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Articles 1 - 4 of 4
Full-Text Articles in Other Chemicals and Drugs
The Effect Of Photoactivated Tmp On Burkholderia Cepacia Biofilms, Reyna G. Osorio, Chandra N. Swiech, Tracy L. Collins
The Effect Of Photoactivated Tmp On Burkholderia Cepacia Biofilms, Reyna G. Osorio, Chandra N. Swiech, Tracy L. Collins
The Research and Scholarship Symposium (2013-2019)
Burkholderia cepacia is an opportunistic pathogen that causes infections in immunocompromised individuals such as cystic fibrosis patients. B. cepacia infections are typically characterized by the formation of complex communities of cells known as biofilms. Because B. cepacia biofilms are difficult to eradicate using antibiotics, it is important to pursue alternative treatment methods. Photodynamic therapy (PDT) is a type of therapy that uses light, a photosensitizer, and oxygen to elicit cell death through the production of reactive oxygen species. PDT has been shown in previous studies to be successful in killing both Pseudomonas aeruginosa and Staphylococcus aureus. In this study, we …
E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins
E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins
The Research and Scholarship Symposium (2013-2019)
Burkholderia cepacia and Candida albicans both exhibit cell-to-cell communication through the use of quorum-sensing molecules (QSM) known as autoinducers. E,E-farnesol is a QSM produced by C. albicans which regulates its conversion from yeast to mycelium. Because there is a positive correlation between the presence of B. cepacia and C. albicans in the lungs of individuals with cystic fibrosis (CF), we examined whether E,E-farnesol had an effect on swarming motility in B. cepacia. Swarming motility was inhibited when B. cepacia was exposed to 250 µM of E,E-farnesol. In addition, there was a 26.8% decrease in rhamnolipid production when cells were grown …
The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson
The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson
The Research and Scholarship Symposium (2013-2019)
Glioblastoma multiforme (GBM) is a WHO grade IV brain tumor. These tumors are highly proliferative, infiltrative, necrotic, angiogenic, and resistant to apoptosis. One major characteristic of GBM is the overexpression of epidermal growth factor receptor (EGFR), which leads to cell growth and proliferation when activated. GBM is very difficult to treat due to its location, heterogeneity, and invasiveness; an effective treatment is therefore needed. The use of flavonoids, which are natural compounds found in many fruits and vegetables, has been studied in the treatment of many different tumor types. Apigenin is a specific flavonoid that has previously been shown to …
Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg
Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg
The Research and Scholarship Symposium (2013-2019)
Individuals with intellectual and developmental disabilities (IDD) are commonly prescribed antiepileptic drugs (AEDs) to manage seizures, manage behavior, and stabilize mood. Though research has been done on the effects of antiepileptic medications in patients with epilepsy, little study has been done on the persons with intellectual and developmental disabilities population. After surveying IDD patients with a history and current use of AEDs on osteoprotective behaviors, we were unable to use SPSS due to incomplete surveys and low sample sizes. However, we were still able to analyze for common themes, and we found that the most prevalent use of AEDs was …