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Oral Biology and Oral Pathology Commons™
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Full-Text Articles in Oral Biology and Oral Pathology
Expression Of Gna12 And Ifitm3, And Their Roles In Oral Carcinogenesis., Gan Chai Phei
Expression Of Gna12 And Ifitm3, And Their Roles In Oral Carcinogenesis., Gan Chai Phei
Student Works (2010-2019)
Oral squamous cell carcinoma (OSCC) is a major health problem worldwide. The heterogeneity of the disease is the main challenge for the improvement of current treatment modalities. Efforts in our laboratory have focused on the molecular profiling of oral cancer in order to understand the mechanisms underlying this disease. Based on the previous microarray data, Guanine nucleotide binding protein alpha-12 (GNA12) and Interferon inducible transmembrane protein 3 (IFITM3) were identified to be up-regulated in oral cancer. Objectives: This study aims to validate the expression of GNA12 and IFITM3 at the mRNA and protein levels in oral cancer tissues and to …
Study Of Bacterial Diversity In The Oral Cavity Of Malaysian Subjects., Teoh Wuen Yew
Study Of Bacterial Diversity In The Oral Cavity Of Malaysian Subjects., Teoh Wuen Yew
Student Works (2010-2019)
About 700 species of bacteria can inhabit the human oral cavity. This project initially investigated the bacterial diversity within the oral cavity of Malaysian subjects by using culture-dependent techniques and 16S rDNA sequence analysis. The second part of the research profiled the antibiotic resistance of the identified oral bacteria by the Etest method. Three sampling sites of the oral cavity from nine healthy subjects were analyzed: the tooth surface, gingival crevice, and dorsum of the tongue. The tooth surface was shown to harbor 41 species, gingival crevice harbored 51 species and tongue dorsum 41 species. On average, each subject carried …
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Student Works (2010-2019)
Introduction Oral cancer is a significant health problem worldwide with almost 300,000 new cases are diagnosed each year. Despite the numerous studies done, and even with the best treatment option utilized, more than 50% of patients with oral cancer will experience relapse. In search for better options for prognostication, researches are now focusing on the molecular biology of cancer, for instance in search of reliable tumor markers. Among the markers reported in the literatures, Cyclin D1 is actively studied protein. Cyclin D1 regulates the cell cycle progression by forming a complex with different cyclin dependant kinase. Dysregulation of cyclin D1 …