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Oral Biology and Oral Pathology Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Oral cancer (2)
- Raman spectroscopy (2)
- Contralateral normal (1)
- Field cancerisation (1)
- Infrared spectroscopy (1)
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- Non stimulated (1)
- Oral brush biopsy cytological samples (1)
- Oral dysplasia (1)
- Oral potentially malignant lesions (1)
- Oral pre-cancer (1)
- Oral pre-cancer. premalignant lesions (1)
- Partial least squares-discriminant analysis (1)
- Potentially malignant lesions (1)
- Potentially malignant lesions disease diagnostics (1)
- Premalignant lesions (1)
- Raman Spectroscopy (1)
- Raman microspectroscopy (1)
- Saliva (1)
- Saliva collection (1)
- Sensitivity and specificity (1)
- Stimulated (1)
- Vibrational Spectroscopy (1)
- Vibrational spectroscopy (1)
Articles 1 - 4 of 4
Full-Text Articles in Oral Biology and Oral Pathology
Raman Spectroscopic Characterisation Of Non Stimulated And Stimulated Human Whole Saliva, Genecy Calado, Isha Behl, Hugh Byrne, Fiona Lyng
Raman Spectroscopic Characterisation Of Non Stimulated And Stimulated Human Whole Saliva, Genecy Calado, Isha Behl, Hugh Byrne, Fiona Lyng
Articles
Human saliva is a unique biofluid which can reflect the physiopathological state of an individual. The wide spectrum of molecules present in saliva, compounded by the close association of salivary composition to serum metabolites, can provide valuable information for clinical diagnostic applications through highly sensitive vibrational spectroscopic techniques such as Raman spectroscopy. However, the nature of saliva, in terms of collection and patient-related characteristics, can be considered factors which may strongly affect the Raman spectral profile of salivary samples and disrupt the search for specific salivary biomarkers in the detection of diseases. The main objective of this study was to …
The Potential Of Raman Spectroscopy In The Diagnosis Of Dysplastic And Malignant Oral Lesions, Ola Ibrahim, M. Toner, Steven Flint, Hugh Byrne, Fiona Lyng
The Potential Of Raman Spectroscopy In The Diagnosis Of Dysplastic And Malignant Oral Lesions, Ola Ibrahim, M. Toner, Steven Flint, Hugh Byrne, Fiona Lyng
Articles
Early diagnosis, treatment and/or surveillance of oral premalignant lesions are important in preventing progression to oral squamous cell carcinoma (OSCC). The current gold standard is through histopathological diagnosis, which is limited by inter and intra observer and sampling errors. The objective of this work was to use Raman spectroscopy to discriminate between benign, mild, moderate and severe dysplasia and OSCC in formalin fixed paraffin preserved (FFPP) tissues. The study included 72 different pathologies from which 17 were benign lesions, 20 mildly dysplastic, 20 moderately dysplastic, 10 severely dysplastic and 5 invasive OSCC. The glass substrate and paraffin wax background were …
Biomedical Applications Of Vibrational Spectroscopy: Oral Cancer Diagnostics, Hugh Byrne, Isha Behl, Genecy Calado, Ola Ibrahim, M. Toner, Sheila Galvin, Claire M. Healy, Steven Flint, Fiona Lyng
Biomedical Applications Of Vibrational Spectroscopy: Oral Cancer Diagnostics, Hugh Byrne, Isha Behl, Genecy Calado, Ola Ibrahim, M. Toner, Sheila Galvin, Claire M. Healy, Steven Flint, Fiona Lyng
Articles
Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.
Raman Microspectroscopic Study For The Detection Of Oral Field Cancerisation Using Brush Biopsy Samples, Isha Behl, Genecy Calado, Anika Vishwakarma, Stephen Flint, Sheila Galvin, Claire Healy, Marina Leite Pimentel, Alison Malkin, Hugh Byrne, Fiona Lyng
Raman Microspectroscopic Study For The Detection Of Oral Field Cancerisation Using Brush Biopsy Samples, Isha Behl, Genecy Calado, Anika Vishwakarma, Stephen Flint, Sheila Galvin, Claire Healy, Marina Leite Pimentel, Alison Malkin, Hugh Byrne, Fiona Lyng
Articles
Field cancerisation (FC) is potentially an underlying cause of poor treatment outcomes of oral squamous cell carcinoma (OSCC). To explore the phenomenon using Raman microspectroscopy, brush biopsies from the buccal mucosa, tongue, gingiva and alveolus of healthy donors (n = 40) and from potentially malignant lesions (PML) of Dysplasia Clinic patients (n = 40) were examined. Contralateral normal samples (n = 38) were also collected from the patients. Raman spectra were acquired from the nucleus and cytoplasm of each cell, and subjected to partial least squares-discriminant analysis (PLS-DA). High discriminatory accuracy for donor and PML samples was achieved for both …