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2021

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Full-Text Articles in Dentistry

Ada News - 11/08/2021, American Dental Association, Publishing Division Nov 2021

Ada News - 11/08/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Baseline Mmp Expression In Periapical Granuloma And Its Relationship With Periapical Wound Healing After Surgical Endodontic Treatment, Muhammad Adeel Ahmed, Muhammad Faraz Anwar, Khalid Ahmed, Marziya Aftab, Fizza Nazim, Muhammad Furqan Bari, Mohammed Mustafa, Fahim Vohra, Ali Alrahlah, Muhammad Nouman Mughal, Syed Hani Abidi Nov 2021

Baseline Mmp Expression In Periapical Granuloma And Its Relationship With Periapical Wound Healing After Surgical Endodontic Treatment, Muhammad Adeel Ahmed, Muhammad Faraz Anwar, Khalid Ahmed, Marziya Aftab, Fizza Nazim, Muhammad Furqan Bari, Mohammed Mustafa, Fahim Vohra, Ali Alrahlah, Muhammad Nouman Mughal, Syed Hani Abidi

Department of Biological & Biomedical Sciences

Background: Matrix metalloproteinases (MMPs) catalyzes the degradation of the extracellular matrix components and have a major role in many physiological processes including wound healing. In the current study, we examined the correlation of baseline MMPs 1, 2, 7, and 9 expressions with periapical wound healing after surgical endodontic treatment.
Methods: 27 patients aged between 15 and 57 years presenting with chronic apical periodontitis or chronic apical abscess of an anterior tooth with previously attempted or failed root canal treatment were included in this study. During surgical endodontic treatment, tissue from the periapical lesion sample was collected and used for gross …


N Y State Dent J November 2021 Nov 2021

N Y State Dent J November 2021

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.


J Mich Dent Assoc November 2021 Nov 2021

J Mich Dent Assoc November 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

  • Cover stories with a “Focus on Advocacy: Helping Dentistry Succeed”, including “MDA Dental PAC: What It Is and Why It Matters “, “2021 Advocacy Success — and More to Come “, and “Dental Programs Maintained in 2021-22 State Budget”.
  • A feature article on “The Anishinaabe Dental Outreach Program”.
  • A feature article, “How Your Website and …


Effect Of Different Irrigation Regimens On Enterococcus Faecalis Elimination From Infected Root Canals (An In-Vitro Comparative Study), Fadl Khaled, Roula Abiad, Khaled Abd El Galil, Essam Osman Oct 2021

Effect Of Different Irrigation Regimens On Enterococcus Faecalis Elimination From Infected Root Canals (An In-Vitro Comparative Study), Fadl Khaled, Roula Abiad, Khaled Abd El Galil, Essam Osman

BAU Journal - Health and Wellbeing

Microorganisms harbored in the complexities of root canal systems might lead to endodontic failures and development of apical periodontitis. Enterococcus faecalis is the most common isolated bacteria in these cases. Aim: This study was conducted to compare the efficiency of four irrigation regimens on the elimination of an inoculated strain of E. faecalis. Materials and Methods: Forty single rooted extracted premolars were inoculated with a standard strain of Enterococcus faecalis (ATCC 29212) and incubated at 37˚C for two weeks to allow infection of the dentinal tubules. The bacterial suspension was replaced with a new one every 48 hours. The teeth …


Anatomical Analysis Of Mandibular Posterior Teeth Using Cbct: An Endo-Surgical Perspective, Shehabeldin Mohamed Saber Prof.Dr., Nawar Nawar Oct 2021

Anatomical Analysis Of Mandibular Posterior Teeth Using Cbct: An Endo-Surgical Perspective, Shehabeldin Mohamed Saber Prof.Dr., Nawar Nawar

Dentistry

Objective: This study sought to analyse the relationship between mandibular posterior teeth and the surrounding anatomical structures. Methods: A total of 170 CBCT images were examined to obtain measurements regarding the following: buccolingual (BL) and mesiodistal (MD) root thickness at the standard level of resection (3 mm from the apex), the thickness of the overlying buccal and lingual bone at the same level, the proximity of the mandibular canal (MC) to the apices of the mandibular posterior teeth, as well as the horizontal location of the mental foramen (MF). Results: The BL root width at 3 mm from the apex …


Detection Of Dental Apical Lesions Using Cnns On Periapical Radiograph, Chun-Wei Li, Szu-Yin Lin, He-Sheng Chou, Tsung-Yi Chen, Yu-An Chen, Sheng-Yu Liu, Yu-Lin Liu, Chiung-An Chen, Yen-Cheng Huang, Shih-Lun Chen, Yi-Cheng Mao, Patricia Angela R. Abu, Wei-Yuan Chiang, Wen-Shen Lo Oct 2021

Detection Of Dental Apical Lesions Using Cnns On Periapical Radiograph, Chun-Wei Li, Szu-Yin Lin, He-Sheng Chou, Tsung-Yi Chen, Yu-An Chen, Sheng-Yu Liu, Yu-Lin Liu, Chiung-An Chen, Yen-Cheng Huang, Shih-Lun Chen, Yi-Cheng Mao, Patricia Angela R. Abu, Wei-Yuan Chiang, Wen-Shen Lo

Department of Information Systems & Computer Science Faculty Publications

Apical lesions, the general term for chronic infectious diseases, are very common dental diseases in modern life, and are caused by various factors. The current prevailing endodontic treatment makes use of X-ray photography taken from patients where the lesion area is marked manually, which is therefore time consuming. Additionally, for some images the significant details might not be recognizable due to the different shooting angles or doses. To make the diagnosis process shorter and efficient, repetitive tasks should be performed automatically to allow the dentists to focus more on the technical and medical diagnosis, such as treatment, tooth cleaning, or …


Congenital Epulis: A Two-Case Report, Monica Ivanov, Bianca Stroe, Valeriu Ardeleanu, Razvan Hainarosie, Vlad Denis Constantin, Anca Silvia Dumitriu, Stana Paunica, Anna Kadar Oct 2021

Congenital Epulis: A Two-Case Report, Monica Ivanov, Bianca Stroe, Valeriu Ardeleanu, Razvan Hainarosie, Vlad Denis Constantin, Anca Silvia Dumitriu, Stana Paunica, Anna Kadar

Journal of Mind and Medical Sciences

Congenital epulis is a rare benign tumor of the newborn that could be detected in the prenatal period. Females are more often affected than males and the premaxillary region is usually the predilection site for this oral mass. Excision is the treatment of choice and no recurrences have been reported so far.

We present our experience with two cases of congenital epulis, detected in the second trimester of gestation and treated shortly after birth with no further complications. Histopathology should differentiate between congenital epulis and other congenital oral tumors even if its clinical appearance is usually enough to make a …


Ada News - 10/11/2021, American Dental Association, Publishing Division Oct 2021

Ada News - 10/11/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Perceptions Of Dental Undergraduates Towards Online Education During Covid-19: Assessment From India, Nepal And Sri Lanka, Pragati Kaurani, Kavita Batra, Himangini Rathore Hooja, Rajlakshmi Banerjee, Rasika Manori Jayasinghe, Dhanushka Leuke Bandara, Navin Agrawal, Vimmi Singh Oct 2021

Perceptions Of Dental Undergraduates Towards Online Education During Covid-19: Assessment From India, Nepal And Sri Lanka, Pragati Kaurani, Kavita Batra, Himangini Rathore Hooja, Rajlakshmi Banerjee, Rasika Manori Jayasinghe, Dhanushka Leuke Bandara, Navin Agrawal, Vimmi Singh

School of Medicine Faculty Research

Purpose: The social distancing mandates instituted during COVID-19 pandemic mark the sudden transition in the mode of dental education’s delivery to the virtual instruction. It is vital to assess students’ perceptions towards virtual learning environments, particularly among those gaining education in resource-strained countries. This cross-sectional study aims to assess the perceptions of dental undergraduates towards online education, environment and transferable skills and patient care during COVID-19 in India, Nepal, and Sri Lanka. Materials and Methods: Dental preclinical and clinical undergraduate students from India, Nepal and Sri Lanka were recruited from November 2020 to March 2021 through a 47-item web-based survey …


Year In Review 2020-2021, Dugoni School Of Dentistry Oct 2021

Year In Review 2020-2021, Dugoni School Of Dentistry

Dugoni Academic Year in Review

Highlights of academic programs, clinical services, research, community outreach and other areas of University of the Pacific's Arthur A. Dugoni School of Dentistry.


New Dentist News (October 2021), Ada Committee On The New Dentist Oct 2021

New Dentist News (October 2021), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.


J Mich Dent Assoc October 2021 Oct 2021

J Mich Dent Assoc October 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

  • A cover story, “Welcoming Colleagues from Different Practice Models”.
  • A feature article from the Journal’s DEI series, “Diversity, Equity, and Inclusion: Perspectives from an LGBTQ Dentist”.
  • A feature article, “Congratulations, 2021 MDA Life Members!”.
  • News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and the Law, Staff Matters, and component news. …


Flowcharts Improve Periodontal Diagnosis By Dental And Dental Hygiene Students, Karo Parsegian, Srinivas Ayilavarapu, Tulsi Patel, Harold A Henson, Nikola Angelov Oct 2021

Flowcharts Improve Periodontal Diagnosis By Dental And Dental Hygiene Students, Karo Parsegian, Srinivas Ayilavarapu, Tulsi Patel, Harold A Henson, Nikola Angelov

Faculty, Staff and Student Publications

BACKGROUND: In 2017, the American Academy of Periodontology and the European Federation of Periodontology updated the classification of periodontal and peri-implant diseases and conditions. The goal of the present crossover study was to develop straightforward, illustrative flowcharts and determine their impact on the accuracy and speed of diagnosing periodontal conditions by predoctoral dental students (DS) and dental hygiene students (DHS).

METHODS: Two flowcharts (a decision-tree flowchart and one based on the periodontal disease/condition entity) were developed using updated diagnostic determinants proposed by the 2017 classification. A total of 26 second-, third-, and fourth-year DS (DS2, DS3, and DS4, respectively) and …


Dental Professionals’ Perspectives Working With Aboriginal Children In Western Australia: A Qualitative Study, A. Durey, Lydia Hearn, S. Lund, M. O’Grady, L. Slack-Smith Sep 2021

Dental Professionals’ Perspectives Working With Aboriginal Children In Western Australia: A Qualitative Study, A. Durey, Lydia Hearn, S. Lund, M. O’Grady, L. Slack-Smith

Research outputs 2014 to 2021

Background: The disproportionate burden of oral disease in Aboriginal children and the issues in accessing mainstream dental services are well documented. Yet little is known about dental professionals’ perspectives in providing oral care for Aboriginal children. This paper presents findings from a study exploring such perspectives.

Methods: Semi-structured interviews were carried out in Western Australia following purposive sampling of non-Aboriginal dentists, dental clinic assistants (dental nurses) and oral health therapists/dental hygienists. Interviews were recorded, transcribed and analysed guided by grounded theory for key themes related to the topic.

Results: Findings included a service delivery model sometimes unresponsive to Aboriginal families’ …


Bacterial Biofilm Growth On Various Dental Stabilization Systems For Avulsed And Luxated Teeth, Mahmoud Mona, Clay Walker, Luciana M. Shaddox, Roberta Pileggi Sep 2021

Bacterial Biofilm Growth On Various Dental Stabilization Systems For Avulsed And Luxated Teeth, Mahmoud Mona, Clay Walker, Luciana M. Shaddox, Roberta Pileggi

Oral Health Practice Faculty Publications

With the increased incidence of traumatic injuries and the advanced understanding of the periodontal and alveolar healing process, teeth splinting has become a common practice for stabilizing traumatized teeth. Consequently, several splinting materials and techniques have been introduced in the past few years. Despite the detrimental role of bacterial biofilm on healing, the level of biofilm development on these material surfaces has not been well investigated. Bacterial biofilms are severely detrimental for periodontal healing of avulsed and luxated teeth. Thus, biofilm growth becomes a critical factor in selecting the material of choice for dental splints. In this study, we aim …


The Influence Of Cbct-Derived 3d-Printed Models On Endodontic Microsurgical Treatment Planning And Confidence Of The Operator, Shreyas Oza, Johnah C. Galicia Sep 2021

The Influence Of Cbct-Derived 3d-Printed Models On Endodontic Microsurgical Treatment Planning And Confidence Of The Operator, Shreyas Oza, Johnah C. Galicia

Orthodontics and Endodontics Theses

Aims Use of 3D printed models in Endodontics has been gaining popularity since the technology to create them became more affordable. Currently, there are no studies that evaluate the influence of 3D models on endodontic surgical treatment planning and on operator confidence. Therefore, aims of this study were to: (i) Determine whether the availability of a 3D printed analogue can influence treatment-planning and operator confidence; and, (ii) Assess which factors of operator confidence are influenced, if any.

Materials and Methods Endodontists were asked to analyze a pre-selected CBCT scan of an endodontic surgical case and to answer a questionnaire that …


Segmental Maxillomandibular Rotational Advancement (Smmra) In The Treatment Of Adult Patients With Severe Obstructive Sleep Apnea, Hsien-Ching Hung, Ya-Ying Teng, Yuh-Jia Hsieh, Yi-Chin Wang, Yu-Chih Wang Sep 2021

Segmental Maxillomandibular Rotational Advancement (Smmra) In The Treatment Of Adult Patients With Severe Obstructive Sleep Apnea, Hsien-Ching Hung, Ya-Ying Teng, Yuh-Jia Hsieh, Yi-Chin Wang, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) occurs as an increased collapsibility of the upper airway during sleep, which threatens health and quality of life. Asian men with greater severity of OSA presents less obese and are connected with craniofacial abnormalities. Although the traditional maxillomandibular advancement (MMA) had the comparable effectiveness to the continuous positive airway pressure therapy, the midfacial esthetics might be compromised in Asian individuals. The modified MMA procedure was proposed to balance the esthetic demands and improvement of OSA symptoms. The case report showed a 25-year-old man presented with a diagnosis of severe OSA. The pretreatment Apnea Hypopnea Index (AHI) …


Protraction Of Maxillary Single Side Teeth For Substitution Of Missing Canine And 1st Molar, Wan-Jung Tsai, Szu-Ching Lee, Tzu-Ying Wu Sep 2021

Protraction Of Maxillary Single Side Teeth For Substitution Of Missing Canine And 1st Molar, Wan-Jung Tsai, Szu-Ching Lee, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

This case report presents a 24-year-old female with Class III skeletal pattern, anterior cross-bite, retroclined upper incisors with missing teeth (23, 26, 46). Upper dental midline was shifted to left for 3.5 mm due to early missing of tooth 23. Maxillary sinus pneumatization was noted at both sides.

Our treatment goal was to correct upper dental midline and anterior crossbite. On the other hand, the patient requested to close all of the extraction space and solve the problem of poor prognostic tooth 36. Therefore, we extracted tooth 14 for crowding relief and midline correction. Interdental screw was used to protract …


Surgical Alteration Of Occlusal Plane Angulation Followed By Orthodontic Application Of Tads And Yin-Yang Arch Wire In Hypodivergent Prognathic Malocclusion, Chih-Hsun Hou, Yi-Min Liu, Chia-Yi Pan, Huei-Mei Tsai Sep 2021

Surgical Alteration Of Occlusal Plane Angulation Followed By Orthodontic Application Of Tads And Yin-Yang Arch Wire In Hypodivergent Prognathic Malocclusion, Chih-Hsun Hou, Yi-Min Liu, Chia-Yi Pan, Huei-Mei Tsai

Taiwanese Journal of Orthodontics

Surgical clockwise pitch rotation of the maxillo-mandibular complex could change the occlusal plane angulation and thereby open the bite. This procedure also increases the mandibular plane angle by forcing the lower face to turn backward and downward; it is the key to correct both skeletal and dental Class III malocclusions.

This case report presents a skeletal deformaty which primarily resulted from excessive transverse growth and reduced vertical growth in the midface and upper dentition. The counterclockwise growth rotation and excessive forward growth mandible aggravated the sagittal jaw bone discrepancy. The dental effect included canted maxillary occlusal plane and severe attrition …


Indication And Timing Of Mucogingival Soft Tissue Augmentation Associated With Orthodontic Treatment, Shun-Jen Yu, Yi-Hao Lee, Aaron Yu-Jen Wu Sep 2021

Indication And Timing Of Mucogingival Soft Tissue Augmentation Associated With Orthodontic Treatment, Shun-Jen Yu, Yi-Hao Lee, Aaron Yu-Jen Wu

Taiwanese Journal of Orthodontics

Gingiva recession is defined as an apical shift of the gingival margin caused by different conditions/pathologies. It is associated with clinical attachment loss. Several studies showed prevalence of gingiva recession in orthodontic patients. Some predisposing factors should be taken carefully considering the effect of the treatment modality. No consensus agreement was identified about the timing of the soft tissue augmentation intervention for orthodontic patients with the risk of gingival recession. However, several critical factors can guide the decision making to obtain the most preferred treatment option.

This article reviews the factors regarding the correlation of gingival margin alteration and orthodontic …


Perception Of And Attitudes On Malocclusion: A Literature Review, Gannaran Narangerel, Hsin-Chung Cheng, Bolormaa Sainbayar, Ganjargal Ganburged Sep 2021

Perception Of And Attitudes On Malocclusion: A Literature Review, Gannaran Narangerel, Hsin-Chung Cheng, Bolormaa Sainbayar, Ganjargal Ganburged

Taiwanese Journal of Orthodontics

Purpose: This study aimed to review published evidence on the perception of and attitude on malocclusion and to examine existing assessment tools and influencing factors.

Methods: PubMed, Cochrane Library, and Scopus databases, as well as electronic archives of the European Journal of Orthodontics, American Journal of Orthodontics and Dentofacial Orthopedics, and Angle Orthodontist, were searched to collect articles that compared perception differences between dental professionals and laypeople. Articles that investigated perceptions of dental professionals were excluded.

Results: The literature search identified 94 articles. A total of 31 suitable studies from 1970 to 2019 were finally considered in the review. …


Could Cephalometric Landmarks Serve As Boundaries Of Maxillary Molar Distalization? A Comparison Between Two- And Three-Dimensional Assessments, Jhong-An Ye, Chi-Yu Tsai, Yi-Hao Lee, Yu-Jen Chang, Shiu-Shiung Lin, Jui-Pin Lai, Te-Ju Wu Sep 2021

Could Cephalometric Landmarks Serve As Boundaries Of Maxillary Molar Distalization? A Comparison Between Two- And Three-Dimensional Assessments, Jhong-An Ye, Chi-Yu Tsai, Yi-Hao Lee, Yu-Jen Chang, Shiu-Shiung Lin, Jui-Pin Lai, Te-Ju Wu

Taiwanese Journal of Orthodontics

Purpose: This study aimed at measuring the differences between the two-dimensional (2D) and three-dimensional (3D) radiographic boundaries for molar distalization, and their correlations for the amount of maxillary molar distalization.

Patients and Methods: A total of 250 consecutive adult patients were retrospectively reviewed. All the enrolled patients possessed Angle Class III malocclusion with moderate maxillary crowding and suitable for camouflage treatment. The spatial differences between the 2D and 3D radiographic boundaries were compared and measured. The correlation among the range of the distalization boundary and studied clinical variables were assessed by Pearson correlation and the linear regression to determine the …


Covid-19 Et Gestion Des Troubles Gastro-Intestinaux : Expérience D’Un Centre Hospitalier Marocaincovid-19, Gastrointestinal Disorders, Pandemic., Hanane Delsa, Mohamed Cherkaoui Jaouad Reda, Amine Benfaida, Anass Nadi, Fedoua Rouibaa Sep 2021

Covid-19 Et Gestion Des Troubles Gastro-Intestinaux : Expérience D’Un Centre Hospitalier Marocaincovid-19, Gastrointestinal Disorders, Pandemic., Hanane Delsa, Mohamed Cherkaoui Jaouad Reda, Amine Benfaida, Anass Nadi, Fedoua Rouibaa

Health Sciences

Pandemic Covid-19 is a real challenge for the medical profession. SARS-CoV-2 virus attacks several human organs, including the digestive tract. Digestive disorders have been described as revealing symptoms or accompanying signs of infection. The treatment of these symptoms must be early and codified. At Cheikh Khalifa International University Hospital in Casablanca, a codified treatment protocol has been proposed to facilitate the management of these disorders.


Variants Of Facial Shape Genes In Patients With Class Ii Or Class I Malocclusion, Mahsa Mortazavi, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar Sep 2021

Variants Of Facial Shape Genes In Patients With Class Ii Or Class I Malocclusion, Mahsa Mortazavi, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar

Orthodontics and Endodontics Theses

Background and purpose: In recent years, questions regarding the genetic and environmental factors affecting variation in human craniofacial morphology have received increasing attention. Medical and clinical genetic research using family studies has proven foundational for our understanding of which genes affect craniofacial variation. On the other hand, cephalometricbased studies showed a relationship between the cranial base and midface characteristics among individuals with different skeletal pattern of malocclusion. The purpose of our pilot study was to analyze specific variants of facial genes that were suggested to be associated with cranial base width and depth in Class II and Class I malocclusions. …


Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha S. Kirakodu, Octavio A. Gonzalez Sep 2021

Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha S. Kirakodu, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was …


Variants Of Pax Gene Family In Patients With Class Ii Or Class I Malocclusion, Mana Naeim, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar Sep 2021

Variants Of Pax Gene Family In Patients With Class Ii Or Class I Malocclusion, Mana Naeim, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar

Orthodontics and Endodontics Theses

Background and Purpose. Orthodontic treatment helps to ensure proper function of teeth and to create healthy smiles. To this aim, the orthodontist’s goal is establishment of an esthetic harmony between soft and hard tissues of the face. Dimensions of facial width and height are crucial for accurate diagnosis and formulation of an efficient treatment plan. A knowledge of genetic determinants of these dimensions in Class II patients will deepen our understanding of etiology of skeletal Class II malocclusions and would make it possible to personalize a patient’s treatment plan. The purpose of our pilot study was to analyze, if specific …


Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu, Octavio A. Gonzalez Sep 2021

Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu, Octavio A. Gonzalez

Dental Medicine Faculty Research

Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was …


Identification Of Micrornas And Gene Regulatory Networks In Cleft Lip Common In Humans And Mice, Hiroki Yoshioka, Aimin Li, Akiko Suzuki, Sai Shankar Ramakrishnan, Zhongming Zhao, Junichi Iwata Sep 2021

Identification Of Micrornas And Gene Regulatory Networks In Cleft Lip Common In Humans And Mice, Hiroki Yoshioka, Aimin Li, Akiko Suzuki, Sai Shankar Ramakrishnan, Zhongming Zhao, Junichi Iwata

Faculty, Staff and Student Publications

The etiology of cleft lip with/without cleft palate (CL/P), one of the most frequent craniofacial birth defects worldwide, is complicated by contributions of both genetic and environmental factors. Understanding the etiology of these conditions is essential for developing preventive strategies. This study thus aims to identify regulatory networks of microRNAs (miRNAs), transcriptional factors (TFs) and non-TF genes associated with cleft lip (CL) that are conserved in humans and mice. Notably, we found that miR-27b, miR-133b, miR-205, miR-376b and miR-376c were involved in the regulation of CL-associated gene expression in both humans and mice. Among the candidate miRNAs, the overexpression of …


Ada News - 09/13/2021, American Dental Association, Publishing Division Sep 2021

Ada News - 09/13/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.