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Oral Biology and Oral Pathology Commons™
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- Porphyromonas gingivalis (13)
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Articles 31 - 39 of 39
Full-Text Articles in Oral Biology and Oral Pathology
Synthesis And Functional Evaluation Of Peptide Modified Poly (Lactic-Co-Glycolic Acid) Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Paridhi Kalia
Electronic Theses and Dissertations
Periodontal disease is an oral inflammatory disorder that afflicts roughly 46% of the adults in the U.S. Currently, treatment of periodontal disease involves the removal of plaque from the gingival pocket (with possible antibiotic treatment) and if necessary, gingival surgery. To our knowledge, no therapeutic approach exists that promotes host-biofilm homeostasis by limiting pathogen recolonization of the oral cavity after prophylaxis or treatment. The interaction of the pathogen Porphyromonas gingivalis with commensal streptococci is critical for initiation of periodontitis and represents a target for limiting P. gingivalis colonization of the oral cavity. Previous studies showed that a synthetic peptide …
Vitamin A Is Essential For Proper Embryonic Submandibular Salivary Gland Growth., Deanna Ellene Buenger
Vitamin A Is Essential For Proper Embryonic Submandibular Salivary Gland Growth., Deanna Ellene Buenger
Electronic Theses and Dissertations
Submandibular salivary glands (SMG) are important for the production of saliva. Salivary glands may be damaged by autoimmune disease, surgery, or radiation therapy. Retinoic acid (RA) is a signaling metabolite derived from Vitamin A that is essential for proper embryonic growth and development; specifically for cardiovascular, limb and craniofacial development. The goal of this study was to determine if there is a reproducible defect in the growth of SMGs in RA deficient mouse embryos compared to wild type. This study aims to characterize SMG growth in RA deficient embryos and determine if the growth could be stimulated by RA in …
Evaluating The Marginal Integrity Of Lithium Disilicate Veneers Fabricated By Digital Impressions And Cad/Cam Compared To Conventional Techniques., Michael C. Guzelian
Evaluating The Marginal Integrity Of Lithium Disilicate Veneers Fabricated By Digital Impressions And Cad/Cam Compared To Conventional Techniques., Michael C. Guzelian
Electronic Theses and Dissertations
This in vitro study compared marginal gap size in anterior lithium disilicate veneers produced by conventional and digital impressions. One typodont right central incisor was prepared for an all-ceramic cast. Ten conventional veneers were fabricated using Type IV stone, PVS, and IPS e.max press, while ten digital veneers were fabricated using Lava COS (3M ESPE) and IPS e.max CAD/CAM processing and milling. Samples were divided double-blindly, captured at 45X magnification, evaluated at three images per orientation (B-D-M-P), and measured at three distances (largest, smallest, best fit) per image. Data points were entered into SPSS code for one-way and two-way ANOVA, …
Interleukin-6 Production And Epithelial Cell Signaling By Telomerase Immortalized Gingival Keratinocytes In Porphyromonas Gingivalis Infection., Himabindu Vuddaraju
Interleukin-6 Production And Epithelial Cell Signaling By Telomerase Immortalized Gingival Keratinocytes In Porphyromonas Gingivalis Infection., Himabindu Vuddaraju
Electronic Theses and Dissertations
P. gingivalis is a major periodontal disease causing pathogen. Gingival epithelial cells being the first line of defense, interact and internalize the bacteria evoking a cell signaling response that finally leads to the release of cytokines. IL-6 is a potent pro- inflammatory cytokine, which is one of the responsible factors for bone resorption, a clinical manifestation of periodontitis. The experimental model study hypothesizes that P. gingivalis infection increases the production of IL-6 in telomerase immortalized gingival keratinocytes (TIGKs) through up-regulation of c-Jun (AP-1 reporter). We observed the IL-6 production post-infection with P. gingivalis WT ATCC33277 and mutants ?0482, ?Ndk and …
Cholinergic Inhibition Of Lipopolysaccharide Induced Matrix Metalloproteinase In Immune Cells., Harrison Black,
Cholinergic Inhibition Of Lipopolysaccharide Induced Matrix Metalloproteinase In Immune Cells., Harrison Black,
Electronic Theses and Dissertations
Background: Matrix metalloproteinase (MMPs) are proteins that have a unique role in immunity, tissue remodeling, and tumorigenesis. MMPs can break down extracellular components, release bioactive molecules, and act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity. Nicotine (3-(1-methyl-2-pyrrolidinyl) pyridine), a key toxic component of tobacco, is thought to dysregulate matrix metalloproteinase secretion in immune cells. Aim: Examine the effect of nicotine on MMP9 secretion and activity in primary monocytes. Methods: Primary monocytes were stimulated with LPS (1 µg/ml) and Nicotine (100 ng/ml) and MMP9 secretion were studied. Gel zymography and ELISA techniques were …
Effect Of Metallic Restoration Artifacts On Maxillofacial Cone Beam Computed Tomography Images., Mitali Binani 1987-
Effect Of Metallic Restoration Artifacts On Maxillofacial Cone Beam Computed Tomography Images., Mitali Binani 1987-
Electronic Theses and Dissertations
Artifacts due to high-density objects (HDO) such as metallic dental restorations on maxillofacial cone beam computed tomographic (CBCT) images can render certain areas unsuitable for diagnosis. It was hypothesized that image quality due to HDO artifacts was affected by CBCT acquisition parameters and the number and configuration of HDO. Simulated complete maxillary and mandibular dental arches were constructed using dental stone and extracted teeth. Conservative coronal dental amalgam (MOD) restorations on premolar and molar teeth were used as HDOs. Gray values (GV) measured on uniform dental stone test cylinders at specific levels from the occlusal plane at three tooth locations …
Implementation Of An Oral Health Intervention For Adults With Intellectual And Developmental Disabilities., Brigit Rene Zaksek
Implementation Of An Oral Health Intervention For Adults With Intellectual And Developmental Disabilities., Brigit Rene Zaksek
Electronic Theses and Dissertations
Often oral care is overlooked during the daily care of adults with intellectual and developmental disabilities (IDD). Due to the integration of adults with IDD from institutions into group homes and private homes, caregivers need to be taught to implement daily oral hygiene protocols. The purpose of this pilot study, conducted by the University of Louisville and the Pacific Institute for Research and Evaluation, was to develop an oral hygiene plan for adults with IDD residing in group homes in the Louisville, Kentucky area that would ultimately improve their oral health and quality of life. This thesis focuses on the …
Neutrophils Alter Epithelial Response To Porphyromonas Gingivalis In A Gingival Crevice Model., Jessica Lynn Bondy-Carey 1987-
Neutrophils Alter Epithelial Response To Porphyromonas Gingivalis In A Gingival Crevice Model., Jessica Lynn Bondy-Carey 1987-
Electronic Theses and Dissertations
A gingival crevice model (epithelial cell-Porphyromonas gingivalis-neutrophil) was established and used to profile gingipain, matrix metalloproteinase (MMP), MMP mediators [neutrophil gelatinase-associated lipocalin (NGAL) and tissue inhibitor of metalloproteinases 1 (TIMP-1)] and cytokine networks. Smoking is the primary environmental risk factor for periodontitis. Therefore, the influence of cigarette smoke extract (CSE) was also monitored in the same model. Porphyromonas gingivalis alone induced low levels of interleukin-1b and interleukin-8 from epithelial cells, but high levels of both cytokines were produced on the addition of neutrophils. Exposure to CSE (100 and 1000 ng mL1 nicotine equivalency) significantly compromised P. gingivalis-induced cytokine secretion (both …
Clinical Efficacy Of Cross-Sectional Imaging Compared With Panoramic Imaging And Virtual 3d Models For The Assessment Of Dental Implant Placement., Moiz Ahmad Khan 1987-
Clinical Efficacy Of Cross-Sectional Imaging Compared With Panoramic Imaging And Virtual 3d Models For The Assessment Of Dental Implant Placement., Moiz Ahmad Khan 1987-
Electronic Theses and Dissertations
Introduction: This study compared the clinical efficacy of panoramic imaging and Cone Beam Computed Tomography (CBCT) in the optimal placement of virtual dental implants in the posterior edentulous bounded regions of the jaws. Material and methods: From a retrospective audit of patient records, fifty-two subjects were recruited with sixty-one dental implant sites in the maxilla and mandible. Physical measurements of the residual alveolar ridge were performed and consensus decisions of optimal implant length and bone graft necessity were obtained using reformatted panoramic alone (RP) or cross-sectional imaging (XS). Results: Horizontal restorative space measurements greater for RP (p=0.001). Shorter implants were …