Dentistry Commons^™

Antimicrobial Peptide Coating Of Dental Implants: Biocompatibility Assessment Of Recombinant Human Beta Defensin-2 For Human Cells, Patrick Warnke, Eske Voss, Paul Russo, Sebastien Stephens, Michael Kleine, Hendrik Terheyden, Qin Liu

Qin Liu

Purpose: Artificial materials such as dental implants are at risk of bacterial contamination in the oral cavity. Human beta defensins (HBDs), small cationic antimicrobial peptides that exert a broad-spectrum antibacterial function at epithelial surfaces and within some mesenchymal tissues, could probably help to reduce such contamination. HBDs also have protective immunomodulatory effects and have been reported to promote bone remodeling. The aim of this study, therefore, was to investigate the influence of recombinant HBD-2 on the proliferation and survival of cells in culture.

Materials and Methods: Human mesenchymal stem cells (hMSCs), human osteoblasts, human keratinocytes (control), and the HeLa cancer …

Comparison Of In Vitro Biocompatibility Of Nanobone(®) And Biooss(®) For Human Osteoblasts, Qin Liu, Timothy Douglas, Christiane Zamponi, Stephan Becker, Eugene Sherry, Sureshan Sivananthan, Frauke Warnke, Jörg Wiltfang, Patrick Warnke

Qin Liu

Introduction:Scaffolds for bone tissue engineering seeded with the patient's own cells might be used as a preferable method to repair bone defects in the future. With the emerging new technologies of nanostructure design, new synthetic biomaterials are appearing on the market. Such scaffolds must be tested in vitro for their biocompatibility before clinical application. However, the choice between a natural or a synthetic biomaterial might be challenging for the doctor and the patient. In this study, we compared the biocompatibility of a synthetic bone substitute, NanoBone®, to the widely used natural bovine bone replacement material BioOss®.Material and methods: The in …

Proliferation Assessment Of Primary Human Mesenchymal Stem Cells On Collagen Membranes For Guided Bone Regeneration, Qin Liu, A. Humpe, D. Kletsas, F. Warnke, S. Becker, T. Douglas, S. Sivananthan, P. Warnke

Qin Liu

Purpose: Human mesenchymal stem cells (hMSCs) hold the potential for bone regeneration because of their self-renewing and multipotent character. The goal of this study was to evaluate the influence of collagen membranes on the proliferation of hMSCs derived from bone marrow. A special focus was set on short-term eluates derived from collagen membranes, as volatile toxic materials washed out from these membranes may influence cell behavior during the short time course of oral surgery.

Materials and Methods: The proliferation of hMSCs seeded directly on a collagen membrane (BioGide) was evaluated quantitatively using the cell proliferation reagent WST-1 (4-3-[4-iodophenyl]-2-[4-nitrophenyl]-2H-[5-tetrazolio]-1, …

An Assessment Of Dental Students’ Empathy Levels In Malaysia, Saad A. Khan Dr

Saad A Khan Dr

No abstract provided.

Who Participates In Web-Assisted Tobacco Interventions? The Quit-Primo And National Dental Practice-Based Research Network Hi-Quit Studies, Rajani S. Sadasivam, Rebecca L. Kinney, Kathryn L. Delaughter, Sowmya R. Rao, Jessica Hillman Williams, Heather L. Coley, Midge N. Ray, Gregg H. Gilbert, Jeroan J. Allison, Daniel E. Ford, Thomas K. Houston

Rajani S. Sadasivam

INTRODUCTION: Smoking is the most preventable cause of death. Although effective, Web-assisted tobacco interventions are underutilized and recruitment is challenging. Understanding who participates in Web-assisted tobacco interventions may help in improving recruitment.

OBJECTIVES: To understand characteristics of smokers participating in a Web-assisted tobacco intervention (Decide2Quit.org).

METHODS: In addition to the typical Google advertisements, we expanded Decide2Quit.org recruitment to include referrals from medical and dental providers. We assessed how the expanded recruitment of smokers changed the users' characteristics, including comparison with a population-based sample of smokers from the national Behavioral Risk Factors Surveillance Survey (BRFSS). Using a negative binomial regression, we …

Prenatal Oral Health Education In U.S. Obstetrics And Gynecology Residencies And Dental Schools: Results Of A National Survey, Megan Weeks, Judith A. Savageau, Hugh Silk

Judith A. Savageau

Background: Pregnant women represent a special population within oral health care. Adverse pregnancy outcomes and increased infant caries can occur when prenatal oral disease is not addressed. Currently, medical and dental clinicians are not meeting the oral health needs of pregnant patients.

Objective: Medical and dental providers are not addressing prenatal oral health (POH) with patients despite knowledge of the risks. The objective of this study was to determine how training in dental schools and OB/Gyn residencies may contribute to this paradox.

Methods: We conducted a national survey of 60 dental school deans and 240 obstetrics and gynecology residency program …

Advantage Of Combined Amalgam-Composite Restoration: In Vitro Leakage Study, Ahmed A. Madfa

Ahmed A. Madfa

Purpose: Evalute the leakage of Class II box composite restorations and compared with composite lined by flowable composite and combined amalgam-composite restoration. Method: Fifty-four Class II box shaped cavities were on the distal (1 mm below CEJ) surfaces, 18 cavities for each. Scotchbond Multi-Purpose adhesive system, Filtek Z250 composite, and a metal band system were used for all. After thermocycling test (1000 cycles, 5–55°C with 30 s) and dye immersion, the teeth were sectioned longitudinally in a mesio-distal direction and dye penetration was recorded. Results: Combine amalgam-composite restorations showed less gingival leakage than composite alone and composite lined by flowable …

Application Of Calcium Phosphate Materials In Dentistry, Ahmed A. Madfa

Ahmed A. Madfa

Calcium phosphate materials are similar to bone in composition and in having bioactive and osteoconductive properties. Calcium phosphate materials in different forms, as cements, composites, and coatings, are used in many medical and dental applications. This paper reviews the applications of these materials in dentistry. It presents a brief history, dental applications, and methods for improving their mechanical properties. Notable research is highlighted regarding (1) application of calcium phosphate into various fields in dentistry; (2) improving mechanical properties of calcium phosphate; (3) biomimetic process and functionally graded materials. This paper deals with most common types of the calcium phosphate materials …

Different Loading Times For Dental Implants - No Clinically Important Differences?, Gary Stafford

Gary L Stafford DMD

Data sources The Cochrane Oral Health Group’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, and Embase databases were searched. Reference lists of identified articles were also scanned for relevant papers. There were no restrictions on language or date of publication.

Study selection Randomised controlled trials (RCTs) of parallel group design and of split-mouth design including root-form osseointegrated dental implants having a follow-up of four months to one year after loading were included.

Data extraction and synthesis Data were independently extracted, in duplicate, by at least two review authors. The outcome measures were prosthesis and implant failures …

Dental Student Indebtedness: Where Did It Come From And Where Will It Lead?, Gary Stafford

Gary L Stafford DMD

Today’s dental school graduates are burdened by an ever-increasing amount of student loan debt from both their undergraduate and predoctoral educations. Although considered to be multifactorial in origin, this article explores the microeconomic theory of supply and demand as a source for rising tuition costs and subsequent educational debt. The historical contex for the cost of a dental education is provided, and serious questions are posed about hou this indebtedness might impact the future of the profession.

Replication Of Known Dental Characteristics In Porcine Skin: Emerging Technologies For The Imaging Specialist, L T. Johnson, Thomas W. Radmer, D C. Jeutter, G F. Corliss, Gary L. Stafford, Tom S. Wirtz, R L. Groffy, J D. Thulin, K W. Ahn, A D. Visotky

Gary L Stafford DMD

No abstract provided.