Open Access. Powered by Scholars. Published by Universities.®
Oral Biology and Oral Pathology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Cytokines (2)
- Mouth Neoplasms (2)
- Oral cancer (2)
- Adhesion of cell (1)
- Age estimation (1)
-
- Alcian blue (1)
- Allele (1)
- Anisotropic hydrogel (1)
- Bacteria (1)
- Bacterial diversity--Malaysia (1)
- Biofilm (1)
- Biomarker (1)
- Buccal mucosa squamous cell carcinoma (1)
- CBCT (1)
- Cancer testes antigens (1)
- Cancer therapy (1)
- Candida (1)
- Carcinoma (1)
- Cell growth (1)
- Chronic periodontitis (1)
- DEFB1 (1)
- Defensin (1)
- Dental aesthetics (1)
- Dental caries--Analysis--Malaysia (1)
- Dentistry (1)
- Eosinophils. (1)
- Exosomes (1)
- Ficus deltoidea (1)
- Gene (1)
- Genotyping (1)
Articles 1 - 16 of 16
Full-Text Articles in Oral Biology and Oral Pathology
Identification Of Serum Anti-Carbamylated Protein Antibodies In Rheumatoid Arthritis Patients With Periodontitis: A Pilot Study, Shruthi Venu Gopal
Identification Of Serum Anti-Carbamylated Protein Antibodies In Rheumatoid Arthritis Patients With Periodontitis: A Pilot Study, Shruthi Venu Gopal
Student Works (2020-2029)
Objectives: In chronic diseases such as rheumatoid arthritis (RA), carbamylation may cause the production of autoantibodies such as the anti-carbamylated protein antibody (anti-CarP) and protein malfunctioning. However, its relation to periodontitis (PD) remains unclear. Therefore, this study aimed to assess the serum levels of anti-carbamylated protein antibodies (anti-CarP) in four groups of participants, the RAPD, RA, PD, and healthy groups and correlate the findings with rheumatological parameters. Materials and methods: This pilot study included a total of 20 participants, with 5 participants each in groups diagnosed with RA and PD (RAPD), only RA, only PD and controls who were free …
Mageb2 Antibody As Potential Diagnostic And Predictive Tool In The Progression Of Oral Cancer, Awang Hasyim Noratikah
Mageb2 Antibody As Potential Diagnostic And Predictive Tool In The Progression Of Oral Cancer, Awang Hasyim Noratikah
Student Works (2020-2029)
Introduction: Oral squamous cell carcinoma (OSCC) represents more than 90% of all oral cancer. Despite advances in diagnostic and therapeutic modalities, mortality and morbidity rates have not improved in the last decade. Hence, alternative diagnostic and therapeutic approaches are urgently needed. Cancer testes antigens (CTA) are proteins that are expressed in various malignant tumours but its expression in normal tissue is restricted to testes and occasionally placental trophoblast. Due to its exclusive presence in different types of malignant tumors, and their ability to trigger immune responses, CTA are considered promising biomarkers for cancer vaccines. A previous protein array study reported …
Differential Expression Of Mucin In Salivary Gland Tumours, Mahamad Apandi Nurul Inaas
Differential Expression Of Mucin In Salivary Gland Tumours, Mahamad Apandi Nurul Inaas
Student Works (2020-2029)
Introduction: Varied alterations in types of secreted mucin may affect the regulation of cell growth, immune response and adhesion of cell. These changes may indirectly contribute to the ability of tumour invasion and metastasis. However, the expression of mucins in salivary gland tumours has not been explored in depth. Objectives: To investigate expressions of mucin in the salivary gland tumour microenvironment and make comparisons between benign and malignant, and minor and major salivary gland tumours. Methods: Special stains were used to stain neutral mucin (Periodic acid Schiff), sialomucin (Alcian Blue) and sulfomucin (Aldehyde Fuschin) within tissues from 6 normal salivary …
Investigation Of Inflammatory Responses Following The Use Of Novel Anisotropic Hydrogel Tissue Expander In The Skin Of Maxillofacial Region, Salim Igdayir Kholoud Mohamed Ali
Investigation Of Inflammatory Responses Following The Use Of Novel Anisotropic Hydrogel Tissue Expander In The Skin Of Maxillofacial Region, Salim Igdayir Kholoud Mohamed Ali
Student Works (2020-2029)
Background: The purpose of tissue expander is to grow healthy supplementary tissue under the controlled of mechanical force exerted by the tissue expander. In the field of reconstructive and plastic surgery, the use of soft tissue expanders are important for growing healthy supplementary tissue. However, the molecular mechanism associated with the inflammatory response associated with the force generated from the use of tissue expanders is still not characterized. Among the many types of tissue expanders, anisotropic type of hydrogel tissue expander was chosen due to its ability to produce controlled incremental inflation on the tissue that enhance cellular adaptation and …
Polymicrobial Interactions Between Selected Microbes Of Oral Biofilm And Differential Expression Of Als Genes And Their Related Proteins, Fahim Ayesha
Student Works (2020-2029)
More than 700 different types of microorganisms dwell in human oral mucosal surfaces. The interactions between these microorganisms contribute to formation of polymicrobial communities on hard and soft tissues as well as on dentures and implants. Candida albicans, a pleomorphic fungus inhabiting oral and gastrointestinal (GIT) mucosa becomes pathogenic in favourable conditions causing local or systemic disease. Since streptococci are early colonisers, the ability of Candida albicans to adhere to streptococci paves the way for an additional surface for candidal colonization and propagation. This study was aimed to investigate polymicrobial interactions between C. albicans, S. sanguinis and S. mitis on …
Potential Of Human Deciduous Periodontal Ligament Stem Cells For Use In Hepatic Lineage And Their Exosome Application On Hepatic Injuries, R. Vasanthan Punitha
Potential Of Human Deciduous Periodontal Ligament Stem Cells For Use In Hepatic Lineage And Their Exosome Application On Hepatic Injuries, R. Vasanthan Punitha
Student Works (2020-2029)
Introduction: Human deciduous periodontal ligament stem cells represent as another source of stem cells from the dental origin. These cells were shown to have multi-potential attributes and also self renewing ability. These easily accessible stem cells candidate could also resolve issues concerning ethical and compatability for the use in regenerative purposes. However, their efficiency towards hepatic lineage differentiation has not been addressed so far. Meanwhile, the main contributor for regenerative properties were supposedly mediated by soluble factors and extracellular vesicles such as exosomes secreted by cells. Objectives: The aims of this study are to isolate, characterize and also to investigate …
Impacts Of Self-Perceived Malocclusion On The Oral Health-Related Quality Of Life Of Young Adults In Malaysia, Mohd Tajudin Zawani
Impacts Of Self-Perceived Malocclusion On The Oral Health-Related Quality Of Life Of Young Adults In Malaysia, Mohd Tajudin Zawani
Student Works (2020-2029)
Objectives: To assess the prevalence, severity and extent of impacts of self-perceived malocclusion on the oral health-related quality of life (OHRQoL) related to dental aesthetics among young Malaysian adults, to compare between those with and without self-perceived malocclusion and to investigate the influence of demographics on the outcome. Methods: Multi-stage random sampling method was used to recruit 589 subjects from tertiary institutions in Malaysia. Study instruments comprised the Aesthetic Component of the Index of Orthodontic Treatment Need (AC-IOTN) and Malaysian version of the Psychosocial Impact of Dental Aesthetics (PIDA) to measure selfperceived malocclusion and its impacts. Analyses included multifactorial ANOVA …
Anticancer Activity Of Ficus Deltoidea And Tualang Honey On Oral Cancer Cells: An In Vivo Study, Alkoshab May Ameen Saeed
Anticancer Activity Of Ficus Deltoidea And Tualang Honey On Oral Cancer Cells: An In Vivo Study, Alkoshab May Ameen Saeed
Student Works (2020-2029)
The use of natural products have been gaining interest, notably in the area of cancer therapy and in this study, natural products rich in antioxidants such as Tualang Honey (Malaysian wild local honey) and Ficus deltoidea (Malaysian local herbal plant), were selected to assess their chemo-preventive and chemotherapeutic activities on oral cancer. The aim of this study is to evaluate the chemo-preventive and chemotherapeutic activities of Ficus deltoidea (FD) and Tualang Honey (TH) in an animal model induced for oral cancer using 4-Nitroquinoline1-oxide (4NQO). A total of 70 male Sprague-Dawley (SD) rats were distributed into ten groups (n=7 per group); …
Expression Of Ki-67, Fscni And Tnfrsf 12a In Histologically Non-Involved Mucosal Surgical Margins As Predictive Markers For Local Relapse In Oral Squamous Cell Carcinoma, Zainul Abidin Nur Fauziani
Expression Of Ki-67, Fscni And Tnfrsf 12a In Histologically Non-Involved Mucosal Surgical Margins As Predictive Markers For Local Relapse In Oral Squamous Cell Carcinoma, Zainul Abidin Nur Fauziani
Student Works (2020-2029)
Introduction: The presence tumour-related genetic alterations in histologically noninvolved mucosal surgical margins was linked to development of local relapse in OSCC. Aims: The present study aimed to determine the association between expression of Ki67, FSCN1 and TNFRSF12A in histologically non-involved mucosal surgical margins of OSCC patients and local relapse. Materials and methods: The study involved a total of 34 OSCC cases including 15 cases of patients who had relapse within the 5 years followup period and 19 cases of patients who did not had relapse. Two-stage sampling was carried out to select the margins’ site, followed by the representative sections …
Clinicopathological Study Of Oral Lichen Planus And Oral Linchenoid Reaction, Gubod Eb Robson
Clinicopathological Study Of Oral Lichen Planus And Oral Linchenoid Reaction, Gubod Eb Robson
Student Works (2020-2029)
Introduction: Oral lichen planus is a chronic inflammatory disease that affects the mucosa of the oral cavity. Oral lichenoid reactions/ lesions share many clinical and histopathological features with oral lichen planus, and represent a response to extrinsic or causative factors (drugs, allergens). Aim: The purpose of this study was to evaluate the clinical and histopathological features of oral lichen planus and oral lichenoid reactions/ lesions. Objectives: The objectives of this study were to assess the clinical and histopathological features of patients diagnosed with oral lichen planus and oral lichenoid reaction/ lesions. This study also sought to investigate the association between …
A Three Dimensional Age Estimation Using Cone Beam Ct In Malaysian Population, Asif Muhammad Khan
A Three Dimensional Age Estimation Using Cone Beam Ct In Malaysian Population, Asif Muhammad Khan
Student Works (2020-2029)
Forensic odontology plays a vital role in the age estimation and identification process during criminal investigations. Forensic science in the past have mainly employed two-dimensional (2D) radiographic assessment of developmental and physiological age related dental parameters for age estimation. However, 2D radiograph doesn’t represent the three-dimensional (3D) anatomical structures. Rapidly evolving CBCT imaging modality can be effectively employed in forensic sciences to overcome the limitations of 2D imaging. The current study aimed to develop a novel method of dental age estimation using 3D surface area analyses of root apices of the developing permanent maxillary canines and mandibular third molars among …
Single Nucleotide Polymorphism Of Prostaglandin-Endoperoxide Synthase (Ptgs2) And Defensin Beta 1 (Defb1) Genes In Malay Chronic Periodontitis Subjects, Jagender Singh Jasmin Kaur
Single Nucleotide Polymorphism Of Prostaglandin-Endoperoxide Synthase (Ptgs2) And Defensin Beta 1 (Defb1) Genes In Malay Chronic Periodontitis Subjects, Jagender Singh Jasmin Kaur
Student Works (2020-2029)
The association of prostaglandin-endoperoxide synthase 2 (PTGS2) and defensin beta 1 (DEFB1) single nucleotide polymorphisms (SNP) with chronic periodontitis (CP) have been widely studied amongst different ethnic groups such as the Chinese and European population. Thus far, no study has been done on the Malay ethnic group. Hence, this study assessed the allele and genotype frequencies of PTGS2 and DEFB1 variants in subjects with CP and periodontally healthy individuals in Malaysian Malays. Samples of 78 Malay CP subjects and 62 periodontally healthy controls were obtained from Malaysian Periodontal Database and Biobanking system (MPDBS) for this study. DNA samples were genotyped …
Identification Of Potential Biomarkers Of Oral Squamous Cell Carcinoma Using Integrated Proteomics And Glycoproteomics And Glycoproteomics Analyses, Yin Ling Wong
Student Works (2020-2029)
Oral cancer is one of the major health concerns worldwide. The 5-year survival rate of oral squamous cell carcinoma (OSCC) has remained at approximately 50% over the past decades. Most OSCCs are diagnosed at an advanced stage due to the delay in diagnosis, suggesting an imperative need in identifying reliable biomarkers to improve the diagnosis, prognosis, and treatment of OSCC. This study aimed to identify potential biomarkers that are involved in the development and progression of OSCC using integrated proteomics and glycoproteomics analyses. Proteomics analysis was performed on serum samples of 10 patients with oral potentially malignant disorder (OPMD), 40 …
Patient Concerns Inventory Head And Neck As An Individualised Approach To Assess Post-Treatment Outcomes Among Oral Cancer Patients In Malaysia, Aminnudin Ainon Natrah
Patient Concerns Inventory Head And Neck As An Individualised Approach To Assess Post-Treatment Outcomes Among Oral Cancer Patients In Malaysia, Aminnudin Ainon Natrah
Student Works (2020-2029)
Background: Oral cancer and its treatment undisputedly impacts patients‘ quality of life, posing a challenge to clinicians in managing them optimally. Identifying patients‘ concerns is central to holistic patient care; as such time constraints faced by clinicians during consultation sessions may pose a barrier in identifying such concerns effectively. The use of PCI-H&N during post-treatment oral cancer consultation sessions has previously shown to be beneficial, simultaneously promoting effective patient- clinician communication during consultations. Objectives: This study aimed to determine the feasibility of the PCI-H&N in assessing post- treatment oral cancer patients concerns and its relationship with patients‘ HRQoL, psychological distress …
Study Of Bacterial Diversity In The Oral Cavity Of Malaysian Subjects., Teoh Wuen Yew
Study Of Bacterial Diversity In The Oral Cavity Of Malaysian Subjects., Teoh Wuen Yew
Student Works (2010-2019)
About 700 species of bacteria can inhabit the human oral cavity. This project initially investigated the bacterial diversity within the oral cavity of Malaysian subjects by using culture-dependent techniques and 16S rDNA sequence analysis. The second part of the research profiled the antibiotic resistance of the identified oral bacteria by the Etest method. Three sampling sites of the oral cavity from nine healthy subjects were analyzed: the tooth surface, gingival crevice, and dorsum of the tongue. The tooth surface was shown to harbor 41 species, gingival crevice harbored 51 species and tongue dorsum 41 species. On average, each subject carried …
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Cyclin D1 Amplification In Tongue And Buccal Mucosa Squamous Cell Carcinoma., Haydar M. Mahdey
Student Works (2010-2019)
Introduction Oral cancer is a significant health problem worldwide with almost 300,000 new cases are diagnosed each year. Despite the numerous studies done, and even with the best treatment option utilized, more than 50% of patients with oral cancer will experience relapse. In search for better options for prognostication, researches are now focusing on the molecular biology of cancer, for instance in search of reliable tumor markers. Among the markers reported in the literatures, Cyclin D1 is actively studied protein. Cyclin D1 regulates the cell cycle progression by forming a complex with different cyclin dependant kinase. Dysregulation of cyclin D1 …