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Full-Text Articles in Carbohydrates
Towards Developing Glut2 Specific Probes For Biochemical And Biomedical Applications, Abdelrahman Ismail
Towards Developing Glut2 Specific Probes For Biochemical And Biomedical Applications, Abdelrahman Ismail
Dissertations, Master's Theses and Master's Reports
Facilitated Glucose transporters (GLUTs) are membrane proteins responsible for the uptake of simple sugars and other structurally similar metabolites in all mammalian cells. One of the hallmarks of cancer is dysfunctional sugar metabolism, known as the Warburg effect, and one of the manifestations of that effect is abnormal GLUT expression. There are 14 known GLUT proteins with different expression patterns in different tissues, and tumors tend to express certain GLUTs that are not present in surrounding healthy tissue. Therefore, selective targeting of GLUTs presents a potentially powerful tool for diagnostics and treatment of cancer and other diseases. This has been …