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Full-Text Articles in Diseases
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith
Theses and Dissertations (ETD)
Retinoblastoma (Rb) is the most common intraocular malignancy in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing challenges in the management of Rb. Vitreous seeds constitute the greatest challenge in treatment of Rb. The unique location of these seeds within the vitreous makes them difficult to treat. Viable seeds showed reduced proliferative capacity and metabolism. making the majority refractory to current chemotherapeutics. This prompted the development of …
Ajulemic Acid Induces Cell Death In Retinoblastoma Cells, Emily A. Evans
Ajulemic Acid Induces Cell Death In Retinoblastoma Cells, Emily A. Evans
Honors Theses
Retinoblastoma is a cancer of the retina affecting one in every 15,000-20,000 births. It is normally diagnosed in infancy or early childhood and although it is treatable, enucleation is commonly required. Other treatments include radiation, photocoagulation, or cryotherapy and are often followed by chemotherapy. In an attempt to find an alternate method of treatment that lowers the frequency of enucleation and the serious side-effects resulting from current treatments, ajulemic acid (AJA), a synthetic derivative of Cannabis, has been used to treat retinoblastoma cells. Thus far, significant cell death has occurred among retinoblastoma cells that have been treated with AJA concentrations …