Oral Biology and Oral Pathology Commons^™

P53 Tumor Suppressor Gene Expression In Ameloblastoma Subtypes: An Immunohistochemical Analysis, Yara Y. Mouselhy, Ahmed Abozekry, Iman M. Abdel Meguid, Raneem F. Obeid, Mai Abdelhalim Hamouda, Hala El-Kammar

Future Dental Journal

Background: Ameloblastoma is the most frequent of the benign epithelial odontogenic tumours. It exhibits a unique biologic behavior which demands meticulous understanding for thorough diagnosis and management. P53 tumor suppressor protein functions as a gatekeeper of cell division, inducing either cell cycle arrest or apoptosis. While mutations in the p53 gene are often detected in human cancers; the role of p53 in ameloblastoma remains elusive.

Material and methods: To investigate p53 expression in ameloblastoma, a retrospective study was designed to evaluate and compare immunohistochemical p53 protein expression patterns, in follicular ameloblastoma, plexiform ameloblastoma and unicystic ameloblastoma. Nine paraffin-embedded archival tissue …

The Effect Of Preparation Design And Thermal Cycling On The Marginal Accuracy Of Hybrid Ceramic Laminate Veneers, Esraa El Bably, Ossama Saleh Abdelghany, Mostafa Aboushahba, Shereen Ahmed Nossair

Future Dental Journal

Aim: This study investigated the effect of preparation design and thermal cycling on the marginal accuracy of hybrid ceramic laminate veneers. Materials and Methods: A total of twenty 3D printed dies of central incisors prepared with 2 preparation designs; butt joint and palatal wrap design were fabricated. Each type of preparation was assigned into 2 subgroups (n=5/each subgroup) according to the type of material used for fabrication of the laminate veneer; hybrid ceramic and lithium disilicate (served as control). Marginal discrepancy was evaluated using a digital microscope before and after thermocycling. Results: Statistically analysis of marginal gaps revealed that before …

Measuring Accuracy Of Dolphin Imaging Software In Predicting Upper Jaw Soft Tissue Profile Changes In Class Ii Adult Patients Treated With Extraction Versus Non-Extraction., Amr Amin Arif, Esam Nasef, Amira Aboalnaga

Future Dental Journal

Abstract

Objective: To assess the accuracy of Dolphin Imaging software in predicting upper jaw profile changes in class II patients treated by extraction and non-extraction.

Methods: The records of 60 Class II div 1 patients were selected; 30 patients treated by extraction of upper first premolar and 30 patients treated by non-extraction. The Pre- and post-treatment lateral cephalometric x-rays of each patient were traced using Dolphin software. The actual hard tissue changes due to treatment were calculated and installed into the prediction module to generate the predicted profile. The soft tissue measurements of the actual post-treatment and predicted profiles were …

Oral Focal Mucinosis: A Case Report, Hala El-Kammar Dr, Yara Youssef, Bassant Mahmoud Moustafa, Iman M. Mostafa, Noha Adel Hassanine, Adham Fahmy, Rami Guiha Dr.

Future Dental Journal

Oral focal mucinosis is a rare lesion with less than 60 cases reported in English literature so far, to the best of our knowledge. It is considered to be the oral counterpart of cutaneous focal mucinosis and/or cutaneous myxoid cyst. Histopathologically, Oral focal mucinosis is demonsterates a well-circumscribed area of myxomatous connective tissue containing mucinous material, surrounded by denser collagenous connective tissue. We present a case of Oral focal mucinosis occurring on the buccal gingiva of the lower jaw.

Expression Of Vimentin, Α-Sma And Tgf-Β In Different Grades Of Oral Squamous Cell Carcinoma, Hala El-Kammar, Waleed F. Esmael, Nermeen S. Afifi

Future Dental Journal

Abstract

Background: Oral Squamous cell carcinoma (OSCC) is typically discovered at an early stage; nevertheless, regional lymph node metastases are prevalent; therefore, surgical excision of the primary tumor is commonly coupled with neck dissection and radiotherapy. Cancer cells become invasive by acquiring a mesenchymal phenotype, a process known as the epithelial-to-mesenchymal transition. Vimentin, α-SMA and TGF-β expressions are believed to take part in EMT and tumor progression. Aim: this work aimed to evaluate the expression of Vimentin, α-SMA and TGF-β on OSCC progression and hence propose potential role as potential prognostic markers or therapeutic targets. Materials and methods: twenty-four specimens …

Computer Guided Versus Conventional Maxillary Sinus Augmentation Using Allogenic Bone Blocks With Simultaneous Implant Placement In Severely Pneumatized Sinuses, Hisham G. Zulhemma Department Of Oral And Maxillofacial Surgery, Future University In Egypt, Egypt. [email protected], Waleed Ragab El-Beialy Professor Of Oral And Maxillofacial Surgery -Cairo University, Egypt. [email protected], Ahmed Abd Elsamad Associate Professor Of Oral And Maxillofacial Radiology– Cairo University, Egypt. [email protected], Ahmed Abozekry Lecturer Of Oral And Maxillofacial Surgery –Future University In Egypt, Egypt. [email protected]

Future Dental Journal

Background: Maxillary sinus lifting is a complex procedure with reported complications in the literature where the presence of sinus septa further complicates the procedure, they including membrane perforation, bleeding. Aim: The aim of this study is to decrease the incidence of membrane perforation which is the most common reported complication, and to determine whether the use of surgical guides could decrease the incidence of membrane perforation. Materials and methods: A total of 12 cases where blindly divided into 2 groups; Group (A) computer guided maxillary sinus lifting and Group (B) conventional sinus lifting, both groups received allogenic bone blocks for …

Therapeutic Effect Of Curcumin, Ginger And Tamarind On Oral And Paraoral Tissues: (Histological Overview), Mona El Deeb, Amany A. Rabea

Future Dental Journal

Background: Biocompatible substances from plant origin have been more in focus in contemporary dentistry. Aim: This review, aimed to highpoint the influence of curcumin, ginger and tamarind on different oral and paraoral tissues from histological point of view. Material and methods: A narrative review was carried out based on publications in PubMed, google and Scopus database. The documents published up to 2021 were included. The research was based on inclusion criteria of 89 studies.Results: Curcumin inhibits alveolar bone resorption, reduces inflammatory cell infiltration, aids in epithelial regeneration and improves salivary glands architecture. Ginger was found to be beneficial in …

Evaluation Of Apoptotic Effect Of Betanin Nanoparticles Against Squamous Cell Carcinoma Cell Line Compared To Doxorubicin, Noha Hassanine [email protected], Future University In Egypt, Amany M. Taha Lecturer, Al Azhar University, Egypt, Eman A. Abohager Professor, Al Azhar University

Future Dental Journal

Objective : to evaluate the anticancer effect of nano sized betanine particles (betanine NP) on squamous cell carcinoma cell line compared to doxorubicin (DOX) by measuring apoptosis through caspase 3. Methods: Three groups of the human tongue squamous cell carcinoma cell line (SCC 25) were created, and two of them were treated with DOX and betanine NP. The third group served as a negative control and was not given any treatment. To evaluate the concentration of caspase 3 using the ElISA technology, different quantities of betanin NP and DOX were administered to SCC25 at 48- and 72-hour intervals.Results: …

Influence Of Etching Methods On The Shear Bond Strength Of A Universal Adhesive System To Sound And Artificial Caries-Affected Dentin, Omnia M. Sami, Essam A. Naguib, Rasha H. Afifi, Shaymaa M. Nagi

Future Dental Journal

Abstract:

This study tested the effect of different etching methods on the bond strength of a universal adhesive system to caries-affected (CAD)and sound dentin. Methods: forty premolars were wet grinded to expose flat occlusal midcoronal dentin. Specimens were equally divided according to the substrate; sound and (CAD) by exposing to pH-cycling for 14 days. Each dentin substrate was bonded with Single Bond^TM universal adhesive applied either after no etching or etching of dentin, then resin composite was built up. Specimens were tested for shear bond strength (SBS). The data was analyzed by two-ways ANOVA. Results: Single Bond^TM universal …

Evaluation Of Facial Soft Tissue Changes In Excessive Gingival Display Cases After Le Forte I Maxillary Impaction Surgery Using 3d Facial Surface Laser Scanner, Ahmed Mohamed Hazem Alshazly A.Al Shazly, Mostafa Mohamed Sayed Taha, Ahmed Abdelmoniem Barakat, Mohamed Diaa Zein El Abdien

Future Dental Journal

Introduction: Facial soft tissue changes in relation to hard tissue movements after orthognathic surgery cases is always of concern to patients , surgical and orthodontics teams. The aim of the present study was to assess facial soft tissue changes and stability using 3D facial laser scanner after orthognathic surgery Le Forte I maxillary impaction in excessive gingival display patients. Methods: The subjects consisted of 12 patients with skeletal vertical maxillary excess (VME) causing an aesthetic concern to the patients in the form of “Gummy smile”, who underwent LeFort I osteotomy with maxillary impaction, Three-dimensional images of the patients …

The Interleukin-17 (Il-17) Concentration In Saliva Of Patients With Oral Lichen Planus, Mai Talaat Elgendi, Radwa Ragheb Hussien, Ahmed Abdel Aziz Hassan, Olfat Shaker

Future Dental Journal

Background: The aim of the present study was to measure the clinical and pain score in these patients and to measure the level of IL-17 in saliva of patients having different forms of Oral lichen planus lesions (OLP).

Subjects and methods: According to sample size calculation, the present study was done on a total of 40 subjects divided into 3 groups Group (I) Twenty patients having erosive/atrophic OLP. Group (II) Ten patients having reticular OLP and Group (III) Ten healthy control patients. Salivary samples were collected from the subjects of the three groups to evaluate the levels of IL-17 using …

The Effect Of Doxorubicin And Thioridazine On Squamous Carcinoma Cell Line, Bassant Mahmoud Moustafa

Future Dental Journal

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers occupying the sixth position worldwide. PI3k/Akt signaling pathway plays a significant role in regulating diverse cellular functions. This includes cell growth, proliferation and survival via inhibition of apoptosis, transcription and protein synthesis. One of the most acknowledged and approved chemotherapeutic agents is Doxorubicin (DOX) which is a non- selective class I anthracycline. In spite of DOX being one of the most acknowledged chemotherapeutic agents, its use has been limited by its toxic side effects and the development of chemoresistance. Nowadays, Thioridazine (TZ) which is …

The Potential Ameliorating Effect Of Bone Marrow Derived Mesenchymal Stem Cells On The Tongue Papillae Of Rats With Experimentally Induced Hypothyroidism, Aya Reyad, Rehab Abdel Moneim

Future Dental Journal

Purpose: This study aimed to evaluate the potential ameliorating effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on tongue papillae of rats with experimentally induced hypothyroidism using environmental scanning electron microscope (ESEM) and fluorescent microscopic evaluation. Material and Methods: For this study 30 adult male albino rats were divided into three groups (ten rats each): (1) Control group: The rats allowed to access freely balanced diet and freshwater supply during the course of the experimental period (8 weeks). (2) Hypothyroidism group: To induce hypothyroidism the rats received carbimazole dissolved in distilled water (5 mg/250g body weight/day) for 35 …

Mesenchymal Chondrosarcoma Simulating A Periodontal Disease: A Case Report, Adham Fahmy, Abanoub Selim, Yara Youssef, Iman Mostafa, Hala El-Kammar

Future Dental Journal

Mesenchymal chondrosarcoma (MCS) is a rare high-grade variant of chondrosarcoma. MSC`s represent about 1% to 9% of chondrosarcomas. Less than 500 cases of MCS have been reported in literature, so far. As opposed to other variants, MSC develops outside of the bone in almost third of the cases. Pain and swelling are the most common symptoms at presentation. The overall prognosis of MSC is poor, with frequent distant metastases. Histopathologically, MCS typically exhibits a biphasic pattern consisting of both small cells, and islands of atypical cartilage. The immunohistochemical profile of this lesion overlaps with several other entities. Resection with wide …

Biofilm Forming Ability Of Bacteria Isolated From Dental Caries: With Reference To Streptococcus Species, Sonali Kaustubh Ambulkar, Vidya Tale, Abhijit Jadhav, Komal Kulkarni

Future Dental Journal

Dental caries is formed by the group of microorganisms attached to a tooth surface embedded in a matrix of polymers. Biofilm plays an important role in the development of dental caries, plaque and other periodontal diseases. The present study is aimed to isolate, identify and characterize bacteria from dental caries. The ability of biofilm formation of these isolates was confirmed by Congo red agar method, Tube method and Microtitre plate method. High biofilm-forming bacteria were identified by 16S rRNA sequencing. Streptococcus mutans, Streptococcus anginosus, Enterococcus faecalis and Rothia dentocariosa are the predominant biofilm forming bacteria associated with dental caries.