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2022

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Articles 781 - 810 of 826

Full-Text Articles in Dentistry

ความสัมพันธ์ระหว่างสภาวะสุขภาพช่องปากและผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมอง, ปัทมาภรณ์ พุ่มเกาะ Jan 2022

ความสัมพันธ์ระหว่างสภาวะสุขภาพช่องปากและผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมอง, ปัทมาภรณ์ พุ่มเกาะ

Chulalongkorn University Theses and Dissertations (Chula ETD)

วิทยานิพนธ์ฉบับมีวัตถุประสงค์เพื่อศึกษาความสัมพันธ์ระหว่างสภาวะสุขภาพช่องปากและผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมองที่โรงพยาบาลจุฬาลงกรณ์ สภากาชาดไทย มีผู้ป่วยโรคหลอดเลือดสมองระยะฟื้นฟูที่กลับมาติดตามอาการในช่วง 3 เดือน ยินยอมเข้าร่วมโครงการวิจัยทั้งสิ้น 86 ราย ผู้ป่วยโรคหลอดเลือดสมองจะได้รับการตรวจสภาวะสุขภาพช่องปาก ทำการสัมภาษณ์ข้อมูลทั่วไป ร่วมกับการเก็บข้อมูลในเวชระเบียนของผู้ป่วย ใช้สถิติเชิงพรรณนาอธิบายลักษณะของผู้ป่วยโรคหลอดเลือดสมอง และใช้สถิติสหสัมพันธ์แบบเพียร์สันและสเปียร์แมนวิเคราะห์ความสัมพันธ์ระหว่างสภาวะสุขภาพช่องปากกับผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมอง ที่ระดับนัยสำคัญ 0.05 สภาวะสุขภาพช่องปากประเมินจากจำนวนฟันธรรมชาติที่เหลืออยู่ จำนวนคู่สบฟันหลังและคะแนนแบบประเมินสภาวะสุขภาพช่องปากและฟันเทียมฉบับดัดแปลง ผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมองจะประเมินจากการเปลี่ยนแปลงของคะแนนค่าความรุนแรงของโรคหลอดเลือดสมอง ผลการวิจัยพบว่าจำนวนฟันธรรมชาติที่เหลืออยู่และจำนวนคู่สบฟันหลังมีความสัมพันธ์อย่างมีนัยสำคัญทางสถิติกับผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมองพบความสัมพันธ์เป็นแบบสหสัมพันธ์เชิงลบ สรุปผลการวิจัย จำนวนฟันธรรมชาติที่เหลืออยู่และจำนวนคู่สบฟันหลังมีความสัมพันธ์กับผลของการฟื้นฟูสมรรถภาพของผู้ป่วยโรคหลอดเลือดสมองโดยพบความสัมพันธ์มีทิศทางตรงกันข้าม ผู้ป่วยที่มีจำนวนฟันธรรมชาติและจำนวนคู่สบฟันหลังที่มากสัมพันธ์กับค่าความรุนแรงของโรคหลอดเลือดสมองตอนผู้ป่วยออกจากโรงพยาบาลที่มีค่าความรุนแรงน้อยกว่า ผู้ป่วยจึงมีอาการเริ่มต้นไม่รุนแรงส่งผลให้มีการเปลี่ยนแปลงความรุนแรงของโรคน้อยกว่า การดูแลสภาวะสุขภาพช่องปากให้อยู่ในสภาพดีและการเก็บรักษาฟันธรรมชาติสภาพดีไว้ให้ได้มากที่สุดอาจจะเป็นปัจจัยร่วมปัจจัยหนึ่งในการลดความเสี่ยงความรุนแรงของโรคหลอดเลือดสมอง

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Knowledge And Attitude Of Patients Indicated Extraction Or Impacted Third Molar Surgery Toward Antibiotic Use, Kamoltham Ekmetipunth Jan 2022

Knowledge And Attitude Of Patients Indicated Extraction Or Impacted Third Molar Surgery Toward Antibiotic Use, Kamoltham Ekmetipunth

Chulalongkorn University Theses and Dissertations (Chula ETD)

In Thailand, there is a significant gap in public knowledge about the use of antibiotics, and antibiotics are easily accessible. People prefer self-medication, leading to antibiotic resistance. Dentists play a role in the use of antibiotics. This study was designed to determine knowledge and attitude of patients related to antibiotic use if extraction or impacted third molar surgery is indicated. A cross-sectional survey with questionnaire was conducted at the Faculty of Dentistry, Chulalongkorn University. The questionnaire consisted of two main sections: demographic data and an evaluation of knowledge and attitude. A 5-point Likert scale was used. Bivariate analysis was conducted …

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The Effect Of Silver Nanoparticles In Addition To Sodium Fluoride On Remineralization Of Artificial Root Dentin Caries, Padchara Kongyodsueb Jan 2022

The Effect Of Silver Nanoparticles In Addition To Sodium Fluoride On Remineralization Of Artificial Root Dentin Caries, Padchara Kongyodsueb

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this in vitro study was to evaluate the remineralization effect of the silver nanoparticles adjunctively to sodium fluoride varnish compared with other remineralizing agents on artificial root caries. Fifty-five root dentin slices size 5x5 mm were sectioned from extracted human teeth of patients aged 60 years old or more. All specimens were immersed in demineralized solution to create artificial caries. The specimens were randomly allocate into five groups according to the remineralizing agents: silver diamine fluoride, silver nanoparticles solution, silver nanoparticle solution followed by the application of sodium fluoride varnish, sodium fluoride varnish and tap water. After …

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Factors Affecting The Reduction Rate Of Odontogenic Cyst After Decompression Based On Three-Dimensional Volumetric Analysis, Sarawut Wongrattanakarn Jan 2022

Factors Affecting The Reduction Rate Of Odontogenic Cyst After Decompression Based On Three-Dimensional Volumetric Analysis, Sarawut Wongrattanakarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study is to investigate factors that affect the reduction rate of odontogenic cysts after decompression based on three-dimensional volumetric analysis. The sample consisted of 30 patients who underwent decompression of odontogenic cysts at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, from 2010-2022. Preoperative and postoperative cone beam computed tomography results were collected. Volumetric analysis was performed to evaluate any differences in the reduction rate and percentage reduction in the volume (PRV) of the cystic lesion according to the sex, age, initial volume of the lesion, duration of decompression, location of the …

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Comparison Of Volumetric Changes At Implant Connector Among Three Different Types Of Abutment After Cyclic Loading, Piyawan Jirayusakamol Jan 2022

Comparison Of Volumetric Changes At Implant Connector Among Three Different Types Of Abutment After Cyclic Loading, Piyawan Jirayusakamol

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to compare the volumetric change of dental implant among three different types of abutments after cyclic loading.Thirty dental implants (4.1x10 mm., Straumann®) were used .All of them were inserted in acrylic resin block with usual surgical protocol to gain primary stability and be able to retrieve for volumetric measurement later. Ten of each dental implant connected with Titanium abutment (Group1: Variobase abutment Straumann®), Gold abutment (Group2: UCLA abutment Straumann®) and Zirconia abutment (Group 3: Care abutment Straumann®) consecutively. Then all specimen was submitted to cyclic loading (1x106 cycles, axial load, 100N, 15 Hz) at …

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Association Among Anterior Maxillary Dental Arch Form, Alveolar Bone Thickness And Sagittal Root Position Of Maxillary Central Incisor : A Cone Beam Computed Tomography Analysis, Suttikiat Somvasoontra Jan 2022

Association Among Anterior Maxillary Dental Arch Form, Alveolar Bone Thickness And Sagittal Root Position Of Maxillary Central Incisor : A Cone Beam Computed Tomography Analysis, Suttikiat Somvasoontra

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: This study evaluated the association among the dental arch form, age-sex groups, and sagittal root position regarding alveolar bone thickness in the maxillary central incisor using cone-beam computed tomography (CBCT) images. Materials and Methods: CBCT images of 280 patients were categorized based on the dental arch form and age-sex groups. Five hundred and sixty sagittal CBCT images of the maxillary central incisors were examined to measure the labial and palatal bone thickness at the root apex level, at the mid-root level and 3 mm apically from cemento-enamel junction, with SRP classification. Chi-square, Kruskal-Wallis test, and multiple linear regression were …

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Study Of Saliva Transcriptome And Proteome In Thai Patients With Dental Fluorosis, Patcharaporn Gavila Jan 2022

Study Of Saliva Transcriptome And Proteome In Thai Patients With Dental Fluorosis, Patcharaporn Gavila

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to examine the expression profiles of RNA and protein in Thai individuals with dental fluorosis and compare them with those without fluorosis. Additionally, the study aimed to establish a correlation between the severity of dental fluorosis, urinary fluoride levels, and water fluoride levels. Methods: Schoolchildren in areas endemic for fluoride in Lamphun and Ratchaburi provinces of Thailand were screened for dental fluorosis severity and then enrolled in the study. Fluoride concentration in 24-hour urine and drinking water samples was measured using an ion-selective fluoride electrode. Saliva samples were collected in sterile tubes and stored …

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Oral Health Service Of Older Adults In Long-Term Care Facilities, Puntawee Barameepipat Jan 2022

Oral Health Service Of Older Adults In Long-Term Care Facilities, Puntawee Barameepipat

Chulalongkorn University Theses and Dissertations (Chula ETD)

To assess oral health service in long-term care facilities in Bangkok Methods: A cross-sectional study was conducted in 50 licensed long-term care facilities in Bangkok. Informed consent was obtained from all participants before conducting phone interviews and administering the questionnaire. The questionnaire covered various aspects, including demographics, health services, and oral health services provided within the long-term care facilities. Results: The study revealed variations in terms of operational years, service capacity, service expense per month, and provision of health services, including oral health services. It was found that the differences in service expenses impacted the provision of denture care for …

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Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly, Ratchawipa Nakphu Jan 2022

Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly, Ratchawipa Nakphu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aims: To evaluate the intention of the elders to use the Silver Diamine Fluoride (SDF) treatment for stopping dental caries progression after being informed Materials and Methods: The elders aged 60-90 years old who are independent and can read Thai were recruited. A questionnaire-guided interview was performed to the elders after introduction of the SDF treatment. The questionnaire-guided interview was guided by the Theory of Reason Action (TRA) composed of 23 questions of 7 constructs including behavioral belief, evaluation of behavioral outcome, normative belief, motivation to comply, attitude towards behavior, subjective norm and intention. The intention to do the SDf …

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Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis, Yanisa Wongbanthit Jan 2022

Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis, Yanisa Wongbanthit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The aim of this study was to evaluate cranio-oro-facial features and masticatory function in Thai subjects with craniosynostosis. Methods: Thirteen craniosynostosis (CS) patients aged between 6 - 17 years old who had treatment at the Princess Sirindhorn Craniofacial (PSC) Center, King Chulalongkorn memorial hospital and thirty age-matched non-CS subjects were recruited. Inform consents were obtained. Medical records were retrieved. Craniofacial and oral examination, radiographic evaluation, photograph, and masticatory function were recorded and compared with data of control subjects and that of Thai norms. Results: Among thirteen CS patients, four cases had cleft palate (30.8%), five had anterior openbite (38.5%), …

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Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand, Yaowapa Chantaraboot Jan 2022

Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand, Yaowapa Chantaraboot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: This study aimed to identify factors related to the oral health status of healthy elderly people in Phon Thong District, Roi Et Province, Thailand. Materials and methods: This cross-sectional study was conducted between 1 May and 25 December 2020 in Phon Thong District, Roi Et Province. A total of 249 male and female elderly people participated in the study. Oral health information was collected by trained dental hygienists using the Thai version of the oral health assessment tool [OHAT]. Data analysis used Mann–Whitney U tests, Chi-Square tests, and Binary logistic regression. Results: There were statistically significant associations between oral …

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Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients, Nachapol Supanumpar Jan 2022

Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients, Nachapol Supanumpar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antiresorptive drugs are widely used to treat osteoporosis. A serious adverse effect of these drugs is medication-related osteonecrosis of the jaw (MRONJ). By informing and educating patients about MRONJ, providing proper dental referral, and monitoring the oral health of patients who receive antiresorptive agents, physicians can reduce the risk of MRONJ. We investigated the awareness and clinical practices of physicians in Thailand with regard to MRONJ. Physicians who prescribed antiresorptive drugs for osteoporosis filled out an online self-administered questionnaire about demographic characteristics, awareness, and practices related to MRONJ. Most respondents agreed that antiresorptive drugs may cause MRONJ (92.3%), that poor …

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Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey, Paratcha Pingsuthiwong Jan 2022

Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey, Paratcha Pingsuthiwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aerosol-generating procedures with contaminated saliva may pose a risk of disease transmission during the COVID-19 pandemic. COVID-19 preventive measures in dental clinics have evolved in response to the pandemic situation. This research investigated the effect of this pandemic on Thai patients' knowledge, attitudes, and behavior toward dental treatment. The online survey was distributed in June 2022. There were 978 participants in the study. The results showed that most participants had accurate knowledge about the COVID-19 transmission route in dentistry. The mean and median level of concern in the following issues were: contracting COVID-19 in daily life (3.06 and 3.03), contracting …

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Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study, Walailuk Kunthikarn Jan 2022

Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study, Walailuk Kunthikarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sodium chloride solution (NaCl) is regarded as the most suitable and recommended medical irrigation, because of the nontoxic and isotonic properties. The previous in vitro study showed that NaCl solution induced migration and extracellular matrix excretion from human gingival fibroblast. However, there is no report concerning the effect of rinsing extraction wound with NaCl solution in clinical trial study. This research study is split mouth single-blind randomized controlled clinical trial to investigate if rinsing with 0.9% and 1.8% NaCl solution on extraction wound can promote soft tissue healing. The operation was performed in 60 socket sites. The patients, who had …

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The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert Jan 2022

The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in hDPSCs. This study aimed to investigate the characteristic of the Jagged1-treated hDPSCs-derived dECM and its biological activity on odonto/osteogenic differentiation SCAPs. Methods: Bioinformatic database of Jagged1-treated hDPSCs was analyzed by NetworkAnalyst. hDPSCs seeded on Jagged1 immobilized surface were maintained with N or OM followed by decellularization procedure, dECM-N or dECM-OM, respectively. SCAPs were reseeded on each dECM with either normal medium or OM. Cell viability was determined by MTT assay. Characteristics of dECMs and SCAPs were evaluated by SEM, EDX, immunofluorescent staining and alcian blue staining. A Multipotential differentiation assay. …

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Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability, Panida Methawit Jan 2022

Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability, Panida Methawit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigated the effects of the pitch (P) and thread shape on orthodontic miniscrew cortical bone microdamage. The relationship between microdamage and primary stability was examined. Ti6Al4V orthodontic miniscrews had custom-made thread heights (H) and pitch sizes and were classified into the following groups: HCPC (control); HCPN (with a narrower pitch); and HTPC (with a taller thread height) (HC = 0.12 mm; HT = 0.36 mm; PC = 0.60 mm; PN = 0.30 mm). The orthodontic miniscrews were inserted in the pilot hole of prepared 1.0-mm-thick tibia cortical bone, and the maximum insertion torque (MIT) and Periotest value (PTV) …

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Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut Jan 2022

Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries in children is the most common chronic oral disease that could disturb their quality of life including their development. Early prevention is a key approach to reducing the prevalence of early childhood caries. However, a reliable caries predictor, as an essential tool for targeted prevention that is important to this approach, is still lacking for infants before caries onset. Therefore, we aimed to develop the caries risk prediction model based on the salivary microbiome of caries-free 1-year-old children to predict caries onset at 1-year follow-up. Using a nested case-control design within a prospective cohort study, 30 saliva samples, …

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Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats, Phanchanit Jindarojanakul Jan 2022

Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats, Phanchanit Jindarojanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hypoxia induces reactive oxygen species (ROS) production in periodontal tissues. Superoxide dismutase 3 (SOD3) is an enzyme protecting cells from ROS. This study investigated SOD3 expression and function during rat orthodontic tooth movement (OTM) and in hypoxia-exposed rat PDL cells. OTM of right maxillary first molars were performed in Sprague-Dawley rats for 1 and 14 days (n = 6 per group). SOD3 and HIF-1α expression were evaluated by immunohistochemistry. SOD3 effects on cell viability and proliferation, ROS production, and mRNA expression of Hif-1α, Rankl, and Opg in PDL cells and osteoclast differentiation were investigated under normoxia and hypoxia. SOD3 expression …

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The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng Jan 2022

The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this in vitro study was to compare the remineralization efficiency among Nano-silver fluoride 400 ppm (NSF400), 38% Silver diamine fluoride (38% SDF) and 5% Sodium fluoride (5% NaF) on artificial dentine caries in permanent molar or premolar teeth. The teeth were sectioned to obtain 120 specimens (3 x 3 x 2 mm3). After artificial caries were created, the lesion depth (LD) was measured using Micro-computed tomography (Micro-CT) (n=15 specimens/group), and the surface microhardness (SMH) was measured using a Knoop microhardness tester (n=15 specimens/group). Subsequently, all specimens were randomly assigned to four groups: Group 1) NSF400, Group 2) …

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Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong Jan 2022

Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Scaffold plays a key role in the context of tissue engineering. It not only provides a structural support for cells, but also creates an appropriate milieu for recruited cells, enhancing the therapeutic effects of cell-based treatments, and enabling the controlled release of biological cues such as growth factors. Collagen is widely used scaffold material in tissue engineering, particularly in periodontal and bone regeneration. Other natural polymers, however, have been developed and can be useful. Therefore, in this study, we aim to investigate the ability of four different natural polymers including collagen, chitosan, silk fibroin, and silk fibroin/gelatin hydrogel in promoting …

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Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis, Pimphorn Meekhantong Jan 2022

Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis, Pimphorn Meekhantong

Chulalongkorn University Theses and Dissertations (Chula ETD)

As a new class of medicines, mRNA platform has proven to be safe and effective. The objective of this study was to investigate the effect of local inflammation on platelet derived growth factor-BB (PDGF-BB) expression after gingival injection of PDGF-BB mRNA in lipid nanoparticles (LNPs) in ligature-induced rat periodontitis and to examine the dose-dependent effect of gingival delivery of mRNA. 3-0 silk was placed around maxillary left second molar for two weeks and removed, while the corresponding molar on the right was non-ligated. Under stereomicroscope, a significant bone loss at ligature sites was observed as compared to the non-ligature sites, …

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Hydroxyapatite Nanoparticle And Bone Scaffold To Deliver Microrna-302a-3p For Bone Healing In A Critical-Sized Bone Defect, Pirawish Limlawan Jan 2022

Hydroxyapatite Nanoparticle And Bone Scaffold To Deliver Microrna-302a-3p For Bone Healing In A Critical-Sized Bone Defect, Pirawish Limlawan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bone tissue engineering is a therapeutic approach for large bone defects. It is being studied to create efficient bone substitution material. However, the autograft with consequence of multiple morbid sites is still a gold standard. This study aimed to use surface modified hydroxyapatite nanoparticle on a 3D-printed tricalcium phosphate/hydroxyapatite (TCP/HA) scaffold to deliver miRNA-302a-3p to enhance bone regeneration as a novel approach for bone tissue engineering. Hydroxyapatite nanoparticles (HA-NPs) were created with hydrothermal method and surface modified with cationic molecule 3-aminopropyltriethoxysilane (APTES) or poly2-(dimethylamino)ethyl methacrylate (PDMAEMA) to enhance miRNA condensation and cellular uptake. The biocompatibility, miRNA condensation ability, cellular uptake …

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Study Of Mutation And Pathomechanism Of Runx2 In Cleidocranial Dysplasia, Sermporn Thaweesapphithak Jan 2022

Study Of Mutation And Pathomechanism Of Runx2 In Cleidocranial Dysplasia, Sermporn Thaweesapphithak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cleidocranial dysplasia (CCD) is a skeletal disorder affecting the skull, teeth, and clavicles, and is associated with the RUNX2 variants. We identified the five variants from five families, three were novel, comprising c.739delA (p.(Ser247Valfs*)), c.901C>T (p.(Gln301*)), and c.1081C>T (p.(Gln361*)) and two were reported, comprising c.673C>T (p.Arg225Trp) and c.674G>A (p.Arg225Gln). All patients exhibited typical CCD features, but we observed the unreported phenotypes, left forth-ray brachymetatarsia. Moreover, we reviewed the C-terminus RUNX2 variants in the CCD patients and found 81 variants that have been reported. To determine, the pathomechanism of CCD caused by the variants in the C-terminus, …

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Comparison Of Early Stability Betweenaggressive And Non-Aggressive Thread Design Implant, Pawida Pataraprasit Jan 2022

Comparison Of Early Stability Betweenaggressive And Non-Aggressive Thread Design Implant, Pawida Pataraprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background and objective A new type of implant with aggressive threads, called the BLX implant, has been designed to provide greater adhesion to the bone. This study investigates the early implant stability between aggressive (BLX) and non-aggressive (BL) thread implants using Implant Stability Quotient (ISQ) values and Implant stability test (IST) values.) Method BLX and BL implants were placed by block randomization (12 BLX implants, 10 BL implants) following the manufacturer protocol. The insertion torque was recorded. The Implant Stability Quotient (ISQ) values were measured immediately after placement and 6 weeks after implant placement while the Implant stability test (IST) …

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Two-Body Wear Resistance Of Four Different Lithium Disilicate, One Zirconia Reinforced Lithium Silicate, And Two Zirconia Cad/Cam Materials, Suchaya Tantrachoti Jan 2022

Two-Body Wear Resistance Of Four Different Lithium Disilicate, One Zirconia Reinforced Lithium Silicate, And Two Zirconia Cad/Cam Materials, Suchaya Tantrachoti

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: to evaluate the volume loss of four different lithium disilicate, one zirconia reinforced lithium silicate, and two zirconia CAD/CAM materials. Methodology: The test conditions were divided into 8 experimental groups (n=6); Amber mill (AM), milled-Celtra Duo (mCD), fired-Celtra Duo (fCD), IPS emax CAD (EM), n!ce (NI), Rosetta SM (RS), Cercon xt (XT), and IPS emax ZirCAD (ZC). Flat square specimens (8 x8 x4 mm3) were prepared. A spherical steatite (D =6mm) was used as an antagonist. The simulated two-body wear was performed using a chewing simulator (120,000 cycles, 50 N, 1.34 Hz, sliding movement 0.5 mm). The volume loss …

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Effectiveness Of Myofunctional Therapy With Frenectomy In Adult Patients With Obstructive Sleep Apnea And Ankyloglossia, Chanadda Preedeewong Jan 2022

Effectiveness Of Myofunctional Therapy With Frenectomy In Adult Patients With Obstructive Sleep Apnea And Ankyloglossia, Chanadda Preedeewong

Chulalongkorn University Theses and Dissertations (Chula ETD)

In recent years, myofunctional therapy has emerged as a noninvasive treatment modality for patients suffering from obstructive sleep apnea (OSA), owing to its lower cost and reduced risk of serious side effects compared to other therapeutic options. Furthermore, myofunctional therapy may be considered for patients who cannot tolerate continuous positive airway pressure (CPAP) or oral appliances. However, ankyloglossia, a congenital condition characterized by restricted tongue movement, has been shown to limit the exercise regimen and compromise the effectiveness of myofunctional therapy. This study aims to explore the effectiveness of myofunctional therapy combined with frenectomy for adult OSA patients with ankyloglossia. …

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ความรู้และทัศนคติของทันตแพทย์ในประเทศไทย เกี่ยวกับภาวะหยุดหายใจขณะหลับจากการอุดกั้น, ทิพย์จุฑา บูรณกิจวิสูตร Jan 2022

ความรู้และทัศนคติของทันตแพทย์ในประเทศไทย เกี่ยวกับภาวะหยุดหายใจขณะหลับจากการอุดกั้น, ทิพย์จุฑา บูรณกิจวิสูตร

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้จึงมีวัตถุประสงค์เพื่อศึกษาระดับความรู้และทัศนคติต่อภาวะหยุดหายใจขณะหลับจากการอุดกั้นของทันตแพทย์ในประเทศไทยจำนวน 494 คน ระหว่างเดือนกรกฎาคมถึงกันยายน พ.ศ.2565 โดยใช้แบบสอบถามออนไลน์ประกอบด้วย 3 ส่วนได้แก่ ข้อมูลทั่วไป ความรู้ และทัศนคติ ผลการศึกษาพบว่าทันตแพทย์มีระดับความรู้น้อย จำนวน 275 คน (ร้อยละ 56.9) เกี่ยวกับคำจำกัดความของโรค พยาธิสรีรวิทยา การวินิจฉัยและการรักษา และผลคะแนนความรู้มีความแตกต่างอย่างมีนัยสำคัญทางสถิติที่ระดับความเชื่อมั่นร้อยละ 95 ของคะแนนความรู้ระหว่างทันตแพทย์ที่เคยฝึกอบรมและไม่เคยฝึกอบรมเกี่ยวกับภาวะหยุดหายใจขณะหลับจากการอุดกั้น ทั้งในและนอกระบบมหาวิทยาลัยทันตแพทยศาสตร์บัณฑิต และระหว่างทันตแพทย์ที่เคยมีประสบการณ์และไม่เคยมีประสบการณ์ในการตรวจคัดกรองผู้ป่วยที่มีภาวะหยุดหายใจขณะหลับจากการอุดกั้น แต่พบว่าทันตแพทย์ผู้ร่วมวิจัยส่วนใหญ่มีทัศนคติเชิงบวกต่อความสำคัญว่าภาวะหยุดหายใจขณะหลับจากการอุดกั้นอาจคุกคามถึงชีวิต และมีความมั่นใจในการตรวจคัดกรองและให้การจัดการภาวะหยุดหายใจขณะหลับจากการอุดกั้น โดยจำนวนร้อยละ 76 เห็นด้วยอย่างยิ่งว่าภาวะหยุดหายใจขณะหลับจากการอุดกั้นเป็นโรคที่มีความสำคัญเพราะอาจคุกคามถึงชีวิตได้ สรุปว่าทันตแพทย์ไทยยังมีระดับความรู้น้อยแต่มีทัศนคติที่ดีต่อภาวะหยุดหายใจขณะหลับจากการอุดกั้น บ่งชี้ให้เห็นว่าทันตแพทย์เห็นคุณค่า รวมถึงให้ความสำคัญและเต็มใจที่จะเรียนรู้เกี่ยวกับภาวะหยุดหายใจขณะหลับจากการอุดกั้น

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Micro-Computed Tomography Analysis Of Bone Regeneration Using Mrna Encoding Bone Morphogenetic Protein-2 With Implant Placement In Rat Femur, Nopparada Lawtrakulngam Jan 2022

Micro-Computed Tomography Analysis Of Bone Regeneration Using Mrna Encoding Bone Morphogenetic Protein-2 With Implant Placement In Rat Femur, Nopparada Lawtrakulngam

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bone morphogenetic protein-2 (BMP-2) has a potential for enhancing bone regeneration and osseointegration around implant materials. However, the drawback of rhBMP-2 protein delivery is instability. Therefore, high doses of rhBMP-2 need to be used clinically, which results in higher costs and more side effects. Although gene-based therapy, can overcome these limitations. Recent clinical studies on BMP-2 mRNA regarding bone regeneration around implant materials are lacking. This study aims to investigate the differences in bone regeneration after implant placement with or without mRNA encoding BMP-2 (m1ᴪ-BMP-2 mRNA) in micro-computed tomography analysis after implant placement in rat femur defects. Forty implant titanium …

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Human Epidermal Growth Factor Release From Hyaluronic Acid-Based Platforms Towards In Vitro Expansion Of Salivary Gland Cells, Toan Phan Van Jan 2022

Human Epidermal Growth Factor Release From Hyaluronic Acid-Based Platforms Towards In Vitro Expansion Of Salivary Gland Cells, Toan Phan Van

Chulalongkorn University Theses and Dissertations (Chula ETD)

Off-the-shelf recombinant growth factors are increasingly used as signaling cues to optimize organoid biofabrication and shorten the in vitro culture time. These factors are mainly produced in prokaryotic systems but lack post-translational modifications. To overcome such limitations and the high production costs related to these common systems, plant molecular farming is a novel, easy adaptable and feasible alternative. Epidermal growth factor (EGF) is a known signaling cue essential for epithelial organogenesis and organoid biofabrication particularly in exocrine glands. This study aims to develop an EGF delivery in vitro platform with Nicotiana benthamiana plant-derived EGF (P-EGF) encapsulated on hyaluronic acid/alginate (HA/Alg) …

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Accuracy Assessment Of 3d Tooth Reconstruction With Novel Segmentation Technique, Thanatchaporn Permwatanachai Jan 2022

Accuracy Assessment Of 3d Tooth Reconstruction With Novel Segmentation Technique, Thanatchaporn Permwatanachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

In modern medicine, three-dimensional (3D) reconstruction has innovative new applications by building cost-effective patient-specific surgical models and prostheses. Concurrently, 3D reconstruction is useful in dental and maxillofacial disciplines for pre-operative planning and surgical simulation. During the 3D reconstruction process, one of the significant procedures is segmentation, which involves extracting interesting structures from undesirable surroundings. In this case, if the digital segmentation is inaccurate, the physical model generated by the virtual model will not properly represent anatomy of the structure, resulting in a discordance between treatment plan and outcome. The study aims to assess the segmental accuracy of the new threshold-based …

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