Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (3)
- Cell Biology (2)
- Cell and Developmental Biology (2)
- Medical Sciences (2)
- Medicinal Chemistry and Pharmaceutics (2)
-
- Pharmacology, Toxicology and Environmental Health (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Bacteria (1)
- Bacterial Infections and Mycoses (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Bioinformatics (1)
- Biotechnology (1)
- Cells (1)
- Chemical Actions and Uses (1)
- Diagnosis (1)
- Diseases (1)
- Equipment and Supplies (1)
- Heterocyclic Compounds (1)
- Immunology and Infectious Disease (1)
- Lipids (1)
- Medical Biotechnology (1)
- Medical Genetics (1)
- Medical Molecular Biology (1)
- Molecular Biology (1)
- Nanomedicine (1)
- Nanotechnology (1)
Articles 1 - 4 of 4
Full-Text Articles in Biological Factors
The Myopia Epidemic: Integrating Genetic, Environmental, And Epigenetic Pathways To Define A Critical Window For Intervention, Pranavika Balaji
The Myopia Epidemic: Integrating Genetic, Environmental, And Epigenetic Pathways To Define A Critical Window For Intervention, Pranavika Balaji
UROP Posters
Myopia, or nearsightedness, has increased rapidly worldwide and is now a major public health concern caused by both genetic and environmental factors. Current understanding shows that too much near work, limited time spent outdoors, and prolonged screen use contribute to abnormal eye growth in individuals who may already have a genetic predisposition. At the molecular level, epigenetic changes and shifts in DNA activity, often influenced by environmental conditions, affect the signaling pathways that regulate eye development and may help explain why myopia is increasingly common among children. This paper synthesizes recent environmental, genetic, and epigenetic research to explain how these …
Comparison Of Free Versus Encapsulated Drugs On 3t3 Differentiation, Simon H. Friedrich, Gabriel Volpe
Comparison Of Free Versus Encapsulated Drugs On 3t3 Differentiation, Simon H. Friedrich, Gabriel Volpe
UROP Posters
The scope of this project was to design, synthesize and test targeted nanoparticles containing hydrophobic and hydrophilic drugs that promote browning in adipose tissue. For hydrophilic drugs the use of liposomes and their hydrophilic core is more useful than the PLGA nanoparticles which have hydrophobic cores. The inhibition of the FOXO1 pathway and modulation of autophagy in adipose tissue can promote browning of white adipose tissue, or an energy burning state where excess energy is burned as heat instead of stored in the cell. If successful, these drugs would offer an alternative treatment for obesity where changes to the patient's …
Effect Of Energy Metabolism On Nf-Kb Activity In Ovarian Cancer, Simren K. Bagri
Effect Of Energy Metabolism On Nf-Kb Activity In Ovarian Cancer, Simren K. Bagri
UROP Posters
NF-kB is a transcription factor involved in cancer cell growth and survival. The activation of NF-kB can be assessed by monitoring phosphorylation of RelA p65 at Ser-536, which is a surrogate of the NF-kB transcription factor activation. The objective of this study was to determine if the loss of ATP leads to NF-kB deficiency and thus, apoptotic cell death of “bad” cells in ovarian cancer cells. The independent variables were metformin (Met), an anti-diabetic medicine, another compound MinB functionally similar to Met and a glucose transporter inhibitor BAY-876. The dependent variables were the resulting effect of Met and MinB on …
Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet
Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet
UROP Posters
The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results of …