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Chemical Variability In The Unregulated Opioid Supply In The South Bronx, Yeireline Rodriguez
Chemical Variability In The Unregulated Opioid Supply In The South Bronx, Yeireline Rodriguez
Student Theses
The unregulated drug supply in the United States has become increasingly unpredictable, contributing to persistently high overdose mortality, particularly in structurally marginalized communities such as the South Bronx. While drug adulteration has long been present in illicit markets, the number and pharmacological diversity of adulterants remained limited for much of the twentieth century. Over the past decade, however, the drug supply has undergone a significant transformation marked by the proliferation of potent synthetic opioids such as fentanyl and its analogues, frequently combined with novel sedatives and chemically diverse adulterants. These shifts have introduced increasing chemical complexity into the street drug …
Engineered Plga Nanofibers For Drug Delivery, Andrew Mancuso
Engineered Plga Nanofibers For Drug Delivery, Andrew Mancuso
Dissertations, Theses, and Capstone Projects
Poly-lactic-co-glycolic acid (PLGA) polymers are rapidly gaining momentum as a platform for next-generation drug delivery systems due to their ease and low cost of synthesis, favorable biocompatibility and biodegradability, and lack of toxicity. In particular, the application of drug-loaded PLGA nanofibers directly to a target tissue may represent a promising alternative to traditional routes of drug administration (e.g., oral, injectable) as they offer the potential to greatly improve bioavailability, increase efficacy, and reduce off-target toxicity. Furthermore, the use of such a system may potentially allow for greater flexibility in clinical drug development, by enabling the use of compounds which have …