Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biomaterials (2)
- Biomedical Engineering and Bioengineering (2)
- Engineering (2)
- Molecular, Cellular, and Tissue Engineering (2)
- Social and Behavioral Sciences (2)
-
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animal Structures (1)
- Biochemical and Biomolecular Engineering (1)
- Bioimaging and Biomedical Optics (1)
- Biological Engineering (1)
- Biomechanics and Biotransport (1)
- Biomedical and Dental Materials (1)
- Chemical Engineering (1)
- Criminology (1)
- Economics (1)
- Education (1)
- Genetic Processes (1)
- Health and Physical Education (1)
- Macromolecular Substances (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Musculoskeletal, Neural, and Ocular Physiology (1)
- Nanomedicine (1)
- Nanoscience and Nanotechnology (1)
- Nanotechnology (1)
- Nervous System (1)
- Institution
- Keyword
-
- 1242 (1)
- 3D Printing (1)
- Adult (1)
- Age Factors (1)
- Alanine Transaminase (1)
-
- Analgesics (1)
- Australia (1)
- Brain tumor (1)
- Breast Cancer (1)
- Case-Control Studies (1)
- Cross-Sectional Studies (1)
- Disruptive (1)
- Emerging (1)
- Female (1)
- Fluorescent imaging (1)
- Glioma (1)
- Healthcare (1)
- Heparin Sulfate (1)
- Humans (1)
- Integration (1)
- Iodine nanoparticles (1)
- Localization (1)
- Longitudinal Studies (1)
- Male (1)
- Nanoparticle localization (1)
- Novel nanoparticles (1)
- Opioid (1)
- Opioid-Related Disorders (1)
- PPC (1)
- Platinum (1)
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Inorganic Chemicals
Distribution And Localization Of Novel Iodine Nanoparticles In The Human Glioma 1242 Growing In The Brains Of Mice, Benjamin Billings
Distribution And Localization Of Novel Iodine Nanoparticles In The Human Glioma 1242 Growing In The Brains Of Mice, Benjamin Billings
Honors Scholar Theses
Observing and designing the in vivo distribution and localization of therapeutic nanoparticles is an essential aspect of developing and understanding novel nanoparticle- based medical treatments. This study investigates novel PEGylated Iodine-based nanoparticles (INPs), an alternate composition to the more widely researched gold nanoparticles (AuNPs), which may help avoid adverse effects associated with AuNPs, such as potential toxicity and skin discoloration, when used in similar applications. Determining the localization of the novel INPs within murine brains containing human glioma U-1242MG cells is critical in assisting the development of radiation dose enhancement therapy for this aggressive cancer. Radiation dose enhancement utilizes the …
What Are The Characteristics Of Vitamin D Metabolism In Opioid Dependence? An Exploratory Longitudinal Study In Australian Primary Care, Albert Stuart Reece, Gary Hulse
What Are The Characteristics Of Vitamin D Metabolism In Opioid Dependence? An Exploratory Longitudinal Study In Australian Primary Care, Albert Stuart Reece, Gary Hulse
Research outputs 2014 to 2021
OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).
DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).
SETTING: Primary care.
PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p
INTERVENTIONS: Nil. Observational study only.
PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels and relevant …
The Effects Of Emerging Technology On Healthcare And The Difficulties Of Integration, Skyler J. Pavlish-Carpenter
The Effects Of Emerging Technology On Healthcare And The Difficulties Of Integration, Skyler J. Pavlish-Carpenter
Honors Undergraduate Theses
Background: Disruptive technology describes technology that is significantly more advanced than previous iterations, such as: 3D printing, genetic manipulation, stem cell research, innovative surgical procedures, and computer-based charting software. These technologies often require extensive overhauls to implement into older systems and must overcome many difficult financial and societal complications before they can be widely used. In a field like healthcare that makes frequent advancements, these difficulties can mean that the technology will not be utilized to its full potential or implemented at all.
Objective: To determine the inhibiting factors that prevent disruptive technology from being implemented in conventional healthcare.
Methods: …
Heparan Sulfate, A New Target For Platinum In Metastatic Tnbc, Samantha J. Katner
Heparan Sulfate, A New Target For Platinum In Metastatic Tnbc, Samantha J. Katner
Theses and Dissertations
Abstract
Heparan Sulfate, A New Target for Platinum in Metastatic TNBC
Author: Samantha J. Katner, Ph.D.
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy
Virginia Commonwealth University, 2018
Advisor: Dr. Nicholas Farrell, Professor, Chemistry Department
Heparan sulfate proteoglycans (HSPGs), composed of the linear polysaccharide heparan sulfate (HS) conjugated to a protein core, are located on the cell surface and extracellular matrix. The HS chains display varying degrees of sulfation, which constitutes the molecular recognition motif for many HS-protein interactions. HSPGs, associated growth factors, and heparanase promote tumor progression by facilitating invasion, angiogenesis, …