Oral Biology and Oral Pathology Commons^™

Dental Morphology In A Juvenile Mammal From The Late Cretaceous Of South America: Tooth Eruption And Development., Kayla E Newton

Electronic Theses and Dissertations

Meridiolestids are a diverse and distinct clade of Cretaceous–Miocene South American dryolestoid mammals ranging in size from small shrew-sized insectivores to large dog- sized omnivores. Cronopio dentiacutus from the Cenomanian La Buitrera locality, Rio Negro Province, Argentina (Candeleros Fm.) is the oldest and best known of them, represented by skull material and associated jaws. A juvenile skull as attributed to Cronopio dentiacutus, based on tooth size and morphology, was collected from the type locality. The specimen includes the skull and both articulated lower jaws. The fossil is poorly ossified and partially flattened; CT scanning reveals most of the dentition …

Aggregatibacter Actinomycetemcomitans Exploits And Modulates The Immune Response By Human Neutrophils For Survival In The Anaerobic Environment., Hazel Ozuna

Electronic Theses and Dissertations

Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative facultative anaerobe and an opportunistic oral pathogen, strongly associated with localized periodontitis and other inflammatory diseases. Periodontitis is a chronic inflammation of the periodontium resulting from the inflammatory response of the host towards the dysbiotic microbial community present at the gingival crevice. The host immune response creates a hostile environment for microorganisms; therefore, it is important for Aa to be able to regulate the necessary genes to survive and thrive in such an environment. Aaexpresses several virulence factors such as a cytolethal distending toxin (Cdt), lipopolysaccharide (LPS) and leukotoxin A (LtxA), …

Effect Of Brushing Time With A Whitening Dentifrice On Surface Roughness Of Anterior Composite Resins, Ahmet Hazar, Sinem Akgül, Sibel Koçak, Mustafa Murat Koçak

Journal of Dentistry Indonesia

Objectives: This study aimed to compare the surface roughness of three anterior composite resins with different filler size, rate, and shape after brushing for 5000, 10000, and 20000 cycles with a whitening dentifrice. Methods: 44 disk-shaped specimens of each material (5mm diameter, 2mm depth) G-aenial Anterior, Harmonize, Asteria were prepared and divided into four groups according to the brushing cycles (Initial, 5000, 10000, and 20000 cycles). Initial surface roughness values (Ra-values) were assessed using a profilometer and measurements were repeated after each brushing cycle. 4 specimens from each composite resin were observed by scanning electron microscopy before and after brushing. …

Evaluation Of The Effect Of Two Polishing Techniques And Thermocycling Process On Surface Roughness, Hardness, And Color Stability Of Composites, Muhammet Fidan, Zeynep Dereli

Journal of Dentistry Indonesia

Objectives: The aim of this study was to evaluate the effect of two polishing techniques and 10.000 thermocycles on the color stability, surface roughness, and hardness of two nanohybrid (Tetric N-Ceram, Escom100) and one bulkfill (Filtek) resin composites. Methods: A total of 60 specimens were prepared using three resin composites and 20 discs from each composite. Specimens for each composite were randomly divided into two different polishing groups (Optrapol rubber and Sof-Lex discs) (n=10). Surface roughness (Ra, μm), microhardness (VHN), and color change (ΔE00) values were measured pre- and post-thermocycling. Two-way analysis of variance (ANOVA) was used to evaluate …

A Comparison Of Four Different Methods Of Prediction Of Mesiodistal Widths Of Unerupted Permanent Canines And Premolars, Waqar Jeelani, Washma Asad, Maheen Ahmed

Journal of Dentistry Indonesia

The success of orthodontic treatment depends upon the accurate assessment of mesiodistal widths of unerupted canines and premolars in mixed dentition stage. There are several methods available for mixed dentition analysis with dubious reliability in our population. Objective: To statistically develop new prediction equations for Pakistani subjects to predict the widths of unerupted upper canines and premolars (U345) and lower canine and premolars (L345) using mesiodistal widths of lower incisors (I1I2) and lower incisors and first molars (I1I2M1) and compare their performance with previously established methods of Moyers and Tanaka-Johnston. Methods: Study was conducted using the data from the dental …

Endodontic Management Of Mandibular First Molar With Four Roots - A Rare Case Report With Clinical Management Guidelines, Shaikh Shahbaz, Huma Iftekhar, Sharique Alam, Zehra Shavez

Journal of Dentistry Indonesia

Mandibular molar is usually two rooted with one mesial and one distal root. Additional roots are rare which requires accurate diagnosis and a methodical and scrupulous endodontic treatment. Objective: This paper aims to report the endodontic management of an unusual case of a mandibular permanent first molar with four roots (two mesial & two distal) and provide a clinical guideline to detect and manage these variant cases. Case report: A 15-year-old boy reported with a deep carious lesion in the lower left first molar (#36). The apical root contour of #36 on an intraoral periapical radiograph taken in different angulations …

Salivary Iga Depression In Drug-Influenced Gingival Enlargement Among Hypertensive Patients, Muhammad Annurdin Sabarudin, Haslina Taib, Wan Majdiah Wan Mohamad, Siti Lailatul Akmar Zainuddin, Wan Syamimee Wan Ghazali, Ahmad Azhar Misran

Journal of Dentistry Indonesia

Drug-influenced gingival enlargement (DIGE) among hypertensive patients is commonly associated with antihypertensive drugs such as calcium channel blockers (CCBs). Immune response alteration is one of the proposed mechanisms for DIGE. Immunoglobulin A (IgA) in saliva which involves in defense mechanism was shown to be affected in patients with DIGE. Objective: This study aimed to determine the association of salivary IgA level with DIGE. Methods: This cross-sectional study comprised 47 hypertensive patients who had consumed antihypertensive drugs for at least 3 months. Twenty-one (44.7%) males and 26 (55.3%) females had participated in this study. Data was analyzed using SPSS version 26.0. …

The Development And Structure Of The Tooth Enamel And The Nature Of Deterioration, Anderson Hill

Senior Honors Theses

The tooth enamel is developed through a careful process to give its characteristic hardness, but bacteria colonization in the form of plaque and certain dietary habits can compromise this. The development of the tooth involves an intricate process that incorporates proteins and minerals to produce the toughest tissue in the human body. The enamel possesses a distinct crystal lattice with many minerals involved. Under acidic conditions, the integrity of the crystals that make up the tooth enamel can become compromised. Harmful bacteria, such as Streptococcus mutans of the mouth combine with carbohydrates that are consumed to produce acids that are …

Impact Of Interleukin-34 On The Promotion Of Bone Osteolysis And Neuroinflammation In Experimental Models Of Alzheimer’S Disease, Anny Ho

All HCAS Student Capstones, Theses, and Dissertations

Alzheimer’s disease (AD) is a growing health concern and is the most common type of dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) peptides, one of the hallmark features of AD neuropathology, can increase RANKL-mediated osteoclast activity leading to the prevalence and severity of inflammatory osteolysis, e.g., osteoporosis and periodontal bone loss. Conversely, osteolytic lesions are associated with increased risk of dementia diagnosis indicating that there is a direct link between dementia and inflammatory osteolysis. It was demonstrated that the neuronal cells primarily produce interleukin-34 (IL-34) and microglia, macrophages, and osteoclast precursors express colony-stimulating factor 1 receptor (CSF-1R), a …

N Y State Dent J April 2022

The New York State Dental Journal

In the April 2022 issue, the reader will find the following feature articles:

• Responding to Online Social Media Posts
• Diode Laser-Assisted Abscission and Low-Level Laser Therapy for Treatment of Mucocele Literature: Update and Case Report
• White Sponge Nevus
• Effects of New York State’s Medicaid Orthodontic Policy Changes on Approved Orthodontic Treatment Complexity

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

White Sponge Nevus: Case Report, David M. Walton Bs, Daria Vaislyeva Dds, Louis Mandel Dds

The New York State Dental Journal

White sponge nevus (WSN) is a rare autosomal dominant asymptomatic keratotic disorder. A case report is presented of a 28-year-old male with a long-standing asymptomatic and widespread oral mucous membrane keratosis. A diagnosis of WSN was made based on his clinical history, the characteristic appearance of the lesion, and the histopathology.

Meta-Analysis Of Two Rnaseq Datasets To Determine Diagnostic Biomarkers And Drug Target Candidates For Periodontitis, Carlos Moreno

Annual Research Symposium

No abstract provided.

Evaluation Of The Neurogenic And Dentinogenic Effect Of Valproic Acid On Undifferentiated Mesenchymal Cells Of Human Dental Pulp, Edward Yeates

Annual Research Symposium

No abstract provided.

Influence Of Etching Methods On The Shear Bond Strength Of A Universal Adhesive System To Sound And Artificial Caries-Affected Dentin, Omnia M. Sami, Essam A. Naguib, Rasha H. Afifi, Shaymaa M. Nagi

Future Dental Journal

Abstract:

This study tested the effect of different etching methods on the bond strength of a universal adhesive system to caries-affected (CAD)and sound dentin. Methods: forty premolars were wet grinded to expose flat occlusal midcoronal dentin. Specimens were equally divided according to the substrate; sound and (CAD) by exposing to pH-cycling for 14 days. Each dentin substrate was bonded with Single Bond^TM universal adhesive applied either after no etching or etching of dentin, then resin composite was built up. Specimens were tested for shear bond strength (SBS). The data was analyzed by two-ways ANOVA. Results: Single Bond^TM universal …

Evaluation Of Facial Soft Tissue Changes In Excessive Gingival Display Cases After Le Forte I Maxillary Impaction Surgery Using 3d Facial Surface Laser Scanner, Ahmed Mohamed Hazem Alshazly A.Al Shazly, Mostafa Mohamed Sayed Taha, Ahmed Abdelmoniem Barakat, Mohamed Diaa Zein El Abdien

Future Dental Journal

Introduction: Facial soft tissue changes in relation to hard tissue movements after orthognathic surgery cases is always of concern to patients , surgical and orthodontics teams. The aim of the present study was to assess facial soft tissue changes and stability using 3D facial laser scanner after orthognathic surgery Le Forte I maxillary impaction in excessive gingival display patients. Methods: The subjects consisted of 12 patients with skeletal vertical maxillary excess (VME) causing an aesthetic concern to the patients in the form of “Gummy smile”, who underwent LeFort I osteotomy with maxillary impaction, Three-dimensional images of the patients …

N Y State Dent J March 2022

The New York State Dental Journal

In the March 2022 issue, the reader will find the following feature articles:

• Orthognathic Surgery and Quality-of-Life Outcomes: Findings from a Hospital-Based Patient Satisfaction Survey
• Recommendations for Co-Prescription of Opioids and Naloxone in the Dental Office
• Papillon-LeFevre Syndrome: A Case Study of Two Siblings
• Treatment of Peri-implant Soft-tissue Deficiency around a Narrow Diameter Implant with Subepithelial Connective-tissue Graft: A Case Report
• Simple Lipoma Mimicking Oral Infiltrating Lipoma: Case Report

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Simple Lipoma Mimicking Oral Infiltrating Lipoma: Case Report, Moacyr Tadeu V. Rodrigues Dds, Msc, Judson N. Brasil Dds, Gabriel A. Guillen Dds, Msc, Cláudio F. Nóia Dds, Phd

The New York State Dental Journal

Lipomas are common soft tissue neoplasms, usually present in the trunk and proximal portions of the extremities and less frequent in the mouth. We reported the case of a 51-year-old patient, affected by an intra/extra-oral swelling for 8 months. Aspiration, surgical excision and histopathological examination confirmed that it was a simple oral lipoma, although clinically and surgically, it mimicked an infiltrating lipoma. Conservative surgical treatment, preferably by an intra-oral approach provides less morbidity and less sequelae for patients.

The Frequency Of Periodontitis In End-Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi-Center Clinical Cross-Sectional Study, Asmaa Ras, Enji A. Ahmed, Radwa Hussein, Eman Khalil

Dentistry

Abstract Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relation‑ ship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis cent‑ ers in Benha Governorate, …

The Effects Of Celiac Disease On Oral Health In Children And Adults, Marissa Balducci, Katarina Jones

Dental Hygiene Student Scholarship

Objectives: Celiac disease (CD) is an autoimmune disorder characterized by intolerance to dietary gluten in genetically predisposed subjects. To ensure affected patients receive optimal dental care, it is necessary for dental professionals to recognize the oral manifestations of celiac disease in both children and adults. Upon associating oral conditions with celiac disease, the dental provider should be able to present recommendations to the patient, contributing to an improvement in their oral health.

Methods: This review of the literature used PubMed to identify relevant professional research articles with publication after 2017. MesH terms utilized in the search process were …

Relationship Between Diabetic Status And Levels Of Salivary Statherin, Nikhil Malhan, David Ojcius, Scott Davis

Orthodontics and Endodontics Theses

Aim: The aim of this study is to determine the varying levels of salivary statherin production in patients with varying levels of risk for diabetes. The goal is to identify a causal relationship and thus, statherin could be used as a preliminary biomarker for identifying patients with diabetes. Materials and Methods: Saliva from 47 participants were collected in order to quantify the levels of statherin production via western blot analysis. Participants were also asked to fill out self-reported questionnaires regarding risk factors for type 2 diabetes. The questionnaire consisted of 7 questions regarding age, sex, history of diabetes, hypertension, level …

The Impact Of Sickle Cell Disease On Gingival Bleeding And Oral Health Of Adults, Natalie Roa

Honors Undergraduate Theses

Oral health may serve as an indicator of overall systemic health, with each disease or condition manifesting differently in the oral cavity. Sickle cell disease (SCD) is a genetic disorder in which sickled red blood cells cause blood vessel occlusion and potentially bleeding in specific sites (e.g., gastrointestinal and intracranial bleeding). With SCD being one of the most common hereditary diseases in the world, it is essential to understand the disease and improve awareness to better treat this population. While studies have been done to evaluate the oral health of persons with SCD, few have explored the occurrence of gingival …

Alteration In Facial Contour Associated With Aging: Case Report, Bohan Lin Ba, Dds, Louis Mandel Dds

The New York State Dental Journal

The authors examined a 73-year-old female because of a chief complaint of bilateral swellings of the parotid gland. After detailed questioning, the authors determined that the perceived facial swelling was caused by the inferior displacement of separate and identifiable facial fat compartments. Aging coupled with gravity results in both a compartmental and intracompartment inferior displacement of facial fat. Long-lasting fillers injected intra-or extra-compartmentally also partake in this inferior migration.

The Influence Of Extracellular Matrix On Human Periodontal Ligament Stem Cell Properties, Daneeya Na Nan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The periodontal ligament (PDL) is a crucial tissue connecting teeth to surrounding alveolar bone, withstanding the mechanical forces of mastication, speech, and deglutition. The extracellular matrix (ECM) of the PDL plays a critical role in maintaining PDL cell stability and function in response to external forces. Mechanotransduction, the process by which cells convert mechanical signals into biochemical signals, is essential for PDL cells to sense and respond to mechanical stimuli. The ECM is a critical mediator of mechanotransduction, as it is responsible for transmitting mechanical forces to cells and regulating cellular responses to mechanical stress. Matricellular proteins, such as periostin …

In Vitro Comparative Sem Analysis Of Nano-Hydroxyapatite Toothpaste And Diode Laser: Evaluation Of Efficacy Of Dentinal Tubular Occlusion, Mohamed Shamel, Sara Elbanna

Dentistry

Introduction Dentin hypersensitivity (DH) is a very common problem that faces many patients and maintaining treatments with a long term effectiveness remains a challenge. Based on hydrodynamic theory, the main approach of overcoming DH are tubular occlusion.

Objectives The aim of this study was to discover the efficacy of diode laser alone and in combination with a desensitizing toothpaste containing nano-hydroxyapatite (nHap) to evaluate dentinal tubule occlusion after acid challenge under scanning electron microscope (SEM).

Material and methods Forty dentin discs were divided into 4 groups: group 1, control; group 2, dentin disc treated with nHap toothpaste for one week; …

The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in hDPSCs. This study aimed to investigate the characteristic of the Jagged1-treated hDPSCs-derived dECM and its biological activity on odonto/osteogenic differentiation SCAPs. Methods: Bioinformatic database of Jagged1-treated hDPSCs was analyzed by NetworkAnalyst. hDPSCs seeded on Jagged1 immobilized surface were maintained with N or OM followed by decellularization procedure, dECM-N or dECM-OM, respectively. SCAPs were reseeded on each dECM with either normal medium or OM. Cell viability was determined by MTT assay. Characteristics of dECMs and SCAPs were evaluated by SEM, EDX, immunofluorescent staining and alcian blue staining. A Multipotential differentiation assay. …

Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries in children is the most common chronic oral disease that could disturb their quality of life including their development. Early prevention is a key approach to reducing the prevalence of early childhood caries. However, a reliable caries predictor, as an essential tool for targeted prevention that is important to this approach, is still lacking for infants before caries onset. Therefore, we aimed to develop the caries risk prediction model based on the salivary microbiome of caries-free 1-year-old children to predict caries onset at 1-year follow-up. Using a nested case-control design within a prospective cohort study, 30 saliva samples, …

Hydroxyapatite Nanoparticle And Bone Scaffold To Deliver Microrna-302a-3p For Bone Healing In A Critical-Sized Bone Defect, Pirawish Limlawan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bone tissue engineering is a therapeutic approach for large bone defects. It is being studied to create efficient bone substitution material. However, the autograft with consequence of multiple morbid sites is still a gold standard. This study aimed to use surface modified hydroxyapatite nanoparticle on a 3D-printed tricalcium phosphate/hydroxyapatite (TCP/HA) scaffold to deliver miRNA-302a-3p to enhance bone regeneration as a novel approach for bone tissue engineering. Hydroxyapatite nanoparticles (HA-NPs) were created with hydrothermal method and surface modified with cationic molecule 3-aminopropyltriethoxysilane (APTES) or poly2-(dimethylamino)ethyl methacrylate (PDMAEMA) to enhance miRNA condensation and cellular uptake. The biocompatibility, miRNA condensation ability, cellular uptake …

Study Of Mutation And Pathomechanism Of Runx2 In Cleidocranial Dysplasia, Sermporn Thaweesapphithak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cleidocranial dysplasia (CCD) is a skeletal disorder affecting the skull, teeth, and clavicles, and is associated with the RUNX2 variants. We identified the five variants from five families, three were novel, comprising c.739delA (p.(Ser247Valfs*)), c.901C>T (p.(Gln301*)), and c.1081C>T (p.(Gln361*)) and two were reported, comprising c.673C>T (p.Arg225Trp) and c.674G>A (p.Arg225Gln). All patients exhibited typical CCD features, but we observed the unreported phenotypes, left forth-ray brachymetatarsia. Moreover, we reviewed the C-terminus RUNX2 variants in the CCD patients and found 81 variants that have been reported. To determine, the pathomechanism of CCD caused by the variants in the C-terminus, …

Human Epidermal Growth Factor Release From Hyaluronic Acid-Based Platforms Towards In Vitro Expansion Of Salivary Gland Cells, Toan Phan Van

Chulalongkorn University Theses and Dissertations (Chula ETD)

Off-the-shelf recombinant growth factors are increasingly used as signaling cues to optimize organoid biofabrication and shorten the in vitro culture time. These factors are mainly produced in prokaryotic systems but lack post-translational modifications. To overcome such limitations and the high production costs related to these common systems, plant molecular farming is a novel, easy adaptable and feasible alternative. Epidermal growth factor (EGF) is a known signaling cue essential for epithelial organogenesis and organoid biofabrication particularly in exocrine glands. This study aims to develop an EGF delivery in vitro platform with Nicotiana benthamiana plant-derived EGF (P-EGF) encapsulated on hyaluronic acid/alginate (HA/Alg) …

N Y State Dent J January 2022

The New York State Dental Journal

In the January 2022 issue, the reader will find the following feature articles:

• A Call to Do Better: Addressing Diversity within the Dental Profession
• Moving on in the New Year
• Destination Dental School: A Remote Pipeline Program to Increase Student Diversity
• Alteration in Facial Contour Associated with Aging

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.