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University of Nevada, Las Vegas

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Articles 1 - 15 of 15

Full-Text Articles in Oral Biology and Oral Pathology

Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan May 2026

Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This investigation used cone beam computed tomography (CBCT) based three dimensional imaging to evaluate correlations between maxillary sinus volume and maxillomandibular skeletal size, position, and dental occlusion in an adult orthodontic population. A retrospective sample of 107 pretreatment CBCT scans (40 males and 67 females), aged 18–59 years, was analyzed. Right and left maxillary sinuses were segmented independently using semi-automatic volumetric segmentation in ITK-SNAP software, and total sinus volume was calculated in cubic millimeters (mm³). Linear and angular skeletal measurements of the maxilla and mandible were obtained using Anatomage TxSTUDIOViewer application software. Patients were categorized according to anteroposterior (A-P) skeletal …

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Assessing The Compliance Of Dental Clinicians Towards Regulatory Infection Control Guidelines Using A Newly Developed Survey Tool: A Pilot Cross-Sectional Study In India, Pragati Kaurani, Kavita Batra, Himangini Rathore Hooja, N. Gopi Chander, Anamitra Bhowmick, Suraj Arora, Suheel Manzoor Baba, Shafait Ullah Khateeb, Anshad M. Abdulla, Vishakha Grover, Priyanka Saluja Sep 2022

Assessing The Compliance Of Dental Clinicians Towards Regulatory Infection Control Guidelines Using A Newly Developed Survey Tool: A Pilot Cross-Sectional Study In India, Pragati Kaurani, Kavita Batra, Himangini Rathore Hooja, N. Gopi Chander, Anamitra Bhowmick, Suraj Arora, Suheel Manzoor Baba, Shafait Ullah Khateeb, Anshad M. Abdulla, Vishakha Grover, Priyanka Saluja

School of Medicine Faculty Research

Adherence to the dental practice regulatory guidelines instituted during the COVID- 19 pandemic is essential to minimize the transmission of SARS-CoV-2 strains. Given the lack of a valid and reliable survey tool to assess the adherence to dental practice guidelines, this study aims to develop, validate, and test a survey tool on a pilot sample of dental clinicians practicing in India. A survey tool was developed/validated through a sequential phasic approach: Phase Ideveloping survey using conceptual and literature framework; Phase II: ascertaining its validity and reliability; Phase III: pilot testing; and Phase IV: assessing construct validity by exploratory factor analysis …

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Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu, Octavio A. Gonzalez Sep 2021

Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu, Octavio A. Gonzalez

Dental Medicine Faculty Research

Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was …

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Molecular Screening And Analysis Reveal Novel Oral Site-Specific Locations For The Cariogenic Pathogen Scardovia Wiggsiae, Steven Mcdaniel, Jaydene Mcdaniel, Katherine M. Howard, Karl Kingsley Jun 2021

Molecular Screening And Analysis Reveal Novel Oral Site-Specific Locations For The Cariogenic Pathogen Scardovia Wiggsiae, Steven Mcdaniel, Jaydene Mcdaniel, Katherine M. Howard, Karl Kingsley

Dental Medicine Faculty Research

Introduction: Scardovia wiggsiae (SW) is a newly identified cariogenic pathogen associated with severe early childhood caries and oral disease. New studies have confirmed the presence of this organism among clinical samples from both pediatric and adult patients. However, the recent discovery of this organism has left researchers with only limited information available regarding the prevalence of this organism—and virtually no information regarding oral site-specific locations. Based upon this lack of information, the overall objective of this study was to perform an oral site-specific analysis of SW prevalence from clinical samples. Methods: Using an approved human subjects protocol, samples (n = …

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Assessment Of Microrna (Mir)-365 Effects On Oral Squamous Carcinoma Cell Line Phenotypes, Jeffery Coon, Karl Kingsley Jun 2021

Assessment Of Microrna (Mir)-365 Effects On Oral Squamous Carcinoma Cell Line Phenotypes, Jeffery Coon, Karl Kingsley

Dental Medicine Faculty Research

miR-365 is a microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers while suppressing these effects in others. Virtually no information is known about the presence or function of miR-365 in oral cancers. Based upon this information, the primary goal of this project was to evaluate the expression of miR-365 in existing oral cancer cell lines. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, and CAL27) were obtained and cultured. RNA was then screened by PCR using primers specific for miR-365, as well as matrix metalloproteinase (MMP-2) and a downstream …

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Microbial Screening Reveals Oral Site-Specific Locations Of The Periodontal Pathogen Selenomonas Noxia, Jaydene Mcdaniel, Steven Mcdaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, Katherine M. Howard Jun 2021

Microbial Screening Reveals Oral Site-Specific Locations Of The Periodontal Pathogen Selenomonas Noxia, Jaydene Mcdaniel, Steven Mcdaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper buccal molar and gingival crevicular fluid (GCF), molecular screening for SN …

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Expression Of Mir-720 Is Correlated With Dnmt3 In Oral Squamous Cell Carcinomas, Andrew Graves, Sukhdeep Sandhu, Karl Kingsley Sep 2020

Expression Of Mir-720 Is Correlated With Dnmt3 In Oral Squamous Cell Carcinomas, Andrew Graves, Sukhdeep Sandhu, Karl Kingsley

Dental Medicine Faculty Research

Background: Many factors are involved with cellular differentiation and pluripotency, such as long non-coding and microRNAs (miRNA). miR-720 has been demonstrated to affect development, differentiation and pluripotency in dental pulp stem cells but has also been linked to many cancers (renal, prostate, skin, colorectal, breast, cervical and esophageal) through shared pathways including DNA methyltransferase family members (DNMT)3a and DNMT3b, which are highly upregulated in many oral cancers. However, little is known about the expression (or function, if expressed) of miR-720 in oral cancers. Based upon this lack of information, the primary objective of this project was to evaluate the expression …

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Relationship Between Oral Health And Clinical Osteoporosis Among Hospitalized Patients With And Without Diabetes, Kenneth Izoura, Gayle Allenback, Amber Champion, Civon Gewelber, Michael Neubauer Feb 2020

Relationship Between Oral Health And Clinical Osteoporosis Among Hospitalized Patients With And Without Diabetes, Kenneth Izoura, Gayle Allenback, Amber Champion, Civon Gewelber, Michael Neubauer

School of Medicine Faculty Research

Objective: Diabetes mellitus (DM) is associated with poor oral health and osteoporosis (OP). The aim of this study was to assess the relationship between OP, periodontal disease (PD), and other dental and health outcomes in a cohort of hospitalized patients with and without DM. Method: Using a cross-sectional study design, we enrolled consecutive hospitalized patients. We administered a questionnaire to gather demographic information, oral health history, smoking history, and history of OP. We inspected their dentition and reviewed their charts. Data were analyzed using t-tests, chi-square tests, and logistic regression models. Result: Out of 301 patients enrolled, 275 had PD, …

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Effects Of Vascular Endothelial Growth Factor (Vegf) On Dental Pulp Stem Cells (Dpsc), Cale Forgues, Eric Mullins, Karl Kingsley May 2019

Effects Of Vascular Endothelial Growth Factor (Vegf) On Dental Pulp Stem Cells (Dpsc), Cale Forgues, Eric Mullins, Karl Kingsley

Dental Medicine Faculty Research

Dental Pulp Stem Cells (DPSCs) are non-embryonic, mesenchymal stem cells that may have significant potential for therapeutic and regenerative biomedical applications. Studies of DPSC differentiation have demonstrated the potential to form many tissue types, including neural, osteogenic and vascular precursors using cytokines and growth factors, such as Vascular Endothelial Growth Factor (VEGF). Eight previously isolated Dental Pulp Stem Cell (DPSC) isolates were grown in culture and treated with VEGF to evaluate any effects on growth, viability or biomarker expression. Administration of VEGF at 10 ng/mL significantly inhibited growth in two rapidly dividing or rDT DPSC isolates, with no other measurable …

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Differential Microrna Expression Of Mir-21 And Mir-155 With Oral Cancer Extracellular Vesicles In Response To Melationin, Matthew Hunsaker, Greta Barba, Karl Kingsley, Katherine M. Howard May 2019

Differential Microrna Expression Of Mir-21 And Mir-155 With Oral Cancer Extracellular Vesicles In Response To Melationin, Matthew Hunsaker, Greta Barba, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Objective: Extracellular vesicles derived from oral cancer cells, which include Exosomes and Oncosomes, are membranous vesicles secreted into the surrounding extracellular environment. These extracellular vesicles can regulate and modulate oral squamous cell carcinoma (OSCC) progression through the horizontal transfer of bioactive molecules including proteins, lipids and microRNA (miRNA). The primary objective of this study was to examine the potential to isolate and evaluate extracellular vesicles (including exosomes) from various oral cancer cell lines and to explore potential differences in miRNA content. Methods: The OSCC cell lines SCC9, SCC25 and CAL27 were cultured in DMEM containing 10% exosome-free fetal bovine serum. …

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A Polymerase Chain Reaction Method For The Detection Of Selenomonas Noxia, Arthuro Mehretu Dec 2011

A Polymerase Chain Reaction Method For The Detection Of Selenomonas Noxia, Arthuro Mehretu

UNLV Theses, Dissertations, Professional Papers, and Capstones

In recent studies, periodontal health has been linked to being overweight and/or obese. Among common oral bacteria, Selenomonas noxia has been implicated in converting periodontal health to disease. Selenomonas spp. have also been found in gastric ulcers, and were misdiagnosed as Helicobacter -like organisms, but no further studies were conducted. The increasing clinical and epidemiological importance of S. noxia necessitates the development of a rapid detection method. In this study, a TaqMan 16S rRNA based real-time Polymerase Chain Reaction (PCR) method was developed, optimized and evaluated for the rapid and specific detection of S. noxia . The 16S PCR assay …

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Gingival Crevicular Fluid (Gcf) Levels Of Interleukin-6 (Il-6), Soluble Glycoprotein 130 (Sgp130), And Soluble Interleukin-6 Receptor (Sil-6r) During Orthodontic Tooth Movement, Mathue Gene Faulkner Dec 2011

Gingival Crevicular Fluid (Gcf) Levels Of Interleukin-6 (Il-6), Soluble Glycoprotein 130 (Sgp130), And Soluble Interleukin-6 Receptor (Sil-6r) During Orthodontic Tooth Movement, Mathue Gene Faulkner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Orthodontic tooth movement requires the precise coordination of a multitude of biological factors in order for proper bone remodeling to occur. Cytokines, such as Interleukin-6 (IL-6), play a critical role in the communication necessary for both bone resorption and bone apposition. IL-6 reacts with receptor proteins, such as soluble IL-6 receptor (sIL-6R), on target cells in order to transmit signals important to both osteoclast and osteoblast activities. Soluble glycoprotein 130 (sgp130), on the other hand, acts as a natural inhibitor to IL-6 activity. The purpose of this investigation was to evaluate the levels of IL-6, sIL-6R, and sgp130 …

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Bacterial Adherence Of Streptococcus Mutans And Lactobacillus Acidophilus On Poly-Methyl Methacrylate And Thermoplastic Polypropene Used In Orthodontic Retention, Lindsay Ann Pfepper Dec 2011

Bacterial Adherence Of Streptococcus Mutans And Lactobacillus Acidophilus On Poly-Methyl Methacrylate And Thermoplastic Polypropene Used In Orthodontic Retention, Lindsay Ann Pfepper

UNLV Theses, Dissertations, Professional Papers, and Capstones

Retention is required in the majority of orthodontic patients throughout the remainder of their life. The two primary removable appliances are known as the traditional Hawley retainer or the vacuum formed retainer. These appliances were developed to maintain the position of the dentition without sacrificing oral health. The orthodontic population is at a higher risk for caries due to plaque accumulation from poor diet, suboptimal oral hygiene and often lack of motivation. These two retainers occupy different niches and are comprised of different materials; therefore the retainers' effect on oral health could be very different. An understanding of which bacteria …

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Retrospective Evaluation Of Microbial Presence In Existing Saliva Repository: A Pcr Based Molecular Survey Of Oral Microbial Populations From Existing Saliva Samples, Jay Ericksen Davis Dec 2011

Retrospective Evaluation Of Microbial Presence In Existing Saliva Repository: A Pcr Based Molecular Survey Of Oral Microbial Populations From Existing Saliva Samples, Jay Ericksen Davis

UNLV Theses, Dissertations, Professional Papers, and Capstones

The overall purpose of this research project is to explore the link between oral health and disease in the University of Nevada, Las Vegas - School of Dental Medicine (UNLV-SDM) clinic patient population. More specifically, the population of interest is the UNLV-SDM orthodontic clinic patient population, which is mostly composed of adults, females, and minorities. The University of Nevada, Las Vegas, School of Dental Medicine, with more than 70,000 active patients and a post-graduate specialty program in Orthodontics is uniquely positioned to perform this type of oral health epidemiology survey, as well as targeted oral microbial testing among populations within …

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Inside Unlv, Cate Weeks, Carol C. Harter, Diane Russell, Holly Ivy De Vore Aug 2004

Inside Unlv, Cate Weeks, Carol C. Harter, Diane Russell, Holly Ivy De Vore

Inside UNLV

No abstract provided.

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