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- HCA Healthcare (34)
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- University of Nebraska Medical Center (4)
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- Humans (4)
- Appendicitis (3)
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- Chemical and Drug Induced Liver Injury (2)
- Colon cancer (2)
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- South Atlantic Division GME Research Day 2023 (10)
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- Gulf Coast Division GME Research Day 2023 (4)
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- Clinical Research in Practice: The Journal of Team Hippocrates (1)
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Articles 31 - 60 of 72
Full-Text Articles in Diseases
Hepatitis B Virus Screening In Asian Immigrants: Community-Based Campaign To Increase Screening And Linkage To Care, Aziza Win
South Atlantic Division GME Research Day 2023
No abstract provided.
Disseminated Miliary Tuberculosis And Intestinal Tuberculosis Mimicking Ibd, Danny Tran, Kunaal Patel, Areeba Asfaq, Brittany Lyons
Disseminated Miliary Tuberculosis And Intestinal Tuberculosis Mimicking Ibd, Danny Tran, Kunaal Patel, Areeba Asfaq, Brittany Lyons
South Atlantic Division GME Research Day 2023
No abstract provided.
Artificial Intelligence In Colonoscopy In A Community Setting, Kunaal Patel, Brett Vanleer-Greenberg
Artificial Intelligence In Colonoscopy In A Community Setting, Kunaal Patel, Brett Vanleer-Greenberg
South Atlantic Division GME Research Day 2023
No abstract provided.
Non-Nec Pneumatosis And Pneumoperitoneum, Arham Aslam, Alexander Soutter
Non-Nec Pneumatosis And Pneumoperitoneum, Arham Aslam, Alexander Soutter
South Atlantic Division GME Research Day 2023
No abstract provided.
Small Intestinal Bacterial Overgrowth Testing Strategies, Carla Bonczak
Small Intestinal Bacterial Overgrowth Testing Strategies, Carla Bonczak
Doctor of Nursing Practice Scholarly Projects
Small Intestinal Bacterial Overgrowth (SIBO) is an overgrowth of bacteria in the small intestine. Symptoms such as bloating, abdominal pain and discomfort, malabsorption, nausea, constipation, or diarrhea overlap with several common GI complaints. SIBO affects millions of people worldwide. Many providers are not aware of SIBO or the guidelines that standardize testing and diagnosing.
The Final Scholarly Project (FSP) was based on a literature review that discovered evidence-based literature on SIBO testing strategies such as gut aspirate and culture, clinical symptom presentation, breath testing, nutrient challenge test, and scintigraphy with either lactulose or hydrogen breath testing. To implement the project, …
Colon Cancer Screening And The Association With Colon Cancer Incidence And Mortality Rates In Ethnic Minority Groups, Jovonne Smith
Colon Cancer Screening And The Association With Colon Cancer Incidence And Mortality Rates In Ethnic Minority Groups, Jovonne Smith
Student Scholar Showcase
Colorectal cancer (CRC) continues to be a public health burden and is the second leading cause of American cancer deaths. Strides have been made in the medical community, and there has been an overall decrease in CRC rates. This decrease is primarily due to a cumulative decline in late-onset colorectal cancer diagnosis (LOCRC), defined as CRC cancer in adults over the age of 50 years. CRC continues to burden American Indians and Alaska Natives (AIAN) and Non-Hispanic Black individuals (NHB) disproportionately. The incidence and mortality rates remain disproportionately higher than other ethnic groups, and the survival rate is lower than …
Hpv-Related Anal Cancer Is Associated With Changes In The Anorectal Microbiome During Cancer Development, Jacob H. Elnaggar, Victoria O. Huynh, Daniel Lin, R. Tyler Hillman, Chike O. Abana, Molly B. El Alam, Katarina C. Tomasic, Tatiana V. Karpinets, Ramez Kouzy, Jae L. Phan, Jennifer Wargo, Emma B. Holliday, Prajnan Das, Melissa P. Mezzari, Nadim J. Ajami, Erica J. Lynn, Bruce D. Minsky, Van K. Morris, Andrea Milbourne, Craig A. Messick, Ann H. Klopp, P. Andrew Futreal, Cullen M. Taniguchi, Kathleen M. Schmeler, Lauren E. Colbert
Hpv-Related Anal Cancer Is Associated With Changes In The Anorectal Microbiome During Cancer Development, Jacob H. Elnaggar, Victoria O. Huynh, Daniel Lin, R. Tyler Hillman, Chike O. Abana, Molly B. El Alam, Katarina C. Tomasic, Tatiana V. Karpinets, Ramez Kouzy, Jae L. Phan, Jennifer Wargo, Emma B. Holliday, Prajnan Das, Melissa P. Mezzari, Nadim J. Ajami, Erica J. Lynn, Bruce D. Minsky, Van K. Morris, Andrea Milbourne, Craig A. Messick, Ann H. Klopp, P. Andrew Futreal, Cullen M. Taniguchi, Kathleen M. Schmeler, Lauren E. Colbert
School of Graduate Studies Faculty Publications
Background: Squamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression of HPV infection to anal dysplasia and cancer are unclear and screening guidelines and approaches for anal dysplasia are less clear than for cervical dysplasia. One potential contributing factor is the anorectal microbiome. In this study, we aimed to identify differences in anal microbiome composition in the settings of HPV infection, anal dysplasia, and anal cancer in this rare disease. Methods: Patients were enrolled in two prospective studies. Patients with anal dysplasia were part of a cross-sectional cohort that enrolled women with high-grade …
Enhanced Ca2+-Channeling Complex Formation At The Er-Mitochondria Interface Underlies The Pathogenesis Of Alcohol-Associated Liver Disease, Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min Kyo Jung, Ibotombi Singh Sinam, Byung Gyu Kim, Bo Yoon Park, Woong Hee Kwon, Hyo Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A. Miller, Romil Saxena, Nicholas J. Skill, Nazmul Huda, Praveen Kusumanchi, Jing Ma, Zhihong Yang, Min Ji Kim, Ji Young Mun, Robert A. Harris, Jae Han Jeon, Suthat Liangpunsakul, In Kyu Lee
Enhanced Ca2+-Channeling Complex Formation At The Er-Mitochondria Interface Underlies The Pathogenesis Of Alcohol-Associated Liver Disease, Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min Kyo Jung, Ibotombi Singh Sinam, Byung Gyu Kim, Bo Yoon Park, Woong Hee Kwon, Hyo Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A. Miller, Romil Saxena, Nicholas J. Skill, Nazmul Huda, Praveen Kusumanchi, Jing Ma, Zhihong Yang, Min Ji Kim, Ji Young Mun, Robert A. Harris, Jae Han Jeon, Suthat Liangpunsakul, In Kyu Lee
School of Medicine Faculty Publications
Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial Ca2+ accumulation in ALD remain elusive. Here, we demonstrate that an aberrant increase in hepatic GRP75-mediated mitochondria-associated ER membrane (MAM) Ca2+-channeling (MCC) complex formation promotes mitochondrial dysfunction in vitro and in male mouse model of ALD. Unbiased transcriptomic analysis reveals PDK4 as a prominently inducible MAM kinase in ALD. Analysis of human ALD cohorts further corroborate these findings. Additional mass spectrometry analysis unveils GRP75 as a downstream phosphorylation target of PDK4. Conversely, non-phosphorylatable GRP75 …
Split And Join: An Efficient Approach For Simulating Stapled Intestinal Anastomosis In Virtual Reality, Di Qi, Suvranu De
Split And Join: An Efficient Approach For Simulating Stapled Intestinal Anastomosis In Virtual Reality, Di Qi, Suvranu De
Engineering Faculty Articles and Research
Colorectal cancer is a life-threatening disease. It is the second leading cause of cancer-related deaths in the United States. Stapled anastomosis is a rapid treatment for colorectal cancer and other intestinal diseases and has become an integral part of routine surgical practice. However, to the best of our knowledge, there is no existing work simulating intestinal anastomosis that often involves sophisticated soft tissue manipulations such as cutting and stitching. In this paper, for the first time, we propose a novel split and join approach to simulate a side-to-side stapled intestinal anastomosis in virtual reality. We mimic the intestine model using …
Eosinophils Protect Against Acetaminophen-Induced Liver Injury Through Cyclooxygenase-Mediated Il-4/Il-13 Production, Long Xu, Yang Yang, Jiali Jiang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L Atkins, Kangho Kim, Elizabeth A Jacobsen, Hua Wang, Cynthia Ju
Eosinophils Protect Against Acetaminophen-Induced Liver Injury Through Cyclooxygenase-Mediated Il-4/Il-13 Production, Long Xu, Yang Yang, Jiali Jiang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L Atkins, Kangho Kim, Elizabeth A Jacobsen, Hua Wang, Cynthia Ju
Journal Articles
BACKGROUND AND AIMS: A better understanding of the underlying mechanism of acetaminophen (APAP)-induced liver injury (AILI) remains an important endeavor to develop therapeutic approaches. Eosinophils have been detected in liver biopsies of patients with APAP overdose. We recently demonstrated a profound protective role of eosinophils against AILI; however, the molecular mechanism had not been elucidated.
APPROACH AND RESULTS: In agreement with our previous data from experiments using genetic deletion of eosinophils, we found that depletion of eosinophils in wild-type (WT) mice by an anti-IL-15 antibody resulted in exacerbated AILI. Moreover, adoptive transfer of eosinophils significantly reduced liver injury and mortality …
A Method Using Longitudinal Laboratory Data To Predict Future Intestinal Complication In Patients With Crohn's Disease., James Irwin, Anton Lord, Emma Ferguson, Lisa A Simms, Katherine Hanigan, Carlos A Montoya, Graham Radford-Smith
A Method Using Longitudinal Laboratory Data To Predict Future Intestinal Complication In Patients With Crohn's Disease., James Irwin, Anton Lord, Emma Ferguson, Lisa A Simms, Katherine Hanigan, Carlos A Montoya, Graham Radford-Smith
Journal Articles
Background
Stenosis, fistulization, and perforation of the bowel are severe outcomes which can occur in patients with Crohn’s disease. Accurate prediction of these events may enable clinicians to alter treatment strategies and avoid these outcomes.
Aims
To study the correlation between longitudinal laboratory testing and subsequent intestinal complications in patients with Crohn’s disease.
Methods
An observational cohort of patients with Crohn’s disease at a single center were analyzed between 01/01/1994 and 06/30/2016. A complication was defined as the development of an intestinal fistula, stenosis, or perforation. Exploratory analysis using Cox regression was performed to select the best statistical method to …
Is It Time To Re-Think Fast? A Systematic Review And Meta-Analysis Of Contrast-Enhanced Ultrasound (Ceus) And Conventional Ultrasound For Initial Assessment Of Abdominal Trauma, Bayu Sutarjono, Matthew Kessel, Dorian Alexander, Ekjot Grewal
Is It Time To Re-Think Fast? A Systematic Review And Meta-Analysis Of Contrast-Enhanced Ultrasound (Ceus) And Conventional Ultrasound For Initial Assessment Of Abdominal Trauma, Bayu Sutarjono, Matthew Kessel, Dorian Alexander, Ekjot Grewal
Journal Articles
BACKGROUND: The Focused Assessment with Sonography for Trauma (FAST) examination using conventional ultrasound has limited utility for detecting solid organ injury. Therefore, this systematic review and meta-analysis compares the performance of contrast-enhanced ultrasound (CEUS) to conventional ultrasound when used as the initial assessment for abdominal trauma prior to computed tomography (CT) imaging.
METHODS: A systematic literature search of major databases was conducted of human studies investigating the diagnostic accuracy of conventional ultrasound and CEUS occurring prior to CT imaging for abdominal trauma. The study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The quality of studies …
Elafibranor Modulates Ileal Macrophage Polarization To Restore Intestinal Integrity In Nash: Potential Crosstalk Between Ileal Il-10/Stat3 And Hepatic Tlr4/Nf-Κb Axes, Andrew Hakeem, Mohamed M. Kamal, Rasha A. Radwan, Basma A. Abdelrahman, Olfat A. Hammam, Mohey M. Elmazar, Aiman S. El-Khatib, Yasmeen M. Attia
Elafibranor Modulates Ileal Macrophage Polarization To Restore Intestinal Integrity In Nash: Potential Crosstalk Between Ileal Il-10/Stat3 And Hepatic Tlr4/Nf-Κb Axes, Andrew Hakeem, Mohamed M. Kamal, Rasha A. Radwan, Basma A. Abdelrahman, Olfat A. Hammam, Mohey M. Elmazar, Aiman S. El-Khatib, Yasmeen M. Attia
Pharmacy
Experimental and clinical evidence implicate disrupted gut barrier integrity in provoking innate immune responses, specifically macrophages, towards the progression of non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptors (PPARs), a subset of the nuclear receptor superfamily, act to fine-tune several metabolic and inflammatory processes implicated in NASH. As such, the current study was carried out to decipher the potential role of dual PPAR α/δ activation using elafibranor (ELA) on ileal macrophage polarization (MP) and its likely impact on the liver in a NASH setting. To achieve this aim, an in vitro NASH model using fat-laden HepG2 cells was first used to validate …
Cytomegalovirus And Nodular Gastric Lesions: A Case Report, Tyler Jones, Daniel Bishev, Vidya Kollu
Cytomegalovirus And Nodular Gastric Lesions: A Case Report, Tyler Jones, Daniel Bishev, Vidya Kollu
North Florida Division GME Research Day 2023
No abstract provided.
Stone-Containing Meckel’S Diverticulitis As A Mimic Of Acute Appendicitis, Justin Denny, David Pardue
Stone-Containing Meckel’S Diverticulitis As A Mimic Of Acute Appendicitis, Justin Denny, David Pardue
South Atlantic Division GME Research Day 2023
No abstract provided.
Midgut Volvulus A Rare Cause Of Acute Abdomen In The Adult Patient, Mason S. Deinema, Saptarshi Biswas
Midgut Volvulus A Rare Cause Of Acute Abdomen In The Adult Patient, Mason S. Deinema, Saptarshi Biswas
South Atlantic Division GME Research Day 2023
No abstract provided.
A Fatal Case Of Lisinopril-Induced Acute Necrotizing Pancreatitis, Omar Masarweh, Feras Al-Moussally, Juan Pablo Meruvia Garron, Anuj Kunadia, Olga Karasik, Abdo Asmar
A Fatal Case Of Lisinopril-Induced Acute Necrotizing Pancreatitis, Omar Masarweh, Feras Al-Moussally, Juan Pablo Meruvia Garron, Anuj Kunadia, Olga Karasik, Abdo Asmar
North Florida Division GME Research Day 2023
No abstract provided.
Applying The Naranjo Scale In Diagnosing An Atypical Case Of Chronic Mycophenolate Mofetil-Induced Colitis In A Heart Transplant Recipient, Emmanuel Magsino, Leeann Hu, Michael Delzoppo, Jorge Restrepo
Applying The Naranjo Scale In Diagnosing An Atypical Case Of Chronic Mycophenolate Mofetil-Induced Colitis In A Heart Transplant Recipient, Emmanuel Magsino, Leeann Hu, Michael Delzoppo, Jorge Restrepo
North Florida Division GME Research Day 2023
No abstract provided.
Complications Of Colonscopies: Splenic Injury Following Routine Screening For Colorectal Cancer, Elisabeth Barrar, Ainsley Freshour
Complications Of Colonscopies: Splenic Injury Following Routine Screening For Colorectal Cancer, Elisabeth Barrar, Ainsley Freshour
South Atlantic Division GME Research Day 2023
No abstract provided.
Severe Thromboembolic Events In Two Pediatric Patients Diagnosed With Ulcerative Colitis (Uc) And Recently Initiated Adalimumab Therapy: A Case Series, Kelly Powell, Shreya Patel, Megan Tate, Abby Alaine Unger, Abigail Haythorn
Severe Thromboembolic Events In Two Pediatric Patients Diagnosed With Ulcerative Colitis (Uc) And Recently Initiated Adalimumab Therapy: A Case Series, Kelly Powell, Shreya Patel, Megan Tate, Abby Alaine Unger, Abigail Haythorn
South Atlantic Division GME Research Day 2023
No abstract provided.
Fatigue More Than Just Anemia: A Case Report Of Undiagnosed Pbc, Sarah Barraza, Payal Passi, George Matus, Michaela Mckissack
Fatigue More Than Just Anemia: A Case Report Of Undiagnosed Pbc, Sarah Barraza, Payal Passi, George Matus, Michaela Mckissack
Central & West Texas GME Research Day 2023
No abstract provided.
Acute Colonic Perforation With Septic Shock Secondary To Disseminated Histoplasmosis In A Autologous Bone Marrow Transplant Recipient, Harsimrandeep Bhatti, Srijisnu De, Enkhbileg Batbileg, Glen Friedman
Acute Colonic Perforation With Septic Shock Secondary To Disseminated Histoplasmosis In A Autologous Bone Marrow Transplant Recipient, Harsimrandeep Bhatti, Srijisnu De, Enkhbileg Batbileg, Glen Friedman
Central & West Texas GME Research Day 2023
No abstract provided.
Appendicitis Mimicry Of A Rare Case Of Early Diagnosed Dolichocolon, A Case Report, Kayla Brown, Mercedes Jolley, Dean Kocay
Appendicitis Mimicry Of A Rare Case Of Early Diagnosed Dolichocolon, A Case Report, Kayla Brown, Mercedes Jolley, Dean Kocay
Central & West Texas GME Research Day 2023
No abstract provided.
A Case Of Acquired Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease And Amyloidosis, Laura Landis, Mitalie Gupta, Ricardo Estrada, Kathryn Hall, Adam Gomez
A Case Of Acquired Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease And Amyloidosis, Laura Landis, Mitalie Gupta, Ricardo Estrada, Kathryn Hall, Adam Gomez
Central & West Texas GME Research Day 2023
No abstract provided.
Massive Small Bowel Resection In A 74-Year-Old Patient With Atrial Fibrillation-Induced Mesenteric Ischemia, Armand Edalati, Bita C. Behaeddin, Raul Aguilar, Shaikh Hai
Massive Small Bowel Resection In A 74-Year-Old Patient With Atrial Fibrillation-Induced Mesenteric Ischemia, Armand Edalati, Bita C. Behaeddin, Raul Aguilar, Shaikh Hai
East Florida Division GME Research Day 2023
Acute mesenteric ischemia (AMI) in the setting of atrial fibrillation is a life-threatening abdominal emergency that requires immediate localization and clinical intervention to restore mesenteric perfusion for the prevention of developing bowel necrosis. As bowel ischemia rapidly progresses, serum metabolic derangements become prominent, guiding practitioners on effective therapeutic options. Ultimately, mesenteric ischemia progressively bolsters the possibility of a patient developing multiple organ dysfunction. Due to this minacious pathogenesis, rapid time to diagnosis can become the difference between life and death. Intraoperatively, emergent surgical intervention regarding bowel resection needs to be thoroughly reviewed and planned based on the patient's medical history …
Tranexamic Acid (Txa) In Upper Gastrointestinal Bleeds – Systematic Review And Meta-Analysis, Nd Ekpa, Harout Hamzoian, Justin Yan
Tranexamic Acid (Txa) In Upper Gastrointestinal Bleeds – Systematic Review And Meta-Analysis, Nd Ekpa, Harout Hamzoian, Justin Yan
Gulf Coast Division GME Research Day 2023
No abstract provided.
Ogilvie's Syndrome: In A Non-Surgical Patient Admitted For Pulmonary Embolism And Acute Cerebrovascular Accident, Kelly Schulte, Matthew Nelson, Daniel L. Levy, Alexander Enurah, Jennifer Griffith
Ogilvie's Syndrome: In A Non-Surgical Patient Admitted For Pulmonary Embolism And Acute Cerebrovascular Accident, Kelly Schulte, Matthew Nelson, Daniel L. Levy, Alexander Enurah, Jennifer Griffith
Continental, MidAmerica, & Mountain Divisions GME Research Day 2023
No abstract provided.
Pregnancy Induced Pancreatitis In The Setting Of Medical Abortion And Severe Hyponatremia, Nd Ekpa, Sheila Chandrahas, Randy Chung
Pregnancy Induced Pancreatitis In The Setting Of Medical Abortion And Severe Hyponatremia, Nd Ekpa, Sheila Chandrahas, Randy Chung
Gulf Coast Division GME Research Day 2023
No abstract provided.
Rates Of Colostomy Creation Following Sacral Nerve Stimulator (Sns) Implantation For Fecal Incontinence, Austin Brown, Melissa Gott, Abby Crume, Michelle Murday
Rates Of Colostomy Creation Following Sacral Nerve Stimulator (Sns) Implantation For Fecal Incontinence, Austin Brown, Melissa Gott, Abby Crume, Michelle Murday
Continental, MidAmerica, & Mountain Divisions GME Research Day 2023
No abstract provided.
Perforated Congenital Sigmoid Diverticula Of A Pediatric Patient, Tamir Bresler, Ryan Meyer, Kevin Palmer, Philip Frykman
Perforated Congenital Sigmoid Diverticula Of A Pediatric Patient, Tamir Bresler, Ryan Meyer, Kevin Palmer, Philip Frykman
Far West Division GME Research Day 2023
No abstract provided.