Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Alternative and Complementary Medicine (1)
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
-
- Biomedical and Dental Materials (1)
- Biophysics (1)
- Biotechnology (1)
- Cancer Biology (1)
- Cell and Developmental Biology (1)
- Diseases (1)
- Macromolecular Substances (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Molecular Biology (1)
- Nanomedicine (1)
- Nanotechnology (1)
- Neoplasms (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Therapeutics (1)
- Virus Diseases (1)
Articles 1 - 2 of 2
Full-Text Articles in Other Chemicals and Drugs
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly
Dissertations, Theses, and Capstone Projects
The potency and specificity of bioactive peptides have propelled these agents to the forefront of pharmacological research. However, delivery of peptides to their molecular target in cells is a major obstacle to their widespread application. A Trojan Horse strategy of packaging a bioactive peptide within a modified protein cage to protect it during transport, and releasing it at the target site, is a promising delivery method. Recent work has demonstrated that the viral capsid of the P22 bacteriophage can be loaded with an arbitrary, genetically-encoded peptide, and externally decorated with a cell-penetrating peptide, such as HIV-Tat, to translocate across in …
An In Vitro And In Vivo Evaluation Of The Anticancer Potential Of Resveratrol And Pterostilbene Against Hpv-E6 Positive Cancers, Kaushiki Chatterjee
An In Vitro And In Vivo Evaluation Of The Anticancer Potential Of Resveratrol And Pterostilbene Against Hpv-E6 Positive Cancers, Kaushiki Chatterjee
Dissertations, Theses, and Capstone Projects
Cervical cancer remains as one of the most prevalent cancers effecting women globally. Lack of awareness and affordable prophylactic and therapeutic options in developing countries drive the need for alternative low-cost approaches. Dietary polyphenols have gained increased attention as possible anti-cancer agents. Our study aims to investigate whether two natural structural analogs, resveratrol and pterostilbene, exhibit anti-HPV (Human papillomavirus) activity in cervical cancer. To determine the efficacy of these polyphenols, extensive in vitro and in vivo analyses were carried out. For the in vitro studies we utilized human HeLa cells (HPV18 positive) and murine TC1 cells (HPV 16 oncogene positive). …