Dietetics and Clinical Nutrition Commons^™

Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In the United States, the major dietary source of protein is poultry meat, particularly chicken. Phosphorus absorption in chickens is a critical problem in poultry production. It therefore is important to understand the cellular and molecular regulation of phosphorous absorption in intestine to increase efficiency of the process. This would provide the benefits of reducing feed costs and reducing phosphorous excretion, thereby contributing to the sustainability of agriculture in the United States. Therefore, the focus of this thesis is determining the effect of vitamin D metabolites involved in phosphate homeostasis using the chicken as a model.

The Effects Of 24r, 25-Dihydroxyvitamin D3 And 24s, 25-Dihydroxyvitamin D3 On Phosphate Transport In Vivo, Yu Meng

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This research studied the effects of the two isomers of 24,25(OH)₂D₃ on phosphate absorption in vivo to increase our understanding of the effects of 24,25(OH)₂D₃ on phosphate transport in vivo, and its two isomers. The current work demonstrates that 24R,25(OH)₂D₃ is capable of decreasing phosphate absorption after a 1h injection in vivo and 24S,25(OH)₂D₃ can increase phosphate absorption after a 5h injection, but this stimulation disappears at time points after 5h.

Since 24,25(OH)₂D₃ is made in vitamin D-replete animals, the observation that 24R,25(OH)₂D …