Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animal Structures (1)
- Animal Studies (1)
-
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Factors (1)
- Biophysics (1)
- Cardiovascular Diseases (1)
- Cardiovascular System (1)
- Chemical Actions and Uses (1)
- Computational Neuroscience (1)
- Diagnosis (1)
- Diseases (1)
- Enzymes and Coenzymes (1)
- Inorganic Chemicals (1)
- Life Sciences (1)
- Medical Biophysics (1)
- Medical Sciences (1)
- Molecular and Cellular Neuroscience (1)
- Neuroscience and Neurobiology (1)
- Other Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Other Biochemistry, Biophysics, and Structural Biology (1)
- Pharmaceutics and Drug Design (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Social and Behavioral Sciences (1)
- Keyword
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Organic Chemicals
Endothelial And Smooth Muscle-Dependent Vascular Reactivity In Immature Arterialized Collateral Capillaries, Caitlin Koeroghlian
Endothelial And Smooth Muscle-Dependent Vascular Reactivity In Immature Arterialized Collateral Capillaries, Caitlin Koeroghlian
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) occurs due to the build up of atherosclerotic plaque and reduces blood flow to cause chronic ischemia. Patients with PAOD may experience intermittent claudication, or the pain in limb skeletal muscles due to a decease in blood flow. Collateral arteries can act as a natural bypass and improve blood flow to hypoxic tissue by creating an alternate route for blood to flow, but not all patients with PAOD have pre-existing collateral networks. Animal studies indicate that tissues without pre-existing collateral networks can form de novo collaterals from capillaries following occlusion of a feed artery. Unfortunately, …
Rescuing Acetylcholinesterase From Nerve Agent Inhibition: Protein Dynamics Driven Drug Discovery, Aiyana M. Emigh, Brian Bennion
Rescuing Acetylcholinesterase From Nerve Agent Inhibition: Protein Dynamics Driven Drug Discovery, Aiyana M. Emigh, Brian Bennion
STAR Program Research Presentations
Severe morbidity and mortality consequences result from irreversible inhibition of human acetylcholinesterase by organophosphates (OPs). Oxime-based reactivators are currently the only available treatments but lack efficacy in the central nervous system (CNS) where the most damage occurs. Computational docking and molecular dynamics (MD) simulations reveal complex structural barriers that may reduce oxime efficacy. These results may guide future drug designs of more effective countermeasures.
Life As A Swimmer, Danielle N. Coville
Life As A Swimmer, Danielle N. Coville
Chemistry and Biochemistry
No abstract provided.