Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Chemistry (2)
- Organic Chemicals (2)
- Physical Sciences and Mathematics (2)
- Amino Acids, Peptides, and Proteins (1)
- Biochemistry (1)
-
- Biochemistry, Biophysics, and Structural Biology (1)
- Biophysics (1)
- Diseases (1)
- Heterocyclic Compounds (1)
- Life Sciences (1)
- Macromolecular Substances (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Microbiology (1)
- Pharmaceutical Preparations (1)
- Pharmaceutics and Drug Design (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physical Chemistry (1)
- Polymer Chemistry (1)
- Structural Biology (1)
- Virology (1)
- Virus Diseases (1)
- Keyword
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Polycyclic Compounds
Applied Molecular Dynamics: From Targeting Viral Helicases, To Understanding The Interactions Of Cucurbituril Complexes In Ionic Solutions, Bryan Raubenolt
Applied Molecular Dynamics: From Targeting Viral Helicases, To Understanding The Interactions Of Cucurbituril Complexes In Ionic Solutions, Bryan Raubenolt
LSU New Orleans Theses and Dissertations
Molecular Dynamics simulations are a highly useful tool in helping understand the fundamental interactions present in a variety of chemical systems. The work discussed here illustrates it’s use in determining the conformational dynamics of the Zika and SARS-Cov-2 helicase in a physiological environment, largely in an effort to discover inhibitors capable of rendering the protein inert. Additionally, we show how it can be used to understand paradoxical trends in the anion-induced precipitation of Cucurbituril cavitands.
Viral helicases are motor proteins tasked with unwinding the viral dsRNA, a crucial step in preparing the strand to be translatable by host cells. By …
Ethoxylation And Polymerization Of Cardanol Derived Bifunctional Monomers, James Mgaya
Ethoxylation And Polymerization Of Cardanol Derived Bifunctional Monomers, James Mgaya
Journal of Humanities and Social Sciences
Cardanol and its derivative; 3-(non-8-enyl)phenol (obtained by ethenolysis reaction of cardanol) were ethoxylated via one-pot reaction with urea and ethylene glycol using Na2CO3/ZnO as co-catalysts. The ethoxylates were later methoxycarbonylated using a 1,2-bis(ditertbutylphosphinomethyl)benzene (DTBPMB) modified palladium catalyst to produce ethoxylated bifunctional monomers. Polymerization of these monomers by heating in the presence of a standard polymerization catalyst, Ti(OBu)4, formed oligomers that were plastic-like. Analysis of these oligomers by MALDI-TOF MS indicated the condensation of up to nine monomer units.
Fluorometric Characterization Of A Methylene Blue Derivative Sensitive To Reactive Oxygen Species (Ros), Matthew Weeks
Fluorometric Characterization Of A Methylene Blue Derivative Sensitive To Reactive Oxygen Species (Ros), Matthew Weeks
Honors Theses
Methylene blue (MB) has many uses within both microbiology and pharmacology. MB can treat disorders such as methemoglobinemia, malaria, Alzheimer’s disease, and certain forms of cancer. MB is also useful for molecular imaging due to its off-on fluorescent capabilities. MB derivatives with a urea bond at the 10-N position have been cleavable by triggers such as light. However, I was interested in sensitivity to reactive oxygen species (ROS). In this study, I wanted to determine if the MB derivative MB-EA exhibited sensitivity to ROS. MB-EA was exposed to varying concentrations of hydrogen peroxide and MB release was measured. I concluded …