Dentistry Commons^™

Spontaneous Condyle-Like Development After Total Resection Of Mandible Giant Osteochondroma: Case Report And A Follow-Up For Five Years, Marco Antonio De Oliveira Filho, Luis Eduardo Almeida, Andrea Doetzer, Allan Giovanini, Osvaldo Malafaia

School of Dentistry Faculty Research and Publications

Osteochondroma manifests as a benign tumor that occurs as an abnormal bony development. This tumor is commonly asymptomatic and presents an exophytic outgrowth on bone surfaces, near synovial joints, a condition that invariably induces evident facial deformities. Treatment for this type of tumor usually involves a surgical approach promoting a total or partial resection of the affected anatomical area associated to prosthetic reconstruction of the bone area extracted. We present a case report about a giant mandibular condyle osteochondroma in a 37-year-old female patient. Her treatment involved a total condylectomy without immediate condylar reconstruction, which would be performed in a …

Recent Advances In Porphyrin-Based Nanocomposites For Effective Targeted Imaging And Therapy, Navid Rabiee, Mohammad Tavakkoli Yaraki, Soha Mokhtari Garakani, Shima Mokhtari Garakani, Sepideh Ahmadi, Aseman Lajevardi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have …

Polymeric Scaffolds For Dental Pulp Tissue Engineering: A Review, Hossein E. Jazayeri, Su-Min Lee, Lauren Kuhn, Farahnaz Fahimipour, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objectives

The purpose of this review is to describe recent developments in pulp tissue engineering using scaffolds and/or stem cells. It is crucial to understand how this approach can revitalize damaged dentin-pulp tissue. Widespread scaffold materials, both natural and synthetic, and their fabrication methods, and stem-progenitor cells with the potential of pulp regeneration will be discussed.

Data and Sources

A review of literature was conducted through online databases, including MEDLINE by using the PubMed search engine, Scopus, and the Cochrane Library.

Study Selection

Studies were selected based on relevance, with a preference given to recent research, particularly from the past …

Biomedical Applications Of Zeolitic Nanoparticles, With An Emphasis On Medical Interventions, Hossein Derakhshankhah, Samira Jafari, Sajad Sarvari, Ebrahim Barzegari, Faezeh Moakedi, Milad Ghorbani, Behrang Shiri Varnamkhasti, Mehdi Jaymand, Zhila Izadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies …

Current Trends And Future Perspectives Of Oral Pathology: Indian Scenario, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

No abstract provided.

In Vitro Evaluation Of Different Protocols For Preventing Microleakage Of Fissure Sealants Placed Following Saliva Contamination, Hayrunnisa Şimşek, A. Rüya Yazici, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Purpose: To evaluate the effect of different enamel conditioning protocols and their re-application on the microleakage of fissure sealants placed following saliva contamination.

Study design: The study included 156 human third molars in 16 subgroups (2×4×2) under two main groups (sealant type): Group A- hydrophobic resin sealant, 3M Clinpro^™ Sealant; Group B- hydrophilic resin sealant, Ultraseal XT Hydro. Each group was then divided according to the type of surface conditioning; 1- Er,Cr:YSSG laser etching, 2- acid-etching, 3- acid-etching+etch-and-rinse adhesive (Prime&Bond^® One Select) and 4- self-etching adhesive (Clearfil^™SE Bond). After contaminating the conditioned occlusal enamel surfaces with …

Multitarget Stool Dna Testing For The Prevention Of Colon Cancer: Outcomes In A Large Integrated Healthcare System, Nimish Vakil, Kristin Ciezki, Nadia Huq, Maharaj Singh

School of Dentistry Faculty Research and Publications

Background and Aims

Multitarget stool DNA (MT-sDNA) testing is used in primary care as a screening test for colon cancer. Test effectiveness and patient compliance were examined in clinical practice.

Methods

We assessed outcomes of MT-sDNA testing in a cohort study conducted in a large integrated healthcare system comprising 15 hospitals and 150 outpatient clinics using advanced electronic data capture (Clarity2 [Epic, Verona, Wisc, USA] and REDCap [Encinitas, Calif, USA]) followed by manual chart review to confirm MT-sDNA test results and to monitor the outcomes of subsequent colonoscopy.

Results

A total of 6835 MT-sDNA tests were performed over 1 year …

Hydrogen Peroxide Preconditioning Promotes Protective Effects Of Umbilical Cord Vein Mesenchymal Stem Cells In Experimental Pulmonary Fibrosis, Tayebeh Mahmoudi, Kamal Abdolmohammadi, Hamed Bashiri, Mehdi Mohammadi, Mohammad Jafar Rezaie, Fardin Fathi, Shohreh Fakhari, Mohammad Ali Rezaee, Ali Jalili, Mohammad Reza Rahmani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few available treatments. Mesenchymal stem cell therapy (MSCT), an innovative approach, has high therapeutic potential when used to treat IPF. According to recent data, preconditioning of MSCs can improve their therapeutic effects. Our research focuses on investigating the anti-inflammatory and antifibrotic effects of H₂O₂-preconditioned MSCs (p-MSCs) on mice with bleomycin-induced pulmonary fibrosis (PF).

Methods

Eight-week-old male C57BL/6 mice were induced with PF by intratracheal (IT) instillation of bleomycin (4 U/kg). Human umbilical cord vein-derived MSCs (hUCV-MSCs) were isolated and exposed to a sub-lethal concentration (15 …

A Glassy Carbon Electrode Modified With Reduced Graphene Oxide And Gold Nanoparticles For Electrochemical Aptasensing Of Lipopolysaccharides From Escherichia Coli Bacteria, Mehrab Pourmadadi, Javad Shabani Shayeh, Meisam Omidi, Fatemeh Yazdian, Masoud Alebouyeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

An electrochemical aptasensor is described for the voltammetric determination of lipopolysaccharide (LPS) from Escherichia coli 055:B5. Aptamer chains were immobilized on the surface of a glassy carbon electrode (GCE) via reduced graphene oxide and gold nanoparticles (RGO/AuNPs). Fast Fourier transform infrared, X-ray diffraction and transmission electron microscopy were used to characterize the nanomaterials. Cyclic voltammetry, square wave voltammetry and electrochemical impedance spectroscopy were used to characterize the modified GCE. The results show that the modified electrode has a good selectivity for LPS over other biomolecules. The hexacyanoferrate redox system, typically operated at around 0.3 V (vs. Ag/AgCl) is used as …

Design Of A New 3d‐Printed Joint Plug, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

This paper introduces a kit of parts as a novel three‐dimensional (3D)–printed joint plug, in which each of the parts function cooperatively to treat cartilage damage in joints of the human body (e.g., hips, wrists, elbow, knee, and ankle). Three required and one optional parts are involved in this plug. The first part is a 3D‐printed hard scaffold (bone portion) to accommodate bone cells, and the second is a 3D‐printed soft scaffold (cartilage portion) overlying the bone portion to accommodate chondrocytes. The third part of joint plug is a permeable membrane, termed film, to cover the entire plug to provide …

Synthesis And Application Of Ce-Doped Tio2 Nanoparticles Loaded On Activated Carbon For Ultrasound-Assisted Adsorption Of Basic Red 46 Dye, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ali Akbar Bazrafshan, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Ce was doped on TiO₂ nanoparticles (NPs), and this association was loaded on activated carbon (Ce-TiO₂-NPs-AC). The characterization was completed by FE-SEM, TEM, and XRD, and finally these NPs were used for the ultrasonic-assisted adsorption of Basic Red 46 (BR 46) from aqueous solution. An experimental model suggested by the central composite design (CCD)—as a branch of response surface methodology (RSM)—provides insight into the influence of variables, such as BR 46 concentration, pH, adsorbent mass, and sonication time, on BR 46 removal. Experimental results revealed that setting conditions at 25 mg L⁻¹ of BR 46, pH …

Conductive Nanofibrous Chitosan/Pedot:Pss Tissue Engineering Scaffolds, Ali Abedi, Mahdi Hasanzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Design of a proper scaffold is the first step in fabrication of a tissue engineering product, which should be able to support cellular growth in in vitro conditions. This study focuses on the fabrication and characterization of chitosan (CS) scaffolds containing PEDOT:PSS, a conductive polymer. The scaffold is primarily designed for cardiac tissue engineering, although it can be used for other applications too. Chitosan scaffolds containing 0.3, 0.6 and 1 wt% of PEDOT:PSS are fabricated through electrospinning. The structure and morphology of scaffolds are characterized by scanning electron microscopy (SEM), 3D Laser Measuring Microscopy and Fourier-transform infrared spectroscopy (FTIR). The …

Matrix Metalloproteinases And Temporomandibular Joint Disorder: A Review Of The Literature, Logan Herm, Ardit Haxhia, Flavio Camejo, Lobat Tayebi, Luis Eduardo Almeida

School of Dentistry Faculty Research and Publications

Temporomandibular disorders (TMD) are progressive degenerative disorders that affect the components of the temporomandibular joint (TMJ), characterized by pain and limitations in function. Matrix metalloproteinases (MMP) are enzymes involved in physiological breakdown of tissue that can have a pathological effect from an increase in activity during inflammation. A PubMed search of the current literature (within the past 10 years) was conducted to identify human studies involving matrix metalloproteinases activity in TMJ components of patients with TMD. Two separate searches results in 34 studies, six of which met inclusion criteria. Immunohistochemistry and gene analysis were used to evaluate MMP expression in …

Billed And Paid Amounts For Preventive Procedures In Dental Medicaid, K. Wagner, Aniko Szabo, Elaye Okunseri, Christopher Okunseri

School of Dentistry Faculty Research and Publications

Objective:

To examine trends and variations in billed and paid amounts for preventive dental procedures by race/ethnicity, age, and sex in Wisconsin dental Medicaid.

Methods:

We analyzed data from the 2001 to 2013 Wisconsin Medicaid claims database for preventive dental procedures for children and adults. Billed and paid amounts for preventive dental procedures were aggregated over a visit and adjusted for inflation based on the Medical Care Consumer Price Index produced by the Bureau of Labor Statistics for 2013. Quantile regression was used to examine the trends over time and the effect of patient demographics.

Result:

At the 50th and …

Gene Therapy In Rheumatoid Arthritis: Strategies To Select Therapeutic Genes, Mahdi Zavvar, Sara Assadiasl, Narjes Soleimanifar, Fatemeh Dadgar Pakdel, Kamal Abdolmohammadi, Yousef Fatahi, Mohsen Abdolmaleki, Hamed Baghdadi, Lobat Tayebi, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

Significant advances have been achieved in recent years to ameliorate rheumatoid arthritis (RA) in animal models using gene therapy approaches rather than biological treatments. Although biological agents serve as antirheumatic drugs with suppressing proinflammatory cytokine activities, they are usually accompanied by systemic immune suppression resulting from continuous or high systemic dose injections of biological agents. Therefore, gene transfer approaches have opened an interesting perspective to deliver one or multiple genes in a target‐specific or inducible manner for the sustained intra‐articular expression of therapeutic products. Accordingly, many studies have focused on gene transferring methods in animal models by using one of …

A Graphene Based–Biomimetic Molecularly Imprinted Polyaniline Sensor For Ultrasensitive Detection Of Human Cardiac Troponin T(Ctnt), Meysam Karimi, Mohammad Rabiee, Mohammadreza Tahriri, Reza Salarian, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In the present work, a biomimetic nano-molecularly imprinted polymer (N-MIP) electrode based on a graphene screen-printed electrode was developed for the ultrasensitive detection of cardiac troponin T (cTnT). The biomimetic cavities for targeted sensing for analyte were fabricated by the electropolymerization of conductive co-polymer matrix of aniline and carboxylated aniline on the graphene oxide (GO) electrode, in the presence template protein (cTnT for cardiac troponin T probe) by cyclic voltammetry. The surface characterization of the sensor was performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV), and scanning electron microscopy (SEM). The best biomimetic surface nanotexture was obtained at …

Self-Assembling Of Graphene Oxide On Carbon Quantum Dot Loaded Liposomes, Mohadeseh Hashemi, Javad Mohammadi, Meisam Omidi, Hugh D.C. Smyth, Bharadwaj Muralidharan, Thomas E. Milner, Amir Yadegari, Davoud Ahmadvand, Mohammad Shalbaf, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This paper describes the design of stimuli-sensitive theranostic nanoparticles, composed of reduced graphene oxide (rGO) self-assembled on thermosensitive liposomes encapsulated doxorubicin (DOX) and carbon quantum dot (CQD) (CQD-DOX-rGO-Tlip). The rGO-Tlip particles have been observed to be flower-shaped objects. The thermoresponsive and theranostic potential of CQD-DOX-rGO-Tlips have been studied using differential scanning calorimetry (DSC), ultraviolet visible spectroscopy (UV–Vis), Raman spectroscopy and photoluminescent assays. The chemo-photothermal potential of rGO–Tlip on MD-MB-231 cells during NIR laser irradiation has been examined using MTT assay. Also, the ability of rGO–Tlip to be taken up by MD-MB-231 cells has been studied using confocal microscopy and flowcytometry. …

Recent Advancements In Aptamer-Bioconjugates: Sharpening Stones For Breast And Prostate Cancers Targeting, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Ronak Afshari, Yousef Fatahi, Rassoul Dinarvand, Sepideh Ahmadi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri

School of Dentistry Faculty Research and Publications

Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and …

Effect Of Biomimetic Mineralization On Enamel And Dentin: A Raman And Edx Analysis, Arndt Guentsch, Mina D. Fahmy, Contanze Wehrle, Sandor Nitzsche, Jürgen Popp, David C. Watts, Stefan Kranz, Christoph Krafft, Bernd W. Sigusch

School of Dentistry Faculty Research and Publications

Objective

To investigate the effect of an experimental biomimetic mineralization kit (BIMIN) on the chemical composition and crystallinity of caries-free enamel and dentin samples in vitro.

Methods

Enamel and dentin samples from 20 human teeth (10 for enamel; 10 for dentin) were divided into a control group without treatment and test samples with BIMIN treatment. Quantitative analysis of tissue penetration of fluoride, phosphate, and calcium was performed using energy-dispersive X-ray spectroscopy (EDX). Mineralization depth was measured by Raman spectroscopy probing the symmetric valence vibration near 960 cm⁻¹ as a marker for crystallinity. EDX data was statistically analyzed using …

Effect Of Finish Line Design And Metal Alloy On The Marginal And Internal Gaps Of Selective Laser Melting Printed Copings, Adel Al Maaz, Geoffrey A. Thompson, Carl Drago, Hongseok An, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

Selective laser melting (SLM) technology has been introduced for printing metal dental restorations from Co-Cr base alloys or Au-Pt high noble alloys. However, information regarding the fit of restorations fabricated by using this technique is limited.

Purpose

The purpose of this in vitro study was to determine the effect of 3 different finish line designs on the marginal and internal gaps of metal copings made from a base (Co-Cr), high noble (Au-Pd-Ag), and noble alloy (Co-Pd) by using the SLM technology.

Material and methods

Three Ivorine right maxillary central incisors were prepared with a chamfer, deep chamfer, …

Temperature And Ph-Responsive Nano-Hydrogel Drug Delivery System Based On Lysine-Modified Poly (Vinylcaprolactam), Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E. Welland, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Background: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems.

Purpose: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed.

Methods: Poly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety …

Effect Of Heat-Treatment Time On Bending Properties Of Cobolt-Chromium Orthodontic Wires, Melanie Hammerbeck

Master's Theses (2009 -)

Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires. Two tempers of CoCr ‘Elgiloy’ wires (Rocky Mountain Orthodontics), blue (B) and yellow (Y), were heat-treated for different durations. The groups (n=20/group/temper) included: 1) as-received (control); 2) brush-flame; 3) 480oC for 5sec; 4) 480oC for 10min; 5) 480oC for 2hr; and 6) 480oC for 5hr. Wire segments were tested by a three-point bend test. Stiffness/flexural modulus, percent recovery, and force values at select deflections were statistically compared …

Efficacy Of Invisalign Attachments: A Retrospective Study, Theresa Karras

Master's Theses (2009 -)

Objective: To compare the efficacy of Invisalign’s (Align Technology, Inc., Santa Clara, CA) optimized and conventional attachments on rotational and extrusive tooth movements.Materials and Methods: Initial, predicted, and achieved digital dental models from 100 orthodontic patients were exported from Invisalign’s ClinCheck software as stereolithography (STL) files and subsequently imported into the Slicer CMF program (open source, version 4.7.0) for superimpositions on posterior teeth with no planned movement. Rotational and extrusive measurements for both optimized and conventional attachment types were made on 382 teeth from the superimposition of the initial and predicted models (“predicted movement”) and from the superimposed initial and …

The Cytotoxicity Effect Of Silver Solder Materials On Human Periodontal Ligament Fibroblast Cells, Joseph Jeffrey Curry

Master's Theses (2009 -)

Objectives:Orthodontic appliances with silver soldering can be in the oral cavity for several years and very few studies have been done to detect the biosafety of the silver solders. The aim of this in vitro study was to compare the cytotoxicity effects of two different solder materials on Human Periodontal Ligament Fibroblast cells (HPLF).Methods:Two commonly used solder materials from two companies, (Leone and Summit) with different metal elements and percentages were studied. The solder samples were exposed to HPLF cells for 48 hours and the cytotoxicity effect of soldered materials on HPLF cells was measured via the MTT colorimetric assay …

The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis - A Micro-Ct Study, Andrei Dan Taut

Master's Theses (2009 -)

Introduction: Vibration in the form of high frequency, low magnitude acceleration has paradoxical effects on craniofacial bones – with anabolic effects under physiological conditions and catabolic effects in the presence of inflammation. The objectives of this study are to establish a murine model for periodontitis and to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature- induced experimental periodontitis.Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment …

Evaluation Of Corrosion Mechanisms In Stainless Steel Orthodontic Retainer Wires, Jamie Martin

Master's Theses (2009 -)

Title: Evaluation of Corrosion Mechanisms in Stainless Steel Orthodontic Retainer WiresAuthors: Jamie Martin, Ghada Nimeri, David BerzinsObjective:Orthodontic retainers fabricated from stainless steel wire and acrylic are prone to several types of corrosion in the oral environment, including stress, crevice, and galvanic corrosion. The aim of this study was to determine the relative effect of stress corrosion, galvanic corrosion, and crevice corrosion on stainless steel retainer wires.Methods:Three different brands of 0.032-inch stainless steel wires were tested. Six new segments (2-inch length) of each brand of wire were tested in each of four tests: 1) in an artificial saliva solution to determine …

Effects Of Dental Composite Resin Monomers On Dental Pulp Cells, Thomas R. Schneider, Roxan Hakami-Tafreshi, Alexandra Tomasino-Perez, Lobat Tayebi, Doug Lobner

School of Dentistry Faculty Research and Publications

Methacrylate monomers found in many dental materials cause toxicity to dental pulp cells but the mechanism of the toxicity is poorly understood. We used cultured human dental pulp cells to test the effects of three commonly used monomers; bisphenol-A-glycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA), and triethyleneglycol dimethacrylate (TEGDMA). The order of toxicity was Bis-GMA>UDMA>TEGDMA. The toxicity correlated inversely with cystine uptake, with TEGDMA stimulating uptake and BisGMA and UDMA inhibiting uptake. Bis-GMA and UDMA induced oxidative stress, while TEGDMA did not. Toxicity correlated poorly with glutathione levels, as all compounds decreased cellular glutathione. TEGDMA is less toxic than …

Stimulus-Responsive Polymeric Nanogels As Smart Drug Delivery Systems, Sakineh Hajebi, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Hossein Roghani-Mamaqani, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in non-target tissues and …

Comparison Of Gingival Retraction Materials Using A New Gingival Sulcus Model, Marco Dederichs, Mina D. Fahmy, Harald Kuepper, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Purpose

To investigate the pressure generated by different retraction materials using a novel gingival sulcus model.

Materials and Methods

A gingival sulcus model was made using a polymer frame filled with silicon. A pressure sensor and a sulcus‐fluid simulation were embedded into the silicon chamber to evaluate the pressure generated by different retraction materials. Six sizes of Ultrapak retraction cords (Ultradent, sizes #000 ‐ 3), 4 retraction pastes (Expazen, Expasyl, Acteon, Access Edge, Traxodent) and 2 retraction gels (Sulcus Blue, Racegel) were analyzed. The mean and median pressure, interquartile range, and standard deviation (SD) of n = 10 repeated measurements …

Bicyclic Peptides: Types, Synthesis And Applications, Shahrzad Ahangarzadeh, Mohammad M. Kanafi, Simzar Hosseinzadeh, Ahad Mokhtarzadeh, Mahmood Barati, Javad Ranjbari, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging …