Diseases Commons^™

Inside Unlv, Cate Weeks, Diane Russell, Carol C. Harter, Martin Watson

Inside UNLV

No abstract provided.

Ua61/6 Newsletter, Issue 2, Wku Institute For Rural Health Development & Research

WKU Archives Records

Newsletter created by and about the Institute for Rural Health Development & Research. This issue contains:

• College of Health & Human Services Has New Dean – John Bonaguro
• Simpson, Staci. Institute Aims to Improve Oral Health of Children
• Whitfield, Beth. WKU Mobile Unit KICS Off Dental Event with Webster County – Kentucky Interdisciplinary Community Screening
• Stone, Glynda. TEACH KY: Teachers Exploring & Advocating Careers in Health in Kentucky
• Institute Sponsors Hispanic Health Fair
• HIV Prevention Counseling & Testing Training Program Initiated at WKU
• New Web-based Course Offered Through Communications Disorders Department at WKU
• Lashley, Donita. Child Passenger Safety Training
• Handy, …

Fetal Alcohol Syndrome Students In The Classroom : An Overview Of Strategies And Implications For Educators, Emily Olson

Graduate Research Papers

Fetal Alcohol Syndrome (FAS) is a very serious disease that is affecting more and more students in schools across America each year. Each of these students with FAS have different levels of severity of the disease and individual needs, but there are general and universal interventions and strategies that can be used by educators when working in the schools with these students. The following is an overview of some of these interventions and strategies that can be used with FAS students. Also included are implications for school psychologists and other educators for development and education in this area to better …

Inside Unlv, Richard Jensen, Donna Mcaleer, Jennifer Vaughan, Cate Weeks, Carol C. Harter, Jeffrey Koep

Inside UNLV

No abstract provided.

Retroviral Delivery Of Connexin Genes To Human Breast Tumor Cells Inhibits In Vivo Tumor Growth By A Mechanism That Is Independent Of Significant Gap Junctional Intercellular Communication, H. Qin, Q. Shao, H. Curtis, J. Galipeau, Daniel Belliveau, T. Wang, M. Alaoui-Jamali, D. Laird

Daniel J. Belliveau

The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors remains poorly understood. In this study human breast tumor cells were found to exhibit diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular communication (HBL100); (b) low levels of Cx43 and sparse intercellular communication (MDA-MB-231); and (c) significant levels of Cx43 and moderate intercellular communication (Hs578T). Although retroviral delivery of Cx43 and Cx26 cDNAs to MDA-MB-231 cells did not achieve an expected substantial rescue of intercellular communication, overexpression of connexin genes did result in a dramatic suppression of tumor growth when connexin-expressing MDA-MB-231 cells were …

Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy

Inside UNLV

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 77, No. 27, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Hall, Rex. Western Suspends Fraternity – Sigma Alpha Epsilon
• Ragan, Jason. Behind the Muckrakers’ Music
• Hoang, Mai. Western Markets Credit Card to Students
• Lord, Joseph. Employees Complain of Mold in Tate Page Hall
• Enrollment Money Can Bring Teachers – University Senate
• Grady, Brian. Editorial Cartoon re: Teacher Relief
• Leslie Bedo Meeting Goals of Student Government Association, But Not Students’
• Ransdell, Troy. Action, Not Complaints – Student Government Association
• Cottrell, Lindsey. Cowgirls Not a Club – Equestrian Team
• Holm, Hollan. Student Government Association to Buy Presents for Potter Children’s Home …

Aggregated Dsred-Tagged Cx43 And Over-Expressed Cx43 Are Targeted To Lysosomes In Human Breast Cancer Cells, H. Qin, Q. Shao, Daniel Belliveau, D. Laird

Daniel J. Belliveau

To investigate if either wild-type or aggregated Cx43 is abnormally targeted to lysosomes in human breast tumor cells, we examined the fate of DsRed-tagged Cx43 and over-expressed Cx43 in communication-deficient HBL-100 and MDA-MB-231 cells. DsRed-tagged Cx43 was assembled into gap junctions in control normal rat kidney cells that express endogenous Cx43 but not in Cx43-negative HBL-100 cells. However, when HBL-100 cells were engineered to coexpress wild-type Cx43 a population of DsRed-tagged Cx43 was rescued and assembled into gap junctions. Co-expression of wild-type Cx26 failed to rescue the assembly of DsRed-tagged Cx43 into gap junctions. Immunolocalization studies revealed that DsRed-tagged Cx43 …

Decision-Making In Ryan White Care Act Planning Bodies: An Analysis Of The Decision-Making Process Of The Joint Committee Of The Jacksonville Hiv/Aids Planning Council And Consortium, Andrea Clarkson Davis

UNF Graduate Theses and Dissertations

The purpose of this study was to determine which factors and the degree to which these factors influenced the Joint Committee when deciding how much money should be allocated to the different services funded by the Ryan White CARE Act. This study focused on the possible explicit and implicit factors influencing the decision-making process and interactions of the members of the HIV/AIDS Joint Prioritization & Allocation Committee in the decisions that were being made on behalf of the people who are infected and affected by this disease.

The methodology included a combination of quantitative and qualitative data, utilizing surveys, coding …

Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza

Daniel J. Belliveau

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that is currently in clinical trial for patients with malignant glioma. G207 exhibits an efficient oncolytic activity in tumor cells, yet minimal toxicity in normal tissue when injected into the brains of HSV-susceptible mice or nonhuman primates. In this study, we evaluated the shedding and biodistribution of clinical-grade G207 after intracerebral inoculation (3 × 107 pfu) in four New World owl monkeys (Aotus nancymae). Using PCR analyses and viral cultures, neither infectious virus nor viral DNA was detected from tear, saliva, or vaginal secretion samples at any time …

Aids Education On College Campuses, Lauretta A. Dienberg

Graduate Research Papers

Many researchers have examined the issue of college students and AIDS. Most have come to the same conclusion, that students know how to protect themselves but don't see AIDS as personal threat to their lives. As colleges become more diverse and more students are able to attend college, these issues probably will become more complex. Coupled with diversity issues, AIDS has now become known as a chronic rather than deadly disease, as a result of progress made toward treating AIDS and through early detection.

Autocrine Hepatocyte Growth Factor Provides A Local Mechanism For Promoting Axonal Growth, X. Yang, J. Toma, S. Bamji, Daniel Belliveau, J. Kohn, M. Park, F. Miller

Daniel J. Belliveau

In this report, we describe a novel local mechanism necessary for optimal axonal growth that involves hepatocyte growth factor (HGF). Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor, the Met tyrosine kinase, both in vivo and in vitro. Exogenous HGF selectively promotes the growth but not survival of cultured sympathetic neurons; the magnitude of this growth effect is similar to that observed with exogenous NGF. Conversely, HGF antibodies that inhibit endogenous HGF decrease sympathetic neuron growth but have no effect on survival. This autocrine HGF is required locally by sympathetic axons for optimal growth, as …

Differential Expression Of Gap Junctions In Neurons And Astrocytes Dervied From P19 Embryonal Carcinoma Cells, Daniel Belliveau, J. Bechberger, K. Rodgers, C. Naus

Daniel J. Belliveau

The P19 embryonal carcinoma cell line represents a pluripotential stem cell that can differentiate along the neural or muscle cell lineage when exposed to different environments. Exposure to retinoic acid induces P19 cells to differentiate into neurons and astrocytes that express similar developmental markers as their embryonic counterparts. We examined the expression of gap junction genes during differentiation of these stem cells into neurons and astrocytes. Untreated P19 cells express at least two gap junction proteins, connexins 26 and 43. Connexin32 could not be detected in these cells. Treatment for 96 hr with 0.3 mM retinoic acid induced the P19 …

Blocking Nerve Growth Factor Binding To The P75 Neurotrophin Receptor On Sympathetic Neurons Transiently Reduces Trka Activation But Does Not Affect Neuronal Survival, C. Lachance, Daniel Belliveau, P. Barker

Daniel J. Belliveau

Nerve growth factor interacts with the trkA tyrosine kinase receptor and with the p75 neurotrophin receptor. It is clear that trkA mediates most, if not all, of the stereotypical responses of sympathetic neurons to nerve growth factor but the role of the p75 neurotrophin receptor is unclear. In this study, we have asked whether a functional interaction between p75 neurotrophin receptor and trkA exists in primary sympathetic neurons by disrupting nerve growth factor binding to p75 neurotrophin receptor. Acute assays reveal that blocking antibodies directed against p75 neurotrophin receptor reduce nerve growth factor-mediated trkA tyrosine phosphorylation and reduce the amount …

Transgenic Mice Expressing The Intracellular Domain Of The P75 Neurotrophin Receptor Undergo Neuronal Apoptosis, M. Majdan, C. Lachance, A. Gloster, R. Aloyz, C. Zeindler, S. Bamji, A. Bhakar, Daniel Belliveau, J. Fawcett, F. Miller, P. Barker

Daniel J. Belliveau

We have asked whether p75NTR may play a role in neuronal apoptosis by producing transgenic mice that express the p75NTR intracellular domain within peripheral and central neurons. These animals showed profound reductions in numbers of sympathetic and peripheral sensory neurons as well as cell loss in the neocortex, where there is normally little or no p75NTR expression. Developmental loss of facial motor neurons was not observed, but induced expression of the p75NTR intracellular domain within adult animals led to increased motor neuron death after axotomy. Biochemical analyses suggest that these effects were not attributable to a p75NTR-dependent reduction in trk …

Ngf And Neurotrophin-3 Both Activate Trka On Sympathetic Neurons But Differentially Regulate Survival And Neuritogenesis, Daniel Belliveau, I. Krivko, C. Lachance, J. Kohn, D. Rusakov, D. Kaplan, F. Miller

Daniel J. Belliveau

In this report we examine the biological and molecular basis of the control of sympathetic neuron differentiation and survival by NGF and neurotrophin-3 (NT-3). NT-3 is as efficient as NGF in mediating neuritogenesis and expression of growth-associated genes in NGF-dependent sympathetic neurons, but it is 20-40-fold less efficient in supporting their survival. Both NT-3 and NGF induce similar sustained, long-term activation of TrkA, while NGF is 10-fold more efficient than NT-3 in mediating acute, short-term TrkA activity. At similar acute levels of TrkA activation, NT-3 still mediates neuronal survival two- to threefold less well than NGF. However, a mutant NT-3 …

Ua12/2/1 College Heights Herald, Vol. 72, No. 16, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Regular features include:

• Just a Second
• Campus Line
• For the Record / Crime Reports
• People Poll
• Sports
• Diversions
• Movie Reviews
• Classifieds

Articles in this issue:

• Hall, Jason. Jack Kemp Pushes Tax Cut
• Blanford, Scarlet. One World Many Cultures, No Barriers – International Festival
• LaBelle, Charboneé. Coming Out Day Stresses Diversity and Education
• Stamper, John. Vigil Stirs Haunting Memories – Alcohol Awareness Week
• Hall, Jason. Committee to Investigate Dumping – WKU Farm
• Student Government Association Resolution Needs Student Support
• Bell, Thomas. Constitution Protects Freedom of Religion
• Carr, Kip. Thanks to …

Ua12/2/1 College Heights Herald, Vol. 72, No. 6, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Regular features include:

• Just a Second
• Campus Line
• For the Record / Crime Reports
• People Poll
• Sports
• Diversions
• Movie Reviews
• Classifieds

Articles in this issue:

• Stamper, John. Hurricane Fran
• VanWinkle, Cara. Bill Clinton Rules Favored – Tobacco
• Baker, Emily. Life With Diabetes is Bittersweet for Many Students
• VanWinkle, Cara. Olympics: Greek Pledges Keep Spirit Alive
• Signs of a World Becoming Less Humane
• Browning, Michelle. Cancer: Protect Yourself from Harmful Rays
• Hall, Jason. Board of Regents Get Frowns, Stars from Students
• Simmons, Darryn. Purpose of Armed Services Questioned
• Miller, Kristen. …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Archives Records

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Brooks, Lynnette and Cindy Calisi. The Effect of Selenium Supplementation on the Immune Response of Mice with Experimental Chagas' Disease
• Hildreth, John. Teasing the Muse
• Jenkins, Rhonda. Steinbeck's Portraits of Prostitutes: Progression of an Author's Vision
• Kirkham, Michelle. The Prenatal Use of Crack Cocaine: How It Affects Children and How Schools Can Respond
• Gibson, Jeanette and Juli McCay. Circadian Rhythm of Brain GABA Levels in the Cockroach, Leucophaea Maderae
• Patterson, Dana. Home Schooling …

Adenovirus-Mediated Gene Transfer Of The Tumor Suppressor, P53, Induces Apoptosis In Postmitotic Neurons, R. Slack, Daniel Belliveau, M. Rosenberg, J. Atwal, H. Lochmuller, R. Aloyz, A. Haghighi, B. Lach, P. Seth, E. Cooper, F. Miller

Daniel J. Belliveau

Programmed cell death is an ongoing process in both the developing and the mature nervous system. The tumor suppressor gene, p53, can induce apoptosis in a number of different cell types. Recently, the enhanced expression of p53 has been observed during acute neurological disease. To determine whether p53 overexpression could influence neuronal survival, we used a recombinant adenovirus vector carrying wild type p53 to transduce postmitotic neurons. A control consisting of the same adenovirus vector background but carrying the lacZ reporter expression cassette was used to establish working parameters for the effective genetic manipulation of sympathetic neurons. We have found …

Ua66/4/2 Highlights, Vol. 1, No. 2, Wku Social Work

WKU Archives Records

Newsletter created by and about the WKU Social Work department. Articles:

• New University Policy
• Westover, Lynn. Change is a Necessity of Life – Poem
• AIDS Education
• News from Association of Student Social Workers
• Association of Student Social Workers Potluck
• Phi Alpha News
• Field Student Spotlight – Ethan Browning & Amy Watson

Cellular Localization Of Gap Junction Mrnas In Developing Rat Brain, Daniel Belliveau, C. Naus

Daniel J. Belliveau

We investigated the developmental expression and cellular resolution of connexin32 and 43 mRNA in the rat brain using in situ hybridization. Utilizing 35S-labelled probes, in situ hybridization was performed on sections of embryonic day 20 and postnatal days 3, 10, 15, 30 and adult brain. Connexin32 mRNA was first detected in brainstem nuclei at postnatal day 3 and in the midbrain at postnatal day 15. The level of this message continued to increase to postnatal day 30 where the level of message reached a plateau or slightly decreased by adulthood. The distribution of signal included the medial vestibular nucleus, dorsal …

Human Immunodeficiency Virus And Acquired Immune Deficiency : Beliefs, Knowledge, And Behaviors Of High-School Students Attending Seventh-Day Adventist Academies, Deborah L. Gray

Dissertations

Problem. Few attempts have been conducted to assess knowledge of HIV/AIDS in the adolescent population attending Seventh-day Adventist secondary schools. This present study was to investigate the HIV/AIDS-related beliefs, HIV/AIDS-related knowledge, and HIV/AIDS-related behaviors of adolescents according to gender, grade level, ethnicity, geographical location, and religious affiliation.

Method. The subjects for this study were 1,292 9th- through 12th-grade students attending selected non-boarding Seventh-day Adventist academies representing three geographical regions of the United States and the Virgin Islands. The survey instrument utilized was the "AIDS Survey for Students" obtained from the U.S. Center for Disease Control. Chi-square analysis was used to …

Cortical Type 2 Astrocytes Are Not Dye Coupled Nor Do They Express The Major Gap Junction Genes Found In The Central Nervous System, Daniel Belliveau, C. Naus

Daniel J. Belliveau

The O‐2A progenitor cell first described from the rat optic nerve is a bipotential precursor of oligodendrocytes and type 2 astrocytes. Each cell expresses specific markers that distinguish them as unique cell types. O‐2A progenitors cultured in high serum preferentially differntiate into type 2 astrocytes and when exposed to defined medium or low serum develop along the oligodendrocyte lineage. We analyzed the gap junction gene expression of type 2 astrocytes to determine if they are coupled to form a syncytium, like their type 1 astrocyte counterparts. Dye coupling experiments demonstrated that cortical type 2 astrocytes are not coupled, while type …

Ua12/2/1 College Heights Herald, Vol. 68, No. 38, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Tungate, Matthew. Some Not Enthused by Bill Clinton Proposals – Politics
• Anna, Cara. Ralph Willard: Coach Appeals for Fan Support – Basketball
• Gagliardi, Melissa. Diddle Arena Beomcing Country Heaven – Concerts
• Broadbent, Stephanie. Safe Sex Can be Kinky & Erotic Speaker Says – Buck Harris, HIV, AIDS
• Howard Lindsey to be Arraigned Tomorrow
• Native American Lecture Coming – Hardin Planetarium
• Hofmann, Martin. Editorial Cartoon Rush Limbaugh
• Molley, Sean. Men Make Mistakes – Thomas Meredith
• Wheeler, Shayne. Prayers for President Thomas Meredith
• Zorn, William. Another Big …

In Vivo Growth Of C6 Glioma Cells Transfected With Connexin43 Cdna, C. Naus, K. Elisevich, D. Zhu, Daniel Belliveau, R. Del Maestro

Daniel J. Belliveau

In order to examine the possible role of intercellular communication via gap junctions in the control of tumor growth, we have transfected C6 glioma cells with connexin43 cDNA. We obtained several clones with variable expression of connexin43. The growth rate of these clones in culture was inversely related to the degree of expression of the transfected cDNA. To examine the growth of these transfected cells in vivo, cells were grown in spinner culture flasks to form spheroids 250–300 µm in diameter. Spheroids of nontransfected C6 cells produced large gliomas. Immunohistochemical and in situ hybridization analyses revealed relatively high levels of …

Regulation Of Connexin32 And Connexin43 Mrna And Protein During Neural Development, Daniel Belliveau, G. Kidder, C. Naus

Daniel J. Belliveau

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 66, No. 22, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Phillips, Noelle. Council on Higher Education Says It Won’t Vote on Doctorate
• Vincent, Bruce. Alpha Gamma Rho Receives One-Year Probation
• Hoover, Amy. Adult Day Services Center Brings Light to Those in Dusk of Life
• Center Street Reopens Tomorrow
• Houchens, Gary & John Martin. Student Campaigning Ending
• Yates, Lauren. AIDS Sufferers Remembered
• Bradley, Jim. Editorial Cartoon – Athletics Budget
• Athletics Needs Money Manager
• McGovern, Matthew. Comments Self-Righteous
• Kuehn, Kenneth. Faculty Salaries Clarified
• Schlicht, Patricia. Letter Offensive
• McCrady, David. Association of Resident Assistants Thanks Staff
• Tatum, Doug. …

Ua12/2/1 College Heights Herald, Vol. 65, No. 34, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Poynter, Chris. Pearce-Ford Tower Dwellers Asking for Breath of Fresh Air
• Howard, Laura. Still Here, Paul Cook’s Duties Mount
• Lockert, Anya. Officials Blame ’83 Act for Low Ratio of Blacks – Desegregation Plan
• Regents Ask for Students’ Opinions
• Bricking, Tanya. More Cooks to Stir Recipe for Budget – Thomas Meredith
• Committee Will Study Athletic Reports
• Rubber Ducky Business Has Holiday Boom
• Wessling, Susan. Group Works to Ban Public Smoking
• Students Need AIDS Education
• Chattin, John. Editorial Cartoon – AIDS Skeleton
• Bright Ideas Projecting New Image …

Ua12/2/1 College Heights Herald, Vol. 65, No. 33, Wku Student Affairs

WKU Archives Records

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Jones, Angie. Students Warned AIDS Will Be Here
• Poynter, Chris. Therapist Wilson Whitehead Shows Clients How to Relax
• Summers, Kaye. Physical Plant, Faculty Senate Protest Insurance Plan
• Bricking, Tanya. New Ideas for Efficiency Committee Will Pay for Bright Ideas
• Gifts to Western Exceed $6 Million
• Tenure Hearing Set for Weekend – Gabe Buntzman
• Deaf Can Communicate with Legislators
• Two Students Arrested on Assault Charges
• Search Committees Need Efficiency
• Chattin, John. Editorial Cartoon – Big Red Searching
• Black, Sam. Ku Klux Klan Protestor Questions Motives
• McMahon, …