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Dietetics and Clinical Nutrition Commons™
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Articles 61 - 90 of 151
Full-Text Articles in Dietetics and Clinical Nutrition
Typical Diet Quality In New Zealand Compared To Other Westernized Countries With An Emphasis On Chronic Disease, Emily Kollar
Typical Diet Quality In New Zealand Compared To Other Westernized Countries With An Emphasis On Chronic Disease, Emily Kollar
Honors Projects
The diet quality was analyzed for people living in New Zealand and people living in other Westernized Countries (United States, Canada, Western Europe) based on the dietary guidelines. Diet quality was analyzed by looking at consumption of food groups such as fruits, vegetables, meat, and seafood as well as nutrients such as saturated/trans/unsaturated fat, sodium, and added sugars. These nutrients have been linked to certain health outcomes and chronic disease; therefore, the prevalence of chronic disease was researched to determine if there was a correlation between New Zealand's diet and their chronic disease rates in comparison to other Westernized countries.
Use Of Smartphone Application To Facilitate Weight Loss And Promote Accountability In Obese And Overweight Patients, Angela M. Turner
Use Of Smartphone Application To Facilitate Weight Loss And Promote Accountability In Obese And Overweight Patients, Angela M. Turner
Evidence-Based Practice Project Reports
In 2015, the U.S. Department of Health and Human Services published a National Health and Nutrition Survey (NHANES) on obesity from 2011 through 2014. From the survey, it was determined that the prevalence of obesity in the U.S. was 36% in adults and 17% in young adults/children (Ogden et al., 2015). Lifestyle modifications including moderation of caloric intake and increased exercise have been shown to be effective for both prevention and treatment of obesity. The purpose of this evidence-based practice (EBP) project involved the design, administration, and evaluation of a technology-assisted weight loss intervention to address the health problem of …
Rising Rural Body-Mass Index Is The Main Driver Of The Global Obesity Epidemic In Adults, Con Burns, Tara Coppinger, Janette Walton, Et Al
Rising Rural Body-Mass Index Is The Main Driver Of The Global Obesity Epidemic In Adults, Con Burns, Tara Coppinger, Janette Walton, Et Al
Publications
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3,4,5,6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to …
Inducing Incentive Sensitization Of Exercise Reinforcement Among Adults Who Do Not Regularly Exercise—A Randomized Controlled Trial, Kyle D. Flack, Kelsey Elise Ufholz, Luann Johnson, James N. Roemmich
Inducing Incentive Sensitization Of Exercise Reinforcement Among Adults Who Do Not Regularly Exercise—A Randomized Controlled Trial, Kyle D. Flack, Kelsey Elise Ufholz, Luann Johnson, James N. Roemmich
Dietetics and Human Nutrition Faculty Publications
Background
Increasing exercise reinforcement, or decreasing sedentary reinforcement, may reduce sedentary activity and promote habitual exercise. Repeated exposures to a reinforcer may increase its reinforcing value (i.e., incentive sensitization). It is not yet known whether incentive sensitization occurs for exercise or factors associated with incentive sensitization for exercise reinforcement. The purpose was to determine whether exercise exposures increase exercise reinforcement relative to a sedentary alternative and whether this sensitization of exercise reinforcement would alter physical or sedentary behavior. This work also determined whether exercise dose, intensity, and preference and tolerance for exercise intensity were associated with incentive sensitization of exercise. …
Social Determinants Of Health And Variability In Weight Trends Of Children Of Low Income Families Living In New Mexico, Molly Aileen Morrison
Social Determinants Of Health And Variability In Weight Trends Of Children Of Low Income Families Living In New Mexico, Molly Aileen Morrison
Individual, Family, and Community Education ETDs
When evaluating the prevalence of obesity rates throughout New Mexico (NM), it appears these rates have reached a plateau. A recent study conducted by the NM Department of Health (DOH) found that NM was among 19 other states that have had a first time decrease in child obesity rates among low income families. However, when examined deeper, when looking at geographical areas throughout NM, hidden geography of weight disparities become apparent. Although obesity rates may have decreased in some areas, they have increased in others. The purpose of this study is to effectively evaluate variability in weight trends between geographical …
Increasing Food Security: Developing And Testing A Nutrition Education Curriculum For A Mobile Food Pantry, Alexandra Lepecha, Kathleen M. Kraft
Increasing Food Security: Developing And Testing A Nutrition Education Curriculum For A Mobile Food Pantry, Alexandra Lepecha, Kathleen M. Kraft
Senior Honors Projects, 2010-2019
Background: The Neighborhood Produce Market (NPM) is a food distribution model similar to a mobile food pantry. NPM stakeholders observed a lack of community engagement and familiarity with produce offered.
Project Description: The objective was to develop a nutrition education curriculum for NPM volunteers to better engage families and community members by providing food samples, recipes, and nutrition education. A stakeholder steering committee guided the needs assessment, curriculum development, volunteer training, and pilot test. The curriculum consisted of food safety, cultural considerations, and nutritional information for nine produce items and food tasting procedures and recipes. Seven student volunteers were trained …
Food Is Medicine: A Low-Cost, Plant-Based Cooking Class Series For Food Pantry Users, Carolyn Ellis
Food Is Medicine: A Low-Cost, Plant-Based Cooking Class Series For Food Pantry Users, Carolyn Ellis
Senior Honors Projects
Food insecurity, defined as the limited or uncertain access to nutritionally adequate, safe, and acceptable food, is a major public health concern. In 2017, 15 million US households were at one point food insecure. Food insecure adults typically have poorer diet quality than food secure adults independent of poverty. Both food insecurity and poor diet quality are associated with diet sensitive chronic diseases including cardiovascular disease, type 2 diabetes, and obesity. People who rely on food pantries are a subgroup of concern due to their limited ability to purchase food. As meat, poultry, and seafood are the most expensive items …
Characterization And Evaluation Of The Probiotic Properties Of The Sporeforming Bacteria, Bacillus Coagulans Unique Is-2, Amy Garrison
Characterization And Evaluation Of The Probiotic Properties Of The Sporeforming Bacteria, Bacillus Coagulans Unique Is-2, Amy Garrison
Department of Food Science and Technology: Dissertations, Theses, and Student Research
Probiotics are live organisms, that when consumed in adequate amounts, confer a health benefit to the host. To achieve probiotic status, each potential strain’s functional properties and their safety to the consumer must be comprehensively evaluated. Probiotic effects have been observed to be strain specific, therefore each new strain of interest must be characterized according to their phenotypic and genetic characteristics. There is a list of characteristics that potential probiotic strains should have to be considered as a probiotic. Potential probiotic strains should be evaluated for their acid and bile salt resistance, antimicrobial activity and adherence and colonization to intestinal …
The Functional Food Diet: A Pilot Study, Caroline Knight, Ralph Hamill
The Functional Food Diet: A Pilot Study, Caroline Knight, Ralph Hamill
MaineHealth Maine Medical Center
Background: Recently, several functional foods have been identified which have health benefits beyond providing energy and substrate molecules for cellular chemistry. These foods are effective in reducing fat absorption and lowering lowdensity lipoprotein (LDL) cholesterol (Asgary, Rasquar, & Keshvari, 2018). In the past, diets low in saturated fat have been found to be ineffective in lowering LDL cholesterol. Statins are capable of lowering LDL cholesterol up to 60% when the latest generation is used at maximal dose (Law, Wald & Rudnicka, 2003). However, some patients do not tolerate statins because of side effects. Evidently, decreasing the LDL lowers the risk …
Body Dissatisfaction And Weight Bias In Children, Megan Janette Jensen
Body Dissatisfaction And Weight Bias In Children, Megan Janette Jensen
Undergraduate Honors Capstone Projects
This article reviews the rate of body dissatisfaction and weight bias among young children. It was initially hypothesized that body-image begins much earlier than adolescence, where most interventions take place. Out of fifty articles read on the subject, forty-five peer reviewed articles were included in this review. The findings of these articles were synthesized for a comprehensive review on the topic. Results suggested that weight bias begins around three years of age, while body dissatisfaction begins around age five for girls, and seven for boys. Rates of body dissatisfaction among children were similar to the rate among adolescents, averaging out …
Influence Of Change In Ph On Whey Expulsion From Cheddar Cheese Curds Made From Recombined Concentrated Milk, Kanak Bulbul
Influence Of Change In Ph On Whey Expulsion From Cheddar Cheese Curds Made From Recombined Concentrated Milk, Kanak Bulbul
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The Western Dairy Center at Utah State University funded this project to investigate cheese research using concentrated milks. Concentrated milk was provided by the South Dakota State University and starter culture for this study was prepared and donated by Vivolac Cultures Corporation, Greenfield, Indiana.
The project initiated as a continuation of a previous study on effects of protein concentration, coagulum cut size and set temperature on curd moisture loss kinetics while stirring during cheesemaking. It was aimed at determining the extent to which pH drop prior to draining and final cheese moisture when using microfiltered concentrated milk.
We performed twelve …
Effect Of Prebiotic, Probiotic, And Enzyme Supplementation On Gut Fermentation, Markers Of Inflammation And Immune Response In Individuals With Gi Symptoms, Kaitlyn Webb
Electronic Theses and Dissertations
Current practices support the use of probiotic and prebiotic supplementation to improve chronic gastrointestinal distress (GID). The aim of this study was to determine the tolerance and benefits of GlutenShield (GS), a prebiotic, probiotic, and enzyme supplement, on adults with GID. Subjects (n=20) took either GS or the placebo for 30 days and completed a pre-treatment FFQ as well as a pre- and post-treatment GID questionnaire, blood draw, and stool sample. Participants consumed more total and saturated fat, and less fiber and whole grains compared to the recommended intake. A significant reduction in IgG2 was observed in the GS group …
May 2019, Swosu Bulldog Wellness Committee
May 2019, Swosu Bulldog Wellness Committee
SWOSU BULLDOG WELLNESS
Physical Fitness and Sports Month
Southwestern Oklahoma State University is supporting the President’s Council on Sports, Fitness & Nutrition in honor of National Physical Fitness and Sports Month. During the month of May, we challenge all adults to get active every day!
Assessment Of Factors That Impact Hydration Status Of Professional And Collegiate Mascots, Caroline Atwell
Assessment Of Factors That Impact Hydration Status Of Professional And Collegiate Mascots, Caroline Atwell
Human Nutrition and Hospitality Management Undergraduate Honors Theses
Mascots have unique physical demands and nutrition needs. They exert themselves tremendously on a variety of game days and at practices throughout the week. Hydration is as significant for mascots as it is for any other athlete, yet there is little to no known research available to help this population achieve a good hydration status. Studying similar populations such as cheerleaders, band members, football players, and firefighters provided a better understanding of mascot hydration. The purpose of this study was to examine the level of hydration knowledge in mascots performing at the collegiate and professional levels and determine the different …
Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant
Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant
Graduate Theses and Dissertations
As individuals enter adulthood, their lifestyles and lifestyle behaviors begin to change drastically. These lifestyle behavior changes in emerging adulthood provide a foundation for future health behaviors that often persist through all of adulthood. The aim of this study was to use Latent profile analyses (LPA) to discover distinct profiles of homogenous groups of young adults based on alcohol, diet, and exercise behaviors. Overall, five distinct profiles for both males and females were identified: Moderates, Unhealthy Eaters, Medium Drinkers, Healthier Eaters and Exercisers, and Heavy Drinkers. Heavy Drinkers and Unhealthy Eaters were the highest risk groups and reported the highest …
Perceived Body Image And Reasons For Exercise Among College Students, Ileana Flores Delgado
Perceived Body Image And Reasons For Exercise Among College Students, Ileana Flores Delgado
Ursidae: The Undergraduate Research Journal at the University of Northern Colorado
Perceptions of an ideal body image constructed by Western culture has led body dissatisfaction levels to increase significantly in the past 30 years. Researchers have found that individuals tend to have inaccurate perceptions of their body shapes that leads to body dissatisfaction. Minimal research however, has been done focusing on the relationship between body image and specific exercise behaviors. The purpose of this qualitative study was to understand how someone’s own body perception affects their exercise behavior, type and frequency. A total of 30 participants were observed for 20 minutes focusing on behaviors like concentration, body surveillance, and confidence while …
Effects Of An 8-Week Pelvic Core Stability And Nutrition Community Programme On Maternal Health Outcomes, Gretchen Elizabeth Krivak, Lori Maria Walton, Veena Raigangar, Mini Sara Abraham, Cherisse Buddy, Magaly Hernandez, Rose Caceras
Effects Of An 8-Week Pelvic Core Stability And Nutrition Community Programme On Maternal Health Outcomes, Gretchen Elizabeth Krivak, Lori Maria Walton, Veena Raigangar, Mini Sara Abraham, Cherisse Buddy, Magaly Hernandez, Rose Caceras
Faculty Publications
Introduction
Women, during the antenatal and post‐partum period, report pelvic, low back pain, stress and urge urinary incontinence, colorectal dysfunction, and other co‐morbidities that negatively affect health‐related quality of life. Exercise and nutrition are important considerations for improving maternal health in this period.
Purpose
The purpose of this study was to examine the effects of a community‐driven nutrition and exercise programme focused on pelvic floor and core stability, healthy nutrition, and breastfeeding counselling over an 8‐week period on pelvic floor and urinary distress (UDI), prolapse and colorectal distress for antenatal and post‐partum women with limited access to health care, and …
Suffering In Silence: Is Gastroparesis Underdiagnosed?, Dennis J. Baumgardner
Suffering In Silence: Is Gastroparesis Underdiagnosed?, Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
In this introduction to Volume 6, Issue 2, the editor-in-chief of the Journal of Patient-Centered Research and Reviews offers additional comment to the clinical review of diabetic gastroparesis authored by Farmer and colleagues (p. 148), regarding the problem of undiagnosed disease. Increased awareness of this entity and appropriate questioning regarding symptoms of diabetic gastroparesis in the primary care setting may prevent the “suffering in silence” experienced by many patients with this complication.
Medically Tailored Meals As A Prescription For Treatment Of Food-Insecure Type 2 Diabetics, Leslie J. Rabaut
Medically Tailored Meals As A Prescription For Treatment Of Food-Insecure Type 2 Diabetics, Leslie J. Rabaut
Journal of Patient-Centered Research and Reviews
Type 2 diabetes mellitus is an immense burden to the health of our population and to our current health care system, and the weight of this burden is only projected to multiply in coming years. A nutritious diet is an indispensable aspect of diabetes treatment, and the lack of access to food engenders poor disease-state control, which correlates with increased health care utilization. Interventions aimed at improving access to food through medically tailored meals (MTMs) have demonstrated effectiveness in improving the health of food-insecure type 2 diabetic patients and reducing health care costs. Further studies are necessary to increase the …
Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu
Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu
Health and Clinical Sciences Faculty Publications
Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60–80 years with a BMI ranging from 18.5–34.9 and vitamin D status of ≤ 32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D3) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks …
Steroid Receptor Coactivator-1 Modulates The Function Of Pomc Neurons And Energy Homeostasis, Yongjie Yang, Agatha A Van Der Klaauw, Liangru Zhu, Tessa M Cacciottolo, Yanlin He, Lukas K J Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M Keogh, Elana Henning, Matthew C Banton, Audrey E Hendricks, Elena G Bochukova, Vanisha Mistry, Katherine L Lawler, Lan Liao, Jianming Xu, Stephen O'Rahilly, Qingchun Tong, Uk10k Consortium, Inês Barroso, Bert W O'Malley, I Sadaf Farooqi, Yong Xu
Steroid Receptor Coactivator-1 Modulates The Function Of Pomc Neurons And Energy Homeostasis, Yongjie Yang, Agatha A Van Der Klaauw, Liangru Zhu, Tessa M Cacciottolo, Yanlin He, Lukas K J Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M Keogh, Elana Henning, Matthew C Banton, Audrey E Hendricks, Elena G Bochukova, Vanisha Mistry, Katherine L Lawler, Lan Liao, Jianming Xu, Stephen O'Rahilly, Qingchun Tong, Uk10k Consortium, Inês Barroso, Bert W O'Malley, I Sadaf Farooqi, Yong Xu
Children’s Nutrition Research Center Staff Publications
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function …
Sports Nutrition Project Based Learning Assignment Reflection, Guillermo Escalante
Sports Nutrition Project Based Learning Assignment Reflection, Guillermo Escalante
Q2S Enhancing Pedagogy
This is a reflection paper of a Sports Nutrition Project Based Learning Assignment that was developed at the 2018 Project Based Learning Workshop and implemented in the Winter 2019 session of KINE 382- Sports Nutrition.
Better Together: A Pilot Study On Cooking Matters For Adults With Developmental Disabilities And Direct Support Professionals, Wesley R Barnhart, Susan M Havercamp, Allison Lorenz, Emily A Yang
Better Together: A Pilot Study On Cooking Matters For Adults With Developmental Disabilities And Direct Support Professionals, Wesley R Barnhart, Susan M Havercamp, Allison Lorenz, Emily A Yang
Ambulatory and Primary Care Articles
Adults with developmental disabilities face barriers to making healthy lifestyle choices that mirror the barriers faced by the direct support professionals who serve them. These two populations, direct support professionals and adults with developmental disabilities, are likely to lead inactive lifestyles, eat unhealthy diets, and be obese. Moreover, direct support professionals influence the nutrition knowledge, attitudes, and health behaviors of the adults with developmental disabilities whom they serve. We piloted a cooking-based nutrition education program, Cooking Matters for Adults, to dyads of adults with developmental disabilities (n = 8) and direct support professionals (n = 7). Team-taught by a …
Creating Oral Health Awareness: Happy Teeth Make Healthy Teeth, Roseanna M. Torres, Dirien Santos, Tatyana Aksaeva, Hanna Jo, Nastassia Liaushun, Anty Lam
Creating Oral Health Awareness: Happy Teeth Make Healthy Teeth, Roseanna M. Torres, Dirien Santos, Tatyana Aksaeva, Hanna Jo, Nastassia Liaushun, Anty Lam
Publications and Research
No abstract provided.
Breaking Down Barriers To Sustainable Eating At The University Of Dayton, Lauren Murray
Breaking Down Barriers To Sustainable Eating At The University Of Dayton, Lauren Murray
Honors Theses
Sustainability is at the forefront in many conversations and innovations at the University of Dayton (UD), ranging from the Hanley Sustainability Institute to the Sustainability club. However, sustainability extends beyond water and energy conservation. In addition to these, students and faculty at UD can impact their carbon footprint through sustainable eating. The purpose of this research was to define sustainable eating, determine the carbon footprint of foods served in the UD dining halls, and develop and evaluate an educational intervention aimed at UD students within the Virginia West Kettering dining hall. The results of this research were considered in the …
A Multi-Faceted Intervention To Improve Diagnosis And Treatment Rates Of Overweight And Obesity By Nurse Practitioners In Primary Care, Susan Disser
Evidence-Based Practice Project Reports
The United States is amid an obesity epidemic (Institute of Medicine, 2012). Indiana ranks as the tenth most overweight state. (America’s Health Rankings, 2018). Despite guidelines outlining the treatment of obesity, primary care providers seldom use these guidelines (Hayes et al., 2017). In a 2010 study, only 28.9% of obese patients received a diagnosis of obesity and less than 25% of these patients received counseling on diet, exercise, or weight loss (Bleich, Pickett-Blackely, & Cooper, 2011). The purpose of this evidence-based practice (EBP) project is to determine if a multi-faceted intervention consisting of academic detailing, reminders, audit with feedback, and …
Abstracts From The 25th Annual Health Care Systems Research Network Conference, April 8–10, 2019, Portland, Oregon
Journal of Patient-Centered Research and Reviews
The Health Care Systems Research Network (HCSRN) is made up of nonprofit health systems with embedded research departments whose scientists are dedicated to public domain research. The network’s annual conference serves as a forum for research teams to disseminate study findings, stimulate new collaborations, and share insights about conducting research in real-world care settings. Abstracts accepted for presentation at HCSRN 2019 are published in this supplement of Journal of Patient-Centered Research and Reviews, the official scientific journal of the conference.
April 2019, Swosu Bulldog Wellness Committee
April 2019, Swosu Bulldog Wellness Committee
SWOSU BULLDOG WELLNESS
National Public Health Week
Join in observing National Public Health Week from April 1-7, 2019 and become part of a growing movement to create the healthiest nation in one generation. During the week, we will celebrate the power of prevention, advocate for healthy and fair policies, share strategies for successful partnerships and champion the role of a strong public health system. Each day of NPHW 2019 will focus on a public health topic. Hoping each topic will spark new conversations and engage new participants in the community. Follow along at this link to see daily themes and ways each of …
Nutrition And Environmental Pollution Extension Curriculum Improved Diet-Related Behaviors And Environmental Health Literacy, Dawn Brewer, Hannah Bellamy, Anna Hoover, Annie Koempel, Lisa Gaetke
Nutrition And Environmental Pollution Extension Curriculum Improved Diet-Related Behaviors And Environmental Health Literacy, Dawn Brewer, Hannah Bellamy, Anna Hoover, Annie Koempel, Lisa Gaetke
Dietetics and Human Nutrition Faculty Publications
Kentucky experiences some of the nation’s worst health outcomes related to obesity, diabetes, high blood pressure, and other age-related chronic diseases linked with oxidative stress and inflammation, which in turn are associated with poor diet, lack of physical activity, and exposure to certain environmental pollutants. In the Commonwealth, deteriorating infrastructure, inappropriate waste disposal, and potential occupational injury related to mining, agriculture, and other regionally important industries exacerbate the need for residents to have basic knowledge of potential environmental health threats. Unfortunately, community-level understanding of the complex connections between environmental exposures and health is limited, with many Kentuckians unaware that the …
Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong
Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong
Publications and Research
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycinesupplemented females were lighter than controls, but there was no effect on weight in males. End‐of‐life necropsies suggested that glycine‐treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine‐supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI‐1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late‐life diseases.