Care Law and Policy

No abstract provided.

The Common Cold: What Pharmacists Need To Know, Peggy Han, Peggy Mcmillan, Jeffery A. Goad

Pharmacy Faculty Articles and Research

A primer on the common cold for pharmacists, including its causes and pathophysiology and how to assess and treat patients.

Quantitative Image Analysis Of Simian Immunodeficiency Virus Replication In Macrophages Coinfected With Mycobacterium Avium Complex, Qingsheng Li, Keith G. Mansfield, Andrew Lackner, Ashley T. Haase

Qingsheng Li Publications

Mycobacterium avium is the most frequent cause of disseminated bacterial infection in patients with human immunodeficiency virus type 1 infection and in rhesus macaques with simian immunodeficiency virus (SIV) infection. This animal model of AIDS was used to test the hypothesis that this frequent association is the result of reciprocal enhancement of replication of both microorganisms. The replication of M. avium and SIV was analyzed in lymphatic tissues obtained from rhesus macaques experimentally inoculated with SIVmac who developed or remained free of overt M. avium infection. In situ hybridization, quantitative image analysis, and staining of M. avium and of macrophages …

Decision-Making In Ryan White Care Act Planning Bodies: An Analysis Of The Decision-Making Process Of The Joint Committee Of The Jacksonville Hiv/Aids Planning Council And Consortium, Andrea Clarkson Davis

UNF Graduate Theses and Dissertations

The purpose of this study was to determine which factors and the degree to which these factors influenced the Joint Committee when deciding how much money should be allocated to the different services funded by the Ryan White CARE Act. This study focused on the possible explicit and implicit factors influencing the decision-making process and interactions of the members of the HIV/AIDS Joint Prioritization & Allocation Committee in the decisions that were being made on behalf of the people who are infected and affected by this disease.

The methodology included a combination of quantitative and qualitative data, utilizing surveys, coding …

A Study On The Effects Of The N-Terminal Amino Acid Sequence On The Activation Of Human T-Cell Leukemia Virus Type 1 Protease, Hidayah Muhammad Kendall

Chemistry & Biochemistry Theses & Dissertations

Human T-cell leukemia virus type 1 (HTL V-1) is dependent upon the enzymatic activity of its protease for maturation. Maturation of the protease is facilitated by cleavage of specific amino acid residues, followed by dimerization. The effects of the amino acid sequence located N-terminally to the cleavage site on the ability of the protease to become active were the focus of the current study. These amino acid sequences were contributed by the plasmid vector into which the protease gene was inserted.

Surface probability analyses (SPAs) of the vectors, as well as for native sequences which produce the mature protease and …

Core-Binding Factor Influences The Disease Specificity Of Moloney Murine Leukemia Virus, Amy F. Lewis, Terryl Stacy, William R. Green, Lekidelu Taddesse-Heath, Janet W. Hartley, Nancy A. Speck

Dartmouth Scholarship

The core site in the Moloney murine leukemia virus (Moloney MLV) enhancer was previously shown to be an important determinant of the T-cell disease specificity of the virus. Mutation of the core site resulted in a significant shift in disease specificity of the Moloney virus from T-cell leukemia to erythroleukemia. We and others have since determined that a protein that binds the core site, one of the core-binding factors (CBF) is highly expressed in thymus and is essential for hematopoiesis. Here we test the hypothesis that CBF plays a critical role in mediating pathogenesis of Moloney MLV in vivo. We …

Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: Fasl/Fas-Mediated Inhibition Of Cd4+ And Cd8+ Antiviral T Cells By Viral Antigen-Positive Veto Cells, Robert F. Rich, William R. Green

Dartmouth Scholarship

C57BL/6 (H-2^b ) mice generate type-specific cytolytic T-lymphocyte (CTL) responses to an immunodominant K^b-restricted epitope, KSPWFTTL located in the membrane-spanning domain of p15TM of AKR/Gross murine leukemia viruses (MuLV). AKR.H-2^b congenic mice, although carrying the responder H-2^b major histocompatibility complex (MHC) haplotype, are low responders or nonresponders for AKR/Gross MuLV-specific CTL, apparently due to the presence of inhibitory AKR.H-2^b cells. Despite their expression of viral antigens and K^b, untreated viable AKR.H-2^b spleen cells cause dramatic inhibition of the C57BL/6 (B6) antiviral CTL response to in vitro stimulation with AKR/Gross MuLV-induced …

In Vitro Anti-Hepatitis B Virus Activities Of 5’-O-Myristoyl Analogue Derivatives Of 3’-Fluoro-2’,3’-Dideoxythymidine (Flt) And 3’-Azido-2’,3’- Dideoxythymidine (Azt), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus, Jyy-Shiang Huang, David L. Tyrrell

Pharmacy Faculty Articles and Research

The objective of this study was to evaluate a dual action prodrug concept wherein an unnatural myristic acid analogue is coupled via an ester moiety to the 5’-position of FLT or AZT. Subsequent intracellular cleavage of the prodrug ester would simultaneously release FLT or AZT that could inhibit reverse transcriptase (RT), and the myristic acid analogue that could inhibit myristoyl- CoA:protein N-myristoyltransferase (NMT). Methods: Cytotoxicity (2.2.15 cell culture), and antihepatitis B activity of 5’-O-myristoyl analogue prodrug derivatives of FLT and AZT (2-8) were evaluated in vitro using human liver hepatitis B virus (HBV) producing 2.2.15 cell lines. Results: The 5’- …

Racism And Hiv/Aids Among African Americans : Dismantling One Addresses The Other, H. Timothy Ewing

Capstone Collection

Nationally, HIV/AIDS transmission rates are rising in African American communities while decreasing in white, gay communities where the disease has been the most devastating. Classism, homophobia, lack of cultural competency/sensitivity, distrust of health care providers, and racism are all social and cultural components which contribute to the spread of this pandemic. Racism has historically impacted the lives of African Americans in many different forms. Unfortunately, racism has also impacted the rate of HIV/AIDS transmission among African American. This project addresses the questions: Does personal, cultural, and institutional racism effect HIV/AIDS transmission among African American in Seattle-King County, and if so …

Fear, Frustration And The Will To Overcome: A Social History Of Poliomyelitis In Western Australia, John H. Smith

Theses: Doctorates and Masters

This thesis investigates community responses to Poliomyelitis, and the Impact of the disease on those who experienced It, particularly during the epidemics that occurred In Western Australia between 1938 and 1956. The research sources an.: W.A. Health Department records, held mostly at the Battye Library, records held by Australian Archives and Royal Perth Hospital, newspaper reports, comparative studies from several states in Australia and overseas, oral history interviews, biographies and personal records. The history of polio has several layers and the presence or the disease In the community evoked varied and ambiguous reactions, summarised here as fear, frustration and the …

Ua12/2/1 College Heights Herald, Vol. 72, No. 16, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Regular features include:

• Just a Second
• Campus Line
• For the Record / Crime Reports
• People Poll
• Sports
• Diversions
• Movie Reviews
• Classifieds

Articles in this issue:

• Hall, Jason. Jack Kemp Pushes Tax Cut
• Blanford, Scarlet. One World Many Cultures, No Barriers – International Festival
• LaBelle, Charboneé. Coming Out Day Stresses Diversity and Education
• Stamper, John. Vigil Stirs Haunting Memories – Alcohol Awareness Week
• Hall, Jason. Committee to Investigate Dumping – WKU Farm
• Student Government Association Resolution Needs Student Support
• Bell, Thomas. Constitution Protects Freedom of Religion
• Carr, Kip. Thanks to …

Counseling And Testing For Hiv Prevention: Costs, Effects, And Cost-Effectiveness Of More Rapid Screening Tests, P. G. Farnham, Robin D. Gorsky, D. R. Holtgrave, Wanda K. Jones, Mary Guinan

School of Public Health Faculty Research

New rapid human immunodeficiency virus (HIV) antibody tests permit many individuals to receive test results and appropriate counseling at one clinic visit. Because currently used tests require significant time for processing, all individuals must return for a second visit for test results and counseling. Since return rates for the second visit are low, the more rapid tests present an opportunity to improve the efficiency of HIV counseling and testing.

The authors compared the costs and effectiveness of the currently used counseling and testing procedure and a streamlined procedure made possible by the new, more rapid screening tests. When test-positive clients …

Preventing Perinatal Transmission Of Hiv Costs And Effectiveness Of A Recommended Intervention, Robin D. Gorsky, P G. Farnham, Walter L. Straus, Blake Caldwell, D R. Holtgrave, R. J. Simonds, M F. Rogers, Mary Guinan

School of Public Health Faculty Research

In the United States, nearly all new human immunodeficiency virus (HIV) infections in children are acquired through perinatal (mother-to-infant) transmission. Each year, approximately 7000 infants are born to HIV-infected women in the United States.¹ Without intervention, an estimated 15-30% of these infants would become infected.² In 1994, results of the AIDS Clinical Trial Group (ACTG) Protocol 076 showed that treatment of infected pregnant women and their infants with zidovudine (ZDV) reduced the rate of perinatal HIV transmission from 25% to 8%.^3,4 Following these findings, the Public Health Service (PHS) issued recommendations for ZDV therapy to prevent perinatal …

Behavioral Science And Public Health: A Necessary Partnership For Hiv Prevention, Martin Fishbein, Mary Guinan

School of Public Health Faculty Research

We are now in the second decade of the AIDS epidemic in the United States. As of October 31, 1995, a total of 311,381 U.S. citizens had t died from AIDS, another 189,929 had been diagnosed with AIDS (1), and it is estimated that nearly l million persons are infected with HIV, the virus that causes AIDS (CDC). Despite the best efforts of biomedical researchers, we still have neither a cure nor a vaccine to prevent this deadly disease. Yet AIDS is a preventable disease; AIDS is first and foremost a consequence of behavior. It is not who you are, …

Transactivation Of The Moloney Murine Leukemia Virus And T-Cell Receptor Beta-Chain Enhancers By Cbf And Ets Requires Intact Binding Sites For Both Proteins., Wanwen Sun, Barbara J. Graves, Nancy A. Speck

Dartmouth Scholarship

The Moloney murine leukemia virus (Mo-MLV) enhancer contains binding sites (LVb and LVc) for the ets gene family of proteins and a core site that binds the polyomavirus enhancer-binding protein 2/core-binding factor (cbf) family of proteins. The LVb and core sites in the Mo-MLV enhancer contribute to its constitutive activity in T cells. All three binding sites (LVb, LVc, and core) are required for phorbol ester inducibility of the Mo-MLV enhancer. Adjacent binding sites for the ets and cbf proteins likewise constitute a phorbol ester response element within the human T-cell receptor beta-chain (TCR beta) enhancer and contribute to constitutive …

Prospects For The Control Of Bolivian Hemorrhagic Fever, Paul E. Kilgore, Clarence J. Peters, James N. Mills, Pierre E. Rollin, Lori Armstrong, Ali S. Khan, Thomas G. Ksiazek

Department of Pharmacy Practice

No abstract provided.