Diseases Commons^™

Autophagy Protein Nrbf2 Has Reduced Expression In Alzheimer's Brains And Modulates Memory And Amyloid-Beta Homeostasis In Mice, Veronik Lachance, Qian Wang, Eric Sweet, Insup Choi, Cui-Zan Cai, Xu-Xu Zhuang, Jessica Li Jiang, Robert D. Blitzer, Ozlem Bozdagi-Gunal, Bin Zhang, Jia-Hong Lu, Zhenyu Yue

Biology Faculty Publications

Background Dysfunctional autophagy is implicated in Alzheimer's Disease (AD) pathogenesis. The alterations in the expression of many autophagy related genes (ATGs) have been reported in AD brains; however, the disparity of the changes confounds the role of autophagy in AD. Methods To further understand the autophagy alteration in AD brains, we analyzed transcriptomic (RNAseq) datasets of several brain regions (BA10, BA22, BA36 and BA44 in 223 patients compared to 59 healthy controls) and measured the expression of 130 ATGs. We used autophagy-deficient mouse models to assess the impact of the identified ATGs depletion on memory, autophagic activity and amyloid-beta (A …

Viral Infections And Interferons In The Development Of Obesity, Yun Tian, Jordan Jennings, Yuanying Gong, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Obesity is now a prevalent disease worldwide and has a multi-factorial etiology. Several viruses or virus-like agents including members of adenoviridae, herpesviridae, slow virus (prion), and hepatitides, have been associated with obesity; meanwhile obese patients are shown to be more susceptible to viral infections such as during influenza and dengue epidemics. We examined the co-factorial role of viral infections, particularly of the persistent cases, in synergy with high-fat diet in induction of obesity. Antiviral interferons (IFNs), as key immune regulators against viral infections and in autoimmunity, emerge to be a pivotal player in the regulation of adipogenesis. In this review, …

Sustainable Solutions, Fall/Winter 2020, Issue 41

Sustain Magazine

No abstract provided.

Digestive System, Janna Jann '20, Andrew Du '20, Ishan Nikam '20, Nikhilesh Gupta '20

Human Diseases Graphic Novels

No abstract provided.

Chlamydia, Lauren Pickett '20, Namit Padgaonkar '20, Vidhi Singh '20, Olivia Orobor '20, Samuel Rabideau '20

Human Diseases Graphic Novels

No abstract provided.

Alzheimer's, Sophia Pribus '20, Shivang Bhaskar '20, Pratibha Bhalla '20, Zahra Vasi '20

Human Diseases Graphic Novels

No abstract provided.

Scabies, Srilalana Appasani '21, Prarthana Prashanth '21, Krishna Thakkar '20, Esha Dani '20

Human Diseases Graphic Novels

No abstract provided.

Shingles, Pratibha Bhalla '20, Zahra Vasi '20, Shivang Bhaskar '20, Sophia Pribus '20

Human Diseases Graphic Novels

No abstract provided.

Invasion Of The Pollen, Elizabeth Murphy '20, Rachel Mason '20, Jodie Meng '20, Shouri Bochetty '21

Human Diseases Graphic Novels

No abstract provided.

Diabetes, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Tuberculosis, Jodie Meng '20, Shouri Bochetty '21, Elizabeth Murphy '20, Rachel Mason '20

Human Diseases Graphic Novels

No abstract provided.

Bell's Palsy Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Melanoma, Esha Dani '20, Krishna Thakkar '20, Prarthana Prashanth '21, Srilalana Appasani '21

Human Diseases Graphic Novels

No abstract provided.

Huntington's Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Addisons Disease, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Pneumonia, Brennan Shapiro '20

Human Diseases Graphic Novels

No abstract provided.

Transient Dynamics Of Infection Transmission In An Intensive Care Unit, Christopher Short, Matthew S. Mietchen, Eric T. Lofgren

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Oscillation In Mathematical Epidemiology, Meredith Greer

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Chronic Kidney Disease From Non-Traditional Causes Throughout Central America, Abigail K. Watson

Senior Theses

Throughout many Central American countries, incidence of chronic kidney disease (CKD) has been on the rise. The disease mainly affects agricultural workers and differs from typical CKD. Patients in these countries often do not have preexisting conditions such as diabetes or hypertension known to be traditional causes of CKD. They also experience increased damage to the kidney tubules, rather than the glomeruli generally more heavily impacted. There has been speculation regarding the causes of CKDnT (chronic kidney disease of nontraditional causes), but no consensus has been reached. Two major hypotheses to explain the high prevalence among Central American sugarcane workers …

An Analysis Of The Rajasthan Public Health System’S Response To The 2019 Dengue Insurgence, Luke Bryan

Independent Study Project (ISP) Collection

Dengue virus is in a pandemic status and is a major public health issue in the modern world. The mosquito-borne disease is largely prevalent in Asia and specifically India, where more than half of the states are considered to have complete presence of the dengue virus. The intricate infrastructure of the Indian public health system looks for dengue cases at all levels and reports to the integrated disease surveillance programme (IDSP).

Analyses of the IDSP and trends of dengue cases was done in response to dengue outbreaks throughout the state. Geographic information system (GIS) maps were created to evaluate a …

Effects Of Dabigatran In Mouse Models Of Aging And Cerebral Amyloid Angiopathy, Neethu Michael, Mher Mahoney Grigoryan, Kelley Kilday, Rachita K. Sumbria, Vitaly Vasilevko, Joanne Van Ryn, David H. Cribbs, Annlia Paganini-Hill, Mark J. Fisher

Pharmacy Faculty Articles and Research

Oral anticoagulants are a critical component of stroke prevention, but carry a risk of brain hemorrhage. These hemorrhagic complications tend to occur in elderly individuals, especially those with predisposing conditions such as cerebral amyloid angiopathy (CAA). Clinical evidence suggests that non-vitamin K antagonist oral anticoagulants are safer than traditional oral anticoagulants. We analyzed whether the anticoagulant dabigatran produces cerebral microhemorrhage (the pathological substrate of MRI-demonstrable cerebral microbleeds) or intracerebral hemorrhage in aged mice with and without hemorrhage-predisposing angiopathy. We studied aged (22 months old) Tg2576 (a model of CAA) and wild-type (WT) littermate mice. Mice received either dabigatran etexilate (DE) …

Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22

Sustain Magazine

No abstract provided.

Sustainable Communities, Fall/Winter 2010, Issue 21

Sustain Magazine

No abstract provided.

Sustainable Building, Spring/Summer 2009, Issue 20

Sustain Magazine

No abstract provided.

Environmental History, Fall/Winter 2009, Issue 19

Sustain Magazine

No abstract provided.

Student Research, Spring/Summer 2008, Issue 18

Sustain Magazine

No abstract provided.

Evolving Pollution Prevention, Fall/Winter 2008, Issue 17

Sustain Magazine

No abstract provided.

Climate Change, Spring/Summer 2007, Issue 16

Sustain Magazine

No abstract provided.

Our Energy Future, Fall/Winter 2007, Issue 15

Sustain Magazine

No abstract provided.

Land Conservation, Spring/Summer 2006, Issue 14

Sustain Magazine

No abstract provided.