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Articles 751 - 780 of 872
Full-Text Articles in Dietetics and Clinical Nutrition
Independent And Interactive Associations Of Negative Affect, Restraint, And Impulsivity In Relation To Binge Eating Among Women, Tyler B. Mason, Kathryn E. Smith, Jason M. Lavender, Robin J. Lewis
Independent And Interactive Associations Of Negative Affect, Restraint, And Impulsivity In Relation To Binge Eating Among Women, Tyler B. Mason, Kathryn E. Smith, Jason M. Lavender, Robin J. Lewis
Psychology Faculty Publications
There is growing recognition that impulsivity may serve as an underlying risk factor for binge eating. In addition, the association of impulsivity with binge eating may be moderated by other affective and cognitive risk factors. This study examined independent and interactive associations of negative affect, dietary restraint, and facets of impulsivity with binge eating. A diverse sample of 566 undergraduate women completed online questionnaires of study variables. Results revealed a three-way interaction of negative affect, dietary restraint, and attentional impulsivity in relation to binge eating. Women who were high on each of these three variables reported the greatest levels of …
Prevalence And Incidence Of Health Risk Factors Among Adolescent Girls, Kylah Pollard, Mohammed Chowdhury, Sarai Bauguess
Prevalence And Incidence Of Health Risk Factors Among Adolescent Girls, Kylah Pollard, Mohammed Chowdhury, Sarai Bauguess
The Kennesaw Journal of Undergraduate Research
Heart Disease has many different risk factors, including hypertension (high blood pressure) and high cholesterol. Research has shown that hypertension can be identified as early as adolescence, and preventative measures can be instilled in this age. However, the relationship between hypertension, high cholesterol, race, and income have not been studied in detail among adolescents. The present study analyzed the effects of different health factors on blood pressure and cholesterol levels in Caucasian and African-American girls ages 9-21 years old, the prime of adolescence. The dataset was part of a larger study completed by the National Heart, Blood, and Lung Institute …
Best And Worst Nutrition Plan, Lawren Kariuki
Best And Worst Nutrition Plan, Lawren Kariuki
Student Scholarship
In this project I chose two fast food restaurants which consisted of 3 meals from each and calculated their nutritional value to compare and contrast the differences.
Linkage, Whole Genome Sequence, And Biological Data Implicate Variants In Rab10 In Alzheimer’S Disease Resilience, Perry G. Ridge, Celeste M. Karch, Simon Hsu, Ivan Arano, Craig C. Teerlink, Mark T. W. Ebbert, Josue D. Gonzalez Murcia, James M. Farnham, Anna R. Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M. Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald G. Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M. Goate, Chris D. Corcoran, Joann T. Tschanz, Lisa A. Cannon-Albright, John S. Kauwe, Alzheimer’S Disease Neuroimaging Initative
Linkage, Whole Genome Sequence, And Biological Data Implicate Variants In Rab10 In Alzheimer’S Disease Resilience, Perry G. Ridge, Celeste M. Karch, Simon Hsu, Ivan Arano, Craig C. Teerlink, Mark T. W. Ebbert, Josue D. Gonzalez Murcia, James M. Farnham, Anna R. Damato, Mariet Allen, Xue Wang, Oscar Harari, Victoria M. Fernandez, Rita Guerreiro, Jose Bras, John Hardy, Ronald G. Munger, Maria Norton, Celeste Sassi, Andrew Singleton, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilüfer Ertekin-Taner, Carlos Cruchaga, Alison M. Goate, Chris D. Corcoran, Joann T. Tschanz, Lisa A. Cannon-Albright, John S. Kauwe, Alzheimer’S Disease Neuroimaging Initative
Nutrition, Dietetics, and Food Sciences Faculty Publications
Background
While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline.
Methods
We used over 200 “AD resilient” individuals and an innovative, pedigree-based approach to identify genetic variants that segregate with AD resilience. First, we performed linkage analyses in pedigrees with resilient individuals and a statistical excess of AD deaths. Second, we used whole genome sequences to identify candidate SNPs in significant linkage regions. Third, we replicated SNPs …
Creating A "Healthier Us" In The Workplace: Promoting A Healthy Lifestyle Through Evidence Based Nutrition Education., Jennifer Brennan Rd, Cso, Janine Gilboy Rd, Ldn, Erin Levine Rd, Cso, Ldn
Creating A "Healthier Us" In The Workplace: Promoting A Healthy Lifestyle Through Evidence Based Nutrition Education., Jennifer Brennan Rd, Cso, Janine Gilboy Rd, Ldn, Erin Levine Rd, Cso, Ldn
Clinical Nutrition Service
No abstract provided.
Assessing The Effect Of Nutritional Interventions On Body Composition Changes During Pregnancy In Moderately Malnourished Malawian Women, Megan K. Kitagawa
Assessing The Effect Of Nutritional Interventions On Body Composition Changes During Pregnancy In Moderately Malnourished Malawian Women, Megan K. Kitagawa
Master's Theses
Background: Malnutrition can affect the body composition changes that occur in healthy pregnancy, resulting in adverse effects to both the mother and infant. Supplementary foods with high quality protein may result in more favorable changes in lean mass and fat mass in pregnant malnourished women.
Objective: To retrospectively assess changes in body composition in moderately malnourished pregnant Malawian women in response to one of three nutritional interventions.
Methods: Height, weight, MUAC, and TSF were measured in pregnant women with MUAC >20.6 cm and19) were compared using ANOVA. If differences were detected, differences between groups were tested using the Tukey HSD …
Cardio-Metabolic Benefits Of Plant-Based Diets., Hana Kahleova, Susan Levin, Neal Barnard
Cardio-Metabolic Benefits Of Plant-Based Diets., Hana Kahleova, Susan Levin, Neal Barnard
Medicine Faculty Publications
Cardio-metabolic disease, namely ischemic heart disease, stroke, obesity, and type 2 diabetes, represent substantial health and economic burdens. Almost one half of cardio-metabolic deaths in the U.S. might be prevented through proper nutrition. Plant-based (vegetarian and vegan) diets are an effective strategy for improving nutrient intake. At the same time, they are associated with decreased all-cause mortality and decreased risk of obesity, type 2 diabetes, and coronary heart disease. Evidence suggests that plant-based diets may reduce the risk of coronary heart disease events by an estimated 40% and the risk of cerebral vascular disease events by 29%. These diets also …
Strategies For Increased Lactic Acid Production From Algal Cake Fermentations At Low Ph By Lactobacillus Casei, Tom J. Overbeck
Strategies For Increased Lactic Acid Production From Algal Cake Fermentations At Low Ph By Lactobacillus Casei, Tom J. Overbeck
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
We explored using de-oiled algal biomass (algal cake) as a low-value substrate for production of lactic acid in fermentations with Lactobacillus casei, and strategies for increasing lactic acid production at low pH. L. casei 12A algal cake (AC) fermentations showed carbohydrate and amino acid availability limit growth and lactic acid production. These nutritional requirements were effectively addressed with enzymatic hydrolysis of the AC using α-amylase, cellulase, and pepsin. Producing 0.075 g lactic acid per g AC from AC digested with all three enzymes. We explored heterologous expression of the cellulase gene (celE) from Clostridium thermocellum and the …
Non-Celiac Gluten Sensitivity Is An Emerging Spectrum Of Gluten Intolerance, Darla O'Dwyer
Non-Celiac Gluten Sensitivity Is An Emerging Spectrum Of Gluten Intolerance, Darla O'Dwyer
Symposium on Arts and Research
People following gluten free diets have become increasingly prevalent. Many people indicate that they feel better on a gluten free diet and that their symptoms return after eating gluten. This is occurring in the absence of celiac disease or a wheat allergy. This new clinical entity is called non-celiac gluten sensitivity (NCGS). Volta and colleagues (2014) cite several reasons for an increase in this condition: 1) farming practices have led to an increase in specific wheat variants that contain high amounts of gluten peptides that maybe toxic to susceptible individuals; 2) dough fermentation has significantly been shortened compared to the …
The Acute Impact Of A High-Fat Load On Pbmcs Among Women: The Impact Of Ethnicity And Weight Status, Regis Pearson
The Acute Impact Of A High-Fat Load On Pbmcs Among Women: The Impact Of Ethnicity And Weight Status, Regis Pearson
Masters Theses & Specialist Projects
Peripheral blood mononuclear cells (PBMCs) can respond to dietary stimuli modulating the up-regulation of pro-inflammatory cell signaling, which is associated with metabolic disease and has been seen to be elevated in African American (AA) when compared to Caucasian American (CA) women. Little is known about the response of PBMCs to a high fat meal among women and the potential impact of ethnicity and/or weight status on this response. The purpose of this study was to examine PBMC response to consuming a high fat meal and the response to culturing PBMCs in media supplemented with lipid among AA and CA women, …
Lactose Intolerance: An Overview Of The Facts And Their Implications, Noelle M. Yeo
Lactose Intolerance: An Overview Of The Facts And Their Implications, Noelle M. Yeo
Honors Program: Senior Projects (Public)
Lactose intolerance is often blamed for the symptoms such as bloating, diarrhea, gas, abdominal pain, and nausea, that ail many people. Patients often do not seek proper diagnosis from a physician and create their own treatment plans, severely restricting lactose intake, without professional guidance. Even those who do seek the care of a physician find that diagnosis is complicated by less-than ideal testing and confusion due to the symptoms common to many other conditions. The misconceptions and inability to confirm a diagnosis of lactose intolerance can cause nutrient deficiencies in these patients, as well as begin a pattern of unnecessary …
Ecological Correlations Of Dietary Food Intake And Mental Health Disorders, Jordan Hoerr, Joshua Fogel, Benjamin Van Voorhees
Ecological Correlations Of Dietary Food Intake And Mental Health Disorders, Jordan Hoerr, Joshua Fogel, Benjamin Van Voorhees
Publications and Research
This paper examines the ecological association of dietary food intake with mental health outcomes on the group level across countries. Published data from the World Mental Health Survey were used to compare lifetime prevalence of four categories of mental health disorders (anxiety disorders, mood disorders, impulse control disorders, and substance use disorders) with a country’s fish/seafood and sugar/sweetener supply quantity using the Spearman rank correlation. Data were compared for 17 countries across the world. Sugar and sweetener supply quantity was significantly and positively associated with anxiety disorders (rho = 0.75, p = 0.001), mood disorders (rho = 0.75, p = …
The School Food Environment And Its Association With Dietary Intake Among Rural Adolescents, Hannah F. Hickey
The School Food Environment And Its Association With Dietary Intake Among Rural Adolescents, Hannah F. Hickey
Theses and Dissertations--Nutrition and Food Systems
The school food environment has the ability to increase the consumption of fruit and vegetables in rural adolescents. This study used a survey to allow adolescents in seven rural counties to self-report their fruit and vegetable intake as well as utilizing the USDA Mathematica tool and the School Nutrition and Meal Cost Study audits to evaluate what food and beverage products were actually available to adolescents. By using these two measures, associations between fruit and vegetable intake and availability of healthy and unhealthy foods were determined. The availability of healthy snacks and beverages was found to be associated with sugar-sweetened …
Steroids: A Growing Dilemma In Athletics, Seara Ontiveros
Steroids: A Growing Dilemma In Athletics, Seara Ontiveros
Nebraska College Preparatory Academy: Senior Capstone Projects
A comprehensive and straight forward description of what exactly steroids are and what they do to the body is described by Gary Wadler, a health major at the New York University School of Medicine, he comments: “When the receptor sites in their bodies, which don’t have much testosterone in them, suddenly are presented with a lot of testosterone, they get activated…The unbalance of hormones increases the red blood cell formations... They’ll get more muscular, more defined. They’ll lose some fat, and increase their lean body mass, [they’ll] get stronger”. Although anabolic steroids and other hormones are consumed by many athletes …
Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson
Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson
Electronic Theses and Dissertations
To determine the effects of a diet that provides 30% energy from protein with ½ as lean, red meat on risk factors of metabolic syndrome in humans. This pilot study was a 3- month, randomized, control, intervention trial with 33 participants (Beef-Intervention n=18; DASH-Control n=15) who displayed markers of metabolic syndrome. Registered Dietitians Nutritionists recruited and educated participants on Beef-Intervention Lean Beef Pattern, (30% of energy from protein with ½ as lean red meat, 40% carbohydrate, 30% fat) or DASH-Control dietary pattern, (15% of energy from protein, 55% carbohydrate and 30 % fat). Of the 33 participants who completed the …
Characterizing Food Insecurity At A Northeast Land-Grant University, Alana Ruth Davidson
Characterizing Food Insecurity At A Northeast Land-Grant University, Alana Ruth Davidson
Honors Theses and Capstones
In 2015, 15.8 million U.S. households were food insecure. While nationally food insecurity is assessed at the household and childhood level, university students are not explicitly monitored. The purpose of this study was to determine the prevalence of food insecurity at a northeast land grant university and characterize the contributing factors. A pilot study (n=211) was conducted in fall 2014 among a general nutrition class and found that 12.4% of students were food insecure, with another 5.7% reported marginal food security. A larger, university wide survey among graduate and undergraduate students was conducted in fall 2015 (n=943) and found that …
Influencing Food Choice: Effects Of Stress And Sleep Deprivation On Dietary Habits Of Young Adults, Amy L. Leiferman
Influencing Food Choice: Effects Of Stress And Sleep Deprivation On Dietary Habits Of Young Adults, Amy L. Leiferman
The Journal of Undergraduate Research
Introduction: Lifelong dietary habits are shaped during young adulthood; hence, preventing poor food choice practices during this period is vital. Stress and sleep deprivation are two important lifestyle elements that affect eating habits. The purpose of this study was to evaluate stress and sleep deprivation as factors contributing to poor dietary choices of college-aged students. Methodology: During finals week, a survey inquiring about sleep duration, perceived stress, and dietary patterns throughout the semester (typical week vs. finals week), was administered to university students (n=83). Fifty-five participants (21 male) provided an ID number, which allowed university-collected demographic and food-purchasing …
Comparing Mindfulness-Enriched Weight Management To Current Standard Practices, Teresa M. Lee
Comparing Mindfulness-Enriched Weight Management To Current Standard Practices, Teresa M. Lee
Theses and Dissertations--Nutrition and Food Systems
Mindfulness-based interventions have been shown to be effective for numerous diet-related conditions. Mindfulness skills have been theorized to be helpful in improving eating behaviors, and thereby weight management. The purpose of this study was to compare the effectiveness of a mindfulness-enriched weight management program to a standard weight loss program over the course of a 12-week intervention, and weight maintenance over six months. This was a two-group randomized experimental design. One group received a standard weight loss program, while the other group received the same program with an additional mindfulness component. Follow up assessments were conducted twice at three-month intervals. …
Sneaky Salt Contributes To High Blood Pressure, Rodney Richmond
Sneaky Salt Contributes To High Blood Pressure, Rodney Richmond
Faculty Research and Publications
No abstract provided.
Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean
Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean
Posters-at-the-Capitol
Title: Higher Unsaturated Fatty Acid Intake and Aerobic Training are Related to Lower Intramyocellular Lipid in Older Adults
1Hillary McLean, 2Maja Redzic, and 3D. Travis Thomas
Department: 1Department of Agriculture, 2Department of Pharmacology and Nutritional Sciences, and 3Department of Clinical Sciences
Funding: R21AG046762-01A1, UL1TR000117, T32DK007778-16
Word Count: 298/300
Intramyocellular lipid (IMCL) is associated with metabolic dysfunction in aging. Exercise is known to influence IMCL accumulation and was recently observed to have a direct association with vitamin D status (25(OH)D) in our lab. In addition, we observed an inverse association between IMCL and dietary unsaturated …
Exploring The Connection Between Community Food Security Initiatives And Social-Cognitive Factors On Dietary Intake, Diana Cuy Castellanos, Josh Keller, Emma Majchrzak
Exploring The Connection Between Community Food Security Initiatives And Social-Cognitive Factors On Dietary Intake, Diana Cuy Castellanos, Josh Keller, Emma Majchrzak
Health and Sport Science Faculty Publications
Food insecurity and poor dietary consumption continue to impact low-income populations in the U.S. However, communities are developing ways to address it at the local level. Community Food Security Initiatives (CFSI) focus on increasing a sustainable, healthy food supply and food system while addressing food insecurity and dietary quality within a community.
The purpose of this study was two-fold: (1) explore CFSIs in low-income areas in a metropolitan Midwest city and (2) examine the effects of the initiatives along with other social-cognitive factors on fruit and vegetable consumption in persons participating in local CFSIs.
This was a mixed-methods study. First, …
Ua12/2/1 Healthy Living Guide, Wku Student Affairs
Ua12/2/1 Healthy Living Guide, Wku Student Affairs
WKU Administration Documents
Special magazine published by the College Heights Herald.
- Collins, Emma. Six Ways to Learn Healthy Eating in Your Dorm
- Austin, Emma. Preston Health & Activities Center Accommodates Users of Varied Abilities
- Henderson, Andrew. If Five Campus Restaurants Had Personality Types
- Burgess, Kelly. How to Make a Light & Fresh Quinoa Fruit Salad
- Carlson, Kylie. New Boxing Gym Swings into Bowling Green – BGKY Boxing
- Adams, Julia. Students Open Discussion on Mental Health
- Healthier Eating with a Meal Plan
- Kast, Monica. Gluten & Allergy Free Station to Open in Fresh – Dining Services
- Sims, Adam. Students Develop Personal Workout Routines
- Cole, …
Benefits Of A Flexitarian Diet: Educating College Students Of Lifestyle Approaches To Reduce The Risk Of Developing Breast And Prostate Cancer, Abbigail Pace
Mahurin Honors College Capstone Experience/Thesis Projects
Practicing the Flexitarian diet, a plant-based diet, in conjunction with physical activity can promote a lifestyle consistent with the American Cancer Society’s recommendations for reducing risks of breast and prostate cancer (American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention, 2015) College students were assessed on knowledge of the relationship between diet and cancer risk prior to and after accessing information on the American Institute of Cancer Research site or the WKU Flexitarian Pinterest Page. Participants were recruited from the National Panhellenic and Interfraternity Council memberships and the International students at Western Kentucky University. Participants completed a …
3-Hydroxy Fatty Acid Induce Trophoblast And Hepatocyte Lipoapoptosis, Taylor Bruett, Taylor Heng, Sathish Kumar Natarajan
3-Hydroxy Fatty Acid Induce Trophoblast And Hepatocyte Lipoapoptosis, Taylor Bruett, Taylor Heng, Sathish Kumar Natarajan
UCARE: Research Products
Acute Fatty Liver of Pregnancy (AFLP) is a very rare and fatal condition for both the mother and the unborn offspring accompanied by severe maternal liver dysfunction. AFLP usually develops during the third trimester of pregnancy with symptoms of liver disease. AFLP is associated with a mutation in the enzyme, long-chain 3-hydroxy acyl CoA dehydrogenase (LCHAD) which is involved in the mitochondrial beta-oxidation of fatty acids. Defective beta-oxidation of fatty acids results in the individual unable to metabolize fatty acids which then causes fatty infiltration in their organs, such as the liver. This interferes with normal function of the liver …
Current And Past Menstrual Status Is An Important Determinant Of Femoral Neck Geometry In Exercising Women, Rebecca J. Mallinson, Nancy I. Williams, Jenna C. Gibbs, Karsten Koehler, Heather C.M. Allaway, Emily Southmayd, M. J. De Souza
Current And Past Menstrual Status Is An Important Determinant Of Femoral Neck Geometry In Exercising Women, Rebecca J. Mallinson, Nancy I. Williams, Jenna C. Gibbs, Karsten Koehler, Heather C.M. Allaway, Emily Southmayd, M. J. De Souza
Department of Nutrition and Health Sciences: Faculty Publications
Menstrual status, both past and current, has been established as an important determinant of bone mineral density (BMD) in young exercising women. However, little is known regarding the association between the cumulative effect of menstrual status and indices of bone health beyond BMD, such as bone geometry and estimated bone strength.
Purpose: This study explores the association between cumulative menstrual status and indices of bone health assessed using dualenergy x-ray absorptiometry (DXA), including femoral neck geometry and strength and areal BMD (aBMD), in exercising women.
Methods: 101 exercising women (22.0 ± 0.4 years, BMI 21.0 ± 0.2 kg/m2, 520±40 min/week …
Hunger Doesn't Take A Spring Break, Jessica Isaacs
Hunger Doesn't Take A Spring Break, Jessica Isaacs
Engagement & Service-Learning Summit
The rates of food insecurity amongst Hoosier children is slightly above the national average. For many of these children, school lunches are their primary source of nutrition. During school breaks, these children are at risk of going hungry. While Purdue Nutrition Society wishes that we could help all Hoosier children stay fed with nutritious meals, for now we are focusing on helping 20 local elementary students most at risk of going hungry over spring break. Working with Glen Acres Elementary in Lafayette, Indiana, a school where in 2014, over 71% of the students qualified for free or reduced lunches, we …
Dyslipidemia And Food Security In Low-Income Us Adolescents: National Health And Nutrition Examination Survey, 2003-2010., June M Tester, Barbara A Laraia, Cindy W Leung, Michele L. Mietus-Snyder
Dyslipidemia And Food Security In Low-Income Us Adolescents: National Health And Nutrition Examination Survey, 2003-2010., June M Tester, Barbara A Laraia, Cindy W Leung, Michele L. Mietus-Snyder
Pediatrics Faculty Publications
INTRODUCTION: Low levels of food security are associated with dyslipidemia and chronic disease in adults, particularly in women. There is a gap in knowledge about the relationship between food security among youth and dyslipidemia and chronic disease. We investigated the relationship between food security status and dyslipidemia among low-income adolescents.
METHODS: We analyzed data from adolescents aged 12 to 18 years (N = 1,072) from households with incomes at or below 200% of the federal poverty level from the National Health and Nutrition Examination Survey (NHANES) 2003-2010. We used logistic regression to examine the relationship between household food security status …
A Pilot Study For Plant The Seed: A Nutrition Education Program Using Local Food Environment To Put Theory Into Action, Yeon Bai, Shahla M. Wunderlich, Karen A. Lee
A Pilot Study For Plant The Seed: A Nutrition Education Program Using Local Food Environment To Put Theory Into Action, Yeon Bai, Shahla M. Wunderlich, Karen A. Lee
Department of Nutrition and Food Studies Scholarship and Creative Works
The purpose of this study is to implement Plant the Seed, a garden-based nutrition education program designed to reconnect children with locally grown food, food environments of the past and present, and the benefits of eating seasonal foods. The pilot study investigates the environmental context and theory variables known to influence healthy food choice behavior. Social Cognitive Theory (SCT) provided a framework for the program’s curriculum and evaluation. The target audience is middle school students. Plant the Seed is a two-part program. In Part 1 (classroom), students participate in practical, interactive activities based on specific educational objectives that target …
Hormonal Responses To Non-Nutritive Sweeteners In Water And Diet Soda., Allison C. Sylvetsky, Rebecca J Brown, Jenny E Blau, Mary Walter, Kristina I Rother
Hormonal Responses To Non-Nutritive Sweeteners In Water And Diet Soda., Allison C. Sylvetsky, Rebecca J Brown, Jenny E Blau, Mary Walter, Kristina I Rother
Exercise and Nutrition Sciences Faculty Publications
BACKGROUND: Non-nutritive sweeteners (NNS), especially in form of diet soda, have been linked to metabolic derangements (e.g. obesity and diabetes) in epidemiologic studies. We aimed to test acute metabolic effects of NNS in isolation (water or seltzer) and in diet sodas.
METHODS: We conducted a four-period, cross-over study at the National Institutes of Health Clinical Center (Bethesda, Maryland). Thirty healthy adults consumed 355 mL water with 0 mg, 68 mg, 170 mg, and 250 mg sucralose, and 31 individuals consumed 355 mL caffeine-free Diet Rite Cola™, Diet Mountain Dew™ (18 mg sucralose, 18 mg acesulfame-potassium, 57 mg aspartame), and seltzer …
Suppression Of Nlrp3 Inflammasome By Γ-Tocotrienol Ameliorates Type 2 Diabetes, Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung
Suppression Of Nlrp3 Inflammasome By Γ-Tocotrienol Ameliorates Type 2 Diabetes, Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung
Department of Nutrition and Health Sciences: Faculty Publications
The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals. We previously reported that γ-tocotrienol (γT3) attenuated adipose tissue inflammation and insulin resistance in diet-induced obesity, but the underlying mechanism remained elusive. Here, we investigated the effects of γT3 on NLRP3 inflammasome activation and attendant consequences on type 2 diabetes. γT3 repressed inflammasome activation, caspase-1 cleavage, and interleukin (IL) 1β secretion in murine macrophages, implicating the inhibition of NLRP3 inflammasome in the anti-inflammatory and antipyroptotic properties of γT3. Furthermore, supplementation of leptin-receptor KO mice …