Open Access. Powered by Scholars. Published by Universities.®

Dentistry Commons™

Open Access. Powered by Scholars. Published by Universities.®

LSU Health New Orleans

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 31 - 60 of 71

Full-Text Articles in Dentistry

Agenda (Pdf), School Of Dentistry Jun 2024

Agenda (Pdf), School Of Dentistry

LSU School of Dentistry Research Day

Agenda for the LSUSD Research Day held June 14, 2024.


Fake Xanax: Designer Emerging Benzodiazepine Epidemic Linked To Morbidity And Mortality A Narrative Review, Alan D. Kaye, Joseph P. Tassin, William C. Upshaw, Camille M. Robichaux, Mark V. Frolov, Mark M. Dupaquier, Julia E. Fox, Jeffrey Sterritt, Jibin Mathew, Sahar Shekoohi, Adam M. Kaye, Amber N. Edinoff May 2024

Fake Xanax: Designer Emerging Benzodiazepine Epidemic Linked To Morbidity And Mortality A Narrative Review, Alan D. Kaye, Joseph P. Tassin, William C. Upshaw, Camille M. Robichaux, Mark V. Frolov, Mark M. Dupaquier, Julia E. Fox, Jeffrey Sterritt, Jibin Mathew, Sahar Shekoohi, Adam M. Kaye, Amber N. Edinoff

School of Dentistry Faculty Publications

Etizolam is a thienodiazepine derivative which produces an anxiolytic effect similar to benzodiazepines such as alprazolam (Xanax). Like classic benzodiazepines, etizolam has a high affinity towards the GABAA receptor, and allosterically potentiates the effects of GABA resulting in neuronal hyperpolarization related to chloride influx. When taken in therapeutic doses, etizolam produces a similar effect to Xanax. Counterfeit Xanax tablets contain variable amounts of etizolam. Tablets with high amounts of etizolam can cause toxicity if ingested, especially when combined with other substances. When toxic symptoms occur in patients, they may include severe sedation, unconsciousness, and depression of the medullary respiratory center. …


Areas Of Interest In Dental Education: A Bibliometric Analysis Of The Last Decade, Eswar Kandaswamy May 2024

Areas Of Interest In Dental Education: A Bibliometric Analysis Of The Last Decade, Eswar Kandaswamy

School of Dentistry Faculty Publications

This study aimed to perform a comprehensive bibliometric analysis of journals focused on dental education (Journal of Dental Education and European Journal of Dental Education) from 2014 to 2023. An ISI Web of Science Search was performed in October 2023 with no filters for language or keywords. Published articles between 2014 and 2018, 2019 and 2023, and 2014-2023, along with the top 100 cited articles published within this period were exported as txt files. Keyword and title word network maps and occurrences were generated using VOS Viewer software. Author-affiliated countries with the most publications were tabulated from the Web of …


Association Of F. Alocis And D. Pneumosintes With Periodontitis Disease Severity And Red Complex Bacteria, Hawaabi F.M. Shaikh, Pratima U. Oswal, Manohar Suresh Kugaji, Sandeep S. Katti, Kishore Gajanan Bhat, Eswar Kandaswamy, Vinayak M. Joshi Apr 2024

Association Of F. Alocis And D. Pneumosintes With Periodontitis Disease Severity And Red Complex Bacteria, Hawaabi F.M. Shaikh, Pratima U. Oswal, Manohar Suresh Kugaji, Sandeep S. Katti, Kishore Gajanan Bhat, Eswar Kandaswamy, Vinayak M. Joshi

School of Dentistry Faculty Publications

Oral biofilms are considered the principal etiological agent in the development of periodontitis. Novel species that may contribute to periodontitis and dysbiosis have been identified recently. The study aims to evaluate the presence of F. alocis and D. pneumosintes in healthy and diseased patients and their association with clinical parameters and with red complex bacteria. The study included 60 subjects, with 30 patients each in the healthy and periodontitis groups. The clinical parameters were noted, and samples were subjected to DNA extraction followed by a polymerase chain reaction. Statistical analysis was performed using the Graph Pad Prism software. Results: F. …


The Effect Of Die Material On The Crown Fracture Strength Of Zirconia Crowns, Akram Sayed Ahmed, Nathaniel C. Lawson, Chin-Chuan Fu, Pranit V. Bora, Edwin Kee, Amir H. Nejat Feb 2024

The Effect Of Die Material On The Crown Fracture Strength Of Zirconia Crowns, Akram Sayed Ahmed, Nathaniel C. Lawson, Chin-Chuan Fu, Pranit V. Bora, Edwin Kee, Amir H. Nejat

School of Dentistry Faculty Publications

BACKGROUND: Determination of the eligibility of several tooth analog materials for use in crown fracture testing. METHODS: A standardized premolar crown preparation was replicated into three types of resin dies (C&B, low modulus 3D printed resin; OnX, high modulus 3D printed resin composite; and highest modulus milled resin composite). 0.8 mm zirconia crowns were bonded to the dies and the maximum fracture load of the crowns was tested. Twelve extracted human premolars were prepared to a standardized crown preparation, and duplicate dies of the prepared teeth were 3D printed out of C&B. Zirconia crowns were bonded to both the dies …


Impaired Neutrophil Extracellular Trap-Forming Capacity Contributes To Susceptibility To Chronic Vaginitis In A Mouse Model Of Vulvovaginal Candidiasis, Junko Yano, Paul L. Fidel Jan 2024

Impaired Neutrophil Extracellular Trap-Forming Capacity Contributes To Susceptibility To Chronic Vaginitis In A Mouse Model Of Vulvovaginal Candidiasis, Junko Yano, Paul L. Fidel

School of Dentistry Faculty Publications

Vulvovaginal candidiasis (VVC), caused by is characterized by aberrant inflammation by polymorphonuclear neutrophils (PMNs) in the vaginal lumen. Data from the established murine model shows that despite potent antifungal properties, PMNs fail to clear due to local heparan sulfate that inhibits the interaction between PMNs and , resulting in chronic vaginal immunopathology. To understand the role of neutrophil extracellular traps (NETs) in defense against at the vaginal mucosa, we investigated the NET-forming capacity of PMNs in chronic VVC-susceptible (CVVC-S/C3H) and -resistant (CVVC-R/CD-1) mouse strains. Immunofluorescence revealed the formation of NETs (release of DNA with PMN-derived antimicrobial proteins) in PMN cocultures …


Standardised Tool For The Assessment Of Bruxism, Daniele Manfredini, Jari Ahlberg, Ghizlane Aarab, Steven Bender, Alessandro Bracci, Peter A. Cistulli, Paulo Cesar Conti, Reny De Leeuw, Justin Durham, Alona Emodi-Perlman, Dominik Ettlin, Luigi M. Gallo, Birgitta Häggman-Henrikson, Christer Hublin, Takafumi Kato, Gary Klasser, Michail Koutris, Gilles J. Lavigne, Daniel Paesani, Ingrid Peroz, Peter Svensson, Peter Wetselaar, Frank Lobbezoo Dec 2023

Standardised Tool For The Assessment Of Bruxism, Daniele Manfredini, Jari Ahlberg, Ghizlane Aarab, Steven Bender, Alessandro Bracci, Peter A. Cistulli, Paulo Cesar Conti, Reny De Leeuw, Justin Durham, Alona Emodi-Perlman, Dominik Ettlin, Luigi M. Gallo, Birgitta Häggman-Henrikson, Christer Hublin, Takafumi Kato, Gary Klasser, Michail Koutris, Gilles J. Lavigne, Daniel Paesani, Ingrid Peroz, Peter Svensson, Peter Wetselaar, Frank Lobbezoo

School of Dentistry Faculty Publications

OBJECTIVE: This paper aims to present and describe the Standardised Tool for the Assessment of Bruxism (STAB), an instrument that was developed to provide a multidimensional evaluation of bruxism status, comorbid conditions, aetiology and consequences. METHODS: The rationale for creating the tool and the road map that led to the selection of items included in the STAB has been discussed in previous publications. RESULTS: The tool consists of two axes, specifically dedicated to the evaluation of bruxism status and consequences (Axis A) and of bruxism risk and etiological factors and comorbid conditions (Axis B). The tool includes 14 domains, accounting …


Id Fellow Quality Improvement Project Shows Gains In Oral Health Exams For People With Hiv, Terrence Park, Lauren Richey, Paula Seal Nov 2023

Id Fellow Quality Improvement Project Shows Gains In Oral Health Exams For People With Hiv, Terrence Park, Lauren Richey, Paula Seal

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11 - 15, 2023, Boston, MA


Bond Strength Of Reline Materials To 3d-Printed Provisional Crown Resins, Jorge Palavicini, Sherrod L. Quin, Wael Zakkour, Karim Zakkour, Safa Manafi Varkiani, Xiaoming Xu, Nathaniel C. Lawson, Amir Hossein Nejat Sep 2023

Bond Strength Of Reline Materials To 3d-Printed Provisional Crown Resins, Jorge Palavicini, Sherrod L. Quin, Wael Zakkour, Karim Zakkour, Safa Manafi Varkiani, Xiaoming Xu, Nathaniel C. Lawson, Amir Hossein Nejat

School of Dentistry Faculty Publications

(1) Purpose: The aim of the present study was to compare the bond strength between two 3D-printed resins designed for long-term provisional crowns and three different reline materials. (2) Materials and Methods: Rectangular specimens were prepared from two 3D-printed resins (Envision Tech and NextDent C&B) and a conventional self-cure PMMA. Transparent tubes filled with three different reline materials including composite resin, Bis-acryl, and PMMA were bonded to the 3D-printed specimens (n = 11 per group, total of 6 study groups). Tubes filled with PMMA were bonded to the prepared PMMA specimens which served as the control group (n = 11, …


Candida-Induced Granulocytic Myeloid-Derived Suppressor Cells Are Protective Against Polymicrobial Sepsis, Shannon Esher Righi, Amanda J. Harriett, Elizabeth A. Lilly, Paul L. Fidel Jr., Mairi C. Noverr Sep 2023

Candida-Induced Granulocytic Myeloid-Derived Suppressor Cells Are Protective Against Polymicrobial Sepsis, Shannon Esher Righi, Amanda J. Harriett, Elizabeth A. Lilly, Paul L. Fidel Jr., Mairi C. Noverr

School of Dentistry Faculty Publications

Polymicrobial intra-abdominal infections (IAI) can lead to life-threatening sepsis with significant morbidity and mortality, especially when pathogenic fungi are involved. We have employed an established clinically relevant mouse model of fungal/bacterial IAI and shown that immunization with low-virulence Candida species, that is, Candida dubliniensis, can induce responses that protect against sepsis via the suppression of lethal inflammation. This protection is dependent on long-lived Gr-1(+) polymorphonuclear leukocytes that display characteristics consistent with myeloid-derived suppressor cells (MDSCs) and trained innate immunity. Here we aimed to functionally and phenotypically characterize these protective Gr-1(+) leukocytes. Compared to nonimmunized control mice, we observed increased levels …


Association Between Acculturation, Dental Floss Use, Dental Visits And Unmet Dental Needs Among Asians In The United States: Findings From National Health And Nutrition Examination Survey (Nhanes) 2011–2018, Ting Luo, Kaylin Beiter, Tung Sung Tseng Aug 2023

Association Between Acculturation, Dental Floss Use, Dental Visits And Unmet Dental Needs Among Asians In The United States: Findings From National Health And Nutrition Examination Survey (Nhanes) 2011–2018, Ting Luo, Kaylin Beiter, Tung Sung Tseng

School of Graduate Studies Faculty Publications

Objectives: The objectives of this study were to examine the associations between acculturation and dental floss, regular dental visits and unmet dental care needs among Asian Americans, as well as the moderating effects of these associations. Methods: This study analysed national representative samples from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. A total of 2763 Asian Americans aged 20 and older were included in this analysis. The primary predictor, acculturation score, was determined by three questions: (i) language spoken at home (higher score for English), (ii) country of birth (higher score for United States) and (iii) length of …


Impacts Of A Duf2207 Family Protein On Streptococcus Mutans Stress Tolerance Responses And Biofilm Formation, Xiaochang Huang, Camile G. Laird, Paul P. Riley, Zezhang Tom Wen Aug 2023

Impacts Of A Duf2207 Family Protein On Streptococcus Mutans Stress Tolerance Responses And Biofilm Formation, Xiaochang Huang, Camile G. Laird, Paul P. Riley, Zezhang Tom Wen

School of Dentistry Faculty Publications

Locus SMU.243 in Streptococcus mutans was annotated as a member of the DUF2207 family proteins highly conserved in all bacteria but with unknown function. To investigate its role in S. mutans physiology, a SMU.243-deficient mutant was constructed using allelic exchange mutagenesis, and the impacts of SMU.243 deletion on bacterial growth, stress tolerance response, and biofilm formation were analyzed. Compared to the wild-type UA159, S. mutans lacking SMU.243 displayed a reduced growth rate and a reduced overnight culture density (p < 0.01) when grown at low pH and in the presence of methyl viologen. Relative to the parent strain, the deficient mutant also had a reduced survival rate following incubation in a buffer of pH 2.8 (p < 0.01) and in a buffer containing hydrogen peroxide at 58 mM after 60 min (p < 0.001) and had a reduced capacity in biofilm formation especially in the presence of sucrose (p < 0.01). To study any ensuing functional/phenotypical links between SMU.243 and uppP, which is located immediately downstream of SMU.243 and encodes an undecaprenyl pyrophosphate phosphatase involved in recycling of carrier lipid undecaprenyl phosphate, a uppP deficient mutant was generated using allelic exchange mutagenesis. Unlike the SMU.243 mutant, deletion of uppP affected cell envelope biogenesis and caused major increases in susceptibility to bacitracin. In addition, two variant morphological mutants, one forming rough colonies and the other forming mucoid, smooth colonies, also emerged following the deletion of uppP. The results suggest that the SMU.243-encoded protein of the DUF2207 family in S. mutans plays an important role in stress tolerance response and biofilm formation, but unlike the downstream uppP, does not seem to be involved in cell envelope biogenesis, although the exact roles in S. mutans’ physiology awaits further investigation.


Treatment Of Periodontitis Affecting Human Primary Teeth—A Systematic Review, Protyusha Guha Biswas, Anusha Mohan, Eswar Kandaswamy Jul 2023

Treatment Of Periodontitis Affecting Human Primary Teeth—A Systematic Review, Protyusha Guha Biswas, Anusha Mohan, Eswar Kandaswamy

School of Dentistry Faculty Publications

The aim of this systematic review is to report the treatment options (Intervention) and outcomes (O) for primary teeth affected by periodontitis (Population) and if the treatment of primary teeth can prevent the spread of periodontitis to permanent teeth (Outcomes). The following databases were searched for papers published before December 2022: PubMed, Embase, Web of Science, and Ebscohost. Studies on children affected by periodontitis involving the primary teeth were included and those on children who presented with periodontitis as a manifestation of systemic disease were excluded. Narrative synthesis and methodological quality assessments were performed for the included studies. Three interventional …


Current Oral Hygiene And Recreational Behavioral Trends In Hiv Disease, Donald E. Mercante, Emily Guarisco, Elizabeth A. Lilly, Arni Rao, Kelly Treas, Clifford J. Beall, Zach Thompson, Ann L. Griffen, Eugene J. Leys, Jose A. Vazquez, Michael E. Hagensee, Paul L. Fidel Jul 2023

Current Oral Hygiene And Recreational Behavioral Trends In Hiv Disease, Donald E. Mercante, Emily Guarisco, Elizabeth A. Lilly, Arni Rao, Kelly Treas, Clifford J. Beall, Zach Thompson, Ann L. Griffen, Eugene J. Leys, Jose A. Vazquez, Michael E. Hagensee, Paul L. Fidel

School of Dentistry Faculty Publications

Objective: HIV disease is evolving with more HIV+ persons experiencing a high quality of life with well-controlled viremia. We recently enrolled a large cohort of HIV+ and clinically relevant HIV− persons for oral microbiome analyses that included a questionnaire related to oral hygiene and recreational behaviors. Here, the questionnaire responses were analyzed for behavioral trends within the cohort, together with trends over time by comparison to a previous geographically centered HIV+ cohort. Methods: Data were collected by questionnaire at baseline visits as cross-sectional assessments. Multivariable analyses were conducted for associations of HIV status as well as age, race, and sex, …


2023 Agenda (Pdf), School Of Dentistry Jun 2023

2023 Agenda (Pdf), School Of Dentistry

LSU School of Dentistry Research Day

Agenda for the LSUSD Research Day held June 9, 2023.


Defining Success In Healthcare Education: Us Dental Student And Faculty Perspectives., David Alexandre Cruz Walma, Mathieu Alexander Cruz Walma, Shirin Khoynezhad, Sang E. Park, Carly Timmons Mckenzie, Et Al Jun 2023

Defining Success In Healthcare Education: Us Dental Student And Faculty Perspectives., David Alexandre Cruz Walma, Mathieu Alexander Cruz Walma, Shirin Khoynezhad, Sang E. Park, Carly Timmons Mckenzie, Et Al

School of Dentistry Faculty Publications

Purpose/objectives Academic metrics and clinical performance are necessary but alone insufficient in describing success in dental education. This paper identifies themes critical for dental student success as commonly cited by both dental students and faculty. Methods Dental faculty interviews and pre-doctoral D2/D3/D4 student focus groups at two dental institutions generated data for thematic analysis. Themes were individually identified then merged, compared, and contrasted to establish a definitive list of key themes reflected in student and faculty comments. Results Twenty-five pre-doctoral students participated in one of four focus groups (two focus groups at each dental institution). Thirteen dental education faculty across …


Acceptability Of Fully Guided Virtual Implant Planning Software Among Dental Undergraduate Students, Shishir Ram Shetty, Colin Murray, Sausan Al Kawas, Sara Jaser, Wael Talaat, Medhini Madi, Vinayak Kamath, Nisha Manila, Raghavendra Shetty, Vidya Ajila May 2023

Acceptability Of Fully Guided Virtual Implant Planning Software Among Dental Undergraduate Students, Shishir Ram Shetty, Colin Murray, Sausan Al Kawas, Sara Jaser, Wael Talaat, Medhini Madi, Vinayak Kamath, Nisha Manila, Raghavendra Shetty, Vidya Ajila

School of Dentistry Faculty Publications

Background: Fully guided implant surgery as a technique is gaining popularity. It has been observed that use of surgical guides improves precision and predictability for dental implant placement. However, like any other newer technology, the acceptance of fully guided dental implant technology among users is based upon its perceived usability. This study aimed at evaluating the perception about using Virtual Implant Planning Software (VIPS) among undergraduate dental students at the university of Sharjah. Methods: Ninety-Six dental surgery students from the University of Sharjah were included in the study. One week after the Virtual Implant Planning Software (Planmeca Romexis version 6.2 …


Research Routes On Awake Bruxism Metrics: Implications Of The Updated Bruxism Definition And Evaluation Strategies., Alessandro Bracci, Frank Lobbezoo, Anna Colonna, Steven Bender, Paulo C. R. Conti, Alona Emodi‐Perlman, Birgitta Häggman‐Henrikson, Gary D. Klasser, Ambra Michelotti, Gilles J. Lavigne, Peter Svensson, Jari Ahlberg, Daniele Manfredini May 2023

Research Routes On Awake Bruxism Metrics: Implications Of The Updated Bruxism Definition And Evaluation Strategies., Alessandro Bracci, Frank Lobbezoo, Anna Colonna, Steven Bender, Paulo C. R. Conti, Alona Emodi‐Perlman, Birgitta Häggman‐Henrikson, Gary D. Klasser, Ambra Michelotti, Gilles J. Lavigne, Peter Svensson, Jari Ahlberg, Daniele Manfredini

School of Dentistry Faculty Publications

Background: With time, due to the poor knowledge on it epidemiology, the need to focus on awake bruxism as a complement of sleep studies emerged. Objective: In line with a similar recent proposal for sleep bruxism (SB), defining clinically oriented research routes to implement knowledge on awake bruxism (AB) metrics is important for an enhanced comprehension of the full bruxism spectrum, that is better assessment and more efficient management. Methods: We summarised current strategies for AB assessment and proposed a research route for improving its metrics. Results: Most of the literature focuses on bruxism in general or SB in particular, …


Independent Effects Of Hiv And Antiretroviral Therapy On The Oral Microbiome Identified By Multivariate Analyses, Clifford J. Beall, Elizabeth A. Lilly, Carolina Granada, Kelly Treas, Kenneth R. Dubois, Shahr B. Hashmi, Jose A. Vazquez, Michael E. Hagensee, Ann L. Griffen, Eugene J. Leys, Paul L. Fidel Apr 2023

Independent Effects Of Hiv And Antiretroviral Therapy On The Oral Microbiome Identified By Multivariate Analyses, Clifford J. Beall, Elizabeth A. Lilly, Carolina Granada, Kelly Treas, Kenneth R. Dubois, Shahr B. Hashmi, Jose A. Vazquez, Michael E. Hagensee, Ann L. Griffen, Eugene J. Leys, Paul L. Fidel

School of Dentistry Faculty Publications

The oral microbiome is an important predictor of health and disease. We recently reported significant yet modest effects of HIV under highly active antiretroviral therapy (ART) on the oral microbiome (bacterial and fungal) in a large cohort of HIV-positive (HIV+) and matched HIV-negative (HIV-) individuals. As it was unclear whether ART added to or masked further effects of HIV on the oral microbiome, the present study aimed to analyze the effects of HIV and ART independently, which also included HIV- subjects on preexposure prophylaxis (PrEP) therapy. Cross-sectional analyses of the effect of HIV devoid of ART (HIV+ ART- versus matched …


Burning Mouth Disorder And Parkinson's Disease: A Scoping Review Of The Literature, O. Guru, Ramesh Balasubramaniam, Gary D. Klasser Feb 2023

Burning Mouth Disorder And Parkinson's Disease: A Scoping Review Of The Literature, O. Guru, Ramesh Balasubramaniam, Gary D. Klasser

School of Dentistry Faculty Publications

Background: Burning mouth disorder (BMD) is a complex medical condition characterized by a burning sensation in the mouth of fluctuating intensity. BMD is considered a diagnosis of exclusion, as oral burning can occur secondary to local or systemic conditions. Parkinson's disease (PD) is one such condition. Objective: To provide a scoping review of the literature by assessing all articles written in English that investigated the relationship between BMD and PD. Materials and Methods: Various databases (PubMed, Ovid, Web of Science, Science Direct and Scopus) and a search platform (EBSCOhost) were searched following similar investigative approaches. Duplicates were removed and reference …


Saliva As A Diagnostic Tool To Measure Polycyclic Aromatic Hydrocarbon Exposure In Dental Patients Exposed To Intimate Partner Violence (Ipv), Aramandla Ramesh, Leslie R. Halpern, Janet H. Southerland, Samuel E. Adunyah, Pandu R. Gangula Feb 2023

Saliva As A Diagnostic Tool To Measure Polycyclic Aromatic Hydrocarbon Exposure In Dental Patients Exposed To Intimate Partner Violence (Ipv), Aramandla Ramesh, Leslie R. Halpern, Janet H. Southerland, Samuel E. Adunyah, Pandu R. Gangula

School of Dentistry Faculty Publications

Background: Social habits such as tobacco use, alcohol consumption, and chemically contaminated diet contribute to poor oral health. Intimate Partner Violence (IPV) is a global public health epidemic which can exacerbate the prevalence of health conditions affecting a victim's lifespan. This study investigates using saliva as a biomarker for detecting levels of benzo(a)pyrene [B(a)P]; a toxicant present in cigarette smoke and barbecued meat in a population of IPV + female patients. Methods: A cross-sectional IRB-approved study utilized 63 female participants (37 African Americans [AA], and 26 non-African Americans [NAA]), who provided consent for the study. Participants submitted samples of saliva, …


Molecular Characteristics Of Periodontal Health: Collagens: Defining The Healthy Human Gingival Collagen Transcriptome, Christina Zachariadou, Thomas Hart, Deborah Hooper, Angelo Mariotti Jan 2023

Molecular Characteristics Of Periodontal Health: Collagens: Defining The Healthy Human Gingival Collagen Transcriptome, Christina Zachariadou, Thomas Hart, Deborah Hooper, Angelo Mariotti

School of Dentistry Faculty Publications

Background: Defining periodontal health has been an ambitious and complex goal. The numerous and varied definitions of what constitutes periodontal health have resulted in a collection of subjective and unreliable clinical findings to diagnose and classify periodontal health and disease. The aim of this study was to fundamentally delineate the molecular characteristics of healthy periodontal tissues in men and women as they age, using the most abundant connective tissue component: Collagens. Methods: Healthy gingival biopsies were separated into “young” (aged 18–35 years, five men/five women) and “old” (≥60 years, five men/four women) age groups depending on biological sex. RNA was …


Revised Fdi Criteria For Evaluating Direct And Indirect Dental Restorations—Recommendations For Its Clinical Use, Interpretation, And Reporting, Reinhard Hickel, Sabine Mesinger, Niek Opdam, Bas Loomans, Roland Frankenberger, Milena Cadenaro, John Burgess, Arnd Peschke, Siegward D. Heintze, Jan Kühnisch Dec 2022

Revised Fdi Criteria For Evaluating Direct And Indirect Dental Restorations—Recommendations For Its Clinical Use, Interpretation, And Reporting, Reinhard Hickel, Sabine Mesinger, Niek Opdam, Bas Loomans, Roland Frankenberger, Milena Cadenaro, John Burgess, Arnd Peschke, Siegward D. Heintze, Jan Kühnisch

School of Dentistry Faculty Publications

Objectives: The FDI criteria for the evaluation of direct and indirect dental restorations were first published in 2007 and updated in 2010. Meanwhile, their scientific use increased steadily, but several questions from users justified some clarification and improvement of the living document. Materials and methods: An expert panel (N = 10) initiated the revision and consensus process that included a kick-off workshop and multiple online meetings by using the Delphi method. During and after each round of discussion, all opinions were collected, and the aggregated summary was presented to the experts aiming to adjust the wording of the criteria as …


Clinical Advantages Of Immediate Posterior Implants With Custom Healing Abutments: Up To 8-Year Follow-Up Of 115 Cases, Richard Akin, Andrew G. Chapple Dec 2022

Clinical Advantages Of Immediate Posterior Implants With Custom Healing Abutments: Up To 8-Year Follow-Up Of 115 Cases, Richard Akin, Andrew G. Chapple

School of Dentistry Faculty Publications

Purpose: Proper management of the soft tissues around dental implants is crucial to their long-term function and esthetics. The purpose of this article is to report the survival rate of immediate posterior implants when using an immediate chair-side technique for custom healing abutments. Materials and Methods: The investigator implemented a retrospective case series analysis of a sample of 115 consecutive patients with 1 posterior dental implant placed between February 1, 2012 and December 9, 2014, in the author's private practice who underwent the previously published technique for immediate custom chair-side healing abutment fabrication. In this descriptive analysis, the primary outcome …


The Effect Of Silver Diamine Fluoride On Bond Strength Of Three Types Of Bulk-Fill Restorative Materials To Dentin., Nasrin Danaeifar, Amir Hossein Nejat, Zafar Cehreli, Richard W. Ballard, Jeffrey T. Johnson Jul 2022

The Effect Of Silver Diamine Fluoride On Bond Strength Of Three Types Of Bulk-Fill Restorative Materials To Dentin., Nasrin Danaeifar, Amir Hossein Nejat, Zafar Cehreli, Richard W. Ballard, Jeffrey T. Johnson

School of Dentistry Faculty Publications

No abstract provided.


Anatomic Considerations Of Perinasal Musculature For Improved Dental Show During Smile In Facial Synkinesis, Laura T. Hetzler, Marcus Hershey, Todd Lambert, Jason Mussell, Lee Mcdaniel, Sara Macdowell Mar 2022

Anatomic Considerations Of Perinasal Musculature For Improved Dental Show During Smile In Facial Synkinesis, Laura T. Hetzler, Marcus Hershey, Todd Lambert, Jason Mussell, Lee Mcdaniel, Sara Macdowell

School of Medicine Faculty Publications

Introduction: There is an anatomic explanation for upper lip and midfacial tethering resulting in lack of motion in facial synkinesis. Objective: To measure the effect of perinasal chemodenervation on dental show in the synkinetic population and clarify the anatomic relationship of perinasal musculature. Methods: Literature search was performed on anatomy of the perinasal modiolus, and anatomic evaluation was performed through human anatomic specimen dissection. Photographic outcomes were observed in synkinetic patients receiving chemodenervation to smile antagonists with and without perinasal muscle injections and assessed through naive observer survey. Retrospective outcomes for all patients receiving perinasal chemodenervation was collected utilizing Facial …


A Wechat-Based Smoking Cessation Intervention For Chinese Smokers: A Pilot Study, Ting Luo, Mirandy S. Li, Donna Williams, Jackson Fritz, Kaylin Beiter, Stephen Phillippi, Qingzhao Yu, Stephen P. Kantrow, Wei Ting Lin, Yu Hsiang Kao, Yongchun Chen, Liwei Chen, Tung-Sung Tseng Feb 2022

A Wechat-Based Smoking Cessation Intervention For Chinese Smokers: A Pilot Study, Ting Luo, Mirandy S. Li, Donna Williams, Jackson Fritz, Kaylin Beiter, Stephen Phillippi, Qingzhao Yu, Stephen P. Kantrow, Wei Ting Lin, Yu Hsiang Kao, Yongchun Chen, Liwei Chen, Tung-Sung Tseng

School of Public Health Faculty Publications

Background: China is the largest tobacco producer and has the highest number of tobacco consumers in the world. Extensive research has demonstrated the utility of social media for smoking cessation. WeChat is the most commonly used social media platform in China, but has not yet been utilized for smoking cessation interventions. The objectives of this study are (1) to evaluate the efficacy of a WeChat-based smoking cessation intervention; and (2) to examine a possible additive effect of integrating oral health and smoking-related information into a tailored, Transtheoretical Model (TTM) guided smoking cessation intervention. Methods: Eligible adults were recruited through WeChat …


A Comparison Of Traditional Orthodontic Polishing Systems With Composite Polishing Systems Following Orthodontic Debonding, Elizabeth A. Melvin, Qingzhao Yu, Xiaoming Xu, Camille G. Laird, Paul C. Armbruster, Richard W. Ballard Dec 2021

A Comparison Of Traditional Orthodontic Polishing Systems With Composite Polishing Systems Following Orthodontic Debonding, Elizabeth A. Melvin, Qingzhao Yu, Xiaoming Xu, Camille G. Laird, Paul C. Armbruster, Richard W. Ballard

School of Public Health Faculty Publications

Introduction: At the completion of treatment, the orthodontic practitioner's goal is to effectively remove all traces of adhesive and return enamel to its initial state. With the advent of new polishing systems being released each year, there may be one product that is superior to others. Aim: The purpose of this study is to determine the efficacy of new polishing systems (in the last 5–10 years) used in general dentistry on enamel surface roughness following debond utilizing profilometery and scanning electron microscopy and compare them to established orthodontic polishing systems results. Methods: Fifty-two mandibular incisors were randomly assigned to one …


A Small Molecule Produced By Lactobacillus Species Blocks Candida Albicans Filamentation By Inhibiting A Dyrk1-Family Kinase, Jessie Macalpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M. Revie, Robert T. Todd, Peter J. Stogios, Hiram Sanchez, Teresa R. O’Meara, Thomas A. Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O. Veri, David R. Andes, Paul L. Fidel, Nicole Robbins, Justin Nodwell, Luke Whitesell, Leah E. Cowen Dec 2021

A Small Molecule Produced By Lactobacillus Species Blocks Candida Albicans Filamentation By Inhibiting A Dyrk1-Family Kinase, Jessie Macalpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M. Revie, Robert T. Todd, Peter J. Stogios, Hiram Sanchez, Teresa R. O’Meara, Thomas A. Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O. Veri, David R. Andes, Paul L. Fidel, Nicole Robbins, Justin Nodwell, Luke Whitesell, Leah E. Cowen

School of Dentistry Faculty Publications

The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacillus are colonizers of human mucosa and can produce compounds with bioactivity against C. albicans. Here, we show that some Lactobacillus species produce a small molecule under laboratory conditions that blocks the C. albicans yeast-to-filament transition, an important virulence trait. It remains unexplored whether the compound is produced in the context of the human host. Bioassay-guided fractionation of Lactobacillus-conditioned medium linked this activity to 1-acetyl-β-carboline (1-ABC). We …


Leukotrienes Are Dispensable For Vaginal Neutrophil Recruitment As Part Of The Immunopathological Response During Experimental Vulvovaginal Candidiasis, Junko Yano, David J. White, Anthony P. Sampson, Floyd L. Wormley, Paul L. Fidel Nov 2021

Leukotrienes Are Dispensable For Vaginal Neutrophil Recruitment As Part Of The Immunopathological Response During Experimental Vulvovaginal Candidiasis, Junko Yano, David J. White, Anthony P. Sampson, Floyd L. Wormley, Paul L. Fidel

School of Dentistry Faculty Publications

Recruitment of polymorphonuclear neutrophils (PMNs) into the vaginal lumen is the hallmark of an acute immunopathologic inflammatory response during vulvovaginal candidiasis (VVC) caused by Candida albicans. Recurrent VVC (RVVC) remains a chronic health burden in affected women worldwide despite the use of antifungal therapy. Based on the role leukotrienes (LTs) play in promoting inflammation, leukotriene receptor antagonists (LTRAs) targeted for LTB4 (etalocib) or LTC4, LTD4, and LTE4 (zafirlukast or montelukast) have been shown to reduce inflammation of epithelial tissues. An open-label pilot study using long-term regimens of zafirlukast in women with RVVC indicated the potential for some relief from recurrent …