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Investigating The Effect Of Sodium Benzoate On Immune Cells And Microbial Populations In The Small Intestine Of Murine Species., Shelby Pedigo
Investigating The Effect Of Sodium Benzoate On Immune Cells And Microbial Populations In The Small Intestine Of Murine Species., Shelby Pedigo
Senior Honors Projects, 2010-2019
Dietary ingredients can influence the mucosal surface morphology and mucosal immunity of the gastrointestinal tract. Additional health concerns and behavioral changes have been attributed to the consumption of foods containing preservatives and additives. Sodium benzoate (SB) is a commonly used bacteriostatic in food and beverages. This study investigates the effects of SB on the gut bacteria and mucosal health in the gastrointestinal tract of laboratory mice. The extent of lymphocytic infiltration in intestinal villi and granular density of Paneth cells in the ileum were used as evaluators of mucosal immunity. Adult C57BL/6 mice were randomly assigned to two …