Diseases Commons^™

A Study On Metastatic Primary Lung Adenocarcinoma In A Marijuana Smoker, Sarah Hendee, Cristina Lee, Maria Aguirre, Dmitriy Scherbak

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

Pulmonary Tumor Thrombotic Microangiopathy Presenting As Rapidly Progressive Pulmonary Hypertension: A Case Report, Ali Basaran, Jacob Slowinski, Tesnim Hamdan, Kumaraswamy Nutalapati, Jason Stanberry, Ahmed Tarbay, Dunn Ryan

West Florida Division GME Research Day 2026

No abstract provided.

Shrinking Lung Syndrome In An Undifferentiated Connective Tissue Disease, Saul Alvarado Maldonado, Justin Gisel, Osama Srour

South Atlantic Division GME Research Days 2026

No abstract provided.

Combined Lung Adenocarcinoma And Carcinoid: A Rare Tumor, Nicholas D'Souza, Tanay Jadhav, Renu Khode

West Florida Division GME Research Day 2026

No abstract provided.

Necrotizing Pneumonia And Alveolar-Pleural Fistula After Foreign Body Aspiration, Vineet Madishetty, Adam Hurwitz, Ritvik Peesapati, Jessica Neugebauer, James Flanagan

West Florida Division GME Research Day 2026

No abstract provided.

Advanced Reperfusion Therapies For Intermediate-Risk Pulmonary Embolism: A Systematic Review And Network Meta-Analysis, Ajith Vivek, Sarah Mohamed, Klaudio Alla, Sushant Sunkaraneni, Michael Denney, Vikram Shah, Fagunkumar Modi

West Florida Division GME Research Day 2026

No abstract provided.

Efficacy Of Ensifentrine In Chronic Obstructive Pulmonary Disease (Copd): A Meta-Analysis Of Randomized Controlled Trials, Muhammad Abdullah, Mustafa Bin Tahir, Natalya Ahsan, Michael Moore, Nagaraja Sharma, Salman Muddassir

West Florida Division GME Research Day 2026

No abstract provided.

Primary Lung Adenocarcinoma Mimicking Miliary Tuberculosis Pattern: A Rare Presentation, Reza Alavi, Casper Chen, Idelisse Suarez Maldonado, William Arvan, Mukesh Patel, Elie Feghali

West Florida Division GME Research Day 2026

No abstract provided.

A Tale Of Two Primaries: Ectopic Papillary Thyroid Carcinoma In A Lung Resection With A Typical Carcinoma, Laura Luu, Laura Glasscock, Christina Maldonado, Vitaly Borodin

West Florida Division GME Research Day 2026

No abstract provided.

Hemoptysis And Shock From A Proximal Bronchial Artery Aneurysm Successfully Treated With Endovascular Embolization, Gautham Raghuthaman, Charmi Mehta, Tamer Hudali

North Texas GME Research Forum 2026

Background: Bronchial artery aneurysm (BAA) is a rare vascular abnormality and an uncommon cause of hemoptysis. Although many BAAs are asymptomatic, rupture can result in life-threatening hemorrhage and shock. Proximal BAAs arising near the bronchial artery origin are particularly rare and may be underrecognized due to nonspecific clinical and radiographic findings.

Case Presentation: Patient is a 49-year-old male with a history of pituitary tumor resection complicated by secondary adrenal insufficiency and hypothyroidism presented with three days of cough, fatigue, and hemoptysis. He was hypotensive and hypoxic on arrival and required vasopressor support with stress-dose corticosteroids. Computed tomography angiography (CTA) of …

Challenges Of Thrombectomy In Submassive Pulmonary Embolism With Patent Foramen Ovale, Sana Khan, Syed Ahmed, Muhammad T. Siddique, Edic Stephanian

North Texas GME Research Forum 2026

BACKGROUND/ INTRODUCTION: Submassive, or intermediate-risk, pulmonary embolism (PE) is defined by preserved systemic blood pressure with evidence of right ventricular (RV) strain. The presence of a patent foramen ovale (PFO) in this setting significantly increases the risk of hypoxemia, paradoxical embolization, and procedural complications during catheter-based interventions. Mechanical thrombectomy has become an important treatment option for selected patients with intermediate- to high-risk PE; however, experience in patients with concomitant large PFOs remains limited.

CASE PRESENTATION: A 78-year-old woman presented with acute dyspnea, hypoxemia, and chest pain and was found to have a saddle PE with severe RV dilation and biomarker …

Roles Of Thyroid Stimulating Hormone (Tsh) And Vitamin D Levels In Asthma Severity And Length Of Stay, Kumail Rizvi, Kenny Tran, Michele Mccarrol, Mohan Sengodan

North Texas GME Research Forum 2026

Background: Asthma exacerbations leading to hospitalization are very common and result from multifactorial causes. This research aims to investigate factors such as thyroid-stimulating hormone (TSH) and Vitamin D, which may play a role in the modulation of asthma-related hospitalizations and patient outcomes. TSH influences numerous cellular processes in the body, particularly during times of stress and illness, yet its role in asthma exacerbations and hospital length of stay remains unclear. Vitamin D has been studied for its role in enhancing medication absorption and regulating immune function, and multiple studies have shown that low serum Vitamin D levels are associated with …

Don’T Blame The Heart When On Steroids: A Rare Case Of Glucocorticoid Dependant Childhood Asthma Causing Non-Ischemic Dilated Cardiomyopathy, Greeshma Molugu, Srinivasan Rajaganapathy, Machaiah Madhrira, Karthik Anand

North Texas GME Research Forum 2026

Background: Steroids are known to have various cardiac side effects, such as hypertension, left ventricular hypertrophy, myocardial infarction, and sudden cardiac death. They are also known to cause rare but potentially life-threatening cardiomyopathy. The mechanisms behind steroid-induced cardiomyopathy are multifactorial, potentially involving direct or indirect myocardial toxicity, such as tissue fibrosis, apoptosis, and alterations in cardiac remodeling pathways via the renin-angiotensin-aldosterone system. Cardiomyopathy is known to occur with anabolic steroid use, but the literature on glucocorticoid-induced cardiomyopathy is scant. We present a rare case of glucocorticoid-induced dilated cardiomyopathy(DCM) in a patient with a history of refractory asthma who was treated …

The Uncommon Suspect: Cavitary Pulmonary Tuberculosis In A Previously Healthy Adult In Colorado, Nikita Zanko, Cristina Lee, Dmitriy Scherbak

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

A Double-Edged Sword: Accelerated Metastasis After Video-Assisted Thoracoscopic Surgery In Advanced Lung Adenocarcinoma, Grace Anne Martin, Kanwar Bir Dhaliwal, Mala Goyal

MidAmerica Division GME Healthcare Symposium 2026

No abstract provided.

Empiric Antibiotic And Corticosteroid Prescribing For Hospitalized Acute Exacerbations Of Copd: Associations With Length Of Stay And Readmissions In A Large Multicenter U.S. Cohort, Kumar Abhishek, Pratyush Kumar, Archana Machavarapu, Munaf Siyamwala, Michael Waxman, Jeffrey Durbin, Kari Nilsen

MidAmerica Division GME Healthcare Symposium 2026

No abstract provided.

Z Variant Heterozygosity In Alpha-1 Antitrypsin Deficiency: Disease Risk And Treatment Implications, Craig P. Hersh, Jeffrey H. Teckman, Pavel Strnad, Aaron Hakim, Tomás P. Carroll, Ian P. Hall, Auyon J. Ghosh, Igor Barjaktarevic, Noel G. Mcelvaney, Joseph E. Kaserman, David A. Lomas, Charlie Strange, M Bradley Drummond, Stephen I. Rennard, Kathi E. Hanna, Virginia C. Clark, Monica P. Goldklang, Peg Iverson, Andrew A. Wilson

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Individuals heterozygous for alpha-1 antitrypsin deficiency (AATD) have one copy of the normal "M" allele and one copy of an abnormal allele ("Z", "S", or another variant) in the SERPINA1 gene. Historically, evidence has been lacking to support the concept that heterozygotes are at increased risk for liver and/or lung complications compared to individuals homozygous for the M allele. However, growing evidence suggests that inheritance of a single Z allele increases the risk of disease in some individuals. The Alpha-1 Foundation convened a workshop on October 27, 2023, in Bethesda, Maryland that included stakeholders from the research, pharmaceutical, and …

Drug-Induced Ild Requiring Ecmo, Arjun Kamath, Jose Garza, Matthew Wagner, Deekshita Valiveti, Percy Thomas, Christopher Ganson, Abhay Vakil, Zuhair Ali

Gulf Coast Division GME Research Day 2026

No abstract provided.

Ivig As Salvage Therapy In Refractory Antisynthetase Syndrome-Associated Ild: A Three-Case Series, Shine Vazhappilly, Julio Paoli-Gonzalez, Jose Herazo-Maya

West Florida Division GME Research Day 2026

No abstract provided.

Bayesian Reanalysis Of Early Remdesivir For The Treatment Of Covid-19 In Outpatients With High Risk Of Progression To Severe Disease, Mazin Abdelghany, Fang Yu, Stephen I. Rennard, Yeongjin Gwon

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Though Bayesian methods are flexible, intuitive, and readily incorporated into clinical decision-making, with particular utility when prior information is available, they remain underutilized in the analysis of clinical trials.

METHODS: In PINETREE, a Phase 3 randomized controlled trial (RCT) of remdesivir (RDV) for the treatment of outpatients with COVID-19 at high risk of severe disease, the primary outcome of COVID-19-related hospitalization or all-cause death was reanalyzed using a range of reference and data-driven priors. Posterior probability distributions were used to calculate the probability that the estimated hazard ratio (HR) was below a range of clinically meaningful specified thresholds and …

Invasive Pulmonary Aspergillosis: A Two-Year Journey, Jason Woods, Padmaditya Sureddi, Nga Van, Danielle Ford

North Texas GME Research Forum 2026

BACKGROUND: Highly active anti-retroviral therapy (HAART) has decreased the incidence of opportunistic infections among persons with HIV. Invasive aspergillosis specifically is uncommon among individuals with clusters of differentiation 4 (CD4) count >100 cells/mm3. Furthermore, treatment of aspergillosis in the HIV-infected population has not been examined systematically. We report a patient with CD4 count >200 cells/mm3, compliant with HAART therapy who developed invasive pulmonary aspergillosis (IPA) over the course of two years that was successfully treated through a combination of bronchial artery embolization and liposomal amphotericin.

CASE PRESENTATION: A 56-year-old man from southern Africa with four-year history of HIV-1 on HAART …

Reducing Respiratory Viral Testing In A Pediatric Emergency Department: A Quality Improvement Initiative, Anna Suessman

North Texas GME Research Forum 2026

Background: Respiratory viral testing in pediatric emergency departments (EDs) is frequently performed despite limited impact on clinical management for many low-risk presentations. Unnecessary testing increases cost and operational burden may delay patient throughput and can provide false reassurance to caregivers. Additionally, pediatric emergency department nurses agreed with overburden and impact to throughput based on overuse of viral testing (qualitative nursing survey conducted on September 4, 2024 showed >98% felt testing was unnecessary). We hypothesized that reducing testing through standardized team education and discharge processes would not negatively affect patient experience. This initiative aimed to decrease unnecessary respiratory viral testing during …

Impact Of Mips Measure 66 On The Incidence Of Pta's, Sydney Finch, Christopher Houston

North Texas GME Research Forum 2026

INTRO

A number of randomized controlled trials indicate that using point-of-care group A strep (POC GAS) testing decreases antibiotic utilization without compromising health outcomes. In 2018, the Merit-based Incentive Payment System (MIPS) measure 66 went into effect requiring the testing for GAS when treating pharyngitis. The intent was to decrease the unnecessary use of antibiotics in the treatment of pharyngitis, given that most cases are viral. Anecdotally, some physicians have noticed the increased incidence of peritonsillar abscesses (PTA). Our research group aims to investigate if there has been a significant increase in incidence of PTAs after the implementation of MIPS …

Initiation, Timing, And Duration Of Prone Positioning In Icu Ards Patients: An Integrative Research Review (Irr), Amanda Everard Thomas

Covenant Nurses Week 2026

No abstract provided.

Type 2 Myocardial Infarction In Adults Admitted For Severe Persistent Asthma With Status Asthmaticus: Evaluating Predictors And Mortality Burden, Kanwar Bir Dhaliwal, Rahul Pawa, Naresh Kodwani

MidAmerica Division GME Healthcare Symposium 2026

No abstract provided.

Baseline Right Ventricular-Pulmonary Arterial Coupling As A Predictor Of Clinical Outcomes In Endobronchial Valve Therapy For Advanced Emphysema, Syed Ali Raza Abidi, Prithvi Basu Roy, Munaf Siyamwala, Amelia Goslin

MidAmerica Division GME Healthcare Symposium 2026

No abstract provided.

Beyond Drainage: Can Pleural Effusion Serve As A Natural Tamponade Against Tumor Hemorrhage? A Case Report And Mechanistic Hypothesis, Pratyush Kumar, Kumar Abhishek, Pankti Shah, Amelia Goslin, Archana Machavarapu, Catherine Joyce, Michael Waxman

MidAmerica Division GME Healthcare Symposium 2026

No abstract provided.

Shaping The Future Of Respiratory Care: A Look Into The Next Decade And Strategic Recommendations By The European Forum For Research And Education In Allergy And Airways Diseases, Xander Bertels, Glenis K. Scadding, Vibeke Backer, Susanne Lou, Wytske J. Fokkens, Peter J. Barnes, Manuel Bernal Sprekelsen, Leif Bjermer, Michael Blaiss, Elena Borzova, Marie-Charlotte Brüggen, Guy G. Brusselle, Lars Olaf Cardell, Diego M. Conti, Marjolein Cornet, Eugenio De Corso, Bernard De Groeve, Ratko Djukanovic, Adam T. Fox, Mina Gaga, Philippe Gevaert, Peter Gibson, Claudia L. Gray, Joseph Han, Liam Heaney, Enrico Heffler, Hans Jürgen Hoffmann, Claire Hopkins, Daniel Jackson, Outi Jauhola, Milos Jesenak, Pål Johansen, Ekaterina Khaleva, Basile Landis, Stella Lee, Valerie Lund, Mika Mäkelä, Marinda Mcdonald, Erik Melén, Joaquim Mullol, Antonio Nieto-García, Ian Pavord, Anju Peters, David Price, Santiago Quirce, Dermot Ryan, Pernilla Sahlstrand-Johnson, Sophie Scheire, Peter Schmid-Grendelmeier, Sven Schneider, Brent A. Senior, Catherine M.E. Shire, Peter K. Smith, Zsolt Szépfalusi, M. Thijs A. Teeling, Michael E. Wechsler, Philippe Houssiau, Klaus F. Rabe, Peter W. Hellings, José Luis Castro

Department of Otolaryngology (ENT) Faculty Publications

Chronic respiratory diseases (CRDs) remain 1 of the leading causes of preventable morbidity and disability worldwide, affecting up to one-third of the total Western population in 2025. Recognizing the substantial burden of inflammatory airway diseases such as asthma, COPD, chronic rhinosinusitis, and respiratory allergy, the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) organized the symposium “Shaping the Future of Respiratory Care” in April 2025 in Brussels, Belgium, at the occasion of the 10-year jubilee. Featuring keynote speakers from the World Health Organization and EUFOREA, this initiative had the following aims: (1) promoting dialogue on translating …

Deletion Of Stim1 In Treg Cells Protects Against Lung Fibrosis And Associated Cardiovascular Complications In A Pre-Clinical Mouse Model, Nagaraja Nagre, Balaji Srinivas, Nicholas Richards, Ryan Washington, Gregory Nicholson, Yan Sanders, Beata Kosmider, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by excessive tissue remodeling and impaired gas exchange. Evidence highlights the critical interplay between immune regulation, calcium signaling, and redox biology implications in the pathogenesis of fibrotic lung disease. Regulatory T-cells (Tregs), known to modulate cardiovascular and immune function, are diminished in IPF, contributing to inflammation and tissue damage. Here, we demonstrate that the stromal interaction molecule 1 (STIM1), a key regulator of intracellular calcium homeostasis, is significantly upregulated in Treg cells isolated from IPF patients and mice subjected to bleomycin-induced lung injury. This upregulation is associated with …

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Department of Biomedical and Translational Sciences Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …